Detailed information for compound 1427822

Basic information

Technical information
  • TDR Targets ID: 1427822
  • Name: N-[3-(1,3-benzothiazol-2-yl)phenyl]-2-ethylbu tanamide
  • MW: 324.44 | Formula: C19H20N2OS
  • H donors: 1 H acceptors: 2 LogP: 4.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)Nc1cccc(c1)c1nc2c(s1)cccc2)CC
  • InChi: 1S/C19H20N2OS/c1-3-13(4-2)18(22)20-15-9-7-8-14(12-15)19-21-16-10-5-6-11-17(16)23-19/h5-13H,3-4H2,1-2H3,(H,20,22)
  • InChiKey: BTHJSNREEQWFKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(1,3-benzothiazol-2-yl)phenyl]-2-ethyl-butanamide
  • N-[3-(1,3-benzothiazol-2-yl)phenyl]-2-ethyl-butyramide
  • D341-1993
  • NCGC00119163-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0117 0.0174
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0138 0.0357 0.0493
Trichomonas vaginalis AGC family protein kinase 0.1008 0.3231 0.3213
Echinococcus granulosus pleckstrin y domain containing family A 0.0116 0.0284 0.0422
Echinococcus multilocularis oxysterol binding protein 3 0.0116 0.0284 0.0422
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0116 0.0284 0.0259
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.1008 0.3231 0.4792
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Brugia malayi Egg laying defective protein 4 0.0065 0.0117 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Schistosoma mansoni rho gtpase activating protein 0.0116 0.0284 0.0422
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1954 0.6359 0.9431
Echinococcus granulosus oxysterol binding protein 9 0.0116 0.0284 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Echinococcus multilocularis pleckstrin y domain containing family A 0.0116 0.0284 0.0422
Trichomonas vaginalis centaurin gamma, putative 0.0116 0.0284 0.0259
Trichomonas vaginalis protein transport protein sec7, putative 0.0116 0.0284 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1008 0.3231 0.4792
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Echinococcus granulosus calcium dependent secretion activator 1 0.0116 0.0284 0.0422
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.0701 1
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0116 0.0284 0.0422
Brugia malayi p70 ribosomal S6 kinase beta 0.294 0.9616 0.9616
Entamoeba histolytica protein kinase, putative 0.0138 0.0357 0.0075
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0138 0.0357 0.0493
Trypanosoma brucei PH domain containing protein, putative 0.0116 0.0284 0.0259
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0116 0.0284 0.0422
Echinococcus granulosus oxysterol binding protein 3 0.0116 0.0284 0.0422
Echinococcus granulosus survival motor neuron protein 1 0.045 0.1388 0.2059
Loa Loa (eye worm) RNA binding protein 0.0059 0.0097 0.0097
Schistosoma mansoni goodpasture antigen-binding protein 0.0116 0.0284 0.0422
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.002 0.003
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0065 0.0117 0.0174
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Echinococcus multilocularis dynamin 1 0.0116 0.0284 0.0422
Trypanosoma cruzi Protein kinase B 0.207 0.6743 1
Brugia malayi beta-lactamase family protein 0.0038 0.0026 0.0026
Trypanosoma brucei rac serine-threonine kinase, putative 0.3056 1 1
Schistosoma mansoni hypothetical protein 0.0092 0.0204 0.0303
Brugia malayi Cadps2 protein 0.0116 0.0284 0.0284
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1008 0.3231 0.4792
Trichomonas vaginalis AGC family protein kinase 0.1008 0.3231 0.3213
Trypanosoma cruzi NIMA-related kinase, putative 0.0138 0.0357 0.0493
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0138 0.0357 0.0332
Schistosoma mansoni oxysterol-binding protein 1 0.0116 0.0284 0.0422
Echinococcus granulosus Oxysterol binding protein 11 0.0116 0.0284 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Onchocerca volvulus 0.0286 0.0846 1
Brugia malayi Cytohesin 3 0.0116 0.0284 0.0284
Echinococcus granulosus nervana 2 0.1932 0.6286 0.9323
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0097 0.0144
Trichomonas vaginalis hypothetical protein 0.0116 0.0284 0.0259
Echinococcus multilocularis nervana 2 0.1932 0.6286 0.9323
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0138 0.0357 0.0532
Echinococcus granulosus cytohesin 1 0.0116 0.0284 0.0422
Toxoplasma gondii ABC1 family protein 0.0038 0.0026 0.0006
