Detailed information for compound 1428085

Basic information

Technical information
  • TDR Targets ID: 1428085
  • Name: hydron; (1-methylpiperidin-3-yl) 2,3-dihydro- 1,4-benzodioxine-7-carboxylate; chloride
  • MW: 313.777 | Formula: C15H20ClNO4
  • H donors: 0 H acceptors: 1 LogP: 2.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCCC(C1)OC(=O)c1ccc2c(c1)OCCO2.Cl
  • InChi: 1S/C15H19NO4.ClH/c1-16-6-2-3-12(10-16)20-15(17)11-4-5-13-14(9-11)19-8-7-18-13;/h4-5,9,12H,2-3,6-8,10H2,1H3;1H
  • InChiKey: HLWBIJAUZVLMGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1-methylpiperidin-3-yl) 2,3-dihydro-1,4-benzodioxine-7-carboxylate hydrochloride
  • hydron; (1-methyl-3-piperidyl) 2,3-dihydro-1,4-benzodioxine-7-carboxylate; chloride
  • (1-methyl-3-piperidyl) 2,3-dihydro-1,4-benzodioxine-7-carboxylate hydrochloride
  • 2,3-dihydro-1,4-benzodioxine-7-carboxylic acid (1-methyl-3-piperidinyl) ester; hydron; chloride
  • 2,3-dihydro-1,4-benzodioxine-7-carboxylic acid (1-methyl-3-piperidinyl) ester hydrochloride
  • 2,3-dihydro-1,4-benzodioxine-7-carboxylic acid (1-methyl-3-piperidyl) ester; hydron; chloride
  • 2,3-dihydro-1,4-benzodioxine-7-carboxylic acid (1-methyl-3-piperidyl) ester hydrochloride
  • SMR000012232
  • 2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid 1-methyl-piperidin-3-yl ester
  • MLS000073313

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax plasmepsin IV, putative 0.1038 0.0958 1
Plasmodium falciparum heat shock protein 90 0.014 0.0112 0.1171
Brugia malayi GCC2 and GCC3 family protein 0.0037 0.0016 0.0022
Schistosoma mansoni hypothetical protein 0.0793 0.0727 0.0727
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0023 0.2092
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0119 0.0093 1
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0023 0.0245
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0624 0.0568 0.0783
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0039 0.0406
Brugia malayi DNA repair protein RAD51 homolog 1 0.0047 0.0025 0.0034
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Echinococcus granulosus cyclin b3 0.0067 0.0044 0.0044
Schistosoma mansoni integrin alpha-ps 0.0069 0.0046 0.0046
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0023 0.0023
Trichomonas vaginalis cyclins, putative 0.0067 0.0044 0.046
Trypanosoma cruzi heat shock protein 90, putative 0.014 0.0112 1
Echinococcus multilocularis beta tubulin 0.0067 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.7724 0.7252 1
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.0119 0.0119
Schistosoma mansoni biogenic amine receptor 0.0624 0.0568 0.0568
Echinococcus granulosus neuropeptide FF receptor 2 0.0624 0.0568 0.0568
Brugia malayi Latrophilin receptor protein 2 0.0963 0.0887 0.1224
Plasmodium falciparum plasmepsin II 0.1038 0.0958 1
Echinococcus multilocularis dna repair protein rad51 1 0.0047 0.0025 0.0025
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0624 0.0568 0.0568
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.0055 0.0055
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0263 0.0228 0.0315
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.0087 0.0087
Brugia malayi putative neuropeptide receptor 0.0624 0.0568 0.0783
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0011 0.0011
Schistosoma mansoni heat shock protein 0.014 0.0112 0.0112
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0624 0.0568 0.0568
Plasmodium vivax heat shock protein, putative 0.0041 0.002 0.0204
Schistosoma mansoni tyrosine kinase 0.0079 0.0055 0.0055
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0052 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Toxoplasma gondii hypothetical protein 0.0025 0.0005 0.0048
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0026 0.0026
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.0047 0.0025 0.026
Echinococcus multilocularis heat shock protein 90 0.014 0.0112 0.0112
Schistosoma mansoni amine GPCR 0.0624 0.0568 0.0568
Echinococcus granulosus endoplasmin 0.0119 0.0093 0.0093
Schistosoma mansoni neuropeptide receptor 0.0624 0.0568 0.0568
Trichomonas vaginalis cyclin B, putative 0.0136 0.0108 0.1131
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0119 0.0093 0.8278
Plasmodium falciparum cysteine repeat modular protein 1 0.0043 0.0021 0.0223
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.0119 0.0164
Plasmodium falciparum conserved protein, unknown function 0.0025 0.0005 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Trichomonas vaginalis tubulin beta chain, putative 0.0067 0.0043 0.0453
Schistosoma mansoni tyrosine kinase 0.0048 0.0026 0.0026
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0009 0.0098
Loa Loa (eye worm) rad51 0.0047 0.0025 0.0034
Echinococcus multilocularis serotonin receptor 0.0624 0.0568 0.0568
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Treponema pallidum Holliday junction DNA helicase (ruvA) 0.0032 0.0011 0.1152
Schistosoma mansoni biogenic amine (5HT) receptor 0.0624 0.0568 0.0568
Trypanosoma brucei heat shock protein 90, putative 0.014 0.0112 0.1542
Echinococcus granulosus tubulin beta 1 chain 0.0067 0.0043 0.0043
Loa Loa (eye worm) BEN-1 protein 0.0067 0.0043 0.006
Loa Loa (eye worm) tubulin beta-1 chain 0.0067 0.0043 0.006
Trichomonas vaginalis heat shock protein, putative 0.0119 0.0093 0.0969
Schistosoma mansoni tyrosine kinase 0.0077 0.0053 0.0053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0765 0.07 0.07
Echinococcus multilocularis cyclin b3 0.0067 0.0044 0.0044
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.0087 0.0087
Loa Loa (eye worm) BEN-1 protein 0.0067 0.0043 0.006
Toxoplasma gondii heat shock protein 90, putative 0.014 0.0112 0.1171
Echinococcus multilocularis integrin alpha 3 0.0118 0.0092 0.0092
Echinococcus multilocularis neuropeptide s receptor 0.1088 0.1004 0.1004
Plasmodium falciparum plasmepsin VII 0.0263 0.0228 0.2382
Echinococcus multilocularis neuropeptide receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0022
