TDR Targets

Basic information

Technical information

TDR Targets ID: 1427420
Name: 3-[(2-methylphenyl)carbamoyl]-1-pentyl-1-phen ylsulfonylurea
MW: 403.495 | Formula: C20H25N3O4S
H donors: 2 H acceptors: 4 LogP: 4.56 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCN(S(=O)(=O)c1ccccc1)C(=O)NC(=O)Nc1ccccc1C
InChi: 1S/C20H25N3O4S/c1-3-4-10-15-23(28(26,27)17-12-6-5-7-13-17)20(25)22-19(24)21-18-14-9-8-11-16(18)2/h5-9,11-14H,3-4,10,15H2,1-2H3,(H2,21,22,24,25)
InChiKey: BIWXXIMRDMKBFJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(2-methylphenyl)carbamoyl]-1-pentyl-1-phenylsulfonyl-urea
3-[[(2-methylphenyl)amino]-oxomethyl]-1-pentyl-1-phenylsulfonylurea
1-amyl-3-[(2-methylphenyl)carbamoyl]-1-phenylsulfonyl-urea
MLS000585019
N-[({[(2-methylphenyl)amino]carbonyl}amino)carbonyl]-N-pentylbenzenesulfonamide
SMR000207401

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	0.0043	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0225	0.0225
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0394	0.2891	0.6129
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.0151	0.0151
Schistosoma mansoni	smad1 5 8 and	0.0089	0.0535	0.0824
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.035	0.2556	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.035	0.2556	0.5419
Brugia malayi	hypothetical protein	0.0149	0.1	0.1
Brugia malayi	steroid hormone receptor	0.004	0.0151	0.0151
Brugia malayi	MH1 domain containing protein	0.0049	0.0225	0.0225
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0397	0.2919	0.6189
Echinococcus multilocularis	Smad4	0.0089	0.0535	0.1133
Schistosoma mansoni	smad1 5 8 and	0.0089	0.0535	0.0824
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.0151	0.0232
Schistosoma mansoni	tar DNA-binding protein	0.0577	0.4313	0.6646
Schistosoma mansoni	Smad4	0.0089	0.0535	0.0824
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.035	0.2556	1
Brugia malayi	Smad1	0.0089	0.0535	0.0535
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.035	0.2556	0.5419
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Brugia malayi	Isocitrate dehydrogenase	0.035	0.2556	0.2556
Echinococcus granulosus	glycosyltransferase protein LARGE2	0.0068	0.0368	0.0781
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0151	0.0232
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.0151	0.0319
Wolbachia endosymbiont of Brugia malayi	isocitrate dehydrogenase	0.0043	0.0172	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0577	0.4313	0.4313
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.0151	0.0151
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.116	0.246
Plasmodium vivax	ataxin-2 like protein, putative	0.0149	0.1	0.3277
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.1255	0.9565	0.9565
Brugia malayi	nuclear receptor RXR	0.0021	0.0005	0.0005
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.0151	0.0319
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.0151	0.0232
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0151	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.0151	0.0151
Schistosoma mansoni	hypothetical protein	0.0858	0.6489	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0151	0.0319
Schistosoma mansoni	Smad4	0.004	0.0152	0.0234
Loa Loa (eye worm)	acetyltransferase	0.0175	0.1198	0.1198
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0397	0.2919	0.6189
Loa Loa (eye worm)	nuclear factor I	0.0049	0.0225	0.0225
Brugia malayi	RNA recognition motif domain containing protein	0.0577	0.4313	0.4313
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.0151	0.0319
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0397	0.2919	0.2919
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.1198	0.1198
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0629	0.4716	1
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.0151	0.0319
Schistosoma mansoni	hypothetical protein	0.0397	0.2919	0.4498
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.0151	0.0319
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0089	0.0535	0.1133
Brugia malayi	Isocitrate dehydrogenase subunit gamma, mitochondrial precursor	0.0043	0.0172	0.0172
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0021	0.0005	0.0011
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.035	0.2556	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.035	0.2556	0.2556
Brugia malayi	ecdysteroid receptor	0.004	0.0151	0.0151
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.035	0.2556	0.5419
Loa Loa (eye worm)	hypothetical protein	0.0375	0.2745	0.2745
Echinococcus multilocularis	mothers against decapentaplegic 2	0.004	0.0152	0.0322
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0257	0.1829	0.3879
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.0151	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Schistosoma mansoni	smad1 5 8 and	0.0089	0.0535	0.0824
Brugia malayi	RNA binding protein	0.0577	0.4313	0.4313
Toxoplasma gondii	LsmAD domain-containing protein	0.0149	0.1	0.3277
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0151	0.0151
Toxoplasma gondii	isocitrate dehydrogenase	0.035	0.2556	1
Echinococcus multilocularis	mothers against decapentaplegic 6	0.004	0.0152	0.0322
Brugia malayi	hypothetical protein	0.0096	0.0589	0.0589
Mycobacterium leprae	PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH)	0.0043	0.0172	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0151	0.0319