Onchocerca volvulus Putative zinc finger protein 0.0116 0.0284 0.32
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0116 0.0284 0.0259
Mycobacterium ulcerans hypothetical protein 0.0043 0.0044 1
Toxoplasma gondii protein kinase domain-containing protein 0.0138 0.0357 0.0351
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0116 0.0284 0.0422
Echinococcus multilocularis protein kinase c epsilon type 0.1008 0.3231 0.4792
Schistosoma mansoni cellular tumor antigen P53 0.0237 0.0685 0.1016
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0138 0.0357 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.0214 0.0214
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Echinococcus multilocularis actin binding protein anillin 0.0116 0.0284 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Echinococcus multilocularis pdz domain containing protein 0.0116 0.0284 0.0422
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0116 0.0284 0.0384
Leishmania major protein kinase, putative 0.0138 0.0357 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0097 0.0144
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0116 0.0284 0.0268
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1008 0.3231 0.4792
Plasmodium falciparum oxysterol-binding protein, putative 0.0116 0.0284 0.0268
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0116 0.0284 0.0422
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0115 0.0115
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Giardia lamblia Kinase, AGC PKA 0.1954 0.6359 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0026
Echinococcus multilocularis calcium dependent secretion activator 1 0.0116 0.0284 0.0422
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0846 0.0822
Trypanosoma cruzi PH domain containing protein, putative 0.0116 0.0284 0.0384
Echinococcus granulosus myotubularin protein 13 0.0116 0.0284 0.0422
Echinococcus multilocularis tumor protein p63 0.1622 0.526 0.7802
Loa Loa (eye worm) AGC/PKN protein kinase 0.1008 0.3231 0.3231
Echinococcus multilocularis myotubularin protein 13 0.0116 0.0284 0.0422
Echinococcus multilocularis serine:threonine protein kinase 38 0.1008 0.3231 0.4792
Loa Loa (eye worm) uncoordinated protein 104 0.0116 0.0284 0.0284
Entamoeba histolytica protein kinase, putative 0.3056 1 1
Echinococcus multilocularis Rho GTPase activating protein 24 0.0116 0.0284 0.0422
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0986 0.3158 0.314
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0116 0.0284 0.0422
Plasmodium vivax PH domain containing protein 0.0116 0.0284 0.0417
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0026
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.0097 0.0097
Echinococcus multilocularis Pleckstrin y 0.0116 0.0284 0.0422
Leishmania major protein kinase, putative 0.0138 0.0357 1
Trypanosoma cruzi PH domain containing protein, putative 0.0116 0.0284 0.0384
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0116 0.0284 0.0422
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0065 0.0117 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Trichomonas vaginalis AGC family protein kinase 0.1008 0.3231 0.3213
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0116 0.0284 0.0259
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0116 0.0284 0.0422
Trypanosoma cruzi PH domain containing protein, putative 0.0116 0.0284 0.0384
Plasmodium falciparum PH domain-containing protein, putative 0.0116 0.0284 0.0268
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0357 0.0075
Entamoeba histolytica protein kinase, putative 0.3056 1 1
Onchocerca volvulus Protein melted homolog 0.0116 0.0284 0.32
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0117 0.0174
Brugia malayi Pre-SET motif family protein 0.0036 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0445 0.1371 0.1118
Echinococcus multilocularis protein kinase c iota type 0.1008 0.3231 0.4792
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0116 0.0284 0.0422
Schistosoma mansoni dynamin 0.0116 0.0284 0.0422
Trichomonas vaginalis centaurin/arf, putative 0.0116 0.0284 0.0259
Echinococcus multilocularis nervana 2 0.1932 0.6286 0.9323
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Echinococcus granulosus microtubule associated protein 2 0.1939 0.6308 0.9356
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0357 0.0075
