Detailed information for compound 1427979

Basic information

Technical information
  • TDR Targets ID: 1427979
  • Name: [2-[(2,3-dimethylcyclohexyl)amino]-2-oxoethyl ] 2-chloropyridine-3-carboxylate
  • MW: 324.803 | Formula: C16H21ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 3.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1C(CCCC1C)NC(=O)COC(=O)c1cccnc1Cl
  • InChi: 1S/C16H21ClN2O3/c1-10-5-3-7-13(11(10)2)19-14(20)9-22-16(21)12-6-4-8-18-15(12)17/h4,6,8,10-11,13H,3,5,7,9H2,1-2H3,(H,19,20)
  • InChiKey: PMIUXZUZSJTYLS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[(2,3-dimethylcyclohexyl)amino]-2-oxo-ethyl] 2-chloropyridine-3-carboxylate
  • 2-chloro-3-pyridinecarboxylic acid [2-[(2,3-dimethylcyclohexyl)amino]-2-oxoethyl] ester
  • 2-chloronicotinic acid [2-[(2,3-dimethylcyclohexyl)amino]-2-keto-ethyl] ester
  • T0516-0368
  • Oprea1_402668

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0018 0.0005 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0244 0.0298
Brugia malayi photoreceptor-specific nuclear receptor 0.0307 0.3009 0.5319
Loa Loa (eye worm) DR-78 0.0019 0.0018 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0244 0.0298
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.004
Trichomonas vaginalis esterase, putative 0.0078 0.0629 0.1157
Toxoplasma gondii hypothetical protein 0.0048 0.0317 0.3305
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0244 0.0298
Schistosoma mansoni ran 0.0025 0.0072 0.0087
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.1973 0.2421
Brugia malayi hypothetical protein 0.0539 0.5418 0.9577
Brugia malayi CXXC zinc finger family protein 0.0058 0.0418 0.0738
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0021
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0133 0.2094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0244 0.0243
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.292 1
Brugia malayi hypothetical protein 0.0019 0.0018 0.0032
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0039 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0072
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0288
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0018 0.0017
Echinococcus granulosus neuropeptide receptor A26 0.052 0.5221 0.6409
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0031 0.01
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0164 0.1707
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0629 0.0628
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0018 0.002
Schistosoma mansoni nuclear receptor 0.0019 0.0018 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Schistosoma mansoni inositol monophosphatase 0.0037 0.0199 0.0242
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0426 0.0522
Mycobacterium tuberculosis Conserved protein 0.0078 0.0629 0.1254
Brugia malayi jmjC domain containing protein 0.0018 0.0005 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0612 0.1079
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0002 0.0002
Brugia malayi mbt repeat family protein 0.0052 0.0352 0.0622
Mycobacterium ulcerans hypothetical protein 0.0078 0.0629 0.4247
Plasmodium falciparum importin beta, putative 0.0033 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0031 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0042 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0629 0.1157
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0629 0.1157
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Onchocerca volvulus 0.0078 0.0629 0.1811
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0244 0.0243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.011 0.0959 0.1695
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0072 0.0071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0031 0.0082
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0042 0.0201
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0352 0.0351
Schistosoma mansoni inositol monophosphatase 0.0037 0.0199 0.0242
Echinococcus multilocularis protein dispatched 1 0.0056 0.0398 0.0397
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Loa Loa (eye worm) hypothetical protein 0.0078 0.0629 0.111
Trichomonas vaginalis glucosylceramidase, putative 0.0362 0.3585 0.6793
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0018 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0199 0.0676
Loa Loa (eye worm) hypothetical protein 0.0562 0.5657 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0037
Schistosoma mansoni importin beta-1 0.0033 0.0164 0.02
Echinococcus multilocularis geminin 0.0374 0.3704 0.3704
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0042 0.0072
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.031 0.3044 0.3043
Loa Loa (eye worm) hypothetical protein 0.0042 0.025 0.0439
Schistosoma mansoni hypothetical protein 0.0047 0.0308 0.0376
Brugia malayi intermediate filament protein 0.0086 0.0714 0.1263
Schistosoma mansoni intermediate filament proteins 0.0086 0.0714 0.0875
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0018 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0244 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0244 0.0431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0417 0.4148 0.5091
Schistosoma mansoni transient receptor potential channel 0.0107 0.093 0.114
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0426 0.0522
Schistosoma mansoni hypothetical protein 0.0357 0.3532 0.4335
Schistosoma mansoni hypothetical protein 0.0374 0.3704 0.4547
Echinococcus granulosus lamin dm0 0.0086 0.0714 0.0875
Schistosoma mansoni hypothetical protein 0.0047 0.0308 0.0376
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0244 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.126 0.1545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0244 0.0429
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0042 0.0038
Toxoplasma gondii exonuclease III APE 0.0022 0.0042 0.0429
Loa Loa (eye worm) hypothetical protein 0.0085 0.0698 0.1231
