Detailed information for compound 1431016

Basic information

Technical information
  • TDR Targets ID: 1431016
  • Name: [4-(4-chlorophenyl)-1-methylpyrrolidin-3-yl]- thiophen-2-ylmethanone
  • MW: 305.822 | Formula: C16H16ClNOS
  • H donors: 0 H acceptors: 1 LogP: 3.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CC(C(C1)c1ccc(cc1)Cl)C(=O)c1cccs1
  • InChi: 1S/C16H16ClNOS/c1-18-9-13(11-4-6-12(17)7-5-11)14(10-18)16(19)15-3-2-8-20-15/h2-8,13-14H,9-10H2,1H3
  • InChiKey: DQDLEPZVHJFUCX-UHFFFAOYSA-N  

Network

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Synonyms

  • [4-(4-chlorophenyl)-1-methyl-pyrrolidin-3-yl]-(2-thienyl)methanone
  • [4-(4-chlorophenyl)-1-methyl-3-pyrrolidinyl]-(2-thienyl)methanone
  • [4-(4-chlorophenyl)-1-methyl-pyrrolidin-3-yl]-thiophen-2-yl-methanone
  • Oprea1_645422
  • 6N-731

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0097 0.0622 0.1246
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0113 0.0741 0.1952
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0221
Echinococcus granulosus cpg binding protein 0.0037 0.0183 0.0365
Echinococcus granulosus nAChR subunit 0.0097 0.0622 0.1246
Schistosoma mansoni lamin 0.0028 0.0122 0.0178
Brugia malayi hypothetical protein 0.0045 0.0241 0.055
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0124 0.0246
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0052 0.0296 0.0475
Trypanosoma cruzi NADH dehydrogenase, putative 0.0113 0.0741 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0174 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0072
Loa Loa (eye worm) hypothetical protein 0.0292 0.2051 0.4683
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0097 0.0622 0.1246
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0234 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0194 0.0633
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0097 0.0622 0.1421
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0024 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0054 0.0121
Brugia malayi hypothetical protein 0.0025 0.0098 0.0223
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0113 0.0741 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0425 0.3027 0.3013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1169 0.8466 0.8463
Mycobacterium tuberculosis Probable reductase 0.032 0.2254 0.4942
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3529 0.7075
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0113 0.0741 0.0722
Brugia malayi hypothetical protein 0.005 0.0277 0.0633
Onchocerca volvulus Putative nachr subunit 0.0303 0.2129 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0425 0.3027 1
Schistosoma mansoni cpg binding protein 0.0037 0.0183 0.0282
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0186 0.0166
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0097 0.0622 0.1421
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.032 0.2254 0.4942
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0209 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.2051 0.3462
Schistosoma mansoni disulfide oxidoreductase 0.0113 0.0741 0.1232
Onchocerca volvulus 0.0035 0.0168 0.0232
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0113 0.0741 0.0722
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0241 0.0221
Onchocerca volvulus 0.005 0.0277 0.0775
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Loa Loa (eye worm) CYP4Cod1 0.0014 0.002 0.0044
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0209 0.0478
Onchocerca volvulus 0.0097 0.0622 0.2494
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0425 0.3027 0.6899
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0113 0.0741 0.1484
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0158 0.0315
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0175 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0054 0.0106
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0277 0.0443
Mycobacterium ulcerans glutaminase 0.0275 0.1924 0.6331
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0186 0.0371
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0175 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0241 0.079
Loa Loa (eye worm) LGC-31 protein 0.0097 0.0622 0.1419
Brugia malayi cytochrome P450 0.0014 0.002 0.0046
Echinococcus granulosus glycine receptor subunit beta 0.0097 0.0622 0.1246
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0113 0.0741 0.1653
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0113 0.0741 0.0722
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0024 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0045 0.0241 0.055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0241 0.055
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0277 0.0554
Brugia malayi MH2 domain containing protein 0.0116 0.0762 0.174
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0425 0.3027 0.6843
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0274 0.0438
Plasmodium falciparum thioredoxin reductase 0.0425 0.3027 0.6843
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Schistosoma mansoni glutamate synthase 0.0113 0.0741 0.1232
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3529 0.7075
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0589
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0186 0.0608
Brugia malayi hypothetical protein 0.0045 0.0241 0.055
Echinococcus granulosus glycine receptor subunit alpha 1 0.0097 0.0622 0.1246
Leishmania major hypothetical protein, conserved 0.0025 0.0098 0.0078
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0113 0.0741 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0113 0.0741 0.1484
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1434 0.3272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0137 0.0205
Onchocerca volvulus 0.005 0.0277 0.0775
Mycobacterium tuberculosis Putative ferredoxin reductase 0.032 0.2254 0.4942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0072
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0113 0.0741 0.2441
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0137 0.0273
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0113 0.0741 0.0722
