Detailed information for compound 1427220

Basic information

Technical information
  • TDR Targets ID: 1427220
  • Name: 8-[(3-methoxyphenyl)methyl]-6-phenylpteridin- 7-one
  • MW: 344.367 | Formula: C20H16N4O2
  • H donors: 0 H acceptors: 3 LogP: 2.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)Cn1c2ncncc2nc(c1=O)c1ccccc1
  • InChi: 1S/C20H16N4O2/c1-26-16-9-5-6-14(10-16)12-24-19-17(11-21-13-22-19)23-18(20(24)25)15-7-3-2-4-8-15/h2-11,13H,12H2,1H3
  • InChiKey: NTKIQKLLOSUUDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[(3-methoxyphenyl)methyl]-6-phenyl-pteridin-7-one
  • 8-[(3-methoxyphenyl)methyl]-6-phenyl-7-pteridinone
  • 8-(3-methoxybenzyl)-6-phenyl-pteridin-7-one
  • PCOP-650710
  • NCGC00011906

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.002 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0095 0.061
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0028 0.0042 0.0422
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Brugia malayi Nuclear hormone receptor-like 1 0.0268 0.0816 0.0813
Trypanosoma cruzi polo-like protein kinase, putative 0.0299 0.0915 1
Brugia malayi Pip kinase protein 1 0.0028 0.0042 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0268 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Brugia malayi hypothetical protein 0.0142 0.0408 0.0405
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0028 0.0042 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0268 0.0816 0.0813
Loa Loa (eye worm) hypothetical protein 0.024 0.0726 0.0726
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0095 0.061
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0003 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0268 0.0816 0.0813
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.035 0.1081 0.1129
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0095 0.0096
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0056 0.0053
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0095 0.0093
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0028 0.0042 0.0422
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0028 0.0042 0.004
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0028 0.0042 0.0422
Echinococcus granulosus lamin dm0 0.0033 0.0056 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.002 0.0264
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0299 0.0915 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0268 0.0816 0.0813
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0268 0.0816 0.0815
Onchocerca volvulus 0.0268 0.0816 0.7419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0268 0.0816 0.0816
Schistosoma mansoni RAR-like nuclear receptor 0.0268 0.0816 0.0852
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0028 0.0042 0.004
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0042 0.0388
Brugia malayi conserved hypotetical protein 0.0127 0.0359 0.0356
Brugia malayi nuclear hormone receptor family member nhr-6 0.0127 0.0359 0.0356
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0268 0.0816 0.0852
Brugia malayi nuclear receptor RXR 0.0142 0.0408 0.0405
Schistosoma mansoni cytochrome P450 0.0021 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0095 0.1007
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Echinococcus multilocularis FTZ F1 alpha 0.0268 0.0816 0.0815
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.002 0.0264
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 1
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0028 0.0042 0.0388
Schistosoma mansoni thyroid hormone receptor 0.0268 0.0816 0.0852
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0142 0.0408 0.0424
Echinococcus granulosus lamin 0.0033 0.0056 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0127 0.0359 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0268 0.0816 0.0816
Loa Loa (eye worm) pip kinase 1 0.0028 0.0042 0.0042
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0324 0.0997 1
Leishmania major cytochrome p450-like protein 0.0021 0.002 0.0183
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.002 0.0264
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0268 0.0816 0.0815
Brugia malayi Nuclear hormone receptor E75 0.0127 0.0359 0.0356
Schistosoma mansoni nuclear hormone receptor 0.0127 0.0359 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Onchocerca volvulus 0.0127 0.0359 0.2959
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.002 0.0264
Echinococcus granulosus GPCR family 2 0.0111 0.031 0.0308
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Loa Loa (eye worm) cytochrome P450 0.0021 0.002 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0142 0.0408 0.0408
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0028 0.0042 0.0422
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0112 0.0312 0.3101
Brugia malayi ecdysone receptor 0.0127 0.0359 0.0356
Brugia malayi N-terminal motif family protein 0.0177 0.0523 0.052
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.002 0.0264
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0268 0.0816 0.0852
Loa Loa (eye worm) nuclear receptor NHR-67 0.0127 0.0359 0.0359
Brugia malayi tailless protein 0.0127 0.0359 0.0356
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0095 0.061
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0028 0.0042 0.0422
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0028 0.0042 0.004
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0299 0.0915 0.0915
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.002 0.0264
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0007 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0268 0.0816 0.0813
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0028 0.0042 0.0422
Brugia malayi cytochrome P450 0.0021 0.002 0.0017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0142 0.0408 0.0406
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0095 0.1007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.3117 1 1
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0028 0.0042 0.0388
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0095 0.061
Onchocerca volvulus Protein ultraspiracle homolog 0.0268 0.0816 0.7419
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0054 0.0557
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.002 0.0264
Loa Loa (eye worm) pip kinase 2 0.035 0.1081 0.1081
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.002 0.0264
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0111 0.031 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0054 0.0557
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0268 0.0816 0.0813
Loa Loa (eye worm) hypothetical protein 0.0142 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Brugia malayi steroid hormone receptor 0.0268 0.0816 0.0813
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0268 0.0816 0.0815
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0054 0.0054
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0028 0.0042 0.0422
Brugia malayi Nuclear hormone receptor E75 0.0127 0.0359 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0268 0.0816 0.0816