Plasmodium falciparum protein kinase 5 0.0045 0.0023 0.0245
Loa Loa (eye worm) hypothetical protein 0.0085 0.0061 0.0084
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni serine-type protease inhibitor 0.5015 0.4701 0.4701
Echinococcus multilocularis 0.0045 0.0023 0.0023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0624 0.0568 0.0568
Schistosoma mansoni cyclin B3 0.0067 0.0044 0.0044
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0047 0.0025 0.2222
Brugia malayi hypothetical protein 0.0263 0.0228 0.0315
Loa Loa (eye worm) neuropeptide F receptor 0.0624 0.0568 0.0783
Leishmania major heat shock protein, putative 0.0041 0.002 0.1743
Giardia lamblia Cyclin A 0.0067 0.0044 0.3929
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0155 0.1617
Echinococcus multilocularis allatostatin A receptor 0.0765 0.07 0.07
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0023 0.2092
Trypanosoma brucei beta tubulin 0.0067 0.0043 0.0597
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0005 0.0048
Brugia malayi neuropeptide F receptor 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0136 0.0108 0.0149
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0041 0.002 0.002
Schistosoma mansoni hypothetical protein 0.043 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis tubulin subunit beta 0.0067 0.0043 0.0043
Schistosoma mansoni excision repair cross-complementing 1 ercc1 0.0032 0.0011 0.0011
Echinococcus granulosus cyclin B 0.0136 0.0108 0.0108
Plasmodium vivax tubulin beta chain, putative 0.0067 0.0043 0.0453
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0023 0.0023
Schistosoma mansoni tyrosine kinase 0.0077 0.0053 0.0053
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0047 0.0025 0.2222
Echinococcus multilocularis cpg binding protein 0.0032 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0624 0.0568 0.0568
Brugia malayi GnHR receptor homolog 0.0624 0.0568 0.0783
Echinococcus granulosus tumor protein p63 0.0408 0.0365 0.0365
Schistosoma mansoni tyrosine kinase 0.0079 0.0055 0.0055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0624 0.0568 0.0568
Brugia malayi Cyclin, N-terminal domain containing protein 0.0136 0.0108 0.0149
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0011
Leishmania major cyclin 0.0136 0.0108 0.9663
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni biogenic amine (5HT) receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0024 0.0004 0.0004
Trypanosoma cruzi CYC2-like cyclin, putative 0.0136 0.0108 0.9663
Schistosoma mansoni ephrin receptor 0.0109 0.0083 0.0083
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.0119 0.0164
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Giardia lamblia DNA helicase 0.0032 0.0011 0.0954
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0011 0.0015
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Trichomonas vaginalis cyclin B, putative 0.0067 0.0044 0.046
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0023 0.0323
Loa Loa (eye worm) hypothetical protein 0.2081 0.194 0.2675
Schistosoma mansoni hypothetical protein 0.0624 0.0568 0.0568
Entamoeba histolytica tubulin family protein 0.0067 0.0043 0.3874
Chlamydia trachomatis glutamine binding protein 0.0082 0.0058 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0023 0.0245
Toxoplasma gondii beta tubulin 0.0067 0.0043 0.0453
Trypanosoma brucei heat shock protein 84, putative 0.0041 0.002 0.0269
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0624 0.0568 0.0568
Echinococcus granulosus neuropeptide s receptor 0.1088 0.1004 0.1004
Echinococcus granulosus dna repair protein rad51 1 0.0047 0.0025 0.0025
Echinococcus granulosus Tubulin beta 2C chain 0.0067 0.0043 0.0043
Trypanosoma cruzi cyclin, putative 0.0136 0.0108 0.9663
Trichomonas vaginalis heat shock protein, putative 0.014 0.0112 0.1171
Entamoeba histolytica cyclin family protein 0.0067 0.0044 0.3929
Trypanosoma brucei Heat shock protein 83, putative 0.014 0.0112 0.1542
Trichomonas vaginalis heat shock protein, putative 0.0119 0.0093 0.0969
Echinococcus granulosus biogenic amine 5HT receptor 0.0624 0.0568 0.0568
Toxoplasma gondii heat shock protein 75, putative 0.0041 0.002 0.0204
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0011 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0624 0.0568 0.0568
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0233 0.0321
Echinococcus multilocularis DNA excision repair protein ERCC 1 0.0032 0.0011 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0624 0.0568 0.0568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Onchocerca volvulus 0.0136 0.0108 0.1547
Brugia malayi G-protein coupled receptor 0.0624 0.0568 0.0783
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Trypanosoma cruzi cyclin 6, putative 0.0136 0.0108 0.9663
Schistosoma mansoni integrin alpha-ps 0.0036 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Mycobacterium tuberculosis Probable holliday junction DNA helicase RuvA 0.0032 0.0011 0.0041
Schistosoma mansoni heat shock protein 0.0041 0.002 0.002
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus multilocularis NMDA receptor 0.0032 0.0011 0.0011
Schistosoma mansoni heat shock protein 0.014 0.0112 0.0112
Onchocerca volvulus 0.0624 0.0568 0.8111
Trichomonas vaginalis tubulin, putative 0.0067 0.0043 0.0453
Giardia lamblia Beta tubulin 0.0067 0.0043 0.3874
Plasmodium vivax aspartyl proteinase, putative 0.1038 0.0958 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0624 0.0568 0.0568
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0269 0.0233 0.0233
Echinococcus granulosus Tubulin beta 2C chain 0.0067 0.0043 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0233 0.2428
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0624 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Entamoeba histolytica hypothetical protein 0.0025 0.0005 0.041
Onchocerca volvulus 0.0624 0.0568 0.8111