Loa Loa (eye worm) rho-GTPase-activating 0.0116 0.0284 0.0284
Brugia malayi TAR-binding protein 0.0059 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Entamoeba histolytica protein kinase 2, putative 0.1954 0.6359 0.6253
Brugia malayi Variant SH3 domain containing protein 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Schistosoma mansoni hypothetical protein 0.0116 0.0284 0.0422
Brugia malayi hypothetical protein 0.0116 0.0284 0.0284
Brugia malayi Protein kinase domain containing protein 0.1008 0.3231 0.3231
Echinococcus granulosus protein kinase c epsilon type 0.1008 0.3231 0.4792
Echinococcus granulosus NDR protein kinase 0.1008 0.3231 0.4792
Brugia malayi beta-lactamase family protein 0.0038 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0116 0.0284 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0026 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0731 0.0731
Echinococcus multilocularis survival motor neuron protein 1 0.045 0.1388 0.2059
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0357 0.0075
Brugia malayi Dynamin 0.0116 0.0284 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.002 0.003
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0138 0.0357 0.0493
Plasmodium falciparum calcium-dependent protein kinase 7 0.0138 0.0357 0.0384
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0138 0.0357 0.0332
Brugia malayi Hr1 repeat family protein 0.1008 0.3231 0.3231
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0116 0.0284 0.32
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1954 0.6359 0.9431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.002 0.003
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0138 0.0357 0.0332
Entamoeba histolytica PH domain containing protein kinase, putative 0.207 0.6743 0.6647
Loa Loa (eye worm) beta-lactamase 0.0038 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0065 0.0115 0.0171
Loa Loa (eye worm) oxysterol binding protein 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Brugia malayi protein kinase C II. 0.1008 0.3231 0.3231
Onchocerca volvulus 0.0116 0.0284 0.32
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1008 0.3231 0.3231
Trichomonas vaginalis centaurin/arf, putative 0.0116 0.0284 0.0259
Toxoplasma gondii hypothetical protein 0.0116 0.0284 0.0276
Toxoplasma gondii AGC kinase 0.294 0.9616 1
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0116 0.0284 0.32
Loa Loa (eye worm) AGC/PKG protein kinase 0.0065 0.0117 0.0117
Toxoplasma gondii Oxysterol-binding protein 0.0116 0.0284 0.0276
Entamoeba histolytica protein kinase, putative 0.0138 0.0357 0.0075
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0116 0.0284 0.0284
Echinococcus multilocularis cytohesin 1 0.0116 0.0284 0.0422
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Onchocerca volvulus 0.0116 0.0284 0.32
Schistosoma mansoni zinc finger protein 0.0116 0.0284 0.0422
Entamoeba histolytica p21-activated kinase 0.0138 0.0357 0.0075
Schistosoma mansoni serine/threonine-protein kinase 0.207 0.6743 1
Toxoplasma gondii phosphatidylinositol transfer protein 0.0116 0.0284 0.0276
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0116 0.0284 0.0422
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0116 0.0284 0.0422
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Echinococcus granulosus Pleckstrin y 0.0116 0.0284 0.0422
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0097 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0097 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.002 0.003
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0065 0.0117 0.0174
Brugia malayi Plekhf2 protein 0.0116 0.0284 0.0284
Schistosoma mansoni serine/threonine-protein kinase 0.207 0.6743 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0116 0.0284 0.0259
Entamoeba histolytica protein kinase, putative 0.0138 0.0357 0.0075
Trypanosoma brucei protein kinase, putative 0.0138 0.0357 0.0332
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1954 0.6359 1
Entamoeba histolytica protein kinase, putative 0.0138 0.0357 0.0075
Brugia malayi beta-lactamase 0.0038 0.0026 0.0026
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0116 0.0284 0.0422
Echinococcus multilocularis Ras associated and pleckstrin y 0.0116 0.0284 0.0422
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.002 0.003
Echinococcus multilocularis oxysterol binding protein 1 0.0116 0.0284 0.0422
