Detailed information for compound 1428633

Basic information

Technical information
  • TDR Targets ID: 1428633
  • Name: 1-(2-hydroxyethylamino)-3-phenothiazin-10-ylp ropan-2-ol
  • MW: 316.418 | Formula: C17H20N2O2S
  • H donors: 3 H acceptors: 2 LogP: 2.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNCC(CN1c2ccccc2Sc2c1cccc2)O
  • InChi: 1S/C17H20N2O2S/c20-10-9-18-11-13(21)12-19-14-5-1-3-7-16(14)22-17-8-4-2-6-15(17)19/h1-8,13,18,20-21H,9-12H2
  • InChiKey: DYMIJVHRNQRZDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-hydroxyethylamino)-3-phenothiazin-10-yl-propan-2-ol
  • 1-(2-hydroxyethylamino)-3-(10-phenothiazinyl)propan-2-ol
  • EU-0074314
  • ST5268872
  • BAS 03011164
  • 1-(2-Hydroxy-ethylamino)-3-phenothiazin-10-yl-propan-2-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0181 0.0213
Mycobacterium ulcerans ATP-dependent DNA helicase II UvrD2 0.0058 0.0566 0.9744
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0321 0.3656 1
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0619 0.0729
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.021 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0061
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0198 0.2213 0.2606
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0158 0.0186
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0059 0.0578 0.0681
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0198 0.2213 0.2213
Schistosoma mansoni lipoxygenase 0.0087 0.0909 0.107
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0059 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.013 0.1409 0.148
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0566 0.1023
Echinococcus multilocularis geminin 0.0354 0.405 0.405
Schistosoma mansoni hypothetical protein 0.0354 0.405 0.477
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0126 0.0126
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Entamoeba histolytica recQ family helicase, putative 0.0097 0.1024 0.353
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1564 0.2808
Trypanosoma brucei ribosomal RNA processing protein 6 0.0059 0.0578 0.1792
Schistosoma mansoni microtubule-associated protein tau 0.0732 0.8492 1
Echinococcus multilocularis smad 0.0026 0.0181 0.0181
Brugia malayi MH2 domain containing protein 0.0026 0.0181 0.0302
Schistosoma mansoni hypothetical protein 0.0021 0.0126 0.0148
Echinococcus granulosus smad 0.0026 0.0181 0.0213
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.01 0.0102
Brugia malayi hypothetical protein 0.0038 0.0329 0.0569
Schistosoma mansoni rab6-interacting 0.0021 0.0126 0.0148
Leishmania major hypothetical protein, conserved 0.0053 0.0499 0.1514
Treponema pallidum ATP-dependent DNA helicase 0.0101 0.1069 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1564 0.1842
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0198 0.2213 0.2606
Schistosoma mansoni loxhd1 0.0021 0.0126 0.0148
Loa Loa (eye worm) hypothetical protein 0.0101 0.1069 0.1119
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0422 0.4845 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0061
Onchocerca volvulus 0.0021 0.0126 0.0798
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0599 0.0599
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0459 0.0805
Brugia malayi 3'-5' exonuclease family protein 0.0059 0.0578 0.1022
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0071 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0227 0.0226
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0071 0.0084
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0059 0.0578 0.0578
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0599 0.0599
Loa Loa (eye worm) RecQ helicase 0.048 0.5532 0.5857
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0071 0.0084
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0198 0.2213 0.4567
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0176 0.1948 0.2294
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0577 0.0597
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0071 0.0061
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0176 0.1948 0.1948
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0181 0.0181
Schistosoma mansoni Smad4 0.0026 0.0181 0.0213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0329 0.0387
Echinococcus multilocularis microtubule associated protein 2 0.0732 0.8492 0.8492
Loa Loa (eye worm) hypothetical protein 0.0198 0.2213 0.2334
Brugia malayi MH1 domain containing protein 0.0026 0.0181 0.0302
Schistosoma mansoni smad1 5 8 and 0.0026 0.0181 0.0213
Brugia malayi hypothetical protein 0.0053 0.0499 0.0879
Brugia malayi jmjC domain containing protein 0.0063 0.0619 0.1095
Echinococcus granulosus geminin 0.0354 0.405 0.477
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.171 0.18
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0459 0.0805
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0126 0.0148
Loa Loa (eye worm) hypothetical protein 0.0251 0.2831 0.299
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1131 0.2024
Mycobacterium ulcerans hypothetical protein 0.0059 0.0578 1
Schistosoma mansoni polycystin 1-related 0.0021 0.0126 0.0148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0459 0.054
Echinococcus granulosus dnaJ subfamily B 0.0421 0.4833 0.5691
Schistosoma mansoni cpg binding protein 0.0031 0.0247 0.0291
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0566 0.1529
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0071 0.0084
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0257 0.2899 1
Schistosoma mansoni smad 0.0026 0.0181 0.0213
Loa Loa (eye worm) cytochrome P450 0.0019 0.01 0.0091
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1352 0.1352
Brugia malayi hypothetical protein 0.0034 0.028 0.0481
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0619 0.0729
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Echinococcus granulosus microtubule associated protein 2 0.0732 0.8492 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.4308 0.4558