Echinococcus granulosus hypothetical protein 0.0624 0.0568 0.0568
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0624 0.0568 0.0568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Trichomonas vaginalis cyclin B, putative 0.0136 0.0108 0.1131
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0023 0.2092
Brugia malayi Cyclin, N-terminal domain containing protein 0.0136 0.0108 0.0149
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0624 0.0568 0.0568
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.0126 0.0174
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0624 0.0568 0.0568
Brugia malayi AKH receptor 0.0624 0.0568 0.0783
Trichomonas vaginalis heat shock protein, putative 0.0041 0.002 0.0204
Echinococcus multilocularis sex peptide receptor 0.0624 0.0568 0.0568
Schistosoma mansoni amine GPCR 0.0624 0.0568 0.0568
Plasmodium falciparum plasmepsin I 0.1038 0.0958 1
Echinococcus granulosus neuropeptides capa receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) aspartic protease BmAsp-2 0.1038 0.0958 0.1321
Plasmodium vivax plasmepsin V, putative 0.0263 0.0228 0.2382
Brugia malayi RE15519p 0.0624 0.0568 0.0783
Schistosoma mansoni memapsin-2 (A01 family) 0.0263 0.0228 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.0624 0.0568 0.0783
Echinococcus multilocularis fmrfamide receptor 0.0624 0.0568 0.0568
Echinococcus granulosus cyclin B3 1 0.0067 0.0044 0.0044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0026 0.0026
Schistosoma mansoni adenoreceptor 0.0624 0.0568 0.0568
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Chlamydia trachomatis exodeoxyribonuclease V subunit alpha 0.0032 0.0011 0.186
Toxoplasma gondii aspartyl protease ASP1 0.1038 0.0958 1
Brugia malayi Angiotensin-converting enzyme family protein 0.0611 0.0556 0.0767
Loa Loa (eye worm) hypothetical protein 0.0263 0.0228 0.0315
Plasmodium falciparum plasmepsin V 0.0263 0.0228 0.2382
Schistosoma mansoni alpha-1 adrenergic receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis Tubulin beta 2C chain 0.0067 0.0043 0.0043
Schistosoma mansoni serine-type protease inhibitor 0.5015 0.4701 0.4701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Toxoplasma gondii hypothetical protein 0.0051 0.0029 0.03
Trichomonas vaginalis heat shock protein, putative 0.0119 0.0093 0.0969
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0011 0.0011
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0269 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0068 0.0045 0.0062
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0011 0.0011
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Plasmodium vivax aspartyl protease, putative 0.0425 0.0381 0.3973
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi CXXC zinc finger family protein 0.003 0.0009 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Loa Loa (eye worm) latrophilin receptor protein 2 0.0963 0.0887 0.1224
Plasmodium falciparum cysteine repeat modular protein 3 0.0025 0.0005 0.0048
Onchocerca volvulus 0.0624 0.0568 0.8111
Schistosoma mansoni neuropeptide F-like receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Onchocerca volvulus 0.0624 0.0568 0.8111
Echinococcus multilocularis neuropeptide FF receptor 2 0.0624 0.0568 0.0568
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0624 0.0568 0.0783
Brugia malayi sulfakinin receptor protein 0.0624 0.0568 0.0783
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0024 0.0004 0.0004
Echinococcus granulosus GPCR family 2 0.0963 0.0887 0.0887
Echinococcus multilocularis insulin receptor 0.0048 0.0026 0.0026
Plasmodium vivax endoplasmin, putative 0.014 0.0112 0.1171
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0023 0.0023
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Treponema pallidum heat shock protein 90 0.0119 0.0093 1
Brugia malayi GCC2 and GCC3 family protein 0.0025 0.0005 0.0006
Loa Loa (eye worm) tubulin beta chain 0.0067 0.0043 0.006
Plasmodium vivax heat shock protein 86, putative 0.014 0.0112 0.1171
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0011 0.0011
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0112 1
Echinococcus multilocularis tubulin beta 1 chain 0.0067 0.0043 0.0043
Loa Loa (eye worm) neuropeptide F receptor 0.0624 0.0568 0.0783
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0233 0.2428
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0009 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Echinococcus multilocularis heat shock protein 0.014 0.0112 0.0112
Onchocerca volvulus Neuropeptide F receptor homolog 0.0624 0.0568 0.8111
Echinococcus granulosus tubulin subunit beta 0.0067 0.0043 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0155 0.1617
Loa Loa (eye worm) hypothetical protein 0.0107 0.0081 0.0112
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Echinococcus granulosus orexin receptor type 2 0.0624 0.0568 0.0568
Brugia malayi beta-tubulin, identical 0.0067 0.0043 0.006
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0023 0.0023
Echinococcus granulosus heat shock protein 0.014 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0006
Echinococcus granulosus DNA excision repair protein ERCC 1 0.0032 0.0011 0.0011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0624 0.0568 0.0568
Chlamydia trachomatis excinuclease ABC subunit C 0.0032 0.0011 0.186
Echinococcus multilocularis dnaJ subfamily B 0.043 0.0385 0.0385
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0119 0.0093 0.0093
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0024 0.0004 0.0004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0624 0.0568 0.0568
Echinococcus granulosus tm gpcr rhodopsin 0.0624 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0025 0.0005 0.0005
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Brugia malayi G protein-coupled receptor 0.0624 0.0568 0.0783
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Echinococcus granulosus beta tubulin 0.0067 0.0043 0.0043
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0136 0.0108 0.9663