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1316 0.2324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0629 0.0771
Loa Loa (eye worm) inositol-1 0.0037 0.0199 0.0349
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0612 0.075
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0629 0.4247
Leishmania major hypothetical protein, conserved 0.0078 0.0629 0.2151
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0133 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0244 0.0431
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0001 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0244 0.0243
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0552 0.0676
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0515 0.091
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0629 0.2151
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0133 0.8068
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0515 0.0908
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0072 0.4361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0417 0.4148 0.4147
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0005 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0005 0.0006
Schistosoma mansoni transient receptor potential channel 0.0074 0.0583 0.0714
Brugia malayi beta-lactamase 0.0078 0.0629 0.1112
Onchocerca volvulus 0.0052 0.0352 0.099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0807 0.0989
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1092 0.1339
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0072
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0253 0.0861
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0005 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0042 0.0075
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0523 0.0641
Loa Loa (eye worm) hypothetical protein 0.0045 0.0286 0.0503
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0629 0.0771
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0018 0.0032
Brugia malayi ecdysone receptor 0.0019 0.0018 0.0032
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0021
Echinococcus granulosus neuropeptide s receptor 0.052 0.5221 0.6409
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0583 0.0582
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0002 0.0001
Schistosoma mansoni ap endonuclease 0.0022 0.0042 0.005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0163 0.0286
Entamoeba histolytica acyl-coA synthetase, putative 0.0021 0.0031 0.0082
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0072 0.0244
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0199 0.0336
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0018 0.0032
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0352 0.0431
Echinococcus multilocularis neuropeptide s receptor 0.052 0.5221 0.5221
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0078 0.0629 0.111
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.1642
Brugia malayi hypothetical protein 0.0022 0.0042 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0031 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0244 0.0431
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0612 0.075
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0042 0.0075
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0023 0.0072
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0018 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0244 0.0429
Mycobacterium ulcerans hypothetical protein 0.0157 0.1451 1
Brugia malayi mbt repeat family protein 0.0052 0.0352 0.0622
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0042 0.2512
Mycobacterium ulcerans beta-lactamase 0.0078 0.0629 0.4247
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0026
Brugia malayi steroid hormone receptor 0.0041 0.0244 0.0431
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0042 0.5
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0352 0.062
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0326 0.0399
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0629 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0244 0.0431
Entamoeba histolytica hypothetical protein 0.0071 0.0552 0.5393
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0244 0.0431
Echinococcus granulosus importin subunit beta 1 0.0033 0.0164 0.02
Brugia malayi follicle stimulating hormone receptor 0.0457 0.4566 0.807
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus granulosus cpg binding protein 0.0061 0.0452 0.0553
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Echinococcus multilocularis snurportin 1 0.0357 0.3532 0.3531
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0031 0.0056
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Echinococcus multilocularis expressed conserved protein 0.0107 0.0933 0.0931
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0042 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0031 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0244 0.0243
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.5267 1
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0629 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0072 0.1132
Schistosoma mansoni hypothetical protein 0.0067 0.0515 0.0631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.2025 0.3579
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0018 0.0032
Brugia malayi Inositol-1 0.0037 0.0199 0.0351
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0059 0.0426 0.0751
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0244 0.0669
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0612 0.075
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0552 0.0551
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0629 0.1112
Entamoeba histolytica hypothetical protein 0.0027 0.0099 0.0774
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0352 0.0351
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0072
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0244 0.0298
