Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0185 | 0.224 | 0.6638 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.018 | 0.0517 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.018 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.4976 | 0.4973 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.018 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0006 | 0.0006 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0185 | 0.224 | 0.6638 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.3371 | 0.6567 |
Brugia malayi | DIX domain containing protein | 0.0019 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.018 | 0.0174 |
Schistosoma mansoni | hypothetical protein | 0.0401 | 0.513 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0586 | 0.7621 | 0.7621 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0401 | 0.513 | 0.513 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.513 | 0.5127 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.7621 | 0.762 |
Loa Loa (eye worm) | TAR-binding protein | 0.027 | 0.3371 | 0.3367 |
Brugia malayi | RNA binding protein | 0.027 | 0.3371 | 0.3371 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0138 | 0.0138 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.018 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0283 | 0.3552 | 0.3548 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0019 | 0.0006 | 0.0006 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.3371 | 0.6567 |
Brugia malayi | glutaminase DH11.1 | 0.0283 | 0.3552 | 0.3552 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.018 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0185 | 0.224 | 0.6638 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.018 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.3371 | 0.6567 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0185 | 0.224 | 0.224 |
Onchocerca volvulus | 0.0763 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0019 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | RNA binding protein | 0.027 | 0.3371 | 0.3367 |
Trichomonas vaginalis | glutaminase, putative | 0.0283 | 0.3552 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0389 | 0.4976 | 0.4973 |
Loa Loa (eye worm) | glutaminase | 0.0283 | 0.3552 | 0.3548 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0138 | 0.7584 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0185 | 0.224 | 0.224 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.224 | 0.4359 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.018 | 0.034 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0185 | 0.224 | 0.2235 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0586 | 0.7621 | 0.7621 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.3371 | 0.6567 |
Brugia malayi | N-terminal motif family protein | 0.0389 | 0.4976 | 0.4976 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.224 | 0.4359 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.018 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0138 | 0.0132 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0586 | 0.7621 | 0.762 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.018 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0185 | 0.224 | 0.6638 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.018 | 0.0517 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0763 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.018 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0185 | 0.224 | 0.6638 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0185 | 0.224 | 0.6638 |
Schistosoma mansoni | glutaminase | 0.0283 | 0.3552 | 0.692 |
Brugia malayi | TAR-binding protein | 0.027 | 0.3371 | 0.3371 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.224 | 0.4359 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.018 | 0.0517 |
Echinococcus granulosus | tar DNA binding protein | 0.027 | 0.3371 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.018 | 0.0517 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0019 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.027 | 0.3371 | 0.3367 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0019 | 0.0006 | 0.0006 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.018 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.018 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.224 | 0.2235 |
Brugia malayi | RNA recognition motif domain containing protein | 0.027 | 0.3371 | 0.3371 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 0.3371 | 0.6567 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.018 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.027 | 0.3371 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.224 | 0.4359 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.018 | 0.018 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.018 | 0.018 |
Mycobacterium ulcerans | glutaminase | 0.0283 | 0.3552 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.