Detailed information for compound 1428042

Basic information

Technical information
  • TDR Targets ID: 1428042
  • Name: (5E)-3-(3-chlorophenyl)-5-[(5-morpholin-4-ylf uran-2-yl)methylidene]imidazolidine-2,4-dione
  • MW: 373.79 | Formula: C18H16ClN3O4
  • H donors: 1 H acceptors: 2 LogP: 2.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)N1C(=O)N/C(=C/c2ccc(o2)N2CCOCC2)/C1=O
  • InChi: 1S/C18H16ClN3O4/c19-12-2-1-3-13(10-12)22-17(23)15(20-18(22)24)11-14-4-5-16(26-14)21-6-8-25-9-7-21/h1-5,10-11H,6-9H2,(H,20,24)/b15-11+
  • InChiKey: OSSCOCGGWZTOFR-RVDMUPIBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-3-(3-chlorophenyl)-5-[(5-morpholino-2-furyl)methylene]imidazolidine-2,4-dione
  • (5E)-3-(3-chlorophenyl)-5-[(5-morpholino-2-furyl)methylene]hydantoin
  • AH-487/41660823
  • STK115926
  • ZINC04470586
  • 3-(3-chlorophenyl)-5-{[5-(4-morpholinyl)-2-furyl]methylene}-2,4-imidazolidinedione
  • MLS000663854
  • SMR000292374

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0021 0.0035 0.0106
Trypanosoma cruzi DNA polymerase eta, putative 0.01 0.079 0.2422
Echinococcus multilocularis peregrin 0.005 0.031 0.0277
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0163 0.1397 0.1367
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0411 0.0525
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0021 0.0035 0.0044
Plasmodium falciparum lysophospholipase, putative 0.0358 0.326 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.044 0.135
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0145 0.061
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.005 0.031 0.0397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Trypanosoma brucei monoglyceride lipase, putative 0.0358 0.326 1
Brugia malayi steroid hormone receptor 0.0024 0.0067 0.0282
Plasmodium falciparum thioredoxin reductase 0.0103 0.0818 0.2508
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0178 0.1197
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0818 0.344
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0103 0.0693
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0174 0.0533
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0021 0.0035 0.0106
Plasmodium falciparum lysophospholipase, putative 0.0358 0.326 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0062 0.043 0.055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0178 0.0228
Schistosoma mansoni hypothetical protein 0.0028 0.0099 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Schistosoma mansoni myelin transcription factor 1 myt1 0.0071 0.0513 0.0656
Leishmania major hypothetical protein, conserved 0.0021 0.0035 0.0106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.233 0.7054
Entamoeba histolytica phosphoglycerate kinase, putative 0.0173 0.1488 0.4505
Brugia malayi Pre-SET motif family protein 0.0036 0.0178 0.075
Brugia malayi mbt repeat family protein 0.0062 0.043 0.181
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0174 0.0533
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0671 0.2822
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0062 0.043 0.1449
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0751 0.0719
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0287 0.0783
Plasmodium falciparum LCCL domain-containing protein 0.0028 0.0099 0.0303
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0147 0.1244 0.5234
Schistosoma mansoni polycystin 1-related 0.0028 0.0099 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.011 0.0888 0.1136
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0241 0.0696
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0416
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0222
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0067 0.0282
Schistosoma mansoni lamin 0.0033 0.0145 0.0185
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0067 0.0282
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.044 0.135
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.326 1
Plasmodium falciparum thioredoxin reductase 0.0036 0.0174 0.0533
Toxoplasma gondii hypothetical protein 0.0021 0.0035 0.0232
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0795 0.3344
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0535 0.0643
Schistosoma mansoni hypothetical protein 0.005 0.031 0.0397
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0103 0.0693
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.044 0.135
Echinococcus granulosus SAM and MBT domain containing protein 0.0062 0.043 0.0508
Plasmodium vivax alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Schistosoma mansoni loxhd1 0.0028 0.0099 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.011 0.0888 0.0856
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0067 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.011 0.0888 0.0856
Loa Loa (eye worm) jmjC domain-containing protein 0.0103 0.0819 0.3446
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0043 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0416
Brugia malayi Thioredoxin reductase 0.0103 0.0818 0.344
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0535 0.1552
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0751 0.2304
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0751 0.2222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0067 0.0282
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0061 0.0418 0.2806
Echinococcus multilocularis neuropeptide s receptor 0.0274 0.246 0.2434
Onchocerca volvulus 0.0182 0.1581 0.6041
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0174 0.014
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.1488 0.4563
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0067 0.0085
Echinococcus granulosus lamin 0.0033 0.0145 0.0141
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0372 0.0434
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.044 0.135
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0071 0.0513 0.048
Toxoplasma gondii phospholipase/carboxylesterase 0.0021 0.0035 0.0232
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0174 0.0511