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0006
Brugia malayi conserved hypotetical protein 0.0019 0.0018 0.0032
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0199 0.0197
Brugia malayi ecdysteroid receptor 0.0041 0.0244 0.0431
Schistosoma mansoni survival motor neuron protein 0.011 0.0959 0.1176
Brugia malayi beta-lactamase family protein 0.0078 0.0629 0.1112
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0031 0.0056
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0018 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.2025 0.3577
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0072 0.0745
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0072 1
Schistosoma mansoni hypothetical protein 0.0047 0.0308 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0574
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Onchocerca volvulus Glucosylceramidase homolog 0.0344 0.3393 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0515 0.0631
Loa Loa (eye worm) hypothetical protein 0.004 0.0233 0.041
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.1005 0.1232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.126 0.1545
Schistosoma mansoni hypothetical protein 0.0067 0.0515 0.0631
Onchocerca volvulus 0.0058 0.0418 0.1185
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0244 0.0431
Loa Loa (eye worm) RNA binding protein 0.0076 0.0612 0.1079
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0072 0.0244
Mycobacterium tuberculosis Conserved protein 0.0078 0.0629 0.1254
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0629 0.111
Brugia malayi beta-lactamase family protein 0.0078 0.0629 0.1112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0244 0.0429
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.1023 0.1254
Schistosoma mansoni zinc finger protein 0.0019 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0539 0.5418 0.9577
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0244 0.0298
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0031 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.1973 0.1972
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0326 0.0399
Loa Loa (eye worm) hypothetical protein 0.0086 0.0714 0.126
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0005 0.0036
Leishmania major DNA polymerase kappa, putative 0.002 0.0023 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0072
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0562 0.5657 1
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0583 0.0582
Loa Loa (eye worm) beta-lactamase 0.0078 0.0629 0.111
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0164 0.0558
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0523 0.0522
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0244 0.0669
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0018 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.292 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0244 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0244 0.0431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Brugia malayi nuclear receptor NHR-88 0.0019 0.0018 0.0032
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0005 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0297 0.0526
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0018 0.0029
Echinococcus granulosus TRP transient receptor potential channel 0.0045 0.0286 0.035
Schistosoma mansoni nuclear receptor 0.0019 0.0018 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0629 0.1254
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0018 0.0017
Brugia malayi jmjC domain containing protein 0.0068 0.0523 0.0925
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0018 0.002
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.292 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0244 0.0298
Echinococcus granulosus dnaJ subfamily B 0.042 0.4187 0.5139
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0583 0.0714
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0042 0.014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0244 0.0298
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0018 0.002
Echinococcus multilocularis transient receptor potential gamma protein 0.0107 0.093 0.0929
Brugia malayi TAR-binding protein 0.0076 0.0612 0.1081
Brugia malayi RNA binding protein 0.0076 0.0612 0.1081
Schistosoma mansoni hypothetical protein 0.0374 0.3704 0.4547
Brugia malayi jmjC domain containing protein 0.0018 0.0005 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0244 0.0298
Schistosoma mansoni patched 1 0.0049 0.0326 0.0399
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0629 0.1157
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0031 0.01
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0018 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0326 0.0579
Toxoplasma gondii ABC1 family protein 0.0078 0.0629 0.6577
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0005 0.0004
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0005 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0714 0.126
Echinococcus multilocularis cpg binding protein 0.0061 0.0452 0.0451
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0318 0.3119 0.3828
Loa Loa (eye worm) hypothetical protein 0.0062 0.046 0.0811
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0807 0.0806
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0072 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0244 0.0429
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0244 0.0243
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0253 0.0861
Onchocerca volvulus 0.011 0.0959 0.2788
Schistosoma mansoni cpg binding protein 0.0061 0.0452 0.0553
Brugia malayi jmjC domain containing protein 0.0018 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0078 0.0629 0.111
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0042 0.3962
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0629 1
Schistosoma mansoni coup transcription factor 0.0041 0.0244 0.0298
