Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2925 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.03 | 0.1026 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2925 | 1 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2925 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2925 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2925 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2821 | 0.9646 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2925 | 0.2925 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2925 | 0.2925 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0029 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.