Detailed information for compound 1429960

Basic information

Technical information
  • TDR Targets ID: 1429960
  • Name: 1-[(2-chlorophenyl)methylsulfonyl]piperidine- 4-carboxamide
  • MW: 316.804 | Formula: C13H17ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C1CCN(CC1)S(=O)(=O)Cc1ccccc1Cl
  • InChi: 1S/C13H17ClN2O3S/c14-12-4-2-1-3-11(12)9-20(18,19)16-7-5-10(6-8-16)13(15)17/h1-4,10H,5-9H2,(H2,15,17)
  • InChiKey: IJXMTWKWYJBSMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-chlorophenyl)methylsulfonyl]-4-piperidinecarboxamide
  • 1-(2-chlorobenzyl)sulfonylisonipecotamide
  • MLS000693232
  • SMR000299658
  • ZINC00381855
  • 1-[(2-chlorobenzyl)sulfonyl]-4-piperidinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.1005 0.3236 0.4785
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Loa Loa (eye worm) uncoordinated protein 104 0.0116 0.0292 0.0278
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.2931 0.9617 0.9616
Entamoeba histolytica PH domain containing protein kinase, putative 0.2064 0.6745 0.6647
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0116 0.0292 0.0276
Echinococcus multilocularis myotubularin protein 13 0.0116 0.0292 0.0409
Schistosoma mansoni hypothetical protein 0.0116 0.0292 0.0432
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1005 0.3236 0.4785
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0138 0.0364 0.0113
Trichomonas vaginalis AGC family protein kinase 0.1005 0.3236 0.3033
Brugia malayi probable spectrin beta chain 0.0116 0.0292 0.0276
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0116 0.0292 0.0409
Trypanosoma cruzi Protein kinase B 0.2064 0.6745 1
Echinococcus multilocularis protein kinase c iota type 0.1005 0.3236 0.4785
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0364 0.0075
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0116 0.0292 0.0432
Brugia malayi Dynamin 0.0116 0.0292 0.0276
Loa Loa (eye worm) oxysterol binding protein 0.0116 0.0292 0.0278
Echinococcus granulosus Protein kinase C brain isozyme 0.1005 0.3236 0.4785
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0116 0.0292 0.0278
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1949 0.6362 0.9406
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0116 0.0292 0.0409
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0138 0.0364 0.0113
Loa Loa (eye worm) Plekhf2 protein 0.0116 0.0292 0.0278
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0116 0.0292 0.0409
Entamoeba histolytica protein kinase, putative 0.0138 0.0364 0.0075
Schistosoma mansoni growth factor receptor-bound protein 0.0116 0.0292 0.0432
Schistosoma mansoni atypical protein kinase C 0.1005 0.3236 0.4797
Echinococcus multilocularis oxysterol binding protein 3 0.0116 0.0292 0.0409
Schistosoma mansoni oxysterol-binding protein 1 0.0116 0.0292 0.0432
Echinococcus multilocularis Pleckstrin y 0.0116 0.0292 0.0409
Schistosoma mansoni goodpasture antigen-binding protein 0.0116 0.0292 0.0432
Schistosoma mansoni dynamin 0.0116 0.0292 0.0432
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0116 0.0292 0.0278
Echinococcus multilocularis GRB2 associated binding protein 3 0.0116 0.0292 0.0409
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1927 0.6289 0.9322
Schistosoma mansoni lamin 0.0033 0.0016 0.0024
Toxoplasma gondii phosphatidylinositol transfer protein 0.0116 0.0292 0.0176
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1927 0.6289 0.9322
Onchocerca volvulus 0.0116 0.0292 1
Loa Loa (eye worm) cytohesin 3 0.0116 0.0292 0.0278
Mycobacterium ulcerans hypothetical protein 0.0043 0.0052 0.5
Brugia malayi TBC domain containing protein 0.0116 0.0292 0.0276
Schistosoma mansoni hypothetical protein 0.0116 0.0292 0.0432
Echinococcus multilocularis serine:threonine protein kinase 38 0.1005 0.3236 0.4785
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0138 0.0364 1
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0124 0.0184
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Echinococcus granulosus nervana 2 0.1927 0.6289 0.9322
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0364 0.0075
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0065 0.0124 0.016
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1005 0.3236 0.3226
Brugia malayi Variant SH3 domain containing protein 0.0116 0.0292 0.0276
Leishmania major folate/biopterin transporter, putative 0.0138 0.0364 1
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0116 0.0292 0.0409
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0116 0.0292 0.0409
Loa Loa (eye worm) hypothetical protein 0.0033 0.0016 0.0002
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0116 0.0292 0.0409
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Entamoeba histolytica protein kinase, putative 0.0138 0.0364 0.0075
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0116 0.0292 0.0409
Plasmodium falciparum calcium-dependent protein kinase 7 0.0138 0.0364 0.0385
