Detailed information for compound 1430015

Basic information

Technical information
  • TDR Targets ID: 1430015
  • Name: 2-(1,3-benzoxazol-2-ylsulfanyl)-N-(4,6-dimeth ylpyrimidin-2-yl)acetamide
  • MW: 314.362 | Formula: C15H14N4O2S
  • H donors: 1 H acceptors: 4 LogP: 2.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nc(C)cc(n1)C)CSc1nc2c(o1)cccc2
  • InChi: 1S/C15H14N4O2S/c1-9-7-10(2)17-14(16-9)19-13(20)8-22-15-18-11-5-3-4-6-12(11)21-15/h3-7H,8H2,1-2H3,(H,16,17,19,20)
  • InChiKey: ARZYORFXUISAPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1,3-benzoxazol-2-ylthio)-N-(4,6-dimethyl-2-pyrimidinyl)acetamide
  • 2-(1,3-benzoxazol-2-ylthio)-N-(4,6-dimethylpyrimidin-2-yl)acetamide
  • 2-(1,3-benzoxazol-2-ylsulfanyl)-N-(4,6-dimethylpyrimidin-2-yl)ethanamide
  • SMR000152075
  • Oprea1_200813
  • T0511-4384
  • MLS000564897
  • ZINC03244163

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni dihydropteridine reductase 0.0052 0.0277 0.0318
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0207 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0366 0.1127
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0052 0.0277 0.029
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0207 0.0218
Trypanosoma brucei pteridine reductase 1 0.1207 0.9867 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0272 0.0276
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0052 0.0277 0.0784
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0479 0.053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.2875 0.8867
Mycobacterium tuberculosis Probable oxidoreductase 0.0068 0.041 0.0442
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0207 0.0238
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0025 0.0078
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.1247 0.1411
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0052 0.0277 0.029
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0052 0.0277 0.029
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.2875 0.8867
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0073 0.0063
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0052 0.0277 0.0277
Entamoeba histolytica hypothetical protein 0.0043 0.0207 0.7221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0207 0.0218
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0207 0.0217
Mycobacterium ulcerans oxidoreductase 0.0052 0.0277 0.029
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0275 0.9907
Loa Loa (eye worm) retinol dehydrogenase 12 0.0052 0.0277 0.0298
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0052 0.0277 0.029
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.128 0.128
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0052 0.0277 0.0784
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0052 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0085 0.0556 0.0618
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0068 0.041 0.0442
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0409 0.3242 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0018 0.002
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0277 0.029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0277 0.029
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0052 0.0277 0.0277
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.107 0.8727 1
Brugia malayi hypothetical protein 0.0043 0.0207 0.0209
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0025 0.0025
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.0277 0.029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7977 0.9138
Brugia malayi Bromodomain containing protein 0.005 0.0264 0.0275
Brugia malayi Bromodomain containing protein 0.0095 0.0632 0.0698
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0025 0.0078
Onchocerca volvulus 0.0068 0.041 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0409 0.3242 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0479 0.053
Loa Loa (eye worm) dihydrofolate reductase 0.107 0.8727 1
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0052 0.0277 0.029
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0277 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0218 0.7629
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0052 0.0277 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0272 0.084
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0073 0.0083
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0218 0.0598
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0218 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.1247 0.1428
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0052 0.0277 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0275 0.0777
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0053 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0018 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.1184 0.1339
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.128 0.1297
Mycobacterium ulcerans hypothetical protein 0.0192 0.1442 0.1628
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0025 0.0026
Brugia malayi dihydrofolate reductase family protein 0.107 0.8727 1
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.1247 0.1404
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0052 0.0277 0.0784
Schistosoma mansoni ap endonuclease 0.0022 0.0025 0.0029
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0057 0.0046
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0409 0.3242 0.3242
Loa Loa (eye worm) hypothetical protein 0.0052 0.0277 0.0298
Loa Loa (eye worm) hypothetical protein 0.0053 0.0289 0.0311
Schistosoma mansoni hypothetical protein 0.0043 0.0207 0.0238
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0277 0.029
Chlamydia trachomatis dihydrofolate reductase 0.107 0.8727 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0052 0.0277 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Loa Loa (eye worm) hypothetical protein 0.0046 0.0231 0.0245
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.041 0.0442
Brugia malayi PHD-finger family protein 0.0034 0.013 0.0121
Schistosoma mansoni bromodomain containing protein 0.008 0.0515 0.059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0277 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0052 0.0277 0.0856
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0025 0.0009
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0052 0.0277 0.0298
Loa Loa (eye worm) oxidoreductase 0.0052 0.0277 0.0298
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0052 0.0277 0.0856
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0272 0.084
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0275 0.0777
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Schistosoma mansoni zinc finger protein 0.0028 0.0077 0.0088
Entamoeba histolytica hypothetical protein 0.0043 0.0207 0.7221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0018 0.002
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.0277 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0275 0.9907
Loa Loa (eye worm) acetyltransferase 0.0169 0.1247 0.1411
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0272 0.084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0025 0.0009
Schistosoma mansoni ap endonuclease 0.0022 0.0025 0.0029
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.107 0.8727 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0052 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0308 0.0333
Echinococcus granulosus zinc finger protein 0.0028 0.0077 0.0068
Trypanosoma brucei oxidoreductase-like protein 0.0068 0.041 0.0416
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0052 0.0277 0.0784
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0277 0.029
Mycobacterium ulcerans short chain dehydrogenase 0.0068 0.041 0.0442
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0052 0.0277 0.0784
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Brugia malayi Dihydrofolate reductase 0.107 0.8727 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0068 0.041 0.1265
Echinococcus granulosus dihydrofolate reductase 0.107 0.8727 1
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0052 0.0277 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0052 0.0277 0.0784
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.2875 0.2875
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0025 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.0207 0.7221
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0409 0.3242 0.3286
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0052 0.0277 0.029
Trichomonas vaginalis hypothetical protein 0.0052 0.0277 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0068 0.041 0.1197
Schistosoma mansoni dihydrofolate reductase 0.107 0.8727 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0277 0.029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1442 0.1628
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.128 0.3947
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0052 0.0277 0.0298
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0025 0.0009
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0052 0.0277 0.0318
Leishmania major oxidoreductase-like protein 0.0068 0.041 0.041
Echinococcus multilocularis zinc finger protein 0.0028 0.0077 0.0068
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0073 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0277 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.041 0.0442
Entamoeba histolytica hypothetical protein 0.0043 0.0207 0.7221
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0409 0.3242 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0275 0.0777
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0409 0.3242 1
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0277 0.029
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0052 0.0277 0.0281
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0275 0.0296
Echinococcus multilocularis dihydrofolate reductase 0.107 0.8727 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.2875 0.2913
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.107 0.8727 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0277 0.0298
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0018 0.002
Schistosoma mansoni hypothetical protein 0.0025 0.0053 0.0061
Plasmodium falciparum enoyl-acyl carrier reductase 0.0052 0.0277 0.0784
Toxoplasma gondii hypothetical protein 0.0059 0.0335 0.0963

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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