Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | Diphosphomevalonate decarboxylase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cuticle collagen 6 homolog | Diphosphomevalonate decarboxylase | 317 aa | 317 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mevalonate galactokinase | 0.0026 | 0.0053 | 0.0054 |
Echinococcus granulosus | tar DNA binding protein | 0.0419 | 0.9939 | 1 |
Giardia lamblia | Diphosphomevalonate decarboxylase | 0.0057 | 0.0829 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.074 | 0.8854 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.074 | 0.8854 |
Trichomonas vaginalis | diphosphomevalonate decarboxylase, putative | 0.0057 | 0.0829 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.074 | 0.069 |
Schistosoma mansoni | diphosphomevalonate decarboxylase | 0.0057 | 0.0829 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0551 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0419 | 0.9939 | 0.9939 |
Echinococcus granulosus | Mevalonate galactokinase | 0.0026 | 0.0053 | 0.0054 |
Mycobacterium tuberculosis | Probable galactokinase GalK (galactose kinase) | 0.0026 | 0.0053 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0419 | 0.9939 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.2753 | 0.2769 |
Echinococcus multilocularis | tar DNA binding protein | 0.0419 | 0.9939 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0133 | 0.2753 | 0.2769 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0422 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0419 | 0.9939 | 0.9939 |
Loa Loa (eye worm) | diphosphomevalonate decarboxylase | 0.0046 | 0.0551 | 0.0501 |
Leishmania major | mevalonate-diphosphate decarboxylase, putative | 0.0057 | 0.0829 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0133 | 0.2753 | 0.2714 |
Brugia malayi | diphosphomevalonate decarboxylase family protein | 0.0057 | 0.0829 | 0.078 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.074 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0133 | 0.2753 | 0.2714 |
Schistosoma mansoni | hypothetical protein | 0.0288 | 0.6646 | 0.6686 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.074 | 0.8854 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.074 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0133 | 0.2753 | 0.2769 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0133 | 0.2753 | 0.2769 |
Entamoeba histolytica | galactokinase, putative | 0.0026 | 0.0053 | 0.5 |
Trypanosoma brucei | mevalonate diphosphate decarboxylase | 0.0057 | 0.0829 | 1 |
Treponema pallidum | hypothetical protein | 0.0026 | 0.0053 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0419 | 0.9939 | 1 |
Echinococcus multilocularis | N acetylgalactosamine kinase | 0.0026 | 0.0053 | 0.0054 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.074 | 0.5 |
Echinococcus granulosus | diphosphomevalonate decarboxylase | 0.0057 | 0.0829 | 0.0834 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.2753 | 0.2769 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.074 | 0.069 |
Onchocerca volvulus | 0.0057 | 0.0829 | 0.5 | |
Echinococcus granulosus | galactokinase | 0.0026 | 0.0053 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0419 | 0.9939 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0133 | 0.2753 | 0.2714 |
Echinococcus multilocularis | GPCR, family 2 | 0.0133 | 0.2753 | 0.2769 |
Trypanosoma cruzi | mevalonate-diphosphate decarboxylase, putative | 0.0057 | 0.0829 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.2753 | 0.2769 |
Schistosoma mansoni | galactokinase | 0.0026 | 0.0053 | 0.0054 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.6067 | 0.6046 |
Echinococcus multilocularis | diphosphomevalonate decarboxylase | 0.0057 | 0.0829 | 0.0834 |
Schistosoma mansoni | tar DNA-binding protein | 0.0419 | 0.9939 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0419 | 0.9939 | 0.9939 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0419 | 0.9939 | 0.9939 |
Brugia malayi | RNA binding protein | 0.0419 | 0.9939 | 0.9939 |
Schistosoma mansoni | tar DNA-binding protein | 0.0419 | 0.9939 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.074 | 0.8854 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.2753 | 0.2769 |
Schistosoma mansoni | mevalonate kinase | 0.0026 | 0.0053 | 0.0054 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.074 | 0.5 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0264 | 0.0212 |
Trypanosoma brucei | mevalonate-diphosphate decarboxylase | 0.0057 | 0.0829 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0419 | 0.9939 | 0.9939 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.6067 | 0.6046 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0288 | 0.6646 | 0.6628 |
Mycobacterium tuberculosis | Possible D-alpha-D-heptose-7-phosphate kinase HddA | 0.0026 | 0.0053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.6646 | 0.6628 |
Echinococcus multilocularis | galactokinase | 0.0026 | 0.0053 | 0.0054 |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0026 | 0.0053 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0422 | 1 | 1 |
Echinococcus granulosus | N acetylgalactosamine kinase | 0.0026 | 0.0053 | 0.0054 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0133 | 0.2753 | 0.2769 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.6067 | 0.6046 |
Trypanosoma cruzi | mevalonate-diphosphate decarboxylase, putative | 0.0057 | 0.0829 | 1 |
Mycobacterium ulcerans | diphosphomevalonate decarboxylase | 0.0057 | 0.0829 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0026 | 0.0053 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0133 | 0.2753 | 0.2769 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2753 | 0.2714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 18.4 um | PUBCHEM_BIOASSAY: Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC - Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 549, 556, 550, 557, 555, 1000, 539 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.