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0138 0.0364 0.0075
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0116 0.0292 0.0409
Trichomonas vaginalis AGC family protein kinase 0.1005 0.3236 0.3033
Echinococcus granulosus cytohesin 1 0.0116 0.0292 0.0409
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1949 0.6362 1
Schistosoma mansoni centaurin alpha 0.0116 0.0292 0.0432
Schistosoma mansoni goodpasture antigen-binding protein 0.0116 0.0292 0.0432
Loa Loa (eye worm) rho-GTPase-activating 0.0116 0.0292 0.0278
Echinococcus granulosus oxysterol binding protein 9 0.0116 0.0292 0.0409
Leishmania major hypothetical protein, conserved 0.0116 0.0292 0.8006
Echinococcus multilocularis expressed conserved protein 0.0065 0.0124 0.016
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0116 0.0292 0.0409
Echinococcus granulosus serine/threonine protein kinase 0.2064 0.6745 1
Entamoeba histolytica protein kinase, putative 0.0138 0.0364 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Entamoeba histolytica protein kinase, putative 0.2931 0.9617 0.9605
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Echinococcus granulosus nervana 2 0.1927 0.6289 0.9322
Echinococcus granulosus NDR protein kinase 0.1005 0.3236 0.4785
Echinococcus granulosus Oxysterol binding protein 11 0.0116 0.0292 0.0409
Echinococcus granulosus pleckstrin y domain containing family A 0.0116 0.0292 0.0409
Echinococcus multilocularis serine:threonine protein kinase N2 0.1005 0.3236 0.4785
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Loa Loa (eye worm) AGC/AKT protein kinase 0.3047 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Trypanosoma cruzi NIMA-related kinase, putative 0.0138 0.0364 0.0113
Echinococcus multilocularis serine threonine protein kinase 0.1005 0.3236 0.4785
Echinococcus granulosus protein kinase c epsilon type 0.1005 0.3236 0.4785
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Echinococcus multilocularis pdz domain containing protein 0.0116 0.0292 0.0409
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0116 0.0292 0.0409
Entamoeba histolytica PH domain containing protein kinase, putative 0.2064 0.6745 0.6647
Echinococcus granulosus pdz domain containing protein 0.0116 0.0292 0.0409
Brugia malayi Hr1 repeat family protein 0.1005 0.3236 0.3225
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Entamoeba histolytica protein kinase, putative 0.0138 0.0364 0.0075
Echinococcus multilocularis oxysterol binding protein 9 0.0116 0.0292 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0138 0.0364 0.0113
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Schistosoma mansoni lamin 0.0033 0.0016 0.0024
Entamoeba histolytica p21-activated kinase 0.0138 0.0364 0.0075
Toxoplasma gondii Oxysterol-binding protein 0.0116 0.0292 0.0176
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Leishmania major serine/threonine-protein kinase a, putative 0.0138 0.0364 1
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0116 0.0292 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0116 0.0292 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.1005 0.3236 0.4785
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Loa Loa (eye worm) AGC/PKN protein kinase 0.1005 0.3236 0.3226
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Echinococcus granulosus protein kinase C gamma type 0.1005 0.3236 0.4785
Schistosoma mansoni hypothetical protein 0.0116 0.0292 0.0432
Toxoplasma gondii AtPH1 family protein 0.0116 0.0292 0.0176
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Brugia malayi Cytohesin 3 0.0116 0.0292 0.0276
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1005 0.3236 0.4785
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0138 0.0364 0.0075
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0065 0.0124 0.016
Loa Loa (eye worm) AGC/PKG protein kinase 0.0065 0.0124 0.011
Onchocerca volvulus 0.0116 0.0292 1
Echinococcus granulosus GRB2 associated binding protein 3 0.0116 0.0292 0.0409
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0116 0.0292 0.0276
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0116 0.0292 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Echinococcus granulosus Glutaredoxin protein 5 0.1927 0.6289 0.9322
Echinococcus multilocularis nervana 2 0.1927 0.6289 0.9322
Echinococcus granulosus dynamin 1 0.0116 0.0292 0.0409
Entamoeba histolytica hypothetical protein 0.0138 0.0364 0.0075
Loa Loa (eye worm) syntrophin-1 0.0116 0.0292 0.0278
Brugia malayi Protein kinase domain containing protein 0.1005 0.3236 0.3225
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Echinococcus granulosus Pleckstrin y 0.0116 0.0292 0.0409
Brugia malayi Protein kinase domain containing protein 0.1005 0.3236 0.3225
Brugia malayi protein kinase C II. 0.1005 0.3236 0.3225
Trichomonas vaginalis AGC family protein kinase 0.1005 0.3236 0.3033
