Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein jagged 1 | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | 0.2065 | 1 | 1 | |
Loa Loa (eye worm) | notch protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | protein jagged 2 | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | notch-like transmembrane receptor | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Cadherin domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | peroxidasin | 0.2065 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2065 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Animal haem peroxidase family protein | 0.2065 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Delta serrate ligand family protein | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | septate junction protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | Peroxidase homolog | 0.2065 | 1 | 1 |
Schistosoma mansoni | slit | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | neural cadherin | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Schistosoma mansoni | notch | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | Peroxidase homolog | 0.2065 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.2065 | 1 | 1 |
Schistosoma mansoni | notch | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2065 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Animal haem peroxidase family protein | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | delta-like protein 1 | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | notch | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | notch | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Animal haem peroxidase family protein | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | Peroxidasin homolog | 0.2065 | 1 | 1 |
Schistosoma mansoni | notch | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | slit 2 protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | fibropellin Ia | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0412 | 0.1709 | 0.5 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | fibropellin Ia | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | Dual oxidase homolog | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0412 | 0.1709 | 0.1709 |
Echinococcus granulosus | protein jagged 1 | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Cadherin domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Giardia lamblia | High cysteine protein | 0.0412 | 0.1709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Animal haem peroxidase family protein | 0.2065 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Muscle positioning protein 4 | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | peroxidasin | 0.2065 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | protein jagged 1 | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | 0.2065 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Blistered cuticle protein 3 | 0.2065 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | protein jagged 1 | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Animal haem peroxidase family protein | 0.2065 | 1 | 1 |
Onchocerca volvulus | 0.2065 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | notch | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | Peroxidasin | 0.2065 | 1 | 1 |
Schistosoma mansoni | notch | 0.0412 | 0.1709 | 0.1709 |
Schistosoma mansoni | cell polarity protein | 0.0412 | 0.1709 | 0.1709 |
Onchocerca volvulus | Peroxidasin homolog | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | EGF-like domain containing protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | animal heme peroxidase | 0.2065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.1709 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.2065 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.