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0035 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0289 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0067 0.0282
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0213 0.058
Echinococcus granulosus Polycystic kidney disease protein 0.0028 0.0099 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Plasmodium vivax unspecified product 0.0021 0.0035 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0372 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0067 0.0282
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0103 0.0316
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.1488 0.4563
Brugia malayi MGC83647 protein 0.0021 0.0035 0.0147
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0163 0.1397 0.175
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0533
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.011 0.0888 0.1136
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0021 0.0035 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Schistosoma mansoni lamin 0.0033 0.0145 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0372 0.1141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.011 0.0888 0.1136
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7818 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.1244 0.3749
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0166 0.1424 0.1785
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0021 0.0035 0.0232
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.1488 0.4563
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0372 0.0476
Trypanosoma brucei unspecified product 0.0056 0.0372 0.1141
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0174 0.1169
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0358 0.326 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0067 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0067 0.0085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0026 0.0079 0.0334
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0818 0.2427
Echinococcus multilocularis PHD finger protein rhinoceros 0.005 0.031 0.0277
Echinococcus granulosus chromobox protein 1 0.0071 0.051 0.0611
Brugia malayi hypothetical protein 0.0022 0.0044 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0022 0.0043 0.0131
Schistosoma mansoni sex comb on midleg homolog 0.0062 0.043 0.055
Leishmania major DNA polymerase eta, putative 0.01 0.079 0.2422
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.2079 0.634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0166 0.0168
Echinococcus granulosus phosphoglycerate kinase 1 0.0173 0.1488 0.1867
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0533
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.2079 0.634
Leishmania major phosphoglycerate kinase B, cytosolic 0.0173 0.1488 0.4563
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0071 0.0513 0.2158
Trypanosoma brucei unspecified product 0.0039 0.0205 0.0628
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.0418 0.128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0067 0.0282
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2574 0.7872
Onchocerca volvulus Alhambra homolog 0.005 0.031 0.0971
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0535 0.1642
Schistosoma mansoni sex comb on midleg homolog 0.0062 0.043 0.055
Toxoplasma gondii peptidase S15, putative 0.0021 0.0035 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.1244 0.3749
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0035 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0147
Schistosoma mansoni transcription factor LCR-F1 0.0022 0.0044 0.0056
Brugia malayi hypothetical protein 0.0028 0.0099 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0067 0.0282
Schistosoma mansoni lipoxygenase 0.0116 0.0945 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Trichomonas vaginalis DNA polymerase eta, putative 0.0056 0.0372 0.1046
Brugia malayi ImpB/MucB/SamB family protein 0.01 0.079 0.3322
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Toxoplasma gondii protein c14orf29, putative 0.0021 0.0035 0.0232
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0056 0.0372 0.1046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0067 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2241 0.9429
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0372 0.1566
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0067 0.0032
Onchocerca volvulus 0.0033 0.0145 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0102 0.0207
Entamoeba histolytica hypothetical protein 0.0022 0.0044 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0035 0.0106
Plasmodium vivax alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Toxoplasma gondii hypothetical protein 0.0021 0.0035 0.0232
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0056
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.2079 0.634
Echinococcus granulosus lipoxygenase domain containing protein 0.0028 0.0099 0.0082
Plasmodium falciparum phd finger protein, putative 0.005 0.031 0.0952
Plasmodium falciparum prodrug activation and resistance esterase 0.0021 0.0035 0.0106
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0795 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0102 0.0207
Trichomonas vaginalis chromobox protein, putative 0.0071 0.051 0.1474
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0173 0.1488 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0358 0.326 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0022 0.0043 0.0008
Entamoeba histolytica hypothetical protein 0.0028 0.0103 0.0213
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.044 0.135
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.1488 0.4563
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.1244 0.3749
Plasmodium vivax glutathione reductase, putative 0.0103 0.0818 0.2508
Brugia malayi Doublecortin family protein 0.0028 0.0099 0.0416
Brugia malayi jmjC domain containing protein 0.0163 0.1397 0.5878
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.1244 0.3749
Schistosoma mansoni peptidase 0.0021 0.0035 0.0044
Treponema pallidum phosphoglycerate kinase 0.0173 0.1488 1
