Detailed information for compound 1429355

Basic information

Technical information
  • TDR Targets ID: 1429355
  • Name: 9-methyl-2-prop-2-enylsulfanylpyrido[2,1-f][1 ,3,5]triazin-4-one
  • MW: 233.29 | Formula: C11H11N3OS
  • H donors: 0 H acceptors: 1 LogP: 2.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCSc1nc(=O)n2c(n1)c(C)ccc2
  • InChi: 1S/C11H11N3OS/c1-3-7-16-10-12-9-8(2)5-4-6-14(9)11(15)13-10/h3-6H,1,7H2,2H3
  • InChiKey: MRPSHKBDYWBWKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-allylsulfanyl-9-methyl-pyrido[2,1-f][1,3,5]triazin-4-one
  • 2-(allylthio)-9-methyl-4-pyrido[2,1-f][1,3,5]triazinone
  • 2-(allylthio)-9-methyl-pyrido[2,1-f][1,3,5]triazin-4-one
  • 9-methyl-2-prop-2-enylsulfanyl-pyrido[2,1-f][1,3,5]triazin-4-one
  • SMR000169907
  • 12J-524S
  • ZINC03134603
  • 2-(allylsulfanyl)-9-methyl-4H-pyrido[1,2-a][1,3,5]triazin-4-one
  • MLS000325591

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0001 0.0001
Echinococcus multilocularis carboxylesterase 5A 0.0423 1 1
Entamoeba histolytica hypothetical protein 0.0043 0 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0738 0.0738
Brugia malayi beta-lactamase family protein 0.0043 0.0001 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0423 1 1
Echinococcus multilocularis acetylcholinesterase 0.0423 1 1
Brugia malayi Carboxylesterase family protein 0.0071 0.0738 0.0738
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0071 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2672 1
Brugia malayi beta-lactamase family protein 0.0043 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.018 0.361 0.361
Echinococcus granulosus carboxylesterase 5A 0.0423 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0 0.5
Loa Loa (eye worm) carboxylesterase 0.0071 0.0738 0.0737
Onchocerca volvulus 0.0071 0.0738 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0071 0.0738 0.1193
Entamoeba histolytica hypothetical protein 0.0043 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0423 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0071 0.0738 1
Brugia malayi Muscleblind-like protein 0.018 0.361 0.361
Onchocerca volvulus 0.0071 0.0738 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.2289 0.8565
Mycobacterium tuberculosis Probable reductase 0.013 0.2289 0.3704
Brugia malayi Carboxylesterase family protein 0.0071 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.018 0.361 0.361
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.036 0.0581
Schistosoma mansoni neuroligin 3 (S09 family) 0.0071 0.0738 0.0738
Plasmodium falciparum thioredoxin reductase 0.0057 0.036 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2289 0.3704
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2672 0.4324
Schistosoma mansoni acetylcholinesterase 0.0071 0.0738 0.0738
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2289 0.3704
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.036 0.036
Brugia malayi Carboxylesterase family protein 0.0423 1 1
Echinococcus multilocularis neuroligin 0.0071 0.0738 0.0738
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0001 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2289 0.3704
Echinococcus granulosus para nitrobenzyl esterase 0.0071 0.0738 0.0738
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2672 0.4324
Onchocerca volvulus 0.0071 0.0738 1
Brugia malayi beta-lactamase 0.0043 0.0001 0.0001
Loa Loa (eye worm) acetylcholinesterase 1 0.0423 1 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.036 1
Brugia malayi Thioredoxin reductase 0.0057 0.036 0.036
Onchocerca volvulus 0.0071 0.0738 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.036 1
Brugia malayi glutathione reductase 0.0057 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2672 0.4324
Loa Loa (eye worm) glutathione reductase 0.0057 0.036 0.0359
Brugia malayi Carboxylesterase family protein 0.0071 0.0738 0.0738
Plasmodium falciparum glutathione reductase 0.0057 0.036 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.361 0.361
Echinococcus multilocularis acetylcholinesterase 0.0423 1 1
Leishmania major trypanothione reductase 0.0057 0.036 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.036 1
Echinococcus granulosus acetylcholinesterase 0.0423 1 1
Echinococcus granulosus acetylcholinesterase 0.0423 1 1
Onchocerca volvulus 0.0071 0.0738 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0071 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Echinococcus multilocularis BC026374 protein (S09 family) 0.0071 0.0738 0.0738
Echinococcus granulosus muscleblind protein 0.018 0.361 0.361
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Entamoeba histolytica hypothetical protein 0.0043 0 0.5
Trichomonas vaginalis spcc417.12 protein, putative 0.0071 0.0738 1
Echinococcus granulosus neuroligin 0.0071 0.0738 0.0738
Loa Loa (eye worm) carboxylesterase 0.0423 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Brugia malayi hypothetical protein 0.0071 0.0738 0.0738
Echinococcus granulosus BC026374 protein S09 family 0.0071 0.0738 0.0738
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2289 0.3704
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6178 1
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.036 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0071 0.0738 0.1193
Schistosoma mansoni gliotactin 0.0071 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Schistosoma mansoni BC026374 protein (S09 family) 0.0071 0.0738 0.0738
Mycobacterium tuberculosis Carboxylesterase LipT 0.0071 0.0738 0.1193
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.036 0.036
Loa Loa (eye worm) carboxylesterase 0.0071 0.0738 0.0737
Loa Loa (eye worm) hypothetical protein 0.0423 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0001 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2289 0.3704
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.036 0.0359
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0738 0.0738
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0071 0.0738 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 1 0.018 0.361 0.361
Loa Loa (eye worm) hypothetical protein 0.0071 0.0738 0.0737
Echinococcus multilocularis para nitrobenzyl esterase 0.0071 0.0738 0.0738
Brugia malayi Carboxylesterase family protein 0.0071 0.0738 0.0738
Trypanosoma brucei trypanothione reductase 0.0057 0.036 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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