TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 491.028 | Formula: C25H19ClN4OS2
H donors: 2 H acceptors: 2 LogP: 6.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1SC(=C(C1=N)c1nc2c(s1)cccc2)Nc1ccccc1)Nc1cccc(c1C)Cl
InChi: 1S/C25H19ClN4OS2/c1-14-16(26)10-7-12-17(14)29-23(31)22-21(27)20(24(33-22)28-15-8-3-2-4-9-15)25-30-18-11-5-6-13-19(18)32-25/h2-13,22,27-28H,1H3,(H,29,31)
InChiKey: LWYDPGRQTYLOHQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	tyrosyl-DNA phosphodiesterase 1	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	tyrosyl-DNA phodphodiesterase 1 (tdp1)	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania braziliensis	tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania mexicana	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	phospholipase/carboxylesterase	0.0065	0.0344	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0045	0.0045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Plasmodium falciparum	BEM46-like protein, putative	0.0065	0.0344	0.0413
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0065	0.0344	0.0344
Plasmodium vivax	PST-A protein	0.0065	0.0344	0.0413
Echinococcus multilocularis	musashi	0.0033	0.0128	0.0113
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.0444	0.0444
Mycobacterium ulcerans	amidase	0.0181	0.1126	0.1128
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0045	0.003
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Plasmodium falciparum	exported lipase 1	0.0065	0.0344	0.0413
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0065	0.0344	1
Echinococcus granulosus	GPCR family 2	0.0019	0.0037	0.0037
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0065	0.0344	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Plasmodium falciparum	prodrug activation and resistance esterase	0.0065	0.0344	0.0413
Brugia malayi	Amidase family protein	0.0181	0.1126	0.1126
Plasmodium falciparum	esterase, putative	0.0065	0.0344	0.0413
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0128	0.0128
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0045	0.0062
Toxoplasma gondii	hypothetical protein	0.0065	0.0344	1
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0181	0.1126	0.5
Brugia malayi	intermediate filament protein	0.0033	0.0128	0.0128
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0065	0.0344	0.0472
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0181	0.1126	0.1128
Plasmodium falciparum	lysophospholipase, putative	0.0065	0.0344	0.0413
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Mycobacterium ulcerans	amidase	0.0181	0.1126	0.1128
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1098	0.728	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Brugia malayi	Cathepsin L-like precursor	0.002	0.0045	0.0045
Trypanosoma cruzi	monoglyceride lipase, putative	0.1098	0.728	1
Leishmania major	hypothetical protein, conserved	0.0065	0.0344	0.0413
Loa Loa (eye worm)	hypothetical protein	0.006	0.0313	0.0313
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0037	0.0037
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.0444	0.0444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Plasmodium falciparum	esterase, putative	0.0065	0.0344	0.0413
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0037	0.0022
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0181	0.1126	0.1113
Loa Loa (eye worm)	amidase	0.0181	0.1126	0.1126
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0065	0.0344	0.0472
Brugia malayi	Cathepsin L-like precursor	0.002	0.0045	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.1098	0.728	1
Echinococcus granulosus	cathepsin l1	0.002	0.0045	0.0045
Echinococcus granulosus	geminin	0.0205	0.1282	0.1282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Onchocerca volvulus		0.0033	0.0128	0.1126
Onchocerca volvulus		0.002	0.0045	0.0396
Mycobacterium ulcerans	amidase	0.0181	0.1126	0.1128
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.0444	0.0444
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Plasmodium vivax	unspecified product	0.0065	0.0344	0.0413
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Plasmodium vivax	unspecified product	0.0065	0.0344	0.0413
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0065	0.0344	0.0472
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0181	0.1126	0.5
Echinococcus multilocularis	cysteine protease	0.002	0.0045	0.003
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0181	0.1126	0.1128
Schistosoma mansoni	hypothetical protein	0.0019	0.0037	0.0037
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.5502	0.5502
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0444	0.0552
Plasmodium vivax	PST-A protein	0.0065	0.0344	0.0413
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Plasmodium falciparum	epoxide hydrolase 2	0.0065	0.0344	0.0413
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0037	0.0022
Onchocerca volvulus		0.002	0.0045	0.0396
Echinococcus multilocularis	cysteine protease	0.002	0.0045	0.003
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0426	0.0527
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0045	0.0045
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0344	0.0344
Brugia malayi	MGC79044 protein	0.0065	0.0344	0.0344
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0015	0.0015
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0316	0.0374
Echinococcus multilocularis	lamin	0.0033	0.0128	0.0113
Plasmodium falciparum	lysophospholipase, putative	0.0065	0.0344	0.0413
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0065	0.0344	0.0413
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Echinococcus multilocularis	geminin	0.0205	0.1282	0.127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Trypanosoma cruzi	amidase, putative	0.0181	0.1126	0.1495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Leishmania major	cathepsin L-like protease	0.0077	0.0426	0.0527
Echinococcus granulosus	lamin	0.0033	0.0128	0.0128
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0065	0.0344	0.0413
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0181	0.1126	0.1128
Schistosoma mansoni	amidase	0.1504	1	1
Trypanosoma cruzi	serine peptidase, putative	0.0065	0.0344	0.0413
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0045	0.0045
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0181	0.1126	0.1126
