Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0167 | 0.1586 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Echinococcus multilocularis | neuroligin | 0.0167 | 0.1586 | 0.1586 |
Echinococcus multilocularis | acetylcholinesterase | 0.099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0167 | 0.1586 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0167 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | carboxylesterase | 0.099 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.099 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0167 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.099 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Brugia malayi | Carboxylesterase family protein | 0.0167 | 0.1586 | 0.1586 |
Onchocerca volvulus | 0.0167 | 0.1586 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0167 | 0.1586 | 0.1586 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0167 | 0.1586 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | carboxylesterase | 0.0167 | 0.1586 | 0.1586 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0167 | 0.1586 | 0.5 |
Onchocerca volvulus | 0.0167 | 0.1586 | 1 | |
Onchocerca volvulus | 0.0167 | 0.1586 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.099 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.099 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Schistosoma mansoni | gliotactin | 0.0167 | 0.1586 | 0.1586 |
Brugia malayi | Carboxylesterase family protein | 0.0167 | 0.1586 | 0.1586 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0167 | 0.1586 | 0.1586 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0167 | 0.1586 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0167 | 0.1586 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0167 | 0.1586 | 0.1586 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0167 | 0.1586 | 0.5 |
Onchocerca volvulus | 0.0167 | 0.1586 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0167 | 0.1586 | 0.1586 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0167 | 0.1586 | 0.1586 |
Schistosoma mansoni | acetylcholinesterase | 0.0167 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1586 | 0.1586 |
Brugia malayi | Carboxylesterase family protein | 0.0167 | 0.1586 | 0.1586 |
Echinococcus granulosus | acetylcholinesterase | 0.099 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.099 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0167 | 0.1586 | 0.1586 |
Brugia malayi | Carboxylesterase family protein | 0.099 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.