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0119 0.0093 0.0358
Schistosoma mansoni tyrosine kinase 0.0048 0.0026 0.0026
Schistosoma mansoni amine GPCR 0.0624 0.0568 0.0568
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Schistosoma mansoni cathepsin D (A01 family) 0.2921 0.2731 0.2731
Onchocerca volvulus 0.0263 0.0228 0.3257
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0026 0.0026
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0047 0.0025 0.2222
Echinococcus multilocularis endoplasmin 0.0119 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0963 0.0887 0.1224
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0611 0.0556 0.0767
Echinococcus granulosus cyclins 0.0067 0.0044 0.0044
Mycobacterium leprae Probable Holliday junction DNA helicase component RuvA 0.0032 0.0011 0.0041
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0112 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0058 0.0222
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.1038 0.0958 1
Onchocerca volvulus 0.0624 0.0568 0.8111
Brugia malayi Pepsin A precursor 0.0263 0.0228 0.0315
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0009 0.0129
Echinococcus granulosus g protein coupled receptor 0.0624 0.0568 0.0568
Onchocerca volvulus 0.0624 0.0568 0.8111
Schistosoma mansoni endoplasmin 0.014 0.0112 0.0112
Onchocerca volvulus 0.0196 0.0165 0.2355
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0011 0.0015
Entamoeba histolytica tubulin family protein 0.0067 0.0043 0.3874
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0233 0.2428
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0024 0.0004 0.0004
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0044 0.046
Schistosoma mansoni histamine h1 receptor 0.0624 0.0568 0.0568
Trichomonas vaginalis cyclin B, putative 0.0136 0.0108 0.1131
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0624 0.0568 0.0568
Echinococcus multilocularis tumor protein p63 0.0408 0.0365 0.0365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0033 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0023 0.0245
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi hypothetical protein 0.0263 0.0228 0.0315
Echinococcus granulosus cyclins 0.0067 0.0044 0.0044
Echinococcus granulosus neuropeptides capa receptor 0.0624 0.0568 0.0568
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0963 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Trypanosoma brucei heat shock protein 90, putative 0.014 0.0112 0.1542
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0624 0.0568 0.0568
Plasmodium falciparum cysteine repeat modular protein 4 0.0025 0.0005 0.0048
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0011 0.0011
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0025 0.0005 0.041
Echinococcus granulosus neuropeptide receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0023 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0023 0.0245
Schistosoma mansoni hypothetical protein 0.0624 0.0568 0.0568
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0233 0.2428
Entamoeba histolytica cyclin, putative 0.0067 0.0044 0.3929
Trypanosoma brucei beta tubulin 0.0067 0.0043 0.0597
Plasmodium falciparum heat shock protein 90, putative 0.0041 0.002 0.0204
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0624 0.0568 0.0783
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0025 0.0005 0.0048
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Trypanosoma cruzi heat shock protein 90, putative 0.0119 0.0093 0.8278
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus granulosus dro:myosuppressin receptor 0.0624 0.0568 0.0568
Schistosoma mansoni cpg binding protein 0.0032 0.0011 0.0011
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0025 0.0005 0.0048
Echinococcus multilocularis g-protein coupled receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.1038 0.0958 0.1321
Brugia malayi GCC2 and GCC3 family protein 0.0025 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0006
Trichomonas vaginalis cyclin D, putative 0.0067 0.0044 0.046
Trichomonas vaginalis cyclins, putative 0.0136 0.0108 0.1131
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.1038 0.0958 0.0958
Echinococcus multilocularis neuropeptide Y receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis Tubulin beta 2C chain 0.0067 0.0043 0.0043
Loa Loa (eye worm) integrin alpha pat-2 0.0238 0.0205 0.0282
Echinococcus granulosus g-protein coupled receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0026 0.0026
Schistosoma mansoni myosin xvIII 0.0624 0.0568 0.0568
Onchocerca volvulus 0.0765 0.07 1
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0023 0.2092
Loa Loa (eye worm) tubulin beta-4 chain 0.0067 0.0043 0.006
Schistosoma mansoni tubulin subunit beta 0.0067 0.0043 0.0043
Onchocerca volvulus 0.0624 0.0568 0.8111
Brugia malayi solute carrier family 40, member 1 0.0196 0.0165 0.0227
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0023 0.2092
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0067 0.0043 0.0043
Echinococcus multilocularis cyclin B3 1 0.0067 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0044 0.0061
Schistosoma mansoni neuropeptide F-like receptor 0.0624 0.0568 0.0568
Toxoplasma gondii beta-tubulin, putative 0.0067 0.0043 0.0453
Giardia lamblia Beta tubulin 0.0067 0.0043 0.3874
Loa Loa (eye worm) hypothetical protein 0.0765 0.07 0.0966
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Toxoplasma gondii kringle domain-containing protein 0.0043 0.0021 0.0223
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0023 0.0023
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0034 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0624 0.0568 0.0568
Echinococcus granulosus integrin alpha ps 0.0069 0.0046 0.0046
Echinococcus granulosus cyclins 0.0067 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis dro:myosuppressin receptor 0.0624 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0963 0.0887 0.0887