Schistosoma mansoni cpg binding protein 0.0061 0.0452 0.0553
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0199 0.0676
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0244 0.0431
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0067 0.0515 0.0908
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0018 0.0017
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0557 0.0683
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0031 0.0056
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0352 0.0431
Echinococcus granulosus intermediate filament protein 0.0086 0.0714 0.0875
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0244 0.0298
Echinococcus multilocularis dnaJ subfamily B 0.042 0.4187 0.4186
Entamoeba histolytica hypothetical protein 0.0071 0.0552 0.5393
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0164 0.0163
Leishmania major hypothetical protein, conserved 0.0018 0.0005 0.0012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0018 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.126 0.2225
Echinococcus granulosus tar DNA binding protein 0.0076 0.0612 0.075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0018 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0244 0.0243
Onchocerca volvulus Huntingtin homolog 0.0137 0.124 0.362
Brugia malayi nuclear hormone receptor 0.0019 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0629 0.111
Brugia malayi hypothetical protein 0.0071 0.0552 0.0976
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0629 0.1254
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.025 0.0305
Echinococcus granulosus nuclear receptor co repressor related ncor 0.031 0.3044 0.3736
Loa Loa (eye worm) hypothetical protein 0.0078 0.0629 0.111
Echinococcus multilocularis protein patched 0.0049 0.0326 0.0325
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0042 0.0082
Echinococcus multilocularis survival motor neuron protein 1 0.0539 0.5418 0.5417
Entamoeba histolytica hypothetical protein 0.0071 0.0552 0.5393
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0099 0.0145
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0135 0.1219 0.1495
Schistosoma mansoni hypothetical protein 0.0047 0.0308 0.0376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0042 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0031 0.0056
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0199 0.0336
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0629 0.2151
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0524 0.5267 0.931
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0956 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0042 0.0652
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0045 0.0286 0.0285
Brugia malayi hypothetical protein 0.002 0.0021 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0244 0.0429
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1451 0.2894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.126 0.1259
Brugia malayi nuclear receptor NHR-67 0.0019 0.0018 0.0032
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0159 0.214
Onchocerca volvulus Huntingtin homolog 0.0137 0.124 0.362
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0629 0.1254
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0557 0.0683
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0005 0.0006
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0026
Echinococcus multilocularis GPCR, family 2 0.0067 0.0515 0.0514
Leishmania major GTP-binding protein, putative 0.0025 0.0072 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0244 0.0429
Loa Loa (eye worm) hypothetical protein 0.0114 0.1005 0.1774
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0072 0.0087
Trichomonas vaginalis ran, putative 0.0025 0.0072 0.0095
Loa Loa (eye worm) hypothetical protein 0.006 0.0441 0.0777
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0244 0.0431
Echinococcus multilocularis sodium channel protein 0.0135 0.1219 0.1218
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0523 0.0641
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0352 0.0431
Brugia malayi hypothetical protein 0.0137 0.124 0.2191
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0199 0.1794
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1326 0.2344
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.1005 0.1776
Brugia malayi CHE-14 protein 0.0049 0.0326 0.0577
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0042 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0352 0.099
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0005 0.0006
Schistosoma mansoni lamin 0.0086 0.0714 0.0875
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0199 0.0336
Brugia malayi nuclear receptor NHR-88 0.0041 0.0244 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0244 0.0431
Leishmania major importin beta-1 subunit, putative 0.0027 0.0099 0.0333
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.1515 0.1858
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0326 0.0574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.126 0.2227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.126 0.1545
Echinococcus multilocularis lamin dm0 0.0086 0.0714 0.0713
Echinococcus granulosus GPCR family 2 0.0067 0.0515 0.0631
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0072 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Brugia malayi isocitrate dehydrogenase 0.0018 0.0001 0.0002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.1005 1
Echinococcus granulosus phd:f box containing protein 0.0018 0.0005 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0133 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0244 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0629 0.1157
Schistosoma mansoni microtubule-associated protein tau 0.0801 0.8146 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0031 0.0058
Onchocerca volvulus 0.0078 0.0629 0.1811
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0023 0.0072