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0028 0.0042 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.0268 0.0816 0.0852
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0268 0.0816 0.0815
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0051
Echinococcus granulosus thyroid hormone receptor alpha 0.0127 0.0359 0.0358
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0169 0.0169
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0142 0.0408 0.0424
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0028 0.0042 0.0422
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0095 0.0093
Giardia lamblia Kinase, PLK 0.0299 0.0915 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0028 0.0042 0.004
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0095 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0268 0.0816 0.0813
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0268 0.0816 0.0815
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0028 0.0042 0.004
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0324 0.0997 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0127 0.0359 0.0358
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0268 0.0816 0.0852
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0324 0.0997 0.0995
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.002 0.0264
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0127 0.0359 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0268 0.0816 0.0815
Loa Loa (eye worm) hypothetical protein 0.0352 0.1085 0.1085
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.002 0.0018
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0127 0.0359 0.0373
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0127 0.0359 0.0358
Schistosoma mansoni thyroid hormone receptor 0.0268 0.0816 0.0852
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0268 0.0816 0.0815
Echinococcus granulosus ecdysone induced protein 78C 0.0268 0.0816 0.0815
Brugia malayi Calcitonin receptor-like protein seb-1 0.0352 0.1085 0.1082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0268 0.0816 0.0815
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0095 0.0093
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.002 0.0264
Schistosoma mansoni peptidase Clp (S14 family) 0.0324 0.0997 0.1042
Echinococcus multilocularis GPCR, family 2 0.0111 0.031 0.0308
Onchocerca volvulus 0.035 0.1081 1
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Schistosoma mansoni coup transcription factor 0.0268 0.0816 0.0852
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.0359 0.0358
Leishmania major cytochrome p450-like protein 0.0021 0.002 0.0183
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0028 0.0042 0.0422
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0028 0.0042 0.0422
Echinococcus multilocularis musashi 0.0033 0.0056 0.0054
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0028 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0127 0.0359 0.0359
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0095 0.1007
Toxoplasma gondii hypothetical protein 0.0112 0.0312 0.3101
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.0915 0.0956
Schistosoma mansoni hypothetical protein 0.024 0.0726 0.0758
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.002 0.0264
Brugia malayi Nuclear hormone receptor-like 1 0.0142 0.0408 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0268 0.0816 0.0813
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0028 0.0042 0.0388
Onchocerca volvulus Serine\/threonine kinase homolog 0.0299 0.0915 0.8386
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0127 0.0359 0.0358
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0054 0.0054
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0028 0.0042 0.0422
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0056 0.0056
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0056 0.0056
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0557
Schistosoma mansoni hypothetical protein 0.0111 0.031 0.0321
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0142 0.0408 0.0408
Schistosoma mansoni lamin 0.0033 0.0056 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.1085 0.1082
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0028 0.0042 0.004
Schistosoma mansoni zinc finger protein 0.0127 0.0359 0.0373
Echinococcus multilocularis lamin 0.0033 0.0056 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0127 0.0359 0.0358
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0324 0.0997 0.0995
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0268 0.0816 0.0813
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0095 0.0093
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0127 0.0359 0.2959
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0054 0.0054
Brugia malayi nuclear receptor RXR 0.0127 0.0359 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0028 0.0042 0.0422
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.002 0.0264
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0095 0.0096
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.002 0.0183
Loa Loa (eye worm) hypothetical protein 0.0045 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.002 0.0264
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0127 0.0359 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0268 0.0816 0.0813
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0112 0.0312 0.3101
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0352 0.1085 0.1085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.031 0.0308
Schistosoma mansoni nuclear hormone receptor 0.0268 0.0816 0.0852
Brugia malayi orphan nuclear receptor NR2E1 0.0127 0.0359 0.0356
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.002 0.0264
Loa Loa (eye worm) hypothetical protein 0.035 0.1081 0.1081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.031 0.0308
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.031 0.031
Brugia malayi intermediate filament protein 0.0033 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Schistosoma mansoni nuclear receptor 0.0127 0.0359 0.0373
Echinococcus granulosus peptidase Clp S14 family 0.0213 0.0637 0.0635
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0268 0.0816 0.7419
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Brugia malayi nuclear receptor NHR-88 0.0268 0.0816 0.0813
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.002 0.0183
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0095 0.0093
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0268 0.0816 0.0813
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0028 0.0042 0.0422
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0127 0.0359 0.2959
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.002 0.0264
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0268 0.0816 0.0815
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0095 0.1007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.031 0.0307
Brugia malayi hypothetical protein 0.0142 0.0408 0.0405
