TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.448 | Formula: C23H24N2O3
H donors: 2 H acceptors: 2 LogP: 3.02 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(o1)C1C(=C(C)N=C2C1=C(O)CCC2)C(=O)Nc1ccccc1C
InChi: 1S/C23H24N2O3/c1-13-7-4-5-8-16(13)25-23(27)20-15(3)24-17-9-6-10-18(26)21(17)22(20)19-12-11-14(2)28-19/h4-5,7-8,11-12,22,26H,6,9-10H2,1-3H3,(H,25,27)
InChiKey: ZZQWLHXSTUPZCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor-like 1	0.0119	0.3323	0.5034
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0119	0.3323	0.5034
Mycobacterium ulcerans	acyl-CoA synthetase	0.0018	0.0145	0.1013
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0136	0.0116
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0119	0.3323	0.5145
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0018	0.0145	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1554	0.2405
Brugia malayi	Bromodomain containing protein	0.0079	0.2054	0.3023
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.1144	0.7883
Echinococcus multilocularis	geminin	0.0174	0.5073	0.5005
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1431	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0741	0.0613
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0056	0.1341	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0741	0.1147
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0741	0.5177
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1144	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0145	0.0224
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0741	0.1052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0119	0.3323	0.5145
Leishmania major	hypothetical protein, conserved	0.0037	0.0741	0.4899
Echinococcus multilocularis	muscleblind protein	0.0147	0.4225	0.4146
Leishmania major	4-coumarate:coa ligase-like protein	0.0018	0.0145	0.0495
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0119	0.3323	0.5034
Echinococcus granulosus	FTZ F1 alpha	0.0119	0.3323	0.3231
Echinococcus multilocularis	ecdysone induced protein 78C	0.0119	0.3323	0.3231
Brugia malayi	nuclear receptor NHR-88	0.0056	0.1341	0.1895
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1144	0.0605
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.1341	0.2529
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.7411	1
Schistosoma mansoni	thyroid hormone receptor	0.0119	0.3323	0.6497
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1098	0.17
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.1144	0.1771
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0119	0.3323	0.3231
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0119	0.3323	0.5145
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0119	0.3323	0.3231
Loa Loa (eye worm)	DR-78	0.0056	0.1341	0.2077
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1431	0.1312
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0254	0.0394
Onchocerca volvulus	Bile acid receptor homolog	0.0119	0.3323	0.4374
Brugia malayi	hypothetical protein	0.0063	0.1554	0.2231
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0741	0.1052
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.056	0.0964
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0119	0.3323	0.5034
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0063	0.1554	0.2954
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.1144	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.2452	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.2452	0.3796
Onchocerca volvulus		0.0048	0.1098	0.1312
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0056	0.1341	0.1222
Entamoeba histolytica	acyl-coA synthetase, putative	0.0018	0.0145	0.5
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0156	0.0242
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0056	0.1341	0.1222
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0056	0.1341	0.2529
Brugia malayi	PHD-finger family protein	0.0026	0.0396	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0118	0.3308	0.5122
Echinococcus granulosus	survival motor neuron protein 1	0.0181	0.529	0.5225
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Brugia malayi	MAP kinase sur-1	0.005	0.1144	0.1583
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0014	0	0.5
Mycobacterium ulcerans	lipase LipD	0.0037	0.0741	0.5177
Schistosoma mansoni	survival motor neuron protein	0.0037	0.0738	0.1321
Echinococcus multilocularis	survival motor neuron protein 1	0.0181	0.529	0.5225
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0119	0.3323	0.6497
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.2452	0.2348
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0119	0.3323	0.3231
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0119	0.3323	0.3231
Brugia malayi	Bromodomain containing protein	0.004	0.0839	0.1099
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0119	0.3323	0.6497
Onchocerca volvulus		0.0037	0.0741	0.082
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0037	0.0738	0.0939
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.2452	0.4752
Schistosoma mansoni	nuclear hormone receptor	0.0119	0.3323	0.6497
Brugia malayi	nuclear receptor NHR-67	0.0056	0.1341	0.1895
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0018	0.0145	0.0206
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0741	0.1052
Brugia malayi	ecdysteroid receptor	0.0119	0.3323	0.5034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0119	0.3323	0.5145
Onchocerca volvulus		0.0031	0.056	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0147	0.4225	0.6541
Brugia malayi	nuclear hormone receptor	0.0056	0.1341	0.1895
Plasmodium vivax	SET domain protein, putative	0.0031	0.056	0.7556
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0119	0.3323	0.6497
Brugia malayi	beta-lactamase family protein	0.0037	0.0741	0.0943
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Brugia malayi	Pre-SET motif family protein	0.0218	0.6459	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.4225	0.6541
Echinococcus granulosus	geminin	0.0174	0.5073	0.5005
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.1144	0.7883
Brugia malayi	nuclear hormone receptor family member odr-7	0.0056	0.1341	0.1895
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1144	0.0605
Leishmania major	4-coumarate:coa ligase-like protein	0.0018	0.0145	0.0495
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.1124	0.1002
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.1341	0.2529
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0056	0.1341	0.2529
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0119	0.3323	0.6497
