Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0679 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0679 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2371 | 0.2371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0132 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0679 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1741 | 0.1741 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.324 | 0.324 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1741 | 0.1741 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0679 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.324 | 0.324 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2371 | 0.2371 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0679 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1741 | 0.1741 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.324 | 0.324 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2371 | 0.2371 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2371 | 0.2371 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0679 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2371 | 0.2371 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0679 | 0.0679 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2371 | 0.2371 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2371 | 0.2371 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2371 | 0.2371 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0679 | 0.0679 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0679 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2371 | 0.2371 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0679 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.324 | 0.324 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -71 % | Inactivation process of guinea pig cardiac Na channels expressed in xenopus oocytes was determined by measuring increase in current integral in presence of compound versus control at 10 uM | ChEMBL. | 7629798 |
Change (functional) | = -71 % | Inactivation process of guinea pig cardiac Na channels expressed in xenopus oocytes was determined by measuring increase in current integral in presence of compound versus control at 10 uM | ChEMBL. | 7629798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.