Brugia malayi Ets-domain containing protein 0.0087 0.0671 0.2822
Echinococcus multilocularis chromobox protein 1 0.0071 0.051 0.0477
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0043 0.0025
Echinococcus granulosus polycomb protein SCMH1 0.0062 0.043 0.0508
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0103 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0043 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0067 0.0041
Loa Loa (eye worm) hypothetical protein 0.005 0.031 0.1306
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0178 0.0144
Leishmania major hypothetical protein, conserved 0.0021 0.0035 0.0106
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0174 0.0533
Schistosoma mansoni kinase 0.0049 0.03 0.0383
Echinococcus granulosus dna polymerase eta 0.01 0.079 0.097
Onchocerca volvulus 0.0028 0.0099 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0818 0.2508
Entamoeba histolytica hypothetical protein 0.0022 0.0044 0.0029
Onchocerca volvulus 0.0048 0.0289 0.0886
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0372 0.0339
Leishmania major DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0056 0.0372 0.1046
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0241 0.0641
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.1244 0.3749
Echinococcus multilocularis dna polymerase eta 0.01 0.079 0.0757
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0103 0.0316
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0067 0.0032
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0067 0.0041
Onchocerca volvulus 0.01 0.0795 0.2903
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0071 0.0513 0.0614
Trypanosoma cruzi serine peptidase, putative 0.0021 0.0035 0.0106
Brugia malayi chromobox protein homolog 3 0.004 0.0213 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Loa Loa (eye worm) hypothetical protein 0.01 0.0795 0.3344
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0248 0.2212 0.2798
Brugia malayi MH2 domain containing protein 0.0144 0.1214 0.5109
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0067 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0067 0.0282
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0751 0.3161
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0067 0.0032
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Echinococcus multilocularis lamin dm0 0.0033 0.0145 0.011
Schistosoma mansoni hypothetical protein 0.0382 0.349 0.4464
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0751 0.3161
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7818 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.011 0.0888 0.1096
Echinococcus granulosus geminin 0.0205 0.1794 0.226
Onchocerca volvulus 0.0062 0.043 0.1449
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Brugia malayi nuclear receptor NHR-88 0.0024 0.0067 0.0282
Echinococcus multilocularis SAM and MBT domain containing protein 0.0062 0.043 0.0397
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Echinococcus granulosus lipoxygenase domain containing protein 0.0028 0.0099 0.0082
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0035 0.0106
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0178 0.0184
Echinococcus granulosus lamin dm0 0.0033 0.0145 0.0141
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.1488 0.1903
Plasmodium vivax multidomain scavenger receptor, putative 0.0028 0.0099 0.0303
Plasmodium falciparum lysophospholipase, putative 0.0021 0.0035 0.0106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0002 0.0002
Plasmodium vivax lysophospholipase, putative 0.0021 0.0035 0.0106
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0248 0.2212 0.2185
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0043 0.001
Trypanosoma brucei DNA polymerase eta, putative 0.01 0.079 0.2422
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0067 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0213 0.0551
Toxoplasma gondii hypothetical protein 0.0021 0.0035 0.0232
Onchocerca volvulus 0.0031 0.0131 0.0253
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0147
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0173 0.1488 1
Loa Loa (eye worm) doublecortin family protein 0.0028 0.0099 0.0416
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1214 0.5109
Plasmodium falciparum phosphoglycerate kinase 0.0173 0.1488 0.4563
Plasmodium vivax phosphoglycerate kinase, putative 0.0173 0.1488 0.4563
Trypanosoma brucei unspecified product 0.0039 0.0205 0.0628
Schistosoma mansoni ets-related 0.0265 0.2377 0.304
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0372 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0067 0.0282
Giardia lamblia PHD finger protein 15 0.005 0.031 0.2085
Loa Loa (eye worm) hypothetical protein 0.004 0.0213 0.0894
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0411 0.0525
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0103 0.0472
Brugia malayi Calcitonin receptor-like protein seb-1 0.0026 0.0079 0.0334
Giardia lamblia Kinase, PLK 0.0096 0.0751 0.5049
Loa Loa (eye worm) glutathione reductase 0.0103 0.0818 0.344
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0824 0.1013
Onchocerca volvulus Glucosylceramidase homolog 0.0097 0.0759 0.2759
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0535 0.1642
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0043 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Mycobacterium tuberculosis Possible lysophospholipase 0.0358 0.326 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0358 0.326 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0173 0.1488 0.4386
Plasmodium vivax PST-A protein 0.0021 0.0035 0.0106
Schistosoma mansoni hypothetical protein 0.0205 0.1794 0.2294
Plasmodium vivax PST-A protein 0.0021 0.0035 0.0106
Mycobacterium ulcerans hydrolase 0.0021 0.0035 0.0106
Leishmania major trypanothione reductase 0.0103 0.0818 0.2508
Plasmodium falciparum epoxide hydrolase 2 0.0021 0.0035 0.0106
Brugia malayi Ets-domain containing protein 0.0087 0.0671 0.2822
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0358 0.326 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.233 0.7117
