Detailed information for compound 1428025

Basic information

Technical information
  • TDR Targets ID: 1428025
  • Name: N-(3,5-difluorophenyl)-4-(oxolane-2-carbonyl) piperazine-1-carbothioamide
  • MW: 355.403 | Formula: C16H19F2N3O2S
  • H donors: 1 H acceptors: 1 LogP: 1.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc(cc(c1)F)NC(=S)N1CCN(CC1)C(=O)C1CCCO1
  • InChi: 1S/C16H19F2N3O2S/c17-11-8-12(18)10-13(9-11)19-16(24)21-5-3-20(4-6-21)15(22)14-2-1-7-23-14/h8-10,14H,1-7H2,(H,19,24)
  • InChiKey: BXJWVEUTMNNERX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,5-difluorophenyl)-4-(tetrahydrofuran-2-carbonyl)piperazine-1-carbothioamide
  • N-(3,5-difluorophenyl)-4-[oxo-(2-tetrahydrofuranyl)methyl]-1-piperazinecarbothioamide
  • N-(3,5-difluorophenyl)-4-(oxolan-2-ylcarbonyl)piperazine-1-carbothioamide
  • STK261775

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.052 1 1
Brugia malayi beta-lactamase family protein 0.0074 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0074 0.1154 0.1154
Leishmania major hypothetical protein, conserved 0.0074 0.1154 1
Onchocerca volvulus 0.0074 0.1154 0.1051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.052 1 1
Mycobacterium leprae Probable lipase LipE 0.0074 0.1154 1
Schistosoma mansoni coup transcription factor 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Brugia malayi Nuclear hormone receptor E75 0.0245 0.4554 0.4554
Brugia malayi beta-lactamase family protein 0.0074 0.1154 0.1154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.052 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1154 0.0937
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1154 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0405 0.0405
Onchocerca volvulus 0.0074 0.1154 0.1051
Brugia malayi Pre-SET motif family protein 0.0251 0.467 0.467
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0245 0.4554 0.4554
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.052 1 1
Onchocerca volvulus 0.0046 0.0608 0.0499
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0275 0.5137 0.5137
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0608 0.5
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1002 0.1002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0405 0.0405
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.052 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.052 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.052 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1154 0.0937
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1002 0.1002
Schistosoma mansoni nuclear receptor nhr-48 0.0245 0.4554 0.4554
Schistosoma mansoni nuclear receptor 0.0245 0.4554 0.4554
Schistosoma mansoni nuclear receptor 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Schistosoma mansoni RAR-like nuclear receptor 0.052 1 1
Brugia malayi hypothetical protein 0.0275 0.5137 0.5137
Schistosoma mansoni thyroid hormone receptor 0.052 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0275 0.5137 0.5137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.052 1 1
Brugia malayi Nuclear hormone receptor E75 0.0245 0.4554 0.4554
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1154 1
Onchocerca volvulus 0.0245 0.4554 0.4491
Brugia malayi Nuclear hormone receptor-like 1 0.0275 0.5137 0.5137
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0359 0.0359
Schistosoma mansoni thyroid hormone receptor 0.052 1 1
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1154 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1154 0.1154
Schistosoma mansoni zinc finger protein 0.0245 0.4554 0.4554
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.052 1 1
Mycobacterium ulcerans hypothetical protein 0.0074 0.1154 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0245 0.4554 0.4554
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0345 0.6518 0.6518
Loa Loa (eye worm) hypothetical protein 0.0074 0.1154 0.1154
Loa Loa (eye worm) steroid hormone receptor 0.052 1 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1002 0.1002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0046 0.0608 0.0608
Echinococcus granulosus ecdysone induced protein 78C 0.052 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0608 0.2981
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1002 0.1002
Echinococcus multilocularis thyroid hormone receptor alpha 0.052 1 1
Echinococcus multilocularis geminin 0.0345 0.6518 0.6518
Echinococcus granulosus retinoic acid receptor rxr beta a 0.052 1 1
Mycobacterium ulcerans hypothetical protein 0.0046 0.0608 0.2981
Brugia malayi nuclear receptor RXR 0.0275 0.5137 0.5137
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0376 0.5
Brugia malayi nuclear receptor RXR 0.0245 0.4554 0.4554
Mycobacterium tuberculosis Conserved protein 0.0074 0.1154 0.0937
Toxoplasma gondii ABC1 family protein 0.0074 0.1154 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.052 1 1
Schistosoma mansoni nuclear hormone receptor 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0379 0.0379
Brugia malayi conserved hypotetical protein 0.0245 0.4554 0.4554
Brugia malayi hypothetical protein 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.052 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1154 0.0937
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0608 0.2981
Echinococcus multilocularis ecdysone induced protein 78C 0.052 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0405 0.0405
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0608 0.0608
Brugia malayi Nuclear hormone receptor-like 1 0.052 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0405 0.0405
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0245 0.4554 0.4554
Loa Loa (eye worm) nuclear receptor NHR-67 0.0245 0.4554 0.4554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.052 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0376
Mycobacterium tuberculosis Conserved protein 0.0074 0.1154 0.0937
Schistosoma mansoni steroid hormone receptor ad4bp 0.052 1 1
Onchocerca volvulus 0.0074 0.1154 0.1051
Brugia malayi nuclear hormone receptor family member odr-7 0.0245 0.4554 0.4554
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.052 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.052 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1154 0.0937
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0245 0.4554 0.4554
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0608 0.2981
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0245 0.4554 0.4554
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0405 0.0405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0608 0.031
Mycobacterium ulcerans beta-lactamase 0.0074 0.1154 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Echinococcus granulosus nuclear receptor nhr 48 0.0245 0.4554 0.4554
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0376
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0608 0.2981
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Brugia malayi nuclear hormone receptor 0.052 1 1
Schistosoma mansoni hypothetical protein 0.0345 0.6518 0.6518
Loa Loa (eye worm) RNA binding protein 0.0066 0.1002 0.1002
Brugia malayi nuclear receptor NHR-88 0.052 1 1