Echinococcus granulosus	isocitrate dehydrogenase NAD subunit	0.0043	0.0172	0.0365
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0397	0.2919	0.2919
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0151	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0577	0.4313	0.6646
Echinococcus multilocularis	Glycosyltransferase protein LARGE1	0.0052	0.0245	0.052
Schistosoma mansoni	hypothetical protein	0.0397	0.2919	0.4498
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.0151	0.0151
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0241	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.0151	0.0151
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.1198	0.254
Schistosoma mansoni	hypothetical protein	0.0397	0.2919	0.4498
Loa Loa (eye worm)	isocitrate dehydrogenase gamma subunit	0.0043	0.0172	0.0172
Echinococcus granulosus	Smad4	0.0089	0.0535	0.1133
Echinococcus multilocularis	GPCR, family 2	0.0397	0.2919	0.6189
Loa Loa (eye worm)	hypothetical protein	0.0858	0.6489	0.6489
Brugia malayi	isocitrate dehydrogenase	0.035	0.2556	0.2556
Brugia malayi	TAR-binding protein	0.0577	0.4313	0.4313
Echinococcus multilocularis	Glycosyl transferase, family 8	0.007	0.0385	0.0817
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.035	0.2556	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.1255	0.9565	0.9565
Schistosoma mansoni	smad	0.004	0.0152	0.0234
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Brugia malayi	isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	0.0043	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0089	0.0535	0.1133
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0394	0.2891	0.6129
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0068	0.0368	0.0781
Brugia malayi	MH2 domain containing protein	0.0089	0.0535	0.0535
Echinococcus multilocularis	isocitrate dehydrogenase (NAD+)	0.0043	0.0172	0.0365
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0068	0.0368	0.0781
Mycobacterium ulcerans	3-isopropylmalate dehydrogenase	0.0043	0.0172	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0382	0.2797	0.2797
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0151	0.0151
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0397	0.2919	0.6189
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0241	0.0511
Echinococcus granulosus	FTZ F1 alpha	0.004	0.0151	0.0319
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Brugia malayi	MH1 domain containing protein	0.0089	0.0535	0.0535
Loa Loa (eye worm)	hypothetical protein	0.004	0.0152	0.0152
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0151	0.0151
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.1255	0.9565	0.9565
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.0151	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Brugia malayi	photoreceptor-specific nuclear receptor	0.004	0.0151	0.0151
Schistosoma mansoni	hypothetical protein	0.0067	0.0361	0.0557
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.035	0.2556	0.3939
Echinococcus granulosus	smad	0.0089	0.0535	0.1133
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0021	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.062	0.4646	0.716
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0067	0.0361	0.0766
Loa Loa (eye worm)	nuclear hormone receptor	0.0373	0.2728	0.2728
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0005	0.0008
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0241	1
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.004	0.0152	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0151	0.0151
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0151	0.0319
Plasmodium falciparum	ataxin-2 like protein, putative	0.0149	0.1	0.3372
Schistosoma mansoni	unc-13 (munc13)	0.0043	0.0172	0.0265
Echinococcus multilocularis	isocitrate dehydrogenase	0.035	0.2556	0.5419
Echinococcus granulosus	GPCR family 2	0.0397	0.2919	0.6189
Loa Loa (eye worm)	MH1 domain-containing protein	0.004	0.0152	0.0152
Brugia malayi	mothers against decapentaplegic homolog 3	0.004	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0397	0.2919	0.4498
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0089	0.0535	0.1133
Brugia malayi	hypothetical protein	0.0021	0.0005	0.0005
Echinococcus granulosus	mothers against decapentaplegic 2	0.004	0.0152	0.0322
Schistosoma mansoni	Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial	0.0043	0.0172	0.0265
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.0151	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0151	0.0151
Schistosoma mansoni	tar DNA-binding protein	0.0577	0.4313	0.6646
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Plasmodium falciparum	ataxin-2 like protein, putative	0.0149	0.1	0.3372
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.035	0.2556	0.5419
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.0151	0.0232
Loa Loa (eye worm)	glycosyl transferase family 8 protein	0.007	0.0385	0.0385
Leishmania major	hypothetical protein, conserved	0.0149	0.1	0.3472
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1	0.1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0067	0.0361	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1691	0.1691
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0068	0.0368	0.0781