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0741	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Schistosoma mansoni	hypothetical protein	0.0037	0.0738	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0741	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Leishmania major	4-coumarate:coa ligase-like protein	0.0018	0.0145	0.0495
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0119	0.3323	0.3231
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0741	0.6215
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.1124	0.2094
Schistosoma mansoni	coup transcription factor	0.0119	0.3323	0.6497
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0119	0.3323	0.3231
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.1144	0.6712
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.2452	0.4752
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0741	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1554	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0145	0.0224
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0741	0.0613
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0119	0.3323	0.5145
Schistosoma mansoni	RAR-like nuclear receptor	0.0119	0.3323	0.6497
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0741	0.5177
Brugia malayi	Nuclear hormone receptor-like 1	0.0063	0.1554	0.2231
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1554	0.2405
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0741	0.1327
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0761	0.0633
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0056	0.1341	0.2077
Schistosoma mansoni	nuclear receptor nhr-48	0.0056	0.1341	0.2529
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0119	0.3323	0.6497
Brugia malayi	hypothetical protein	0.0056	0.1341	0.1895
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0741	0.1052
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1431	1
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.1144	0.0605
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0119	0.3323	0.3231
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0741	0.6215
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1144	0.2135
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.1547	0.1431
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0056	0.1341	0.2077
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0145	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0145	0.0224
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0119	0.3323	0.5034
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0119	0.3323	0.3231
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.2452	0.4752
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0741	0.1052
Echinococcus granulosus	zinc finger protein	0.0021	0.022	0.0085
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0119	0.3323	0.3231
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.1144	0.1022
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0056	0.1341	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Brugia malayi	hypothetical protein	0.0181	0.529	0.8147
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0119	0.3323	0.5034
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0741	0.1052
Brugia malayi	ecdysone receptor	0.0056	0.1341	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1124	0.174
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0119	0.3323	0.3231
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0741	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0119	0.3323	0.3231
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0063	0.1554	0.2405
Trypanosoma brucei	protein kinase, putative	0.005	0.1144	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0056	0.1341	0.1222
Brugia malayi	beta-lactamase	0.0037	0.0741	0.0943
Loa Loa (eye worm)	steroid hormone receptor	0.0119	0.3323	0.5145
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.1144	0.1022
Brugia malayi	Nuclear hormone receptor E75	0.0056	0.1341	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.056	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Onchocerca volvulus		0.0037	0.0738	0.0816
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.2452	0.3653
Echinococcus granulosus	muscleblind protein	0.0147	0.4225	0.4146
Echinococcus granulosus	thyroid hormone receptor alpha	0.0056	0.1341	0.1222
Brugia malayi	tailless protein	0.0056	0.1341	0.1895
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.1144	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0119	0.3323	0.6497
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Brugia malayi	conserved hypotetical protein	0.0056	0.1341	0.1895
Schistosoma mansoni	hypothetical protein	0.0022	0.0254	0.0353
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0741	0.5177
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0119	0.3323	0.3231
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Loa Loa (eye worm)	hypothetical protein	0.0181	0.529	0.8189
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Echinococcus multilocularis	FTZ F1 alpha	0.0119	0.3323	0.3231
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.2452	0.2348
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.1144	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0741	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Onchocerca volvulus		0.0037	0.0741	0.082
Mycobacterium ulcerans	acyl-CoA synthetase	0.0018	0.0145	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0118	0.3308	0.5122
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0983	0.1522
Brugia malayi	nuclear receptor RXR	0.0056	0.1341	0.1895
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0523	0.0393
Toxoplasma gondii	ABC1 family protein	0.0037	0.0741	0.2078
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0119	0.3323	0.5034
Echinococcus multilocularis	nuclear receptor nhr 48	0.0056	0.1341	0.1222
Schistosoma mansoni	nuclear receptor	0.0056	0.1341	0.2529
Brugia malayi	hypothetical protein	0.0056	0.1341	0.1895
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0119	0.3323	0.3231
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0741	0.1147
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.1547	0.1431
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0119	0.3323	0.5034
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0318	0.0184
Schistosoma mansoni	thyroid hormone receptor	0.0119	0.3323	0.6497
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.1124	0.2094
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.704	1
Onchocerca volvulus		0.0037	0.0741	0.082
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0018	0.0145	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0119	0.3323	0.5034
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0741	0.1147