Brugia malayi Phosphoglycerate kinase 0.0173 0.1488 0.6259
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0103 0.0316
Echinococcus multilocularis chromobox protein 1 0.0071 0.051 0.0477
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0067 0.0085
Loa Loa (eye worm) hypothetical protein 0.0173 0.1488 0.6259
Plasmodium vivax hypothetical protein, conserved 0.005 0.031 0.0952
Brugia malayi mbt repeat family protein 0.0062 0.043 0.181
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0067 0.0041
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0174 0.0959
Brugia malayi jmjC domain containing protein 0.006 0.0411 0.1729
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.061
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.1488 0.1903
Loa Loa (eye worm) hypothetical protein 0.0085 0.0652 0.2742
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0067 0.0282
Echinococcus multilocularis polycomb protein SCMH1 0.0062 0.043 0.0397
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0174 0.0533
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0174 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0067 0.0282
Onchocerca volvulus 0.0286 0.2574 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0174 0.0533
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0372 0.1141
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0358 0.326 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0173 0.1488 0.4563
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0067 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0067 0.0282
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0067 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.0513 0.2158
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0084 0.0351
Brugia malayi Heterochromatin protein 1 0.0071 0.051 0.2147
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0358 0.326 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0067 0.0085
Echinococcus granulosus jumonji domain containing protein 0.0069 0.0498 0.0594
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.1488 0.4505
Schistosoma mansoni DNA polymerase eta 0.01 0.079 0.101
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0411 0.0377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0026 0.0079 0.0334
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0179
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0174 0.0733
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0021 0.0035 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0205 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0067 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0147 0.1244 0.3749
Plasmodium vivax PST-A protein 0.0021 0.0035 0.0106
Toxoplasma gondii hypothetical protein 0.0021 0.0035 0.0232
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0067 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.011 0.0888 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0067 0.0282
Brugia malayi PHD-finger family protein 0.005 0.031 0.1306
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0147 0.1244 0.5234
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0035 0.0106
Loa Loa (eye worm) MBCTL1 0.0071 0.0513 0.2158
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0021 0.0035 0.0106
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0358 0.326 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0131 0.0549
Brugia malayi Phosphoglycerate kinase 0.0063 0.044 0.1852
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0178 0.0228
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0166 0.1424 0.1394
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0035 0.0106
Plasmodium falciparum esterase, putative 0.0358 0.326 1
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0358 0.326 1
Toxoplasma gondii PHD-finger domain-containing protein 0.005 0.031 0.2085
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0021 0.0035 0.0106
Plasmodium vivax PST-A protein 0.0358 0.326 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0067 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Echinococcus granulosus neuropeptide s receptor 0.0274 0.246 0.3116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0022 0.0044 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0174 0.0511
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0067 0.0032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.233 0.7117
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0067 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0067 0.0282
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Treponema pallidum NADH oxidase 0.0036 0.0174 0.0511
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Schistosoma mansoni coup transcription factor 0.0024 0.0067 0.0085
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0372 0.1046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0067 0.0282
Mycobacterium ulcerans lysophospholipase 0.0358 0.326 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0145 0.061
Plasmodium falciparum lysophospholipase, putative 0.0021 0.0035 0.0106
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0178 0.0144
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0795 0.0763
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0067 0.0282
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0067 0.0085
Schistosoma mansoni chromobox protein 0.0071 0.051 0.0652
Brugia malayi glutathione reductase 0.0103 0.0818 0.344
Echinococcus multilocularis RUN 0.0028 0.0099 0.0064
Plasmodium vivax PST-A protein 0.0021 0.0035 0.0106
Trypanosoma brucei monoglyceride lipase, putative 0.0358 0.326 1
Trypanosoma brucei polo-like protein kinase 0.0096 0.0751 0.2304
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.011 0.0888 0.3737
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0022 0.0044 0.001
Plasmodium falciparum glutathione reductase 0.0036 0.0174 0.0533
Plasmodium falciparum BEM46-like protein, putative 0.0021 0.0035 0.0106
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0751 0.2304
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0021 0.0035 0.0232