Brugia malayi Variant SH3 domain containing protein 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.002 0.003
Trichomonas vaginalis centaurin alpha, putative 0.0116 0.0284 0.0259
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Leishmania major hypothetical protein, conserved 0.0116 0.0284 0.7803
Loa Loa (eye worm) hypothetical protein 0.1008 0.3231 0.3231
Echinococcus multilocularis expressed conserved protein 0.0065 0.0117 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Echinococcus multilocularis Pleckstrin y 0.0116 0.0284 0.0422
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0092 0.0204 0.0204
Onchocerca volvulus 0.0116 0.0284 0.32
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1954 0.6359 1
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0116 0.0284 0.0268
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0116 0.0284 0.0284
Schistosoma mansoni microtubule-associated protein tau 0.1939 0.6308 0.9356
Echinococcus multilocularis Oxysterol binding protein 11 0.0116 0.0284 0.0422
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Onchocerca volvulus 0.0116 0.0284 0.32
Entamoeba histolytica protein kinase, putative 0.294 0.9616 0.9605
Entamoeba histolytica hypothetical protein 0.0138 0.0357 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0026 0.0039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0016 0.0023
Echinococcus granulosus serine/threonine protein kinase 0.207 0.6743 1
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Brugia malayi probable spectrin beta chain 0.0116 0.0284 0.0284
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0138 0.0357 0.0332
Brugia malayi Pleckstrin Homology Domain 0.0116 0.0284 0.0284
Echinococcus multilocularis tar DNA binding protein 0.0059 0.0097 0.0144
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Echinococcus multilocularis Glutaredoxin protein 5 0.1932 0.6286 0.9323
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Echinococcus granulosus Rho GTPase activating protein 24 0.0116 0.0284 0.0422
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.0115
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1954 0.6359 0.9429
Echinococcus granulosus GRB2 associated binding protein 3 0.0116 0.0284 0.0422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Brugia malayi Oxysterol binding protein 0.0116 0.0284 0.0284
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0138 0.0357 0.0493
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0116 0.0284 0.0259
Brugia malayi Uncoordinated protein 104 0.0116 0.0284 0.0284
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Echinococcus granulosus beta 1 syntrophin 0.0116 0.0284 0.0422
Echinococcus granulosus cGMP dependent protein kinase 1 0.0065 0.0117 0.0174
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1008 0.3231 0.3231
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0097 0.0144
Leishmania major hypothetical protein, conserved 0.0116 0.0284 0.7803
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.1008 0.3231 0.4792
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Loa Loa (eye worm) PH domain-containing protein 0.0116 0.0284 0.0284
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0138 0.0357 1
Brugia malayi MAX-1A 0.0116 0.0284 0.0284
Entamoeba histolytica ARF GTPase activating protein, putative 0.0116 0.0284 0.0000000051361
Entamoeba histolytica protein kinase, putative 0.1008 0.3231 0.3033
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0116 0.0284 0.0422
Entamoeba histolytica PH domain containing protein kinase, putative 0.207 0.6743 0.6647
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0026 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0026 0.0026
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Echinococcus granulosus cGMP dependent protein kinase 1 0.0065 0.0117 0.0174
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0116 0.0284 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Loa Loa (eye worm) hypothetical protein 0.045 0.1388 0.1388
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Loa Loa (eye worm) Plekhf2 protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1008 0.3231 0.3231
Onchocerca volvulus 0.0038 0.0026 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Brugia malayi Protein kinase domain containing protein 0.1008 0.3231 0.3231
Schistosoma mansoni goodpasture antigen-binding protein 0.0116 0.0284 0.0422