Brugia malayi Plekhf2 protein 0.0116 0.0292 0.0276
Entamoeba histolytica protein kinase 2, putative 0.1949 0.6362 0.6253
Echinococcus granulosus DCC interacting protein 13 beta 0.0116 0.0292 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0138 0.0364 0.012
Echinococcus multilocularis oxysterol binding protein 1 0.0116 0.0292 0.0409
Onchocerca volvulus 0.0116 0.0292 1
Plasmodium falciparum oxysterol-binding protein, putative 0.0116 0.0292 0.0269
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0116 0.0292 1
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0116 0.0292 0.0269
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0116 0.0292 1
Entamoeba histolytica protein kinase, putative 0.1005 0.3236 0.3033
Entamoeba histolytica protein kinase, putative 0.3047 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0138 0.0364 0.0113
Echinococcus multilocularis Oxysterol binding protein 11 0.0116 0.0292 0.0409
Schistosoma mansoni zinc finger protein 0.0116 0.0292 0.0432
Echinococcus multilocularis Pleckstrin y 0.0116 0.0292 0.0409
Trypanosoma cruzi rac serine-threonine kinase, putative 0.2064 0.6745 1
Echinococcus granulosus protein kinase c iota type 0.1005 0.3236 0.4785
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0116 0.0292 0.0278
Onchocerca volvulus 0.0116 0.0292 1
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1949 0.6362 0.943
Toxoplasma gondii AGC kinase 0.2931 0.9617 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0065 0.0124 0.016
Brugia malayi Egg laying defective protein 4 0.0065 0.0124 0.0108
Onchocerca volvulus 0.0116 0.0292 1
Leishmania major hypothetical protein, conserved 0.0116 0.0292 0.8006
Toxoplasma gondii protein kinase domain-containing protein 0.0138 0.0364 0.0253
Echinococcus granulosus calcium dependent secretion activator 1 0.0116 0.0292 0.0409
Loa Loa (eye worm) hypothetical protein 0.1005 0.3236 0.3226
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0138 0.0364 0.0113
Entamoeba histolytica hypothetical protein 0.0138 0.0364 0.0075
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0138 0.0364 0.0075
Schistosoma mansoni intermediate filament proteins 0.0033 0.0016 0.0024
Brugia malayi hypothetical protein 0.0116 0.0292 0.0276
Schistosoma mansoni hypothetical protein 0.0116 0.0292 0.0432
Loa Loa (eye worm) PH domain-containing protein 0.0116 0.0292 0.0278
Echinococcus multilocularis beta 1 syntrophin 0.0116 0.0292 0.0409
Trypanosoma cruzi NIMA-related kinase, putative 0.0138 0.0364 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0138 0.0364 0.0113
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1949 0.6362 0.943
Echinococcus granulosus oxysterol binding protein 1 0.0116 0.0292 0.0409
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0116 0.0292 0.0278
Echinococcus multilocularis rac serine:threonine kinase 0.2064 0.6745 1
Echinococcus multilocularis Rho GTPase activating protein 24 0.0116 0.0292 0.0409
Echinococcus granulosus Pleckstrin y 0.0116 0.0292 0.0409
Brugia malayi Cadps2 protein 0.0116 0.0292 0.0276
Onchocerca volvulus Protein melted homolog 0.0116 0.0292 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0138 0.0364 1
Echinococcus granulosus cGMP dependent protein kinase 0.0065 0.0124 0.016
Brugia malayi Dynamin 0.0116 0.0292 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Trypanosoma brucei protein kinase, putative 0.0138 0.0364 0.0075
Schistosoma mansoni dynamin 0.0116 0.0292 0.0432
Brugia malayi MAX-1A 0.0116 0.0292 0.0276
Schistosoma mansoni myotubularin-related protein 0.0116 0.0292 0.0432
Trypanosoma brucei rac serine-threonine kinase, putative 0.3047 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0138 0.0364 0.0113
Echinococcus granulosus myotubularin protein 13 0.0116 0.0292 0.0409
Schistosoma mansoni serine/threonine-protein kinase 0.2064 0.6745 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0016 0.0002
Schistosoma mansoni hypothetical protein 0.0116 0.0292 0.0432
Echinococcus granulosus cGMP dependent protein kinase 1 0.0065 0.0124 0.016
Schistosoma mansoni oxysterol-binding protein 1 0.0116 0.0292 0.0432
Brugia malayi Oxysterol-binding protein 0.0116 0.0292 0.0276
Onchocerca volvulus outspread protein homolog 0.0116 0.0292 1
Onchocerca volvulus Putative zinc finger protein 0.0116 0.0292 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1949 0.6362 1
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0116 0.0292 0.0432
Entamoeba histolytica protein kinase, putative 0.0138 0.0364 0.0075
Echinococcus multilocularis dynamin 1 0.0116 0.0292 0.0409
Echinococcus multilocularis nervana 2 0.1927 0.6289 0.9322
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0138 0.0364 0.0113
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0116 0.0292 0.0269
Echinococcus granulosus Rho GTPase activating protein 24 0.0116 0.0292 0.0409
Echinococcus multilocularis pleckstrin y domain containing family A 0.0116 0.0292 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1005 0.3236 0.3226
