Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.2763 | 0.3055 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5368 | 0.5937 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.2763 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.2763 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.2763 | 0.3055 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.9042 | 0.9042 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0139 | 0.0139 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.6752 | 0.7468 |
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0052 | 0.9042 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 1 | 1 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0052 | 0.9042 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.6752 | 0.6752 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.6752 | 0.7468 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0052 | 0.9042 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.5368 | 0.5368 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0052 | 0.9042 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0052 | 0.9042 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0052 | 0.9042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 1 | 1 |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0052 | 0.9042 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.2763 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0052 | 0.9042 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.2763 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0052 | 0.9042 | 0.9042 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.5368 | 0.5368 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2763 | 0.2763 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.2763 | 0.3055 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.2763 | 0.3055 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.6752 | 0.7468 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.6752 | 0.7468 |
Brugia malayi | hypothetical protein | 0.0028 | 0.2763 | 0.2763 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0052 | 0.9042 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 66 uM | PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 66 uM | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8199 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.