Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | microphthalmia-associated transcription factor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1856 | 0.1578 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0481 | 0.0686 |
Echinococcus multilocularis | transcription factor eb | 0.013 | 0.6052 | 0.5917 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0064 | 0.2525 | 0.2269 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2953 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2269 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0331 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.1856 | 0.2392 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.1856 | 0.1578 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.1856 | 0.1578 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6786 | 0.8689 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.1856 | 0.1578 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.5028 | 0.4858 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0064 | 0.2525 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0331 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2269 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2269 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2269 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1433 | 0.114 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1433 | 1 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.013 | 0.6052 | 0.7798 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0481 | 0.0686 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6786 | 0.8689 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0331 | 0.0426 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1856 | 0.1578 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2269 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1433 | 0.114 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0331 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.3253 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0481 | 0.0686 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1433 | 0.1846 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0162 | 0.7761 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1433 | 0.114 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0481 | 0.0686 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0331 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0481 | 0.062 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.013 | 0.6018 | 0.7655 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1856 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1856 | 0.2053 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0481 | 0.0686 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0064 | 0.2525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.6018 | 0.7655 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0064 | 0.2525 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0064 | 0.2525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1856 | 0.1578 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0481 | 0.0203 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0064 | 0.2525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.7761 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.1856 | 0.1578 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1433 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus granulosus | transcription factor eb | 0.013 | 0.6052 | 0.5917 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0331 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0064 | 0.2525 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.1856 | 0.1578 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0064 | 0.2525 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1433 | 0.114 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.1856 | 0.2392 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0111 | 0.5028 | 0.6479 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.1856 | 0.1578 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0064 | 0.2525 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0162 | 0.7761 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0481 | 0.0686 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.2269 |
Brugia malayi | Isocitrate dehydrogenase | 0.0064 | 0.2525 | 0.3253 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6786 | 0.8745 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0064 | 0.2525 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5028 | 0.6322 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0064 | 0.2525 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0162 | 0.7761 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.1856 | 0.2053 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1433 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0331 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0481 | 0.0686 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0481 | 0.0686 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 14.706 uM | PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] | ChEMBL. | No reference |
AC50 (functional) | = 14.706 uM | PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] | ChEMBL. | No reference |
AC50 (functional) | = 14.706 uM | PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] | ChEMBL. | No reference |
EC50 (functional) | > 120 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 0.9466 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6626 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (binding) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.