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0119	0.3323	0.3231
Onchocerca volvulus	Huntingtin homolog	0.0118	0.3308	0.4354
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0741	0.1327
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0119	0.3323	0.6497
Brugia malayi	nuclear hormone receptor	0.0119	0.3323	0.5034
Brugia malayi	hypothetical protein	0.0118	0.3308	0.501
Brugia malayi	photoreceptor-specific nuclear receptor	0.0119	0.3323	0.5034
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0056	0.1341	0.1647
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0056	0.1341	0.1222
Onchocerca volvulus		0.0248	0.7411	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1431	0.1312
Schistosoma mansoni	zinc finger protein	0.0056	0.1341	0.2529
Schistosoma mansoni	nuclear receptor	0.0056	0.1341	0.2529
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Schistosoma mansoni	zinc finger protein	0.0021	0.022	0.0283
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0056	0.1341	0.1222
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1431	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.056	0.0964
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0741	0.1147
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0119	0.3323	0.5145
Onchocerca volvulus	Protein ultraspiracle homolog	0.0119	0.3323	0.4374
Onchocerca volvulus		0.0119	0.3323	0.4374
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0119	0.3323	0.5034
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0136	0.0116
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1431	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0063	0.1554	0.1437
Brugia malayi	steroid hormone receptor	0.0119	0.3323	0.5034
Schistosoma mansoni	retinoic acid receptor RXR	0.0119	0.3323	0.6497
Brugia malayi	hypothetical protein	0.0063	0.1554	0.2231
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.1098	0.2042
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1554	0.2405
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0741	0.0943
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0119	0.3323	0.4374
Brugia malayi	Pre-SET motif family protein	0.0031	0.056	0.0657
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0056	0.1341	0.1222
Brugia malayi	Nuclear hormone receptor E75	0.0056	0.1341	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0741	0.1147
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.2452	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1554	0.2405
Onchocerca volvulus	Huntingtin homolog	0.0118	0.3308	0.4354
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0318	0.0184
Schistosoma mansoni	hypothetical protein	0.0174	0.5073	1
Onchocerca volvulus		0.0056	0.1341	0.1647
Plasmodium falciparum	acyl-CoA synthetase	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0119	0.3323	0.5034
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0218	0.6459	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0841	0.1303
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.1144	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0056	0.1341	0.2077
Echinococcus granulosus	ecdysone induced protein 78C	0.0119	0.3323	0.3231
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.1144	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0056	0.1341	0.1222
Brugia malayi	Steroid receptor seven-up type 2	0.0119	0.3323	0.5034
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0761	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1341	0.2077
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0119	0.3323	0.5034
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.1144	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145
Schistosoma mansoni	hypothetical protein	0.0174	0.5073	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0741	0.1052
Brugia malayi	Nuclear hormone receptor-like 1	0.0063	0.1554	0.2231
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0741	0.5177
Echinococcus multilocularis	tumor protein p63	0.033	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.1144	1
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.4225	0.4146
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0741	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1912	0.296
Mycobacterium ulcerans	acyl-CoA synthetase	0.0018	0.0145	0.1013
Onchocerca volvulus		0.0056	0.1341	0.1647
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1431	0.2708
Echinococcus multilocularis	zinc finger protein	0.0021	0.022	0.0085
Brugia malayi	orphan nuclear receptor NR2E1	0.0056	0.1341	0.1895
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0145	0.1013
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0741	0.1052
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0741	0.6215
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.1124	0.1002
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0318	0.048
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0063	0.1554	0.2954
Schistosoma mansoni	bromodomain containing protein	0.0066	0.1666	0.3179
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0119	0.3323	0.5034
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1431	0.2032
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0145	0.0206
Brugia malayi	Muscleblind-like protein	0.0147	0.4225	0.6462
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.1144	0.1022
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1431	0.2708
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0018	0.0145	0.1013
Brugia malayi	nuclear receptor NHR-88	0.0119	0.3323	0.5034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0119	0.3323	0.5145
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0063	0.1554	0.1437
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0741	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0056	0.1341	0.1895
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0018	0.0145	0.1013
Brugia malayi	nuclear receptor RXR	0.0063	0.1554	0.2231
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0119	0.3323	0.5034
Echinococcus granulosus	nuclear receptor nhr 48	0.0056	0.1341	0.1222
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0018	0.0145	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.092	0.1424
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0741	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0056	0.1341	0.1647
Brugia malayi	beta-lactamase family protein	0.0037	0.0741	0.0943
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0056	0.1341	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0119	0.3323	0.5145

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1560634

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1427275