Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Echinococcus multilocularis | dna polymerase eta | 0.0147 | 0.4607 | 0.7732 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0088 | 0.1987 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0164 | 0.5376 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0088 | 0.1987 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Loa Loa (eye worm) | acetyltransferase | 0.0164 | 0.5376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4607 | 0.7732 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0147 | 0.4607 | 0.7732 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0088 | 0.1987 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0088 | 0.1987 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0147 | 0.4607 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.018 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0088 | 0.1987 | 0.3199 |
Schistosoma mansoni | DNA polymerase eta | 0.0147 | 0.4607 | 0.7732 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0164 | 0.5376 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.043 |
Echinococcus granulosus | dna polymerase eta | 0.0147 | 0.4607 | 0.8873 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0164 | 0.5376 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.043 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0088 | 0.1987 | 0.3621 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0088 | 0.1987 | 0.043 |
Leishmania major | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.043 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0088 | 0.1987 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Echinococcus granulosus | dna polymerase kappa | 0.0088 | 0.1987 | 0.3621 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0147 | 0.4607 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0088 | 0.1987 | 0.3199 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Leishmania major | DNA polymerase eta, putative | 0.0147 | 0.4607 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0086 | 0.1869 | 1 |
Trypanosoma brucei | unspecified product | 0.0088 | 0.1987 | 0.3199 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.043 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0159 | 0.517 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0088 | 0.1987 | 0.3199 |
Giardia lamblia | DINP protein human, muc B family | 0.0088 | 0.1987 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0088 | 0.1987 | 0.3199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.