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.7724 0.7252 1
Onchocerca volvulus 0.0624 0.0568 0.8111
Echinococcus granulosus heat shock protein 90 0.014 0.0112 0.0112
Schistosoma mansoni tubulin subunit beta 0.0067 0.0043 0.0043
Echinococcus granulosus dnaJ subfamily B 0.043 0.0385 0.0385
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0023 0.0023
Brugia malayi larval opioid receptor 0.0624 0.0568 0.0783
Brugia malayi Serotonin receptor 0.0624 0.0568 0.0783
Echinococcus granulosus 7TM GPCR rhodopsin 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0013
Trichomonas vaginalis cyclins, putative 0.0085 0.006 0.0629
Entamoeba histolytica cyclin family protein 0.0067 0.0044 0.3929
Echinococcus granulosus sex peptide receptor 0.0624 0.0568 0.0568
Echinococcus granulosus cyclins 0.0067 0.0044 0.0044
Echinococcus granulosus cyclins 0.0067 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Plasmodium falciparum plasmepsin III 0.0263 0.0228 0.2382
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0233 0.0321
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trypanosoma brucei beta tubulin 0.0067 0.0043 0.0597
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Trichomonas vaginalis cyclins, putative 0.0136 0.0108 0.1131
Schistosoma mansoni tubulin subunit beta 0.0067 0.0043 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0009 0.0833
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0023 0.2092
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0024 0.0004 0.0004
Schistosoma mansoni growth hormone secretagogue receptor 0.0624 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0963 0.0887 0.0887
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0009 0.0013
Schistosoma mansoni tyrosine kinase 0.0146 0.0119 0.0119
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Echinococcus granulosus tachykinin peptides receptor 99D 0.0624 0.0568 0.0568
Plasmodium falciparum plasmepsin X 0.0425 0.0381 0.3973
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Onchocerca volvulus 0.0624 0.0568 0.8111
Wolbachia endosymbiont of Brugia malayi Holliday junction DNA helicase RuvA 0.0032 0.0011 0.1152
Plasmodium falciparum tubulin beta chain 0.0067 0.0043 0.0453
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Onchocerca volvulus 0.0624 0.0568 0.8111
Echinococcus multilocularis integrin alpha ps 0.0033 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0077 0.0053 0.0053
Brugia malayi Serotonin receptor 0.0624 0.0568 0.0783
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0624 0.0568 0.0783
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0082 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni neuropeptide f receptor 76f 0.0624 0.0568 0.0568
Echinococcus multilocularis neuropeptides capa receptor 0.0624 0.0568 0.0568
Schistosoma mansoni opsin-like receptor 0.0624 0.0568 0.0568
Leishmania major RAD51/dmc1 protein 0.0047 0.0025 0.2222
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0112 1
Loa Loa (eye worm) beta-tubulin 0.0067 0.0043 0.006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0624 0.0568 0.0783
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0117 0.0091 0.0125
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.0119 0.0119
Schistosoma mansoni opsin-like receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0033 0.0033
Trichomonas vaginalis endoplasmin, putative 0.0062 0.0039 0.0406
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2773 0.2591 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0095 0.0131
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Giardia lamblia CEGP1 protein 0.0025 0.0005 0.041
Trichomonas vaginalis cyclins, putative 0.0136 0.0108 0.1131
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) G-protein coupled receptor 0.0624 0.0568 0.0783
Entamoeba histolytica heat shock protein 90, putative 0.014 0.0112 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0041 0.0041
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0011 0.0015
Trichomonas vaginalis tubulin epsilon chain, putative 0.0067 0.0043 0.0453
Brugia malayi G protein-coupled receptor F59B2.13 0.0624 0.0568 0.0783
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.5643 0.5293 0.5293
Trichomonas vaginalis cyclin B, putative 0.0136 0.0108 0.1131
Brugia malayi ephrin receptor 1 precursor 0.0052 0.003 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Brugia malayi Dopamine receptor protein 1 0.0624 0.0568 0.0783
Echinococcus granulosus g protein coupled receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0963 0.0887 0.1224
Brugia malayi aspartic protease BmAsp-2, identical 0.0263 0.0228 0.0315
Plasmodium falciparum endoplasmin, putative 0.0062 0.0039 0.0406
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Giardia lamblia Hypothetical protein 0.0067 0.0044 0.3929
Echinococcus granulosus neuropeptide Y receptor 0.0624 0.0568 0.0568
Plasmodium falciparum cysteine repeat modular protein 2 0.0025 0.0005 0.0048
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0067 0.0043 0.0453
Echinococcus multilocularis Tubulin beta 2C chain 0.0067 0.0043 0.0043
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0624 0.0568 0.0783
Echinococcus multilocularis neuropeptides capa receptor 0.0624 0.0568 0.0568
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0023 0.0323
Plasmodium vivax aspartyl proteinase, putative 0.0263 0.0228 0.2382
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0023 0.2092
Echinococcus granulosus glutamate receptor 2 0.0048 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.003 0.0009 0.0833
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.1038 0.0958 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0067 0.0044 0.0044
Onchocerca volvulus 0.0624 0.0568 0.8111
Giardia lamblia Heat shock protein HSP 90-alpha 0.0119 0.0093 0.8278
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0624 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0963 0.0887 0.0887