Brugia malayi	MH1 domain containing protein	0.0089	0.0535	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0397	0.2919	0.2919
Brugia malayi	nuclear receptor NHR-88	0.004	0.0151	0.0151
Brugia malayi	MH1 domain containing protein	0.0049	0.0225	0.0225
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.0151	0.0232
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.035	0.2556	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0257	0.1829	0.1829
Loa Loa (eye worm)	hypothetical protein	0.004	0.0151	0.0151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.0151	0.0151
Loa Loa (eye worm)	TK/ABL protein kinase	0.0629	0.4716	0.4716
Schistosoma mansoni	tar DNA-binding protein	0.0577	0.4313	0.6646
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.1198	0.1846
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0151	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.0151	0.0151
Loa Loa (eye worm)	MH2 domain-containing protein	0.004	0.0152	0.0152
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0021	0.0005	0.0008
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.0151	0.0151
Brugia malayi	nuclear hormone receptor	0.004	0.0151	0.0151
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.035	0.2556	1
Schistosoma mansoni	Smad4	0.004	0.0152	0.0234
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.0151	0.0232
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.0151	0.0232
Echinococcus granulosus	mothers against decapentaplegic 6	0.004	0.0152	0.0322
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.0151	0.0151
Brugia malayi	Steroid receptor seven-up type 2	0.0394	0.2891	0.2891
Schistosoma mansoni	coup transcription factor	0.004	0.0151	0.0232
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0629	0.4716	1
Echinococcus granulosus	Glycosyl transferase family 8	0.007	0.0385	0.0817
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.0151	0.0232
Loa Loa (eye worm)	RNA binding protein	0.0577	0.4313	0.4313
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0397	0.2919	0.6189
Schistosoma mansoni	glycosyltransferase-related	0.007	0.0385	0.0594
Echinococcus multilocularis	smad	0.0089	0.0535	0.1133
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.0151	0.0232
Loa Loa (eye worm)	MH2 domain-containing protein	0.1312	1	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.035	0.2556	1
Brugia malayi	Probable isocitrate dehydrogenase	0.0043	0.0172	0.0172
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0089	0.0535	0.0824
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0151	0.0151
Echinococcus granulosus	tar DNA binding protein	0.0577	0.4313	0.9145
Schistosoma mansoni	tar DNA-binding protein	0.0577	0.4313	0.6646
Brugia malayi	Probable isocitrate dehydrogenase	0.0043	0.0172	0.0172
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.0151	0.0151
Echinococcus granulosus	isocitrate dehydrogenase NAD	0.0043	0.0172	0.0365
Loa Loa (eye worm)	MH1 domain-containing protein	0.0089	0.0535	0.0535
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0151	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.0151	0.0319
Loa Loa (eye worm)	MH2 domain-containing protein	0.0089	0.0535	0.0535
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.0151	0.0151
Brugia malayi	hypothetical protein	0.0021	0.0005	0.0005
Loa Loa (eye worm)	Smad1	0.0089	0.0535	0.0535
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0005	0.0005
Echinococcus multilocularis	conserved hypothetical protein	0.0052	0.0245	0.052
Loa Loa (eye worm)	transcription factor SMAD2	0.1312	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.004	0.0151	0.0319
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0005	0.0005
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0208	0.5
Schistosoma mansoni	isocitrate dehydrogenase	0.0043	0.0172	0.0265
Toxoplasma gondii	isocitrate dehydrogenase	0.035	0.2556	1
Echinococcus granulosus	Glycosyltransferase protein LARGE1	0.0052	0.0245	0.052
Loa Loa (eye worm)	hypothetical protein	0.1255	0.9565	0.9565
Brugia malayi	MH2 domain containing protein	0.0089	0.0535	0.0535
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.0151	0.0319
Brugia malayi	Latrophilin receptor protein 2	0.0397	0.2919	0.2919
Schistosoma mansoni	smad	0.0089	0.0535	0.0824
Loa Loa (eye worm)	TAR-binding protein	0.0577	0.4313	0.4313
Brugia malayi	latrophilin 2 splice variant baaae	0.0858	0.6489	0.6489
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0021	0.0005	0.0011
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0172	0.0172
Echinococcus granulosus	mothers against decapentaplegic 5	0.0089	0.0535	0.1133
Brugia malayi	MH2 domain containing protein	0.004	0.0152	0.0152
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.035	0.2556	0.5419
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0151	0.0232
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0208	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.0151	0.0319
Echinococcus multilocularis	isocitrate dehydrogenase (NAD) subunit	0.0043	0.0172	0.0365
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.035	0.2556	1
Brugia malayi	Glycosyl transferase family 8 protein	0.007	0.0385	0.0385
Echinococcus multilocularis	tar DNA binding protein	0.0577	0.4313	0.9145

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (binding)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1557260

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1427420