Echinococcus granulosus glycine receptor subunit beta 0.0097 0.0622 0.1246
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0633
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0113 0.0741 0.1484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.011 0.0356
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0277 0.0443
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0017 0.0032
Brugia malayi hypothetical protein 0.0016 0.0033 0.0075
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0241 0.0382
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0044
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0241 0.0221
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0241 0.0549
Schistosoma mansoni hypothetical protein 0.0019 0.0054 0.0063
Echinococcus multilocularis nAChR subunit 0.0052 0.0296 0.0591
Schistosoma mansoni hypothetical protein 0.0113 0.0741 0.1232
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0097 0.0622 0.1246
Leishmania major NADH dehydrogenase, putative 0.0113 0.0741 0.0722
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1745 0.3985
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0241 0.0551
Toxoplasma gondii hypothetical protein 0.005 0.0277 0.0589
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0303 0.2129 0.4861
Onchocerca volvulus 0.0049 0.0274 0.076
Mycobacterium ulcerans ferredoxin reductase 0.0113 0.0741 0.2396
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0137 0.0273
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0425 0.3027 0.6913
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0622 0.1421
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1169 0.8466 0.8463
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0097 0.0622 0.1246
Onchocerca volvulus 0.0236 0.1643 0.7577
Echinococcus granulosus neuropeptide s receptor 0.0471 0.336 0.6738
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0186 0.0166
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0241 0.0482
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0277 0.0443
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0097 0.0622 0.1421
Loa Loa (eye worm) hypothetical protein 0.0165 0.1125 0.2567
Onchocerca volvulus 0.0165 0.1125 0.4996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0113 0.0741 0.0722
Brugia malayi Cation transporter family protein 0.0097 0.0622 0.1421
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0122 0.0278
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.2051 0.5731
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0741 0.0722
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0017 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0461 0.0756
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0186 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0355 0.0811
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0622 0.1421
Loa Loa (eye worm) hypothetical protein 0.0292 0.2051 0.4683
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0054 0.0106
Loa Loa (eye worm) glutathione reductase 0.061 0.4379 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0113 0.0741 0.1502
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0241 0.0221
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0113 0.0741 0.2396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1028 0.744 0.7434
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0113 0.0741 0.1484
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0113 0.0741 0.1653
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0186 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0241 0.079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0036
Loa Loa (eye worm) GABA receptor subunit 0.0052 0.0296 0.0673
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0241 0.055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0186 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.011 0.0356
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0113 0.0741 0.1484
Schistosoma mansoni hypothetical protein 0.0178 0.1216 0.2041
Loa Loa (eye worm) hypothetical protein 0.0303 0.2129 0.4861
Plasmodium vivax amine transporter, putative 0.005 0.0277 0.0419
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0113 0.0741 0.2396
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0165 0.1125 0.1885
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Schistosoma mansoni cpg binding protein 0.0035 0.0168 0.0258
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0622 0.1421
Mycobacterium ulcerans dehydrogenase 0.0113 0.0741 0.2396
Schistosoma mansoni lamin 0.0028 0.0122 0.0178
Schistosoma mansoni inositol monophosphatase 0.0037 0.0186 0.0288
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0277 0.0554
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0113 0.0741 0.2396
Loa Loa (eye worm) hypothetical protein 0.0165 0.1125 0.2567
Loa Loa (eye worm) hypothetical protein 0.003 0.0137 0.0311
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0425 0.3027 0.6843
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1028 0.744 0.7434
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0113 0.0741 0.1594
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0113 0.0741 0.1594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0175 0.0155
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0113 0.0741 0.0722
Loa Loa (eye worm) inositol-1 0.0037 0.0186 0.0423
Mycobacterium ulcerans monoxygenase 0.0113 0.0741 0.2396
Echinococcus granulosus glutamate synthase 0.0113 0.0741 0.1484
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0425 0.3027 0.6843
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0113 0.0741 0.0722
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0097 0.0622 0.1419
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0425 0.3027 1
Schistosoma mansoni cpg binding protein 0.0037 0.0183 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.011 0.0356
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0024 0.0012
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.005 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0072
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0186 0.0371
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0113 0.0741 0.2396