Echinococcus multilocularis	abhydrolase domain containing 3	0.0065	0.0344	0.0329
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Schistosoma mansoni	fatty-acid amide hydrolase	0.1504	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Plasmodium vivax	PST-A protein	0.0065	0.0344	0.0413
Loa Loa (eye worm)	amidase	0.0181	0.1126	0.1126
Onchocerca volvulus		0.0182	0.1134	1
Echinococcus multilocularis	lamin dm0	0.0033	0.0128	0.0113
Trypanosoma cruzi	amidase, putative	0.0181	0.1126	0.1495
Plasmodium vivax	hypothetical protein, conserved	0.0065	0.0344	0.0413
Leishmania major	cathepsin L-like protease	0.0077	0.0426	0.0527
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0065	0.0344	0.0413
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0065	0.0344	0.0413
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0026	0.0026
Plasmodium vivax	PST-A protein	0.0065	0.0344	0.0413
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.0444	0.061
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Schistosoma mansoni	hypothetical protein	0.0205	0.1282	0.1282
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Schistosoma mansoni	hypothetical protein	0.0019	0.0037	0.0037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.0444	0.043
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1504	1	1
Mycobacterium ulcerans	peptide amidase, GatA	0.0181	0.1126	0.1128
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0045	0.0396
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0065	0.0344	1
Leishmania major	cathepsin L-like protease	0.0077	0.0426	0.0527
Brugia malayi	Cathepsin L-like precursor	0.002	0.0045	0.0045
Brugia malayi	putative amidase	0.0181	0.1126	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0128	0.0128
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0037	0.0037
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0045	0.0045
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Schistosoma mansoni	lamin	0.0033	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0011	0.0011
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0045	0.0396
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1098	0.728	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0045	0.0045
Brugia malayi	Cathepsin L-like precursor	0.002	0.0045	0.0045
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0065	0.0344	0.0344
Brugia malayi	MGC83647 protein	0.0065	0.0344	0.0344
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Plasmodium falciparum	exported lipase 2	0.0065	0.0344	0.0413
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0065	0.0344	0.0472
Plasmodium vivax	hypothetical protein, conserved	0.0065	0.0344	0.0413
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0065	0.0344	0.0472
Trichomonas vaginalis	conserved hypothetical protein	0.1098	0.728	1
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0181	0.1126	0.1128
Loa Loa (eye worm)	hypothetical protein	0.1504	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0128	0.0128
Loa Loa (eye worm)	cysteine protease	0.002	0.0045	0.0045
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0045	0.003
Mycobacterium ulcerans	hypothetical protein	0.1098	0.728	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0877	0.0877
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.0426	0.0527
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0045	0.0045
Brugia malayi	hypothetical protein	0.0182	0.1134	0.1134
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0181	0.1126	0.1495
Toxoplasma gondii	hypothetical protein	0.0065	0.0344	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0344	0.0344
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0045	0.0045
Mycobacterium ulcerans	lysophospholipase	0.1098	0.728	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0344	0.0344
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0065	0.0344	0.0472
Onchocerca volvulus		0.002	0.0045	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.002	0.0045	0.0045
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1098	0.728	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.0444	0.0552
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0313	0.0313
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0065	0.0344	0.0413
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0045	0.003
Leishmania major	hypothetical protein, conserved	0.0181	0.1126	0.1495
Loa Loa (eye worm)	fibroinase	0.002	0.0045	0.0045
Toxoplasma gondii	phospholipase	0.0065	0.0344	1
Schistosoma mansoni	hypothetical protein	0.0205	0.1282	0.1282
Loa Loa (eye worm)	ctsf protein	0.002	0.0045	0.0045
Toxoplasma gondii	peptidase S15, putative	0.0065	0.0344	1
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0065	0.0344	1
Plasmodium vivax	lysophospholipase, putative	0.0065	0.0344	0.0413
Mycobacterium ulcerans	amidase	0.0181	0.1126	0.1128
Schistosoma mansoni	hypothetical protein	0.0041	0.0185	0.0185
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0185	0.0185
Trypanosoma brucei	monoglyceride lipase, putative	0.1098	0.728	1
Entamoeba histolytica	hypothetical protein	0.0065	0.0344	0.0472
Plasmodium falciparum	esterase, putative	0.1098	0.728	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0181	0.1126	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1098	0.728	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1098	0.728	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0065	0.0344	0.0472
Onchocerca volvulus		0.002	0.0045	0.0396
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0065	0.0344	0.0472
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0128	0.0128
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0181	0.1126	0.1128
Echinococcus granulosus	lamin dm0	0.0033	0.0128	0.0128
Onchocerca volvulus		0.0033	0.0128	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0344	0.0344
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0128	0.0128
Schistosoma mansoni	peptidase	0.0065	0.0344	0.0344
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0037	0.0037
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0426	0.0527
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0065	0.0344	0.0413
Schistosoma mansoni	lamin	0.0033	0.0128	0.0128
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0313	0.0313
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0065	0.0344	0.0344
