Detailed information for compound 1430006

Basic information

Technical information
  • TDR Targets ID: 1430006
  • Name: 2-[(3-chloro-4-methoxyphenyl)methylsulfanyl]- 4,5-dihydro-1H-imidazole hydrochloride
  • MW: 293.213 | Formula: C11H14Cl2N2OS
  • H donors: 1 H acceptors: 0 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)CSC1=NCCN1.Cl
  • InChi: 1S/C11H13ClN2OS.ClH/c1-15-10-3-2-8(6-9(10)12)7-16-11-13-4-5-14-11;/h2-3,6H,4-5,7H2,1H3,(H,13,14);1H
  • InChiKey: QEYVLWLDKBTQSW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(3-chloro-4-methoxyphenyl)methylsulfanyl]-4,5-dihydro-1H-imidazole; hydron; chloride
  • 2-[(3-chloro-4-methoxy-phenyl)methylsulfanyl]-4,5-dihydro-1H-imidazole; hydron; chloride
  • 2-[(3-chloro-4-methoxy-phenyl)methylsulfanyl]-4,5-dihydro-1H-imidazole hydrochloride
  • 2-[(3-chloro-4-methoxyphenyl)methylthio]-4,5-dihydro-1H-imidazole; hydron; chloride
  • 2-[(3-chloro-4-methoxyphenyl)methylthio]-4,5-dihydro-1H-imidazole hydrochloride
  • 2-[(3-chloro-4-methoxy-benzyl)thio]-4,5-dihydro-1H-imidazole; hydron; chloride
  • 2-[(3-chloro-4-methoxy-benzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride
  • MLS000071192
  • SMR000057701

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0108 0.0644 0.2296
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0785 0.0767
Loa Loa (eye worm) hypothetical protein 0.0351 0.2998 0.2998
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0654 0.5936 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.0785 0.0785
Onchocerca volvulus 0.0122 0.0785 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0108 0.0644 0.2499
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.0785 0.0785
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0108 0.0644 0.2296
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0785 0.1323
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0301 0.2518 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0122 0.0785 0.0785
Schistosoma mansoni hypothetical protein 0.0205 0.1581 0.1564
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0108 0.0644 0.2296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.002 0.0033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0238 0.0401
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0108 0.0644 0.2499
Echinococcus multilocularis geminin 0.0205 0.1581 0.1581
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0108 0.0644 0.2296
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0108 0.0644 0.2296
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0122 0.0785 0.0767
Onchocerca volvulus 0.0066 0.0238 0.2849
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0108 0.0644 0.2296
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0108 0.0644 0.2296
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Echinococcus granulosus thioredoxin glutathione reductase 0.0118 0.0742 0.0742
Loa Loa (eye worm) GABA receptor subunit 0.0066 0.0238 0.0238
Brugia malayi Cytochrome P450 family protein 0.0108 0.0644 0.1085
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0108 0.0644 0.3577
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0108 0.0644 0.2296
Loa Loa (eye worm) hypothetical protein 0.0294 0.2444 0.2444
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Onchocerca volvulus 0.0122 0.0785 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0755 0.0755
Echinococcus granulosus nAChR subunit 0.0066 0.0238 0.0238
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0108 0.0644 0.3577
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Echinococcus multilocularis nAChR subunit 0.0066 0.0238 0.0238
Echinococcus granulosus nAChR subunit 0.0122 0.0785 0.0785
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0166 0.1206 0.4747
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0122 0.0785 0.0785
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0108 0.0644 0.2499
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0122 0.0785 0.0785
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0108 0.0644 0.2499
Onchocerca volvulus 0.0066 0.0238 0.2849
Leishmania major hypothetical protein, conserved 0.0043 0.002 0.011
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0057 0.0146 0.0146
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0108 0.0644 0.3577
Brugia malayi Cation transporter family protein 0.0122 0.0785 0.1323
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.002 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0227 0.1801 0.1801
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0785 0.1323
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0146 0.0126
Onchocerca volvulus 0.0057 0.0146 0.1648
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0108 0.0644 0.2499
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0122 0.0785 0.0785
Schistosoma mansoni calcium-activated potassium channel 0.0742 0.6787 0.678
Mycobacterium tuberculosis Probable oxidoreductase 0.0166 0.1206 0.4747
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0108 0.0644 0.2296
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0136 0.0915 0.3582
Brugia malayi cytochrome P450 0.0108 0.0644 0.1085
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0108 0.0644 0.2296
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0122 0.0785 0.1323
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0122 0.0785 0.1323
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0122 0.0785 0.0785
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0108 0.0644 0.2499
Leishmania major trypanothione reductase 0.0118 0.0742 0.412
Echinococcus multilocularis small conductance calcium activated potassium 0.1074 1 1
Mycobacterium tuberculosis Probable reductase 0.0136 0.0915 0.3582
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0108 0.0644 0.2499
Trichomonas vaginalis esterase, putative 0.0043 0.002 0.5
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Loa Loa (eye worm) hypothetical protein 0.006 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0122 0.0785 0.0785
Brugia malayi Cation transporter family protein 0.0122 0.0785 0.1323
Loa Loa (eye worm) hypothetical protein 0.0286 0.2365 0.2365
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0057 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Onchocerca volvulus 0.006 0.0177 0.2056
Leishmania major cytochrome p450-like protein 0.0108 0.0644 0.3577
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0122 0.0785 0.0767