Schistosoma mansoni acetylcholine receptor subunit beta 0.0045 0.0241 0.0382
Schistosoma mansoni acetylcholine receptor-related 0.0045 0.0241 0.0382
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0113 0.0741 0.1692
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0054 0.0123
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0425 0.3027 0.607
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0097 0.0622 0.1421
Treponema pallidum NADH oxidase 0.0425 0.3027 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0113 0.0741 0.1692
Echinococcus multilocularis serotonin transporter 0.0292 0.2051 0.4112
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0633
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0134 0.0435
Loa Loa (eye worm) hypothetical protein 0.0292 0.2051 0.4683
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0097 0.0622 0.1246
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0113 0.0741 0.2441
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0045 0.0241 0.055
Schistosoma mansoni hypothetical protein 0.0019 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0113 0.0741 0.1594
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0303 0.2129 0.4268
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0631
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0277 0.0443
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Echinococcus granulosus nAChR subunit 0.0052 0.0296 0.0591
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1028 0.744 0.7434
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0017 0.0038
Schistosoma mansoni glutamate synthase 0.0113 0.0741 0.1232
Giardia lamblia NADH oxidase lateral transfer candidate 0.0425 0.3027 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0798 0.1821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0174 0.0569
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0622 0.1421
Onchocerca volvulus 0.0045 0.0241 0.0595
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0425 0.3027 0.6652
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0097 0.0622 0.1419
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0097 0.0622 0.1421
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0425 0.3027 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0241 0.0382
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.032 0.2254 0.4942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Leishmania major trypanothione reductase 0.061 0.4379 0.4367
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0425 0.3027 0.5124
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0113 0.0741 0.2396
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1378 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0277 0.0554
Trypanosoma cruzi trypanothione reductase, putative 0.0425 0.3027 0.3013
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Schistosoma mansoni cytochrome P450 0.0014 0.002 0.0006
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0113 0.0741 0.1793
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Loa Loa (eye worm) hypothetical protein 0.0041 0.0216 0.049
Schistosoma mansoni hypothetical protein 0.0014 0.002 0.0006
Schistosoma mansoni hypothetical protein 0.0178 0.1216 0.2041
Schistosoma mansoni hypothetical protein 0.0019 0.0054 0.0063
Echinococcus granulosus geminin 0.0178 0.1216 0.2437
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1378 1 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0113 0.0741 0.1653
Trichomonas vaginalis glutamate synthase, putative 0.0113 0.0741 0.2441
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0004
Plasmodium vivax glutathione reductase, putative 0.061 0.4379 1
Trypanosoma brucei trypanothione reductase 0.061 0.4379 0.4367
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1169 0.8466 0.8463
Brugia malayi glutathione reductase 0.061 0.4379 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0097 0.0622 0.1419
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.4987 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0632 0.4541 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0137 0.0268
Loa Loa (eye worm) glutaminase 2 0.0275 0.1924 0.4392
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Onchocerca volvulus 0.0165 0.1125 0.4996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0097 0.0622 0.1246
Loa Loa (eye worm) hypothetical protein 0.0049 0.0274 0.0624
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0113 0.0741 0.1594
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0024 0.0055
Giardia lamblia Thioredoxin reductase 0.0113 0.0741 0.1793
Leishmania major hypothetical protein, conserved 0.0113 0.0741 0.0722
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0045 0.0241 0.0481
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0024 0.0046
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.2051 0.4683
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0137 0.0205
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0017 0.0032
Brugia malayi Inositol-1 0.0037 0.0186 0.0425
Echinococcus granulosus glycine receptor subunit alpha 1 0.0097 0.0622 0.1246
Schistosoma mansoni neurotransmitter gated ion channel 0.0052 0.0296 0.0475
Onchocerca volvulus 0.005 0.0277 0.0775
Loa Loa (eye worm) cytochrome P450 0.0014 0.002 0.0044
Trichomonas vaginalis glutamate synthase, putative 0.0113 0.0741 0.2441
Echinococcus granulosus GPCR family 2 0.0019 0.0054 0.0106
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0113 0.0741 0.2441
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0045 0.0241 0.0481
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.4987 0.8459
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0122 0.0276
Schistosoma mansoni sulfide quinone reductase 0.0113 0.0741 0.1232
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0097 0.0622 0.1421
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0097 0.0622 0.1419
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Loa Loa (eye worm) thioredoxin reductase 0.061 0.4379 1
Echinococcus granulosus lamin dm0 0.0028 0.0122 0.0242
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0209 0.0418