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.1098	0.728	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0065	0.0344	0.0472
Echinococcus granulosus	Phospholipase carboxylesterase	0.0065	0.0344	0.0344
Toxoplasma gondii	hypothetical protein	0.0065	0.0344	1
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0065	0.0344	0.0329
Schistosoma mansoni	hypothetical protein	0.0019	0.0037	0.0037
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1504	1	1
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.5502	0.5495
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0185	0.0185
Toxoplasma gondii	hypothetical protein	0.0065	0.0344	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0045	0.0045
Echinococcus granulosus	intermediate filament protein	0.0033	0.0128	0.0128
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.0444	0.0444
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.5502	0.5502
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.1098	0.728	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0181	0.1126	0.1126
Trichomonas vaginalis	conserved hypothetical protein	0.1098	0.728	1
Onchocerca volvulus		0.002	0.0045	0.0396
Brugia malayi	Protein C20orf22	0.0065	0.0344	0.0344
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0444	0.0145
Onchocerca volvulus		0.002	0.0045	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1134	0.1134
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0037	0.0022
Entamoeba histolytica	hypothetical protein	0.0065	0.0344	0.0472
Trypanosoma cruzi	serine peptidase, putative	0.0065	0.0344	0.0413
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0045	0.0062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Echinococcus granulosus	abhydrolase domain containing 3	0.0065	0.0344	0.0344
Trypanosoma brucei	monoglyceride lipase, putative	0.1098	0.728	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0344	0.0344
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0065	0.0344	0.0344
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0065	0.0344	0.0413
Leishmania major	monoglyceride lipase, putative	0.1098	0.728	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Mycobacterium ulcerans	amidase	0.0181	0.1126	0.1128
Brugia malayi	MH2 domain containing protein	0.0144	0.0877	0.0877
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0877	0.0877
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1504	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0426	0.0527
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0065	0.0344	0.0329
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0065	0.0344	0.0413
Toxoplasma gondii	protein c14orf29, putative	0.0065	0.0344	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0045	0.0062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0045	0.0062
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0181	0.1126	1
Mycobacterium tuberculosis	Possible lysophospholipase	0.1098	0.728	1
Plasmodium vivax	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Schistosoma mansoni	hypothetical protein	0.0019	0.0037	0.0037
Entamoeba histolytica	;Alias	0.0065	0.0344	0.0472
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0045	0.0062
Entamoeba histolytica	cysteine protease, putative	0.002	0.0045	0.0062
Plasmodium falciparum	lysophospholipase, putative	0.1098	0.728	1
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0181	0.1126	0.1126
Plasmodium vivax	lysophospholipase, putative	0.0065	0.0344	0.0413
Brugia malayi	Amidase family protein	0.0181	0.1126	0.1126
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0219	0.0204
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0065	0.0344	0.0472
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0181	0.1126	0.1128
Plasmodium vivax	lysophospholipase, putative	0.0065	0.0344	0.0413
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0181	0.1126	0.1113
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0045	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0313	0.0313
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0344	0.0472
Plasmodium vivax	hypothetical protein, conserved	0.0065	0.0344	0.0413
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1504	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0011	0.0011
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0045	0.003
Plasmodium falciparum	lysophospholipase, putative	0.1098	0.728	1
Plasmodium vivax	PST-A protein	0.1098	0.728	1
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0219	0.0219
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0381	0.0465
Leishmania major	hypothetical protein, conserved	0.0065	0.0344	0.0413
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.1098	0.728	1
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0181	0.1126	0.1495
Schistosoma mansoni	fatty-acid amide hydrolase	0.0181	0.1126	0.1126
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0426	0.0119
Plasmodium falciparum	lysophospholipase, putative	0.1098	0.728	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0045	0.0062
Plasmodium vivax	PST-A protein	0.0065	0.0344	0.0413
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0444	0.0552
Plasmodium vivax	alpha/beta hydrolase, putative	0.0065	0.0344	0.0413
Onchocerca volvulus		0.002	0.0045	0.0396
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0045	0.0045

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 79.37 um	PUBCHEM_BIOASSAY: Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma). (Class of assay: confirmatory) [Related pubchem assays: 631, 731, 1032, 1300 ]	ChEMBL.	No reference
EC50 (functional)	> 79.37 um	PUBCHEM_BIOASSAY: Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma). (Class of assay: confirmatory) [Related pubchem assays: 1032, 631, 731 ]	ChEMBL.	No reference
EC50 (functional)	> 79.37 um	PUBCHEM_BIOASSAY: Dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma). (Class of assay: confirmatory) [Related pubchem assays: 1032, 631, 731 ]	ChEMBL.	No reference
Potency (binding)	= 1.9953 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.9953 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	31.6228 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	37.933 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1581201

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1430930