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0009 0.0098
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0624 0.0568 0.0783
Trypanosoma brucei beta tubulin 0.0067 0.0043 0.0597
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0136 0.0108 0.0149
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.0026 0.0026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0624 0.0568 0.0783
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0624 0.0568 0.0568
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Schistosoma mansoni integrin alpha 0.0154 0.0126 0.0126
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Onchocerca volvulus 0.0624 0.0568 0.8111
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.1038 0.0958 0.0958
Brugia malayi Dopamine receptor protein 2 0.0624 0.0568 0.0783
Toxoplasma gondii heat shock protein HSP90 0.014 0.0112 0.1171
Loa Loa (eye worm) hypothetical protein 0.0117 0.0091 0.0125
Mycobacterium ulcerans heat shock protein 90 0.0119 0.0093 0.0358
Echinococcus multilocularis g protein coupled receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis 0.0034 0.0013 0.0013
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.0026 0.0026
Schistosoma mansoni opsin-like receptor 0.0624 0.0568 0.0568
Trypanosoma cruzi beta tubulin, putative 0.0067 0.0043 0.3874
Schistosoma mansoni hypothetical protein 0.0624 0.0568 0.0568
Echinococcus granulosus heat shock protein 90 0.0119 0.0093 0.0093
Plasmodium falciparum plasmepsin VI 0.1038 0.0958 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0023 0.0031
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Echinococcus granulosus tm gpcr rhodopsin 0.0624 0.0568 0.0568
Echinococcus granulosus integrin alpha ps 0.0033 0.0012 0.0012
Schistosoma mansoni glutamate receptor NMDA 0.0269 0.0233 0.0233
Plasmodium vivax protein kinase Crk2 0.0045 0.0023 0.0245
Echinococcus granulosus somatostatin receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus granulosus G protein coupled receptor 139 0.0624 0.0568 0.0568
Echinococcus multilocularis neuropeptide receptor 1.0644 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0624 0.0568 0.0783
Schistosoma mansoni tubulin subunit beta 0.0067 0.0043 0.0043
Brugia malayi Eukaryotic aspartyl protease family protein 0.0263 0.0228 0.0315
Echinococcus multilocularis orexin receptor type 2 0.0624 0.0568 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0233 0.2428
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Chlamydia trachomatis Holliday junction ATP-dependent DNA helicase RuvA 0.0032 0.0011 0.186
Echinococcus granulosus Tubulin beta 2C chain 0.0067 0.0043 0.0043
Echinococcus multilocularis cyclin B 0.0136 0.0108 0.0108
Schistosoma mansoni cpg binding protein 0.003 0.0009 0.0009
Echinococcus multilocularis heat shock protein 90 0.0119 0.0093 0.0093
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.1038 0.0958 0.0958
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0624 0.0568 0.0568
Onchocerca volvulus 0.006 0.0037 0.0527
Mycobacterium ulcerans Holliday junction DNA helicase RuvA 0.0032 0.0011 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0033 0.0045
Echinococcus granulosus serotonin receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0624 0.0568 0.0568
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0037 0.0037
Entamoeba histolytica protein kinase, putative 0.0026 0.0006 0.0491
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0033 0.0033
Schistosoma mansoni cpg binding protein 0.0032 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0624 0.0568 0.0568
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0011 0.0011
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0023 0.0032
Loa Loa (eye worm) TK/EPH protein kinase 0.0138 0.011 0.0152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0033 0.0045
Trypanosoma cruzi cyclin, putative 0.0136 0.0108 0.9663
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) heat shock protein 75 0.0041 0.002 0.0027
Echinococcus granulosus integrin alpha 3 0.0118 0.0092 0.0092
Echinococcus granulosus neuropeptide receptor A26 0.1088 0.1004 0.1004
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0058 0.0222
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0023 0.0023
Onchocerca volvulus 0.003 0.0009 0.013
Trypanosoma brucei mitotic cyclin 6 0.0136 0.0108 0.149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.3044 0.2847 0.3925
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0025 0.0005 0.0048
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi Hsp90 protein 0.0041 0.002 0.0027
Loa Loa (eye worm) melatonin receptor type 1A 0.0624 0.0568 0.0783
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0041 0.002 0.002
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2773 0.2591 1
Trypanosoma brucei RNA helicase, putative 0.0793 0.0727 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0624 0.0568 0.0568
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0011 0.0011
Mycobacterium ulcerans excinuclease ABC subunit C 0.0032 0.0011 0.0041
Brugia malayi hypothetical protein 0.003 0.0009 0.0013
Brugia malayi hypothetical protein 0.0624 0.0568 0.0783
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.5643 0.5293 0.5293
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0067 0.0043 0.0043
Brugia malayi ORL1-like opioid receptor 0.0624 0.0568 0.0783
Echinococcus granulosus peptide allatostatin:somatostatin 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trichomonas vaginalis cyclin D, putative 0.0067 0.0044 0.046
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0624 0.0568 0.0568
Echinococcus multilocularis G protein coupled receptor 139 1.0644 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Trypanosoma cruzi heat shock protein 90, putative 0.0098 0.0073 0.6535
Schistosoma mansoni neuropeptide receptor 0.0624 0.0568 0.0568
Onchocerca volvulus 0.0107 0.0081 0.1157
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0011 0.0011
