Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.2367 | 0.2367 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2367 | 0.3661 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.2367 | 0.2367 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3628 | 0.3628 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.2367 | 0.2367 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0742 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0742 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2367 | 0.2367 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0742 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0742 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2367 | 0.3661 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3628 | 0.5609 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2367 | 0.6526 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3628 | 0.3628 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2367 | 0.3661 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3628 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2367 | 0.6526 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0742 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3628 | 0.3628 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0742 | 0.0742 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0066 | 0.0066 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.2367 | 0.6526 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3628 | 0.5609 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2367 | 0.6526 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3628 | 0.3628 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3628 | 0.3628 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.2367 | 0.6526 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2367 | 0.3661 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3628 | 0.3628 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3628 | 0.5609 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.6467 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3628 | 0.5609 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.6467 | 0.6467 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0742 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3628 | 0.5609 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2367 | 0.6526 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0742 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0742 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.011 | 0.6467 | 0.6467 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.