Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0598 | 0.1647 |
Onchocerca volvulus | 0.0062 | 0.0449 | 0.5 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0062 | 0.0449 | 0.0449 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0062 | 0.0449 | 0.1235 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0598 | 0.1647 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0.0449 | 1 |
Schistosoma mansoni | gliotactin | 0.0062 | 0.0449 | 0.1235 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0449 | 0.1235 |
Schistosoma mansoni | acetylcholinesterase | 0.0062 | 0.0449 | 0.1235 |
Onchocerca volvulus | 0.0062 | 0.0449 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0598 | 0.1647 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0118 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0118 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0449 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0598 | 0.1647 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0449 | 0.1235 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0062 | 0.0449 | 0.0449 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0118 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0368 | 0.3632 | 0.3632 |
Onchocerca volvulus | 0.0062 | 0.0449 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0449 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0.0449 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0449 | 0.1235 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0062 | 0.0449 | 0.1235 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0062 | 0.0449 | 0.0449 |
Echinococcus multilocularis | acetylcholinesterase | 0.0368 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0368 | 0.3632 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0449 | 0.1235 |
Onchocerca volvulus | 0.0062 | 0.0449 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0449 | 0.1235 |
Brugia malayi | Carboxylesterase family protein | 0.0368 | 0.3632 | 1 |
Onchocerca volvulus | 0.0062 | 0.0449 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.3632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0449 | 0.1235 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0598 | 0.1647 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0118 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0598 | 0.1647 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0598 | 0.1647 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0118 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0368 | 0.3632 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0368 | 0.3632 | 0.3632 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0118 | 1 |
Echinococcus multilocularis | neuroligin | 0.0062 | 0.0449 | 0.0449 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0598 | 0.1647 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0.0449 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0598 | 0.1647 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0598 | 0.1647 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0.0449 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0062 | 0.0449 | 0.1235 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0598 | 0.1647 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0118 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0118 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0598 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0368 | 0.3632 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0368 | 0.3632 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0368 | 0.3632 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0368 | 0.3632 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0368 | 0.3632 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0062 | 0.0449 | 0.1235 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0598 | 0.1647 |
Brugia malayi | hypothetical protein | 0.002 | 0.0006 | 0.0016 |
Brugia malayi | hypothetical protein | 0.003 | 0.0118 | 0.0326 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0449 | 0.1235 |
Echinococcus granulosus | neuroligin | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.3632 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0449 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0449 | 0.1235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.6213 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.