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.0087 0.0087
Trypanosoma brucei heat shock protein, putative 0.014 0.0112 0.1542
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0624 0.0568 0.8111
Loa Loa (eye worm) tubulin beta-2A chain 0.0067 0.0043 0.006
Echinococcus granulosus beta tubulin 0.0067 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Brugia malayi follicle stimulating hormone receptor 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus granulosus g protein coupled receptor 0.0624 0.0568 0.0568
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0023 0.2092
Entamoeba histolytica cysteine-rich surface protein, putative 0.0025 0.0005 0.041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0044
Schistosoma mansoni cyclin B 0.0136 0.0108 0.0108
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0624 0.0568 0.0568
Brugia malayi G-protein coupled receptor 0.0624 0.0568 0.0783
Trichomonas vaginalis cyclin A, putative 0.0136 0.0108 0.1131
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0023 0.2092
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.0026 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis serotonin receptor 0.0624 0.0568 0.0568
Trypanosoma cruzi heat shock protein, putative 0.0041 0.002 0.1743
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0146 0.2084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Echinococcus granulosus endonuclease reverse transcriptase 0.0025 0.0005 0.0005
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0011 0.0011
Brugia malayi Endoplasmin precursor 0.014 0.0112 0.0155
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0011 0.0011
Chlamydia trachomatis DNA ligase 0.0032 0.0011 0.186
Entamoeba histolytica heat shock protein 90, putative 0.014 0.0112 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.3044 0.2847 0.3925
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Giardia lamblia G2/mitotic-specific cyclin B 0.0136 0.0108 0.9663
Echinococcus multilocularis integrin alpha ps 0.0069 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis fmrfamide receptor 0.0624 0.0568 0.0568
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Echinococcus granulosus 7tm_1 domain containing protein 0.0624 0.0568 0.0568
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0011 0.0011
Echinococcus granulosus fmrfamide receptor 0.0624 0.0568 0.0568
Echinococcus granulosus allatostatin A receptor 0.0765 0.07 0.07
Brugia malayi Protein kinase domain containing protein 0.0048 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Echinococcus granulosus neuropeptide Y receptor 0.0624 0.0568 0.0568
Echinococcus granulosus tubulin beta 4A class IVa 0.0067 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Onchocerca volvulus 0.0624 0.0568 0.8111
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0023 0.2092
Toxoplasma gondii Hsp90 domain-containing protein 0.0041 0.002 0.0204
Loa Loa (eye worm) TYRA-2 protein 0.0624 0.0568 0.0783
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.0047 0.0025 0.026
Loa Loa (eye worm) endoplasmin 0.014 0.0112 0.0155
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0624 0.0568 0.0783
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0006
Trypanosoma cruzi Heat shock protein 83, putative 0.014 0.0112 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0624 0.0568 0.0568
Echinococcus multilocularis GPCR, family 2 0.0963 0.0887 0.0887
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0026 0.0035
Plasmodium falciparum cyclin 0.0067 0.0044 0.046
Brugia malayi latrophilin 2 splice variant baaae 0.2081 0.194 0.2675
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0005 0.041
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0263 0.0228 0.0315
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0026 0.0026
Echinococcus granulosus Tubulin beta 2C chain 0.0067 0.0043 0.0043
Toxoplasma gondii beta-1 tubulin, putative 0.0067 0.0043 0.0453
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Echinococcus multilocularis ephrin type A receptor 4 A 0.0134 0.0107 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Loa Loa (eye worm) heat shock protein 90 0.014 0.0112 0.0155
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0043 0.0021 0.0223
Giardia lamblia Heat shock protein HSP 90-alpha 0.014 0.0112 1
Schistosoma mansoni neuropeptide receptor 1.0644 1 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0119 0.0093 0.0358
Echinococcus granulosus alpha 1A adrenergic receptor 0.0624 0.0568 0.0568
Echinococcus granulosus tm gpcr rhodopsin 0.0624 0.0568 0.0568
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0023 0.0023
Entamoeba histolytica DNA repair protein RAD51, putative 0.0047 0.0025 0.2222
Echinococcus multilocularis neuropeptide receptor A26 0.1088 0.1004 0.1004
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0009 0.0098
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0011 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0624 0.0568 0.0568
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0624 0.0568 0.0568
Brugia malayi Dopamine receptor 0.0624 0.0568 0.0783
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Echinococcus granulosus cpg binding protein 0.0032 0.0011 0.0011
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Giardia lamblia Beta tubulin 0.0067 0.0043 0.3874
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0015 0.002
Brugia malayi aspartic protease BmAsp-1, identical 0.0263 0.0228 0.0315
Plasmodium falciparum heat shock protein 90, putative 0.0041 0.002 0.0204
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0047 0.0025 0.2222
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0023 0.0023
Echinococcus multilocularis Tubulin beta 2C chain 0.0067 0.0043 0.0043
Onchocerca volvulus 0.0624 0.0568 0.8111
Brugia malayi PDZ domain containing protein 0.0025 0.0004 0.0006
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0009 0.0833
Giardia lamblia Hypothetical protein 0.0025 0.0005 0.041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0006