Schistosoma mansoni nuclear hormone receptor 0.0245 0.4554 0.4554
Brugia malayi nuclear receptor NHR-67 0.0245 0.4554 0.4554
Brugia malayi nuclear receptor NHR-88 0.0245 0.4554 0.4554
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0405 0.0405
Brugia malayi Steroid receptor seven-up type 2 0.052 1 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.1154 0.0937
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.0405
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1154 0.1154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.9037 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0608 0.2981
Loa Loa (eye worm) hypothetical protein 0.0275 0.5137 0.5137
Brugia malayi Nuclear hormone receptor family member nhr-40 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1154 0.1154
Loa Loa (eye worm) nuclear hormone receptor 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0074 0.1154 0.1154
Echinococcus granulosus tar DNA binding protein 0.0066 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0245 0.4554 0.4554
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0376 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0245 0.4554 0.4491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0275 0.5137 0.5137
Echinococcus granulosus geminin 0.0345 0.6518 0.6518
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1154 0.0937
Brugia malayi Nuclear hormone receptor family member nhr-3 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0668 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-25 0.052 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.052 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0608 0.2981
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1154 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1002 0.1002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0668 0.0668
Echinococcus granulosus FTZ F1 alpha 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Schistosoma mansoni hypothetical protein 0.0034 0.0359 0.0359
Brugia malayi MH2 domain containing protein 0.0123 0.2136 0.2136
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0608 0.0608
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0608 0.2981
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.052 1 1
Brugia malayi ecdysone receptor 0.0245 0.4554 0.4554
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0245 0.4554 0.4554
Loa Loa (eye worm) beta-lactamase 0.0074 0.1154 0.1154
Schistosoma mansoni Tr4/Tr2 (homologue) 0.052 1 1
Brugia malayi beta-lactamase 0.0074 0.1154 0.1154
Brugia malayi Pre-SET motif family protein 0.0036 0.0405 0.0405
Brugia malayi tailless protein 0.0245 0.4554 0.4554
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1002 0.1002
Onchocerca volvulus 0.052 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.052 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0275 0.5137 0.5137
Brugia malayi hypothetical protein 0.0275 0.5137 0.5137
Mycobacterium ulcerans lipase LipD 0.0074 0.1154 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.052 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0668 0.0668
Plasmodium vivax SET domain protein, putative 0.0036 0.0405 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.052 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.052 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.052 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1154 0.1154
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0275 0.5137 0.5137
Brugia malayi RNA binding protein 0.0066 0.1002 0.1002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.052 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0245 0.4554 0.4554
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1002 0.1002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0608 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.052 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.052 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0608 0.0608
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0245 0.4554 0.4491
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0275 0.5137 0.5137
Brugia malayi nuclear hormone receptor family member nhr-6 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.052 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.052 1 1
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1154 1
Brugia malayi TAR-binding protein 0.0066 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0376
Onchocerca volvulus Bile acid receptor homolog 0.052 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.0275 0.5137 0.5137
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2136 0.2136
Onchocerca volvulus 0.0286 0.5358 0.5304
Onchocerca volvulus 0.0245 0.4554 0.4491
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0608 0.031
Brugia malayi hypothetical protein 0.0245 0.4554 0.4554
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0245 0.4554 0.4554
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0668 0.0668
Echinococcus granulosus thyroid hormone receptor alpha 0.0245 0.4554 0.4554
Loa Loa (eye worm) DR-78 0.0245 0.4554 0.4554
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1154 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0275 0.5137 0.5137
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1154 0.0937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0245 0.4554 0.4554
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1154 0.1154
Onchocerca volvulus Protein ultraspiracle homolog 0.052 1 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1002 0.1002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1154 0.1154
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2136 0.2136
Echinococcus multilocularis nuclear receptor nhr 48 0.0245 0.4554 0.4554
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.467 0.467
Schistosoma mansoni nuclear hormone receptor 0.052 1 1
Brugia malayi nuclear hormone receptor 0.0245 0.4554 0.4554
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1154 0.0937
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1154 0.5
Echinococcus multilocularis FTZ F1 alpha 0.052 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0608 0.0608
Brugia malayi photoreceptor-specific nuclear receptor 0.052 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0245 0.4554 0.4554
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0376 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0608 0.0608
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.052 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.052 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0245 0.4554 0.4554
Trichomonas vaginalis set domain proteins, putative 0.0286 0.5358 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.5137 0.5137
Onchocerca volvulus 0.0036 0.0405 0.0294
Brugia malayi Nuclear hormone receptor-like 1 0.0275 0.5137 0.5137
Loa Loa (eye worm) hypothetical protein 0.052 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0608 0.5
Brugia malayi steroid hormone receptor 0.052 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.052 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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