Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0662 | 0.2591 | 0.2459 |
Echinococcus granulosus | GPCR family 2 | 0.0777 | 0.3066 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0777 | 0.3066 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0777 | 0.3066 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0662 | 0.2591 | 0.2545 |
Brugia malayi | TAR-binding protein | 0.0662 | 0.2591 | 0.2545 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0255 | 0.0912 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.2975 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.2975 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0255 | 0.0912 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0777 | 0.3066 | 0.4516 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.2455 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0662 | 0.2591 | 0.3816 |
Schistosoma mansoni | hypothetical protein | 0.0777 | 0.3066 | 0.4516 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0255 | 0.0912 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.2975 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0255 | 0.0912 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0777 | 0.3066 | 0.2943 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1678 | 0.6791 | 0.6771 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.075 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0255 | 0.0912 | 0.2975 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0255 | 0.0912 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.2455 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0777 | 0.3066 | 0.4516 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0255 | 0.0912 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1678 | 0.6791 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.2975 |
Loa Loa (eye worm) | hypothetical protein | 0.1678 | 0.6791 | 0.6733 |
Schistosoma mansoni | hypothetical protein | 0.0777 | 0.3066 | 0.4516 |
Loa Loa (eye worm) | hypothetical protein | 0.0777 | 0.3066 | 0.2943 |
Schistosoma mansoni | tar DNA-binding protein | 0.0662 | 0.2591 | 0.3816 |
Loa Loa (eye worm) | hypothetical protein | 0.0539 | 0.2082 | 0.1941 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0777 | 0.3066 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0662 | 0.2591 | 0.3816 |
Brugia malayi | RNA binding protein | 0.0662 | 0.2591 | 0.2545 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0255 | 0.0912 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.0855 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0662 | 0.2591 | 0.2459 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0255 | 0.0912 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0777 | 0.3066 | 0.3023 |
Echinococcus granulosus | tar DNA binding protein | 0.0662 | 0.2591 | 0.845 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.1343 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0539 | 0.2082 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.0855 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0175 | 0.0113 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0777 | 0.3066 | 0.3023 |
Echinococcus multilocularis | tar DNA binding protein | 0.0662 | 0.2591 | 0.845 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0777 | 0.3066 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0662 | 0.2591 | 0.3816 |
Schistosoma mansoni | tar DNA-binding protein | 0.0662 | 0.2591 | 0.3816 |
Brugia malayi | N-terminal motif family protein | 0.0539 | 0.2082 | 0.2032 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0255 | 0.0912 | 0.2975 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0255 | 0.0912 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0255 | 0.0912 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0662 | 0.2591 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.2455 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0777 | 0.3066 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3294 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.5858 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.