Toxoplasma gondii aspartyl protease ASP3 0.0425 0.0381 0.3973
Echinococcus granulosus Tubulin beta 2C chain 0.0067 0.0043 0.0043
Brugia malayi Tubulin beta-1 chain 0.0067 0.0043 0.006
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0034 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0624 0.0568 0.0568
Schistosoma mansoni neuropeptide receptor 0.0624 0.0568 0.0568
Echinococcus multilocularis somatostatin receptor 0.0624 0.0568 0.0568
Giardia lamblia hypothetical protein 0.0032 0.0011 0.0954
Echinococcus granulosus ephrin type A receptor 4 A 0.0134 0.0107 0.0107
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0624 0.0568 0.0568
Brugia malayi putative neuropeptide receptor NPR1 0.0624 0.0568 0.0783
Schistosoma mansoni tubulin subunit beta 0.0067 0.0043 0.0043
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0026 0.0026
Echinococcus multilocularis endonuclease reverse transcriptase 0.0025 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Trichomonas vaginalis tubulin alpha chain, putative 0.0067 0.0043 0.0453
Echinococcus granulosus rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni cyclins 0.0067 0.0044 0.0044
Onchocerca volvulus 0.0263 0.0228 0.3257
Echinococcus multilocularis integrin alpha ps 0.0069 0.0046 0.0046
Giardia lamblia Grp94/Hsp90 0.0119 0.0093 0.8278
Loa Loa (eye worm) aspartyl protease 6 0.0263 0.0228 0.0315
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0023 0.0032
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0624 0.0568 0.0783
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0023 0.0023
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0044 0.0061
Toxoplasma gondii DNA repair protein rad10 subfamily protein 0.0032 0.0011 0.0112
Brugia malayi heat shock protein 90 0.014 0.0112 0.0155
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0263 0.0228 0.0228
Plasmodium falciparum plasmepsin IX 0.0425 0.0381 0.3973
Plasmodium falciparum plasmepsin IV 0.1038 0.0958 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0082 0.0058 0.6197
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0146 0.1524
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0263 0.0228 0.2382
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0624 0.0568 0.0568
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0963 0.0887 0.0887
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Onchocerca volvulus 0.0624 0.0568 0.8111
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0233 0.2428
Wolbachia endosymbiont of Brugia malayi transcription elongation factor NusA 0.0032 0.0011 0.1152
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0011 0.0011
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0082 0.0058 0.6197
Trypanosoma cruzi heat shock protein 85, putative 0.0119 0.0093 0.8278
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0067 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0045 0.0023 0.0032
Brugia malayi neuropeptide F receptor 0.0624 0.0568 0.0783
Echinococcus multilocularis beta tubulin 0.0067 0.0043 0.0043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0624 0.0568 0.0568
Schistosoma mansoni tubulin subunit beta 0.0067 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0196 0.0165 0.0227
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Schistosoma mansoni DNA repair protein RAD51 0.0047 0.0025 0.0025
Onchocerca volvulus 0.0025 0.0005 0.0066
Plasmodium falciparum plasmepsin VIII, putative 0.0263 0.0228 0.2382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0624 0.0568 0.0568
Onchocerca volvulus 0.0037 0.0016 0.0224
Plasmodium vivax aspartyl protease, putative 0.0425 0.0381 0.3973
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0041 0.002 0.1743
Plasmodium vivax aspartyl protease, putative 0.0263 0.0228 0.2382
Brugia malayi cell division control protein 2 homolog 0.0045 0.0023 0.0032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0034 0.036
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0024 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0052 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Onchocerca volvulus 0.0624 0.0568 0.8111
Schistosoma mansoni hypothetical protein 0.0963 0.0887 0.0887
Leishmania major heat shock protein 83-1 0.014 0.0112 1
Trichomonas vaginalis cyclin B3, putative 0.0067 0.0044 0.046
Plasmodium vivax heat shock protein 90, putative 0.0041 0.002 0.0204
Schistosoma mansoni biogenic amine receptor 0.0624 0.0568 0.0568
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2773 0.2591 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0033 0.0033
Schistosoma mansoni endoplasmin 0.014 0.0112 0.0112
Trichomonas vaginalis tubulin epsilon chain, putative 0.0067 0.0043 0.0453
Schistosoma mansoni amine GPCR 0.0624 0.0568 0.0568
Echinococcus granulosus insulin receptor 0.0048 0.0026 0.0026
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.0055 0.0055
Brugia malayi GCC2 and GCC3 family protein 0.0025 0.0005 0.0006
Brugia malayi Melatonin receptor type 1A 0.0624 0.0568 0.0783
Echinococcus multilocularis neuropeptide Y receptor 0.0624 0.0568 0.0568
Leishmania major beta tubulin 0.0067 0.0043 0.3874
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis g protein coupled receptor 0.0624 0.0568 0.0568
Schistosoma mansoni cathepsin D (A01 family) 0.2921 0.2731 0.2731
Echinococcus multilocularis cyclins 0.0067 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.2081 0.194 0.194
Entamoeba histolytica cyclin, putative 0.0136 0.0108 0.9663
Toxoplasma gondii aspartyl protease 0.0263 0.0228 0.2382
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0041 0.002 0.0279
Loa Loa (eye worm) hypothetical protein 0.0624 0.0568 0.0783
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0033 0.0033
Trichomonas vaginalis cyclins, putative 0.0136 0.0108 0.1131

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 50 um PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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