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0026 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.1008 0.3231 0.4792
Loa Loa (eye worm) AGC/NDR protein kinase 0.1008 0.3231 0.3231
Onchocerca volvulus 0.0038 0.0026 0.0074
Echinococcus multilocularis beta 1 syntrophin 0.0116 0.0284 0.0422
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0357 0.0075
Schistosoma mansoni vav2 0.0116 0.0284 0.0422
Onchocerca volvulus 0.0237 0.0685 0.8053
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0116 0.0284 0.0422
Brugia malayi MH2 domain containing protein 0.0227 0.0652 0.0652
Schistosoma mansoni hypothetical protein 0.0116 0.0284 0.0422
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0026 0.5
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.1008 0.3231 0.4792
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Trichomonas vaginalis alpha chimerin, putative 0.0116 0.0284 0.0259
Mycobacterium leprae Probable lipase LipE 0.0038 0.0026 0.5
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0116 0.0284 0.0422
Toxoplasma gondii hypothetical protein 0.0116 0.0284 0.0276
Brugia malayi hypothetical protein 0.045 0.1388 0.1388
Trichomonas vaginalis centaurin beta, putative 0.0116 0.0284 0.0259
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0138 0.0357 0.0493
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0138 0.0357 0.0351
Echinococcus granulosus DCC interacting protein 13 beta 0.0116 0.0284 0.0422
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0138 0.0357 0.0493
Onchocerca volvulus outspread protein homolog 0.0116 0.0284 0.32
Trypanosoma cruzi PH domain containing protein, putative 0.0116 0.0284 0.0384
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0116 0.0284 0.0417
Echinococcus multilocularis DCC interacting protein 13 beta 0.0116 0.0284 0.0422
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0026 0.0039
Onchocerca volvulus 0.0038 0.0026 0.0074
Brugia malayi Dynamin 0.0116 0.0284 0.0284
Echinococcus multilocularis GRB2 associated binding protein 3 0.0116 0.0284 0.0422
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0095 0.0214 0.0214
Brugia malayi Pre-SET motif family protein 0.0251 0.0731 0.0731
Echinococcus multilocularis serine:threonine protein kinase N2 0.1008 0.3231 0.4792
Schistosoma mansoni serine/threonine kinase 0.1008 0.3231 0.4792
Loa Loa (eye worm) cytohesin 3 0.0116 0.0284 0.0284
Echinococcus granulosus tumor protein p63 0.1622 0.526 0.7802
Schistosoma mansoni syntrophin 0.0116 0.0284 0.0422
Schistosoma mansoni hypothetical protein 0.0116 0.0284 0.0422
Loa Loa (eye worm) AGC/AKT protein kinase 0.3056 1 1
Trichomonas vaginalis AGC family protein kinase 0.1124 0.3614 0.3598
Brugia malayi RNA binding protein 0.0059 0.0097 0.0097
Schistosoma mansoni growth factor receptor-bound protein 0.0116 0.0284 0.0422
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Schistosoma mansoni dynamin 0.0116 0.0284 0.0422
Echinococcus multilocularis rac serine:threonine kinase 0.207 0.6743 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0116 0.0284 0.0422
Echinococcus multilocularis Pleckstrin y 0.0116 0.0284 0.0422
Echinococcus granulosus cGMP dependent protein kinase 0.0065 0.0117 0.0174
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1932 0.6286 0.9323
Leishmania major folate/biopterin transporter, putative 0.0138 0.0357 1
Trichomonas vaginalis kinesin light chain, putative 0.0116 0.0284 0.0259
Brugia malayi Oxysterol-binding protein 0.0116 0.0284 0.0284
Echinococcus granulosus protein kinase C gamma type 0.1008 0.3231 0.4792
Loa Loa (eye worm) transcription factor SMAD2 0.0227 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0026
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.1008 0.3231 0.3231
Schistosoma mansoni zinc finger protein 0.0116 0.0284 0.0422
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Schistosoma mansoni survival motor neuron protein 0.0092 0.0204 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0026
Trichomonas vaginalis AGC family protein kinase 0.3056 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.207 0.6743 1
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0138 0.0357 0.0332
Echinococcus granulosus Glutaredoxin protein 5 0.1932 0.6286 0.9323
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.294 0.9616 0.9616
Onchocerca volvulus 0.0116 0.0284 0.32