Echinococcus granulosus PHD finger protein rhinoceros 0.005 0.031 0.0354
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Plasmodium vivax SET domain protein, putative 0.0036 0.0178 0.0546
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0103 0.0316
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0173 0.1488 0.4505
Brugia malayi Protein C20orf22 0.0021 0.0035 0.0147
Plasmodium vivax unspecified product 0.0021 0.0035 0.0106
Entamoeba histolytica hypothetical protein 0.0022 0.0044 0.0029
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0067 0.0085
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0043 0.0008
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0174 0.0533
Echinococcus multilocularis neuropeptide receptor A26 0.0274 0.246 0.2434
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0002 0.0007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.2079 0.626
Schistosoma mansoni lipoxygenase 0.0166 0.1424 0.1822
Onchocerca volvulus 0.0033 0.0145 0.031
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0067 0.0041
Schistosoma mansoni intermediate filament proteins 0.0033 0.0145 0.0185
Echinococcus granulosus dna polymerase kappa 0.0056 0.0372 0.0434
Brugia malayi latrophilin 2 splice variant baaae 0.0018 0.0001 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0067 0.0282
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0021 0.0035 0.0232
Trypanosoma cruzi monoglyceride lipase, putative 0.0358 0.326 1
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.051 0.2147
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Echinococcus granulosus histone acetyltransferase MYST2 0.0071 0.0513 0.0614
Trichomonas vaginalis chromobox protein, putative 0.0071 0.051 0.1474
Plasmodium falciparum esterase, putative 0.0021 0.0035 0.0106
Plasmodium falciparum glutathione reductase 0.0103 0.0818 0.2508
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Echinococcus multilocularis histone acetyltransferase MYST2 0.0071 0.0513 0.048
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0021 0.0035 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.326 1
Brugia malayi hypothetical protein 0.0028 0.0099 0.0416
Plasmodium vivax lysophospholipase, putative 0.0021 0.0035 0.0106
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.011 0.0888 0.3737
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0067 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0751 0.0961
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0067 0.0085
Mycobacterium ulcerans hypothetical protein 0.0358 0.326 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0035 0.0106
Entamoeba histolytica hypothetical protein 0.0022 0.0044 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Mycobacterium ulcerans phosphoglycerate kinase 0.0173 0.1488 0.4563
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0358 0.326 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0022 0.0043 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Echinococcus multilocularis phosphoglycerate kinase 1 0.0173 0.1488 0.1458
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0533
Echinococcus multilocularis geminin 0.0205 0.1794 0.1765
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0174 0.0533
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0145 0.061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0535 0.1642
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.044 0.135
Brugia malayi polk-prov protein 0.0017 0 0.0001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0022 0.0043 0.0025
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0535 0.0502
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0174 0.0533
Loa Loa (eye worm) hypothetical protein 0.0032 0.0139 0.0586
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Onchocerca volvulus 0.0028 0.0099 0.0127
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0671 0.0817
Trypanosoma cruzi serine peptidase, putative 0.0021 0.0035 0.0106
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0535 0.1642
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0411 0.0483
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.1488 0.4505
Echinococcus multilocularis jumonji domain containing protein 0.0069 0.0498 0.0464
Echinococcus granulosus intermediate filament protein 0.0033 0.0145 0.0141
Plasmodium falciparum esterase, putative 0.0021 0.0035 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0751 0.2222
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0205 0.0628
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0818 0.2508
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0671 0.0638
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0174 0.0533
Echinococcus multilocularis Polycystic kidney disease protein 0.0028 0.0099 0.0064
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0043 0.0131
Plasmodium falciparum lysophospholipase, putative 0.0358 0.326 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0035 0.0106
Loa Loa (eye worm) PHD-finger family protein 0.005 0.031 0.1306
Toxoplasma gondii phospholipase 0.0021 0.0035 0.0232
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0174 0.0533
Toxoplasma gondii thioredoxin reductase 0.0103 0.0818 0.5495
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0809 0.2399
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0174 0.1169
Brugia malayi hypothetical protein 0.0182 0.1581 0.6653
Echinococcus multilocularis lamin 0.0033 0.0145 0.011
Trypanosoma brucei trypanothione reductase 0.0103 0.0818 0.2508
Trichomonas vaginalis glucosylceramidase, putative 0.0097 0.0759 0.2244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0372 0.1046
Echinococcus granulosus RUN 0.0028 0.0099 0.0082
Brugia malayi intermediate filament protein 0.0033 0.0145 0.061
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0795 0.1016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0067 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0287 0.0783
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0411 0.1729
Chlamydia trachomatis phosphoglycerate kinase 0.0173 0.1488 1