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0133 0.1378
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0253 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0629 0.2151
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0018 0.0017
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0612 0.1079
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.5267 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.3009 0.5318
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1285 0.4399
Echinococcus granulosus survival motor neuron protein 1 0.0539 0.5418 0.6651
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0583 0.0714
Mycobacterium ulcerans hypothetical protein 0.0021 0.0031 0.0056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.4566 0.807
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0629 0.1254
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.5267 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0042 0.0072
Mycobacterium ulcerans lipase LipD 0.0078 0.0629 0.4247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.126 0.1259
Brugia malayi nuclear receptor RXR 0.0022 0.0042 0.0075
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0629 0.1254
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.1005 0.1003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0042 0.014
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0426 0.0425
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0244 0.0298
Echinococcus granulosus geminin 0.0374 0.3704 0.4547
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Onchocerca volvulus 0.0086 0.0714 0.2063
Echinococcus granulosus transient receptor potential gamma protein 0.0107 0.093 0.114
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0099 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0244 0.0431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Loa Loa (eye worm) MBCTL1 0.0059 0.0426 0.0751
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0557 0.0683
Echinococcus granulosus microtubule associated protein 2 0.0801 0.8146 1
Onchocerca volvulus 0.0086 0.0714 0.2063
Schistosoma mansoni cpg binding protein 0.0058 0.0418 0.0511
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0244 0.0431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0253 0.0861
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0244 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0612 0.075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0244 0.0431
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0418 0.0736
Loa Loa (eye worm) hypothetical protein 0.0078 0.0629 0.111
Echinococcus multilocularis lamin 0.0086 0.0714 0.0713
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0362 0.3585 0.6793
Onchocerca volvulus 0.0021 0.0031 0.0037
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0629 0.1254
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0515 0.091
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0326 0.0325
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0039 0.0046
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0031 0.0056
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0352 0.0431
Schistosoma mansoni hypothetical protein 0.042 0.4187 0.5139
Plasmodium vivax importin-beta 2, putative 0.0033 0.0164 0.2596
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0612 0.1081
Mycobacterium leprae Probable lipase LipE 0.0078 0.0629 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0159 0.0314
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1285 0.4399
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0199 0.2068
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0005 0.0012
Schistosoma mansoni transient receptor potential channel 4 0.0107 0.093 0.114
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0042 0.0041
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0023 0.0072
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0133 0.8068
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0099 0.0145
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0515 0.0514
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0244 0.0298
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0005 0.0209
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0018 0.0029
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0018 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0133 0.0451
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.004
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0244 0.0298
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1316 0.2324
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0072 0.0126
Loa Loa (eye worm) hypothetical protein 0.0041 0.0244 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0072
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0499 0.5009 1
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0714 0.126
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0552 0.0676
Echinococcus multilocularis microtubule associated protein 2 0.0801 0.8146 0.8146
Brugia malayi jmjC domain containing protein 0.0071 0.0557 0.0985
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0135 0.1219 0.4173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0232
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0072
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0199 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Schistosoma mansoni ran 0.0025 0.0072 0.0087
Brugia malayi hypothetical protein 0.0022 0.0042 0.0075
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0524 0.5267 0.931
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0199 0.0676
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0244 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.126 0.1545
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Loa Loa (eye worm) hypothetical protein 0.0145 0.1326 0.2342
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0199 0.0676
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0018 0.0032