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.002 0.003
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0138 0.0357 0.0493
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Echinococcus multilocularis serine:threonine protein kinase N2 0.1008 0.3231 0.4792
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0116 0.0284 0.0422
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0116 0.0284 0.0259
Echinococcus multilocularis microtubule associated protein 2 0.1939 0.6308 0.9356
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0116 0.0284 0.0422
Onchocerca volvulus 0.0116 0.0284 0.32
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0284 0.0259
Echinococcus multilocularis oxysterol binding protein 9 0.0116 0.0284 0.0422
Loa Loa (eye worm) MH2 domain-containing protein 0.0227 0.0652 0.0652
Echinococcus granulosus pdz domain containing protein 0.0116 0.0284 0.0422
Echinococcus granulosus Pleckstrin y 0.0116 0.0284 0.0422
Echinococcus granulosus serine threonine protein kinase nrc 0.1954 0.6359 0.9431
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0026 0.0026
Echinococcus granulosus dynamin 1 0.0116 0.0284 0.0422
Echinococcus granulosus serine:threonine protein kinase N2 0.1008 0.3231 0.4792
Loa Loa (eye worm) TAR-binding protein 0.0059 0.0097 0.0097
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0116 0.0284 0.0284
Echinococcus multilocularis serine threonine protein kinase 0.1008 0.3231 0.4792
Trypanosoma cruzi NIMA-related kinase, putative 0.0138 0.0357 0.0493
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0116 0.0284 0.0268
Brugia malayi Syntrophin-1 0.0116 0.0284 0.0284
Echinococcus granulosus oxysterol binding protein 1 0.0116 0.0284 0.0422
Echinococcus granulosus tar DNA binding protein 0.0059 0.0097 0.0144
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0138 0.0357 0.0332
Onchocerca volvulus 0.0092 0.0204 0.223
Schistosoma mansoni atypical protein kinase C 0.1008 0.3231 0.4792
Loa Loa (eye worm) syntrophin-1 0.0116 0.0284 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0116 0.0284 0.0417
Schistosoma mansoni centaurin alpha 0.0116 0.0284 0.0422
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1932 0.6286 0.9323
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0116 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Toxoplasma gondii AtPH1 family protein 0.0116 0.0284 0.0276
Leishmania major serine/threonine-protein kinase a, putative 0.0138 0.0357 1
Trichomonas vaginalis protein transport protein sec7, putative 0.0116 0.0284 0.0259
Echinococcus granulosus nervana 2 0.1932 0.6286 0.9323
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Schistosoma mansoni myotubularin-related protein 0.0116 0.0284 0.0422
Onchocerca volvulus 0.0116 0.0284 0.32
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0357 0.0332
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0138 0.0357 0.0493
Brugia malayi TBC domain containing protein 0.0116 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.0116 0.0284 0.0422
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0116 0.0284 0.0284
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0116 0.0284 0.0384
Loa Loa (eye worm) hypothetical protein 0.0116 0.0284 0.0284
Echinococcus granulosus Protein kinase C brain isozyme 0.1008 0.3231 0.4792
Entamoeba histolytica protein kinase, putative 0.0138 0.0357 0.0075
Trypanosoma cruzi hypothetical protein 0.0116 0.0284 0.0384
Entamoeba histolytica hypothetical protein 0.0138 0.0357 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0026 0.0026
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0116 0.0284 0.0422
Loa Loa (eye worm) hypothetical protein 0.0237 0.0685 0.0685
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0116 0.0284 0.0422
Schistosoma mansoni oxysterol-binding protein 1 0.0116 0.0284 0.0422
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0116 0.0284 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0284 0.0417
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.1008 0.3231 0.4792
Echinococcus granulosus protein kinase c iota type 0.1008 0.3231 0.4792
Brugia malayi PH domain containing protein 0.0116 0.0284 0.0284
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0116 0.0284 0.0268
Echinococcus granulosus Pleckstrin y 0.0116 0.0284 0.0422

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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