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.021 0.2288
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0071 0.0071
Echinococcus granulosus bloom syndrome protein 0.048 0.5532 0.6514
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0198 0.2213 0.2334
Schistosoma mansoni hypothetical protein 0.0176 0.1948 0.2294
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0101 0.1069 0.3527
Brugia malayi hypothetical protein 0.013 0.1409 0.2527
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Brugia malayi hypothetical protein 0.0021 0.0126 0.0202
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0499 0.1031
Leishmania major cytochrome p450-like protein 0.0028 0.021 0.0489
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.171 0.3074
Brugia malayi hypothetical protein 0.0021 0.0126 0.0202
Onchocerca volvulus 0.0021 0.0126 0.0798
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.3984
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0071 0.0061
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0126 0.0118
Echinococcus granulosus cpg binding protein 0.0031 0.0247 0.0291
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0126 0.0126
Schistosoma mansoni survival motor neuron protein 0.0051 0.0482 0.0567
Schistosoma mansoni hypothetical protein 0.0176 0.1948 0.2294
Schistosoma mansoni DNA helicase recq1 0.0198 0.2213 0.2606
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0034
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.01 0.0275
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0071 0.0084
Trichomonas vaginalis DNA helicase recq1, putative 0.048 0.5532 1
Entamoeba histolytica recQ family helicase, putative 0.0257 0.2899 1
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0071 0.0084
Echinococcus granulosus GPCR family 2 0.0049 0.0459 0.054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.171 0.3074
Schistosoma mansoni hypothetical protein 0.0354 0.405 0.477
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0014 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0499 0.1031
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0181 0.0213
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0329 0.0387
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0158 0.0158
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0126 0.0126
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0499 0.1514
Echinococcus multilocularis GPCR, family 2 0.0049 0.0459 0.0459
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Echinococcus multilocularis Smad4 0.0026 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0106 0.1131 0.1332
Loa Loa (eye worm) hypothetical protein 0.0049 0.0459 0.0472
Leishmania major exosome subunit rrp6p homologue, putative 0.0059 0.0578 0.1792
Loa Loa (eye worm) Smad1 0.0026 0.0181 0.0177
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0071 0.0084
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0176 0.1948 0.3505
Echinococcus multilocularis cpg binding protein 0.0031 0.0247 0.0247
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1564 0.1645
Schistosoma mansoni blooms syndrome DNA helicase 0.0379 0.4343 0.5114
Echinococcus multilocularis bloom syndrome protein 0.048 0.5532 0.5532
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0181 0.0177
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.01 0.0102
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.01 0.0102
Loa Loa (eye worm) hypothetical protein 0.0156 0.171 0.18
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0325 0.3701 1
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.021 0.0489
Loa Loa (eye worm) CYP4Cod1 0.0028 0.021 0.0207
Onchocerca volvulus Huntingtin homolog 0.013 0.1409 1
Echinococcus granulosus Smad4 0.0026 0.0181 0.0213
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.3984
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1564 0.1564
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0176 0.1948 0.2294
Schistosoma mansoni hypothetical protein 0.0421 0.4833 0.5691
Entamoeba histolytica recQ family DNA helicase 0.0101 0.1069 0.3687
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0499 0.1514
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0059 0.0578 0.1562
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0059 0.0578 0.1582
Onchocerca volvulus Huntingtin homolog 0.013 0.1409 1
Leishmania major cytochrome p450-like protein 0.0019 0.01 0.0102
Schistosoma mansoni smad1 5 8 and 0.0026 0.0181 0.0213
Echinococcus granulosus RUN 0.0021 0.0126 0.0148
Brugia malayi Doublecortin family protein 0.0021 0.0126 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1564 0.1842
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0059 0.0578 0.1792
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0071 0.0061
Loa Loa (eye worm) nuclear factor I 0.0014 0.0046 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0459 0.0459
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0058 0.0566 0.1168
Schistosoma mansoni rab6-interacting 0.0021 0.0126 0.0148
Entamoeba histolytica exosome component 10, putative 0.0059 0.0578 0.1994
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.021 0.0207
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1352 0.1592
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.2831 0.2831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1564 0.1842
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.01 0.0102
Plasmodium vivax JmjC domain containing protein 0.0016 0.0071 0.0193
Schistosoma mansoni apoptosis regulator bax 0.0176 0.1948 0.2294
Loa Loa (eye worm) 3'-5' exonuclease 0.0059 0.0578 0.0599
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0599 0.0705
Schistosoma mansoni DNA helicase recq5 0.0198 0.2213 0.2606
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0181 0.0181
Brugia malayi cytochrome P450 0.0019 0.01 0.0156
Schistosoma mansoni blooms syndrome DNA helicase 0.0101 0.1069 0.1259
Echinococcus multilocularis RUN 0.0021 0.0126 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0619 0.0642