Brugia malayi RNA, U transporter 1 0.0095 0.0806 0.1425
Loa Loa (eye worm) hypothetical protein 0.0137 0.124 0.2189
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0042 0.005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0297 0.0523
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0523 0.0522
Schistosoma mansoni hypothetical protein 0.011 0.0959 0.1176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0018 0.002
Echinococcus granulosus lamin 0.0086 0.0714 0.0875
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0067 0.0515 0.0631
Plasmodium vivax JmjC domain containing protein 0.0018 0.0005 0.0054
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0629 0.4247
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.292 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0037
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.025 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.126 0.1545
Schistosoma mansoni ap endonuclease 0.0022 0.0042 0.005
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0714 0.1263
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0026
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0099 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.5267 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Schistosoma mansoni hypothetical protein 0.0145 0.1326 0.1626
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0199 1
Brugia malayi hypothetical protein 0.0019 0.0018 0.0032
Brugia malayi Importin beta-1 subunit 0.0033 0.0164 0.029
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0244 0.0243
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0042 0.005
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0612 0.075
Brugia malayi Transient-receptor-potential like protein 0.0045 0.0286 0.0506
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0042 0.005
Schistosoma mansoni hypothetical protein 0.0071 0.0552 0.0676
Onchocerca volvulus 0.0078 0.0629 0.1811
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0557 0.0983
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.5221 0.5221
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0018 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.5267 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0042 0.014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0244 0.0298
Echinococcus granulosus expressed conserved protein 0.0107 0.0933 0.1143
Entamoeba histolytica Ran family GTPase 0.0025 0.0072 0.0508
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0005 0.0003
Trypanosoma brucei unspecified product 0.002 0.0023 0.0072
Brugia malayi MH2 domain containing protein 0.0144 0.1316 0.2325
Mycobacterium tuberculosis Conserved protein 0.0078 0.0629 0.1254
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0426 0.0522
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0005 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0344 0.3393 0.6426
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Brugia malayi hypothetical protein 0.003 0.0133 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0524 0.5267 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0629 0.1157
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0244 0.0669
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0244 0.0298
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0352 0.0431
Loa Loa (eye worm) hypothetical protein 0.0137 0.124 0.2189
Leishmania major hypothetical protein, conserved 0.003 0.0133 0.0451
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0426 0.0425
Brugia malayi nuclear hormone receptor 0.0041 0.0244 0.0431
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0026
Brugia malayi nuclear receptor RXR 0.0019 0.0018 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0244 0.0298
Loa Loa (eye worm) hypothetical protein 0.0052 0.0352 0.062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0348 0.1188
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0018 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0244 0.0429
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0031 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0005 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0357 0.3532 0.6242
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0612 0.0611
Schistosoma mansoni hypothetical protein 0.0067 0.0515 0.0631
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0005 0.0036
Onchocerca volvulus 0.0041 0.0244 0.0669
Echinococcus granulosus snurportin 1 0.0357 0.3532 0.4335
Loa Loa (eye worm) hypothetical protein 0.004 0.0233 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0244 0.0298
Schistosoma mansoni lamin 0.0086 0.0714 0.0875
Brugia malayi tailless protein 0.0019 0.0018 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0164 0.0558
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0244 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0031 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0244 0.0298
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0244 0.0243
Leishmania major DNA polymerase eta, putative 0.002 0.0023 0.0072
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1285 0.4399
Echinococcus granulosus sodium channel protein 0.0135 0.1219 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0244 0.0431
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0026
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0042 0.005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0199 0.1234
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0426 0.0753
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.1515 0.1513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0029
Entamoeba histolytica hypothetical protein 0.0071 0.0552 0.5393
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0072
Echinococcus multilocularis musashi 0.0086 0.0714 0.0713
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0629 0.1254
Schistosoma mansoni transient receptor potential channel 0.0074 0.0583 0.0714

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.