Brugia malayi Pre-SET motif family protein 0.0251 0.2241 0.9429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Loa Loa (eye worm) fli-1 protein 0.0265 0.2377 1
Leishmania major monoglyceride lipase, putative 0.0358 0.326 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0174 0.1169
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0174 0.0432
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0043 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0102 0.0809 0.2399
Echinococcus granulosus ubiquitin specific protease 41 0.0022 0.0043 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0372 0.1566
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.2079 0.634
Schistosoma mansoni rab6-interacting 0.0028 0.0099 0.0126
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0241 0.0641
Schistosoma mansoni hypothetical protein 0.0205 0.1794 0.2294
Echinococcus granulosus neuropeptide receptor A26 0.0274 0.246 0.3116
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0751 0.273
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0173 0.1488 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0043 0.0131
Loa Loa (eye worm) hypothetical protein 0.0182 0.1581 0.6653
Leishmania major DNA polymerase eta, putative 0.0061 0.0418 0.128
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0535 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1214 0.5109
Schistosoma mansoni chromobox protein 0.0071 0.051 0.0652
Brugia malayi ecdysteroid receptor 0.0024 0.0067 0.0282
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.2079 0.634
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0067 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Schistosoma mansoni rab6-interacting 0.0028 0.0099 0.0126
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.044 0.135
Schistosoma mansoni gabp alpha 0.0087 0.0671 0.0858
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0067 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0067 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.0533
Toxoplasma gondii PHD-finger domain-containing protein 0.005 0.031 0.2085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0067 0.0282
Plasmodium falciparum exported lipase 2 0.0021 0.0035 0.0106
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0022 0.0043 0.0287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0181
Brugia malayi Fli-1 protein 0.0265 0.2377 1
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0174 0.0533
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0056 0.0372 0.1141
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0174 0.0533
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0174 0.0432
Echinococcus multilocularis musashi 0.0033 0.0145 0.011
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0103 0.0213
Brugia malayi MGC79044 protein 0.0021 0.0035 0.0147
Brugia malayi nuclear hormone receptor 0.0024 0.0067 0.0282
Giardia lamblia Phosphoglycerate kinase 0.0173 0.1488 1
Plasmodium vivax lysophospholipase, putative 0.0021 0.0035 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0213 0.0551
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0751 0.2304
Echinococcus granulosus chromobox protein 1 0.0071 0.051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0075 0.0549 0.2311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0067 0.0282
Schistosoma mansoni jumonji domain containing protein 0.013 0.1076 0.1376
Loa Loa (eye worm) mbt repeat family protein 0.0062 0.043 0.181
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.233 0.7117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0282
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0535 0.3598
Echinococcus multilocularis dna polymerase kappa 0.0056 0.0372 0.0339
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0147
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0021 0.0035 0.0232
Echinococcus multilocularis lipoxygenase domain containing protein 0.0028 0.0099 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0067 0.0032
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0103 0.0316
Brugia malayi Bromodomain containing protein 0.005 0.031 0.1306
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.044 0.135
Mycobacterium tuberculosis Probable reductase 0.0234 0.2079 0.634
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0372 0.1141
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0021 0.0035 0.0106
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0174 0.0533
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0751 0.0921
Echinococcus multilocularis lipoxygenase domain containing protein 0.0028 0.0099 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0067 0.0282
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0372 0.1141
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7818 0.781
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0035 0.0106
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0535 0.0685
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0084 0.0351
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0067 0.0032
Plasmodium vivax PST-A protein 0.0021 0.0035 0.0106
Loa Loa (eye worm) hypothetical protein 0.0062 0.043 0.181
Giardia lamblia DINP protein human, muc B family 0.0056 0.0372 0.2501
Echinococcus granulosus peregrin 0.005 0.031 0.0354
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0043 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0067 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0205 0.0628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0178 0.0228
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0022 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.01 0.079 0.3322
Plasmodium falciparum exported lipase 1 0.0021 0.0035 0.0106
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0372 0.0476
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0824 0.0791
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0021 0.0035 0.0106

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 21.302 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and receptor-interacting serine-threonine kinase 2 (RIPK2): Fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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