Trypanosoma cruzi NADH dehydrogenase, putative 0.0113 0.0741 0.0722
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0241 0.0221
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0097 0.0622 0.103
Echinococcus granulosus serotonin transporter 0.0292 0.2051 0.4112
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0113 0.0741 0.2396
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0425 0.3027 0.6843
Echinococcus multilocularis lamin dm0 0.0028 0.0122 0.0242
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0113 0.0741 0.1594
Loa Loa (eye worm) ACC-1 protein 0.0097 0.0622 0.1419
Onchocerca volvulus 0.0113 0.0741 0.3084
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0025 0.0058
Onchocerca volvulus 0.0292 0.2051 0.9611
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0168 0.0547
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0303 0.2129 0.4268
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0137 0.0273
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0113 0.0741 0.1653
Brugia malayi excitatory GABA receptor EXP-1A 0.0097 0.0622 0.1421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Schistosoma mansoni hypothetical protein 0.0041 0.0216 0.0338
Echinococcus granulosus thioredoxin glutathione reductase 0.061 0.4379 0.878
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0277 0.0443
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0355 0.0809
Plasmodium falciparum ferrodoxin reductase-like protein 0.0113 0.0741 0.1502
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0113 0.0741 0.1692
Plasmodium falciparum amino acid transporter, putative 0.005 0.0277 0.0419
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0303 0.2129 0.4268
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0113 0.0741 0.1484
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0113 0.0741 0.1594
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0741 0.0722
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0052 0.0296 0.0676
Toxoplasma gondii hypothetical protein 0.005 0.0277 0.0589
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0277 0.0554
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0113 0.0741 0.1502
Plasmodium vivax SET domain protein, putative 0.003 0.0137 0.0092
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0186 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0072
Brugia malayi Cation transporter family protein 0.0165 0.1125 0.2568
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0425 0.3027 0.3013
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0113 0.0741 0.0722
Loa Loa (eye worm) programmed cell death 8 0.0113 0.0741 0.169
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.032 0.2254 0.4942
Brugia malayi hypothetical protein 0.0045 0.0241 0.055
Trichomonas vaginalis apoptosis inducing factor, putative 0.0113 0.0741 0.2441
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0113 0.0741 0.1502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0174 0.0569
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0622 0.103
Plasmodium falciparum thioredoxin reductase 0.061 0.4379 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0097 0.0622 0.1246
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Brugia malayi Thioredoxin reductase 0.061 0.4379 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0631
Trichomonas vaginalis glutathione reductase, putative 0.0425 0.3027 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0165 0.1125 0.1885
Brugia malayi follicle stimulating hormone receptor 0.025 0.1745 0.3986
Plasmodium vivax ferrodoxin reductase, putative 0.0113 0.0741 0.1502
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0122 0.0276
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0045 0.0241 0.0481
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0113 0.0741 0.1484
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0425 0.3027 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0054 0.0123
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0186 0.038
Loa Loa (eye worm) hypothetical protein 0.0113 0.0741 0.169
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0113 0.0741 0.1594
Echinococcus multilocularis musashi 0.0028 0.0122 0.0242
Echinococcus multilocularis nAChR subunit 0.0097 0.0622 0.1246
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0022
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0097 0.0622 0.1419
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0277 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0127 0.0411
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0078
Brugia malayi glutamate synthase 0.0113 0.0741 0.1692
Entamoeba histolytica thioredoxin reductase, putative 0.0113 0.0741 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0589
Loa Loa (eye worm) glutaminase 0.0275 0.1924 0.4392
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0113 0.0741 0.2441
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1028 0.744 0.7434
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0277 0.0443
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0303 0.2129 0.4268
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0113 0.0741 0.2441
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0209 0.0476
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0046
Echinococcus multilocularis GPCR, family 2 0.0019 0.0054 0.0106
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.336 0.6738
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0097 0.0622 0.1246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0241 0.079
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0425 0.3027 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0622 0.1421
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0054 0.0106
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0296 0.0475
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Trypanosoma brucei NADH dehydrogenase 0.0113 0.0741 0.0722
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0004
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.336 0.6738
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0296 0.0676
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0113 0.0741 0.0722