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.031 0.0308
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0142 0.0408 0.0406
Loa Loa (eye worm) DR-78 0.0127 0.0359 0.0359
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 0.5
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0028 0.0042 0.0388
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Brugia malayi ecdysteroid receptor 0.0268 0.0816 0.0813
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.3117 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0324 0.0997 1
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.035 0.1081 0.1079
Brugia malayi nuclear hormone receptor family member odr-7 0.0127 0.0359 0.0356
Loa Loa (eye worm) hypothetical protein 0.0111 0.031 0.031
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0112 0.0312 0.2983
Brugia malayi Latrophilin receptor protein 2 0.0111 0.031 0.0307
Echinococcus granulosus nuclear receptor nhr 48 0.0127 0.0359 0.0358
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.002 0.0168
Brugia malayi nuclear hormone receptor 0.0268 0.0816 0.0813
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0028 0.0042 0.0422
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.002 0.0183
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0268 0.0816 0.0815
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.0523 0.456
Brugia malayi Cytochrome P450 family protein 0.0021 0.002 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0054 0.0557
Brugia malayi Pip kinase protein 2 0.035 0.1081 0.1078
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.035 0.1081 0.1079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0268 0.0816 0.0852
Loa Loa (eye worm) hypothetical protein 0.0268 0.0816 0.0816
Onchocerca volvulus 0.0127 0.0359 0.2959
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.0726 0.0723
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.3117 1 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.0523 0.0523
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0127 0.0359 0.0358
Brugia malayi photoreceptor-specific nuclear receptor 0.0268 0.0816 0.0813
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0007 0.0007
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0028 0.0042 0.0388
Echinococcus granulosus intermediate filament protein 0.0033 0.0056 0.0054
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0054 0.0349
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0028 0.0042 0.0422
Schistosoma mansoni nuclear receptor nhr-48 0.0127 0.0359 0.0373
Brugia malayi Nuclear hormone receptor-like 1 0.0142 0.0408 0.0405
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0028 0.0042 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.002 0.0264
Loa Loa (eye worm) steroid hormone receptor 0.0268 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0324 0.0997 0.0997
Echinococcus multilocularis ecdysone induced protein 78C 0.0268 0.0816 0.0815
Echinococcus multilocularis peptidase Clp (S14 family) 0.0213 0.0637 0.0635
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0213 0.0637 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0299 0.0915 1
Trypanosoma brucei polo-like protein kinase 0.0299 0.0915 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0268 0.0816 0.0852
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.002 0.0264
Echinococcus granulosus FTZ F1 alpha 0.0268 0.0816 0.0815
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0028 0.0042 0.0422
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Brugia malayi nuclear receptor NHR-67 0.0127 0.0359 0.0356
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0299 0.0915 0.0914
Loa Loa (eye worm) hypothetical protein 0.0142 0.0408 0.0408
Echinococcus multilocularis 0.0021 0.002 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0268 0.0816 0.0816
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.002 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0148 0.0429 0.4426
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.0359 0.0358
Brugia malayi hypothetical protein 0.0127 0.0359 0.0356
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.035 0.1081 0.1129
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0213 0.0637 1
Loa Loa (eye worm) FYVE zinc finger family protein 0.0028 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0299 0.0915 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.002 0.0264
Brugia malayi nuclear hormone receptor 0.0127 0.0359 0.0356
Brugia malayi hypothetical protein 0.0127 0.0359 0.0356
Echinococcus granulosus Nuclear hormone receptor HR96 0.0127 0.0359 0.0358
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0095 0.061
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.2976 0.9543 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0127 0.0359 0.0358
Schistosoma mansoni steroid hormone receptor ad4bp 0.0268 0.0816 0.0852
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0324 0.0997 1
Schistosoma mansoni lamin 0.0033 0.0056 0.0055
Schistosoma mansoni intermediate filament proteins 0.0033 0.0056 0.0055
Schistosoma mansoni kinase 0.0152 0.0441 0.0459
Brugia malayi serine/threonine-protein kinase plk-2 0.0299 0.0915 0.0912
Trypanosoma cruzi polo-like protein kinase, putative 0.0299 0.0915 1
Brugia malayi Probable ClpP-like protease 0.0324 0.0997 0.0994
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0213 0.0637 0.6312
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0268 0.0816 0.0815
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0268 0.0816 0.0813
Loa Loa (eye worm) hypothetical protein 0.0142 0.0408 0.0408
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0359 0.0359
Schistosoma mansoni nuclear receptor 0.0127 0.0359 0.0373
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0142 0.0408 0.0408
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0268 0.0816 0.0852
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0324 0.0997 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0268 0.0816 0.0815
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0268 0.0816 0.0813
Schistosoma mansoni hypothetical protein 0.0111 0.031 0.0321
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.031 0.0308
Brugia malayi nuclear receptor NHR-88 0.0127 0.0359 0.0356
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0299 0.0915 0.0914
Loa Loa (eye worm) nuclear hormone receptor 0.0127 0.0359 0.0359
Echinococcus multilocularis lamin dm0 0.0033 0.0056 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0148 0.0429 0.4426
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0268 0.0816 0.0813
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.002 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0268 0.0816 0.0816
Onchocerca volvulus Bile acid receptor homolog 0.0268 0.0816 0.7419
Brugia malayi Cytochrome P450 family protein 0.0067 0.0169 0.0165
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.002 0.0183
Schistosoma mansoni hypothetical protein 0.0111 0.031 0.0321

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (ADMET) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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