Echinococcus granulosus beta 1 syntrophin 0.0116 0.0292 0.0409
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1005 0.3236 0.3226
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0116 0.0292 0.0409
Echinococcus granulosus Pleckstrin y 0.0116 0.0292 0.0409
Giardia lamblia Kinase, AGC PKA 0.1949 0.6362 0.5
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Echinococcus multilocularis calcium dependent secretion activator 1 0.0116 0.0292 0.0409
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1005 0.3236 0.4785
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0138 0.0364 0.0075
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0116 0.0292 0.0432
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Schistosoma mansoni serine/threonine kinase 0.1005 0.3236 0.4797
Toxoplasma gondii hypothetical protein 0.0116 0.0292 0.0176
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Echinococcus granulosus serine:threonine protein kinase N2 0.1005 0.3236 0.4785
Echinococcus multilocularis Ras associated and pleckstrin y 0.0116 0.0292 0.0409
Onchocerca volvulus 0.0116 0.0292 1
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.1005 0.3236 0.4785
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0116 0.0292 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Trichomonas vaginalis AGC family protein kinase 0.3047 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.2064 0.6745 1
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0116 0.0292 0.0409
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0116 0.0292 0.0409
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.1005 0.3236 0.4785
Brugia malayi Uncoordinated protein 104 0.0116 0.0292 0.0276
Echinococcus multilocularis actin binding protein anillin 0.0116 0.0292 0.0409
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Echinococcus granulosus oxysterol binding protein 3 0.0116 0.0292 0.0409
Onchocerca volvulus 0.0116 0.0292 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0364 0.0075
Brugia malayi p70 ribosomal S6 kinase beta 0.2931 0.9617 0.9616
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0116 0.0292 0.0409
Plasmodium falciparum PH domain-containing protein, putative 0.0116 0.0292 0.0269
Brugia malayi Oxysterol binding protein 0.0116 0.0292 0.0276
Leishmania major protein kinase, putative 0.0138 0.0364 1
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0116 0.0292 0.0409
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0138 0.0364 0.0253
Echinococcus multilocularis serine:threonine protein kinase N2 0.1005 0.3236 0.4785
Echinococcus multilocularis DCC interacting protein 13 beta 0.0116 0.0292 0.0409
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Schistosoma mansoni zinc finger protein 0.0116 0.0292 0.0432
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.1005 0.3236 0.3226
Echinococcus multilocularis Pleckstrin y 0.0116 0.0292 0.0409
Trichomonas vaginalis AGC family protein kinase 0.112 0.3619 0.3427
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0138 0.0364 0.0075
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0116 0.0292 0.0432
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0138 0.0364 0.0075
Brugia malayi Syntrophin-1 0.0116 0.0292 0.0276
Brugia malayi Pleckstrin Homology Domain 0.0116 0.0292 0.0276
Echinococcus multilocularis Glutaredoxin protein 5 0.1927 0.6289 0.9322
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Entamoeba histolytica hypothetical protein 0.0442 0.1372 0.1113
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0364 0.0075
Schistosoma mansoni rho gtpase activating protein 0.0116 0.0292 0.0432
Loa Loa (eye worm) hypothetical protein 0.0116 0.0292 0.0278
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0983 0.3163 0.2958
Schistosoma mansoni vav2 0.0116 0.0292 0.0432
Toxoplasma gondii hypothetical protein 0.0116 0.0292 0.0176
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Loa Loa (eye worm) AGC/NDR protein kinase 0.1005 0.3236 0.3226
Echinococcus multilocularis protein kinase c epsilon type 0.1005 0.3236 0.4785
Entamoeba histolytica protein kinase, putative 0.3047 1 1
Echinococcus multilocularis cytohesin 1 0.0116 0.0292 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0124 0.0184
Leishmania major protein kinase, putative 0.0138 0.0364 1
Brugia malayi Variant SH3 domain containing protein 0.0116 0.0292 0.0276
Echinococcus granulosus serine threonine protein kinase nrc 0.1949 0.6362 0.943
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0364 0.0075
Brugia malayi PH domain containing protein 0.0116 0.0292 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.1005 0.3236 0.4797
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0016 0.0002
Schistosoma mansoni syntrophin 0.0116 0.0292 0.0432

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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