Schistosoma mansoni inositol monophosphatase 0.0037 0.0186 0.0288
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0113 0.0741 0.2441
Onchocerca volvulus 0.0097 0.0622 0.2494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0174 0.0569
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Loa Loa (eye worm) acetylcholine receptor protein 0.0045 0.0241 0.0548
Schistosoma mansoni nAChR subunit 0.0045 0.0241 0.0382
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0113 0.0741 0.0722
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0113 0.0741 0.2441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0108 0.0349
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0303 0.2129 0.4268
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0277 0.0554
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0113 0.0741 0.1653
Schistosoma mansoni glutamate synthase 0.0113 0.0741 0.1232
Onchocerca volvulus 0.0165 0.1125 0.4996
Plasmodium falciparum glutathione reductase 0.0425 0.3027 0.6843
Trichomonas vaginalis mercuric reductase, putative 0.0425 0.3027 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0425 0.3027 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0632 0.4541 1
Brugia malayi Pre-SET motif family protein 0.003 0.0137 0.0313
Schistosoma mansoni hypothetical protein 0.0494 0.3529 0.5977
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0113 0.0741 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0277 0.0443
Brugia malayi CXXC zinc finger family protein 0.0035 0.0168 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0072
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Brugia malayi Pre-SET motif family protein 0.0208 0.1434 0.3274
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0762 0.1738
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0241 0.0997
Echinococcus granulosus lamin 0.0028 0.0122 0.0242
Mycobacterium tuberculosis Probable oxidoreductase 0.0632 0.4541 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0631
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0276
Mycobacterium ulcerans NADH dehydrogenase 0.0113 0.0741 0.2396
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0403 0.0879
Schistosoma mansoni hypothetical protein 0.0051 0.0291 0.0466
Plasmodium vivax thioredoxin reductase, putative 0.061 0.4379 1
Echinococcus multilocularis glycine receptor subunit beta 0.0097 0.0622 0.1246
Brugia malayi hypothetical protein 0.0045 0.0241 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0355 0.0811
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0277 0.0443
Chlamydia trachomatis thioredoxin reductase 0.0113 0.0741 0.1686
Mycobacterium ulcerans hypothetical protein 0.0113 0.0741 0.2396
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Echinococcus multilocularis thioredoxin glutathione reductase 0.061 0.4379 0.878
Plasmodium falciparum glutathione reductase 0.061 0.4379 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0113 0.0741 0.1594
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0054 0.0106
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.002 0.0039
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0113 0.0741 0.0722
Giardia lamblia Glutamate synthase 0.0113 0.0741 0.1793
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0241 0.055
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0312 0.2201 0.5027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0622 0.103
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0113 0.0741 0.1484
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0277 0.0554
Entamoeba histolytica disulphide oxidoreductase, putative 0.0113 0.0741 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0113 0.0741 0.1594
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0046
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0069 0.0049
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0113 0.0741 0.2396
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0113 0.0741 0.1484
Toxoplasma gondii thioredoxin reductase 0.061 0.4379 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0303 0.2129 0.4863
Echinococcus granulosus intermediate filament protein 0.0028 0.0122 0.0242
Mycobacterium ulcerans glutamate synthase subunit beta 0.0113 0.0741 0.2396
Echinococcus multilocularis glutamate synthase 0.0113 0.0741 0.1484
Schistosoma mansoni sulfide quinone reductase 0.0113 0.0741 0.1232
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0277 0.0633
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0045 0.0241 0.0548
Echinococcus multilocularis glycine receptor subunit beta 0.0097 0.0622 0.1246
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0622 0.1421
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0113 0.0741 0.1484
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0277 0.0554
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0241 0.0482
Onchocerca volvulus 0.003 0.0137 0.0077
Leishmania major hypothetical protein, conserved 0.0113 0.0741 0.0722
Loa Loa (eye worm) hypothetical protein 0.006 0.0355 0.0809
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0108 0.0349
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0097 0.0622 0.1246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1378 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0622 0.1421
Brugia malayi glutaminase DH11.1 0.0275 0.1924 0.4394
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0277 0.0554
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0622 0.103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0017 0.0032
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1643 0.5423
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0045 0.0241 0.0481
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0293
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0097 0.0622 0.1246
Loa Loa (eye worm) ACC-1 protein 0.0097 0.0622 0.1419
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0241 0.0382
Schistosoma mansoni intermediate filament proteins 0.0028 0.0122 0.0178
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0168 0.0547
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0121
Loa Loa (eye worm) serotonin transporter b 0.0292 0.2051 0.4683
Onchocerca volvulus 0.0052 0.0296 0.0868