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.002 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0166 0.1206 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0227 0.1801 0.6549
Loa Loa (eye worm) hypothetical protein 0.0598 0.5389 0.5389
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Onchocerca volvulus 0.0122 0.0785 1
Echinococcus multilocularis nAChR subunit 0.0122 0.0785 0.0785
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0765 0.1289
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0122 0.0785 0.0785
Schistosoma mansoni hypothetical protein 0.0108 0.0644 0.0625
Onchocerca volvulus 0.0122 0.0785 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0108 0.0644 0.2499
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.5
Echinococcus granulosus cytochrome P450 2K1 0.0108 0.0644 0.0644
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0122 0.0785 0.0785
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0057 0.0146 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0108 0.0644 0.2499
Onchocerca volvulus Putative nachr subunit 0.0122 0.0785 1
Loa Loa (eye worm) CYP4Cod1 0.0227 0.1801 0.1801
Schistosoma mansoni calcium-activated potassium channel 0.1074 1 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0108 0.0644 0.2499
Onchocerca volvulus 0.0057 0.0146 0.1648
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Schistosoma mansoni acetylcholine receptor-related 0.0057 0.0146 0.0126
Loa Loa (eye worm) ACC-1 protein 0.0122 0.0785 0.0785
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0136 0.0915 0.3582
Trypanosoma brucei cytochrome P450, putative 0.0227 0.1801 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Schistosoma mansoni acetylcholine receptor subunit beta 0.0057 0.0146 0.0126
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0396 0.0667
Brugia malayi excitatory GABA receptor EXP-1A 0.0122 0.0785 0.1323
Loa Loa (eye worm) cytochrome P450 family protein 0.0389 0.3366 0.3366
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0163 0.0274
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0136 0.0915 0.7546
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0324 0.2739 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0108 0.0644 0.2499
Schistosoma mansoni lipoxygenase 0.0129 0.0846 0.0828
Loa Loa (eye worm) ACC-1 protein 0.0122 0.0785 0.0785
Schistosoma mansoni nAChR subunit 0.0057 0.0146 0.0126
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Plasmodium falciparum glutathione reductase 0.0118 0.0742 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0122 0.0785 0.1323
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0108 0.0644 0.2499
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0108 0.0644 0.2499
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0785 0.0785
Schistosoma mansoni hypothetical protein 0.1074 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0136 0.0915 0.3582
Onchocerca volvulus 0.0058 0.0163 0.1869
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0057 0.0146 0.0246
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0391 0.3387 0.3387
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0108 0.0644 0.2296
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0057 0.0146 0.0246
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0108 0.0644 0.2296
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0108 0.0644 0.2499
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.002 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7671 0.7671
Onchocerca volvulus 0.0122 0.0785 1
Schistosoma mansoni hypothetical protein 0.0082 0.0396 0.0377
Loa Loa (eye worm) LGC-31 protein 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.012 0.0765 0.0765
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0057 0.0146 0.0146
Mycobacterium tuberculosis Probable dehydrogenase 0.0136 0.0915 0.3582
Trypanosoma cruzi cytochrome P450, putative 0.0227 0.1801 1
Brugia malayi Cation transporter family protein 0.0122 0.0785 0.1323
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0136 0.0915 0.3582
Brugia malayi hypothetical protein 0.0057 0.0146 0.0246
Echinococcus multilocularis 0.0108 0.0644 0.0644
Loa Loa (eye worm) glutathione reductase 0.0118 0.0742 0.0742
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0785 0.0785
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0785 0.1323
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0108 0.0644 0.2499
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0785 0.1323
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0146 0.0126
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0057 0.0146 0.0146
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0108 0.0644 0.2296
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0108 0.0644 0.2499
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.0785 0.0785
Brugia malayi Cytochrome P450 family protein 0.0389 0.3366 0.5671
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0118 0.0742 0.289
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0108 0.0644 0.3577
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.0785 0.0785
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0765 0.0765
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0785 0.1323
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0785 0.0767
Brugia malayi hypothetical protein 0.0057 0.0146 0.0246
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2289 0.9086
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0057 0.0146 0.0146
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0066 0.0238 0.0218
Brugia malayi Cytochrome P450 family protein 0.0227 0.1801 0.3033
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0122 0.0785 0.0785
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0785 0.1323
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0108 0.0644 0.2296
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2365 0.2365
Mycobacterium leprae putative cytochrome p450 0.0108 0.0644 0.5264
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Brugia malayi hypothetical protein 0.0286 0.2365 0.3984
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0057 0.0146 0.0246
Mycobacterium leprae Conserved hypothetical protein 0.0108 0.0644 0.5264
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0324 0.2739 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0057 0.0146 0.0146
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Brugia malayi beta-lactamase family protein 0.0043 0.002 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0043 0.002 0.0268
Schistosoma mansoni hypothetical protein 0.0205 0.1581 0.1564
