Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0204 | 0.5521 | 0.5521 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0024 | 0.0316 | 0.0637 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.2345 | 0.4128 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.3319 | 0.3319 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0024 | 0.0316 | 0.0637 |
Schistosoma mansoni | smad | 0.0024 | 0.0316 | 0.0378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.3319 | 0.593 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0112 | 0.0112 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.053 | 0.1303 |
Brugia malayi | MH2 domain containing protein | 0.0024 | 0.0316 | 0.0316 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.053 | 0.1303 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0094 | 0.2345 | 0.6962 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.5521 | 0.5521 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0017 | 0.0112 | 0.0112 |
Echinococcus granulosus | GPCR family 2 | 0.0094 | 0.2345 | 0.6962 |
Brugia malayi | N-terminal motif family protein | 0.0353 | 0.9843 | 0.9843 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.053 | 0.053 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.053 | 0.1303 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0024 | 0.0316 | 0.0637 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0017 | 0.0112 | 0.0112 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0353 | 0.9843 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0358 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.053 | 0.053 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.0316 | 0.0316 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.053 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0094 | 0.2345 | 0.2345 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.053 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0094 | 0.2345 | 0.6962 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.3319 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0094 | 0.2345 | 0.6962 |
Echinococcus granulosus | smad | 0.0024 | 0.0316 | 0.0637 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.053 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0112 | 0.0112 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.053 | 0.1303 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.053 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.3319 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.053 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0024 | 0.0316 | 0.0316 |
Brugia malayi | RNA binding protein | 0.0128 | 0.3319 | 0.3319 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0024 | 0.0316 | 0.0316 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0017 | 0.0112 | 0.0112 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.053 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0094 | 0.2345 | 0.6962 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.3319 | 0.593 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0094 | 0.2345 | 0.2345 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.053 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.053 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0024 | 0.0316 | 0.0378 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0017 | 0.0112 | 0.0112 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.053 | 0.0773 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0094 | 0.2345 | 0.6962 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.053 | 0.1303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.3319 | 0.593 |
Echinococcus multilocularis | Smad4 | 0.0024 | 0.0316 | 0.0637 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0024 | 0.0316 | 0.0378 |
Brugia malayi | DIX domain containing protein | 0.0017 | 0.0112 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.2345 | 0.4128 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0017 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.053 | 0.053 |
Schistosoma mansoni | hypothetical protein | 0.0204 | 0.5521 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.053 | 0.5 |
Brugia malayi | Smad1 | 0.0024 | 0.0316 | 0.0316 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0024 | 0.0316 | 0.0637 |
Schistosoma mansoni | smad1 5 8 and | 0.0024 | 0.0316 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0112 | 0.0112 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.3319 | 0.3319 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.2345 | 0.2345 |
Schistosoma mansoni | Smad4 | 0.0024 | 0.0316 | 0.0378 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.053 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0298 | 0.8257 | 0.8257 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.8257 | 0.8257 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0298 | 0.8257 | 0.8257 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.9843 | 0.9843 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0298 | 0.8257 | 0.8257 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.2345 | 0.4128 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.3319 | 0.3319 |
Echinococcus granulosus | Smad4 | 0.0024 | 0.0316 | 0.0637 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | Smad1 | 0.0024 | 0.0316 | 0.0316 |
Brugia malayi | MH2 domain containing protein | 0.0024 | 0.0316 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.3319 | 0.593 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.0316 | 0.0316 |
Echinococcus multilocularis | smad | 0.0024 | 0.0316 | 0.0637 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.3319 | 0.3319 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.3319 | 0.593 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.2345 | 0.4128 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.053 | 0.1303 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.3319 | 0.3319 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0094 | 0.2345 | 0.2345 |
Schistosoma mansoni | smad1 5 8 and | 0.0024 | 0.0316 | 0.0378 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0358 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.