Echinococcus granulosus microtubule associated protein 2 0.0693 0.4987 1
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0113 0.0741 0.2441
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0113 0.0741 0.1594
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.2051 0.4684
Schistosoma mansoni nAChR subunit 0.0097 0.0622 0.103
Onchocerca volvulus 0.0097 0.0622 0.2494
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0425 0.3027 0.3013
Trypanosoma cruzi trypanothione reductase, putative 0.061 0.4379 0.4367
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0158 0.0304
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0277 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0137 0.0205
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0158 0.0304
Echinococcus multilocularis cpg binding protein 0.0037 0.0183 0.0365
Echinococcus multilocularis 0.0014 0.002 0.0039
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.2051 0.4683
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0216 0.0492
Schistosoma mansoni hypothetical protein 0.0019 0.0054 0.0063
Leishmania major hypothetical protein, conserved 0.0113 0.0741 0.0722
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0113 0.0741 0.1484
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0277 0.0554
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.2051 0.3462
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0113 0.0741 0.169
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0097 0.0622 0.1246
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0514
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0097 0.0622 0.1246
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0312 0.2201 0.5027
Schistosoma mansoni nAChR subunit 0.0045 0.0241 0.0382
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.061 0.4379 0.9641
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0296 0.0676
Onchocerca volvulus 0.0052 0.0296 0.0868
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0168 0.0382
Trichomonas vaginalis glutaminase, putative 0.0275 0.1924 0.6353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0137 0.0205
Echinococcus granulosus tumor protein p63 0.0336 0.2372 0.4755
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0098 0.0078
Toxoplasma gondii NADPH-glutathione reductase 0.0425 0.3027 0.6899
Echinococcus multilocularis geminin 0.0178 0.1216 0.2437
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0014 0.0027
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0303 0.2129 0.4268
Onchocerca volvulus 0.0045 0.0241 0.0595
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0277 0.0633
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.032 0.2254 0.4942
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0277 0.0443
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0762 0.1738
Brugia malayi hypothetical protein 0.0045 0.0241 0.055
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0241 0.0221
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1419
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0052 0.0296 0.0676
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1169 0.8466 0.8463
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0045 0.0241 0.0548
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0673
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0097 0.0622 0.1246
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0425 0.3027 0.607
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0113 0.0741 0.1952
Toxoplasma gondii selenide, water dikinase 0.0113 0.0741 0.1653
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0113 0.0741 1
Plasmodium falciparum transporter, putative 0.005 0.0277 0.0419
Brugia malayi Cation transporter family protein 0.0097 0.0622 0.1421
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0113 0.0741 0.2441
Echinococcus multilocularis lamin 0.0028 0.0122 0.0242
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0741 0.0722
Plasmodium vivax hypothetical protein, conserved 0.005 0.0277 0.0419
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0277 0.0554
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0632 0.4541 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0113 0.0741 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0394
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0045 0.0241 0.0481
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0186 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0174 0.0569
Schistosoma mansoni glutaminase 0.0275 0.1924 0.3246
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0024 0.0053
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0098 0.0178
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0024 0.0004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0425 0.3027 0.3013
Echinococcus multilocularis tumor protein p63 0.0336 0.2372 0.4755
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0277 0.0554
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0622 0.1421
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0113 0.0741 0.2441
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0622 0.1421
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0113 0.0741 0.1502
Brugia malayi intermediate filament protein 0.0028 0.0122 0.0278
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0234 0.037
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.336 0.6738
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0046
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0113 0.0741 0.1952
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0241 0.0997
Loa Loa (eye worm) hypothetical protein 0.0045 0.0241 0.0548
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0241 0.0221
Mycobacterium tuberculosis Probable dehydrogenase 0.032 0.2254 0.4942
Entamoeba histolytica hypothetical protein 0.0052 0.0296 0.198
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0113 0.0741 0.1484
Onchocerca volvulus 0.0045 0.0241 0.0595
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0045 0.0241 0.055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0025 0.0056

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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