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0539 0.1473
Loa Loa (eye worm) apoptosis regulator protein 0.0176 0.1948 0.2053
Schistosoma mansoni cpg binding protein 0.003 0.0227 0.0268
Brugia malayi jmjC domain containing protein 0.0061 0.0599 0.106
Echinococcus multilocularis 0.0019 0.01 0.01
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0459 0.0472
Brugia malayi hypothetical protein 0.0251 0.2831 0.5105
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0126 0.0259
Brugia malayi MH1 domain containing protein 0.0014 0.0046 0.0058
Loa Loa (eye worm) hypothetical protein 0.0176 0.1948 0.2053
Brugia malayi MH2 domain containing protein 0.0026 0.0181 0.0302
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.6052
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0051 0.0482 0.0567
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0812 0.9434 1
Schistosoma mansoni hypothetical protein 0.0019 0.01 0.0118
Brugia malayi Bloom's syndrome protein homolog 0.048 0.5532 1
Echinococcus granulosus phd:f box containing protein 0.0016 0.0071 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0499 0.1514
Brugia malayi MH2 domain containing protein 0.0376 0.4308 0.7782
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0071 0.0084
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0126 0.0148
Mycobacterium leprae conserved hypothetical protein 0.0059 0.0578 1
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0499 0.1349
Loa Loa (eye worm) hypothetical protein 0.0106 0.1131 0.1185
Brugia malayi Cytochrome P450 family protein 0.0028 0.021 0.0354
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Brugia malayi CXXC zinc finger family protein 0.003 0.0227 0.0386
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0257 0.2899 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0014 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1564 0.1842
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.4308 0.4558
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0097 0.1024 0.2765
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0071 0.0071
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.01 0.0102
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0071 0.0195
Schistosoma mansoni hypothetical protein 0.0176 0.1948 0.2294
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0071 0.0084
Brugia malayi Smad1 0.0026 0.0181 0.0302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0459 0.054
Onchocerca volvulus 0.003 0.0227 0.1527
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0329 0.0329
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.2831 0.3333
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0459 0.0459
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0126 0.0148
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0091 0.0107
Giardia lamblia Sgs1 DNA helicase, putative 0.0198 0.2213 1
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0499 0.1366
Brugia malayi MH1 domain containing protein 0.0026 0.0181 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0617 0.0727
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0091 0.0091
Brugia malayi Cytochrome P450 family protein 0.0019 0.01 0.0156
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0599 0.0705
Trichomonas vaginalis DNA helicase recq, putative 0.0257 0.2899 0.5241
Loa Loa (eye worm) hypothetical protein 0.013 0.1409 0.148
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0181 0.0213
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0014 0.0014
Trypanosoma brucei cytochrome P450, putative 0.0028 0.021 0.0489
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0101 0.1069 0.2923
Schistosoma mansoni cytochrome P450 0.0019 0.01 0.0118
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0071 0.0147
Schistosoma mansoni hypothetical protein 0.0024 0.0158 0.0186
Schistosoma mansoni lipoxygenase 0.0125 0.1352 0.1592
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0176 0.1948 0.1948
Loa Loa (eye worm) hypothetical protein 0.0053 0.0499 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1564 0.1842
Onchocerca volvulus 0.0051 0.0482 0.335
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0578 0.1045
Trichomonas vaginalis DNA helicase recq, putative 0.048 0.5532 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0118
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0619 0.0729
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.4833 0.4833
Brugia malayi Cytochrome P450 family protein 0.0028 0.021 0.0354
Schistosoma mansoni hypothetical protein 0.0038 0.0329 0.0387
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0071 0.0195
Leishmania major cytochrome p450-like protein 0.0019 0.01 0.0102
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0101 0.1069 0.3527
Schistosoma mansoni Smad4 0.0011 0.0014 0.0017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0257 0.2899 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0118
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0482 0.0847
Schistosoma mansoni Smad4 0.0011 0.0014 0.0017
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0176 0.1948 0.2294
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0014 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.021 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1564 0.1564
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0059 0.0578 0.0681
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0198 0.2213 0.2213
Mycobacterium tuberculosis Probable ATP-dependent DNA helicase II UvrD2 0.0058 0.0566 0.9744
Schistosoma mansoni cpg binding protein 0.0031 0.0247 0.0291
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.6052
Brugia malayi Cytochrome P450 family protein 0.0059 0.0577 0.1019
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.01 0.0118
Brugia malayi MH1 domain containing protein 0.0014 0.0046 0.0058
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0126 0.0339
Schistosoma mansoni smad 0.0011 0.0014 0.0017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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