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.002 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.0163 0.0143
Trypanosoma cruzi trypanothione reductase, putative 0.0118 0.0742 0.412
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0108 0.0644 0.2296
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0108 0.0644 0.2499
Loa Loa (eye worm) hypothetical protein 0.1074 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0108 0.0644 0.3577
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7671 0.7671
Loa Loa (eye worm) hypothetical protein 0.0654 0.5936 0.5936
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0785 0.1323
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0785 0.1323
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Brugia malayi Thioredoxin reductase 0.0118 0.0742 0.125
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0122 0.0785 0.0785
Trypanosoma cruzi cytochrome P450, putative 0.0227 0.1801 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0785 0.1323
Loa Loa (eye worm) beta-lactamase 0.0043 0.002 0.002
Loa Loa (eye worm) thioredoxin reductase 0.0118 0.0742 0.0742
Brugia malayi Cytochrome P450 family protein 0.0227 0.1801 0.3033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0118 0.0742 0.0742
Brugia malayi hypothetical protein 0.0057 0.0146 0.0246
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0108 0.0644 0.2296
Plasmodium vivax glutathione reductase, putative 0.0118 0.0742 1
Trypanosoma brucei trypanothione reductase 0.0118 0.0742 0.412
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0785 0.0767
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.002 0.011
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0108 0.0644 0.2499
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Schistosoma mansoni survival motor neuron protein 0.0058 0.0163 0.0143
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0057 0.0146 0.0246
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0108 0.0644 0.2296
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7671 0.7666
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0108 0.0644 0.2499
Toxoplasma gondii thioredoxin reductase 0.0118 0.0742 1
Plasmodium falciparum thioredoxin reductase 0.0118 0.0742 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0066 0.0238 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0227 0.1801 0.1801
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.002 0.002
Echinococcus multilocularis tumor protein p63 0.0408 0.3551 0.3551
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0122 0.0785 0.1323
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0238 0.0401
Leishmania major cytochrome p450-like protein 0.0108 0.0644 0.3577
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Loa Loa (eye worm) acetylcholine receptor protein 0.0057 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0066 0.0238 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Brugia malayi hypothetical protein 0.0057 0.0146 0.0246
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0108 0.0644 0.2296
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0108 0.0644 0.2296
Brugia malayi glutathione reductase 0.0118 0.0742 0.125
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0066 0.0238 0.0218
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0108 0.0644 0.2296
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.0785 0.0785
Toxoplasma gondii cytochrome p450 superfamily protein 0.0108 0.0644 0.8682
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0122 0.0785 0.0785
Schistosoma mansoni nAChR subunit 0.0057 0.0146 0.0126
Plasmodium vivax thioredoxin reductase, putative 0.0118 0.0742 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.002 0.011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0238 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0108 0.0644 0.2499
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0122 0.0785 0.1323
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.5
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0122 0.0785 0.0785
Toxoplasma gondii ABC1 family protein 0.0043 0.002 0.0268
Brugia malayi hypothetical protein 0.0057 0.0146 0.0246
Brugia malayi beta-lactamase 0.0043 0.002 0.0033
Schistosoma mansoni lipoxygenase 0.009 0.0471 0.0452
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0122 0.0785 0.0785
Echinococcus granulosus geminin 0.0205 0.1581 0.1581
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0122 0.0785 0.0785
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0122 0.0785 0.0785
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2365 0.2365
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0122 0.0785 0.1323
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.0846 0.0846
Echinococcus granulosus tumor protein p63 0.0408 0.3551 0.3551
Leishmania major cytochrome p450-like protein 0.0227 0.1801 1
Schistosoma mansoni nAChR subunit 0.0122 0.0785 0.0767
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0057 0.0146 0.0146
Onchocerca volvulus 0.0057 0.0146 0.1648
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0785 0.0785
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0122 0.0785 0.0785
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.002 0.002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.0846 0.0846
Onchocerca volvulus 0.0122 0.0785 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.002
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0177 0.0158
Loa Loa (eye worm) cytochrome P450 0.0108 0.0644 0.0644
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0066 0.0238 0.0401
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0122 0.0785 0.0785
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0765 0.1289
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0066 0.0238 0.0401
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0057 0.0146 0.0246
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0146
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0785 0.0785
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0166 0.1206 0.4747
Schistosoma mansoni cytochrome P450 0.0108 0.0644 0.0625
Brugia malayi beta-lactamase family protein 0.0043 0.002 0.0033
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0122 0.0785 0.0767

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.021 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
Potency (functional) 0.0169 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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