Detailed information for compound 143107

Basic information

Technical information
  • TDR Targets ID: 143107
  • Name: [(9E)-10,14-dimethyl-1-phosphonopentadeca-9,1 3-dienyl]phosphonic acid
  • MW: 396.396 | Formula: C17H34O6P2
  • H donors: 4 H acceptors: 6 LogP: 3.44 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C\CCCCCCCC(P(=O)(O)O)P(=O)(O)O)/CCC=C(C)C
  • InChi: 1S/C17H34O6P2/c1-15(2)11-10-13-16(3)12-8-6-4-5-7-9-14-17(24(18,19)20)25(21,22)23/h11-12,17H,4-10,13-14H2,1-3H3,(H2,18,19,20)(H2,21,22,23)/b16-12+
  • InChiKey: QWSVITIVTMBVIK-FOWTUZBSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(9E)-10,14-dimethyl-1-phosphono-pentadeca-9,13-dienyl]phosphonic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Squalene synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania donovani farnesyltransferase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania mexicana farnesyltransferase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania braziliensis squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma cruzi squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania major squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Candida albicans squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma cruzi squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Candida albicans squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma brucei gambiense farnesyltransferase, putative,squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania infantum squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0048 0.0063 0.0109
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0009 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.002 0.0012
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0009 0.0001
Trypanosoma brucei cytochrome P450, putative 0.0062 0.0112 0.045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0095 0.0173
Echinococcus granulosus FTZ F1 alpha 0.0088 0.02 0.0383
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0095 0.0173
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0118
Brugia malayi Cytochrome P450 family protein 0.0074 0.015 0.0488
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0043 0.0045 0.0145
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.049 0.5698
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0166 0.0324
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0095 0.0173
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0095 0.0173
Schistosoma mansoni neuropeptide receptor 0.0057 0.0095 0.0182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0095 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.02 0.0383
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0057 0.0098
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2941 1 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.002 0.0004
Schistosoma mansoni neuropeptide receptor 0.0057 0.0095 0.0182
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0112 0.0429
Schistosoma mansoni amine GPCR 0.0057 0.0095 0.0182
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0043 0.0045 0.0172
Brugia malayi nuclear receptor NHR-67 0.0042 0.004 0.013
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0027 0.1172
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0043 0.0045 0.0145
Schistosoma mansoni amine GPCR 0.0057 0.0095 0.0182
Echinococcus granulosus serotonin receptor 0.0057 0.0095 0.0173
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0095 0.0308
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0009 0.0029
Brugia malayi Ets-domain containing protein 0.007 0.0138 0.0448
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0166 0.0158
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.004 0.0063
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0095 0.0173
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.004 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0029 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0215 0.0423
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0043 0.0045 0.0028
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0095 0.0173
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0089 0.0289
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) beta-lactamase 0.0078 0.0166 0.054
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0095 0.0182
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 0.02 0.2203
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0009 0.0001
Schistosoma mansoni zinc finger protein 0.0042 0.004 0.0072
Trypanosoma brucei unspecified product 0.0034 0.0015 0.0048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0063 0.0109
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.002 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.08 0.2661
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0055
Brugia malayi G-protein coupled receptor 0.0057 0.0095 0.0308
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0029 0.5797
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Onchocerca volvulus 0.0057 0.0095 0.0939
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0017 0.0055
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.002 0.0769
Brugia malayi G-protein coupled receptor 0.0057 0.0095 0.0308
Brugia malayi tailless protein 0.0042 0.004 0.013
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0095 0.0173
Brugia malayi Cytochrome P450 family protein 0.0062 0.0112 0.0363
Schistosoma mansoni opsin-like receptor 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0046 0.0057 0.0186
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.004 0.013
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0347 0.0686
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Brugia malayi intermediate filament protein 0.0056 0.0089 0.0289
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0095 0.0182
Schistosoma mansoni hypothetical protein 0.0094 0.0221 0.0435
Onchocerca volvulus 0.0035 0.0017 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Loa Loa (eye worm) hypothetical protein 0.0082 0.018 0.0585
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 0.02 0.0383
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0095 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 0.02 0.0649
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.002 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0095 0.0308
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.08 0.26
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.002 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0017 0.0026
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0166 0.0158
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0095 0.0182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Schistosoma mansoni nuclear hormone receptor 0.0042 0.004 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0017 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 0.02 0.0649
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0029 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.004 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Brugia malayi isocitrate dehydrogenase 0.0032 0.0008 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.002 0.0024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0533 0.1728 0.5615
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0029 0.0069
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0095 0.0173
Schistosoma mansoni gabp alpha 0.007 0.0138 0.0267
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.002 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.08 0.2661
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.0731 0.2377
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0347 0.0686
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0166 0.0529
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0095 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0095 0.0173
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0062 0.0112 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.002 0.0012
Brugia malayi ORL1-like opioid receptor 0.0057 0.0095 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 0.02 0.0649
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.002 0.0012
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0095 0.0308
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0166 0.015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.042 0.1365
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0095 0.0173
Entamoeba histolytica hypothetical protein 0.0107 0.0264 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.02 0.0649
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.08 0.2661
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.002 0.0012
Echinococcus multilocularis musashi 0.0056 0.0089 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0027 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0166 0.0324
Echinococcus granulosus voltage gated potassium channel 0.0036 0.002 0.0024
Schistosoma mansoni adenoreceptor 0.0057 0.0095 0.0182
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0094 0.0221 0.2465
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.018 0.0352
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0095 0.0182
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0138 0.0259
Schistosoma mansoni histamine h1 receptor 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0055 0.0085 0.0278
Brugia malayi conserved hypotetical protein 0.0042 0.004 0.013
Echinococcus granulosus jun protein 0.0085 0.0189 0.0361
Brugia malayi nuclear hormone receptor 0.0042 0.004 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0189 0.0361
Onchocerca volvulus 0.0078 0.0166 0.1799
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0043 0.0045 0.0073
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 0.02 0.0649
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0095 0.0173
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0027 0.0077
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 0.02 0.0383
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi RNA binding protein 0.0131 0.0347 0.1128
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0166 0.054
Toxoplasma gondii exonuclease III APE 0.0038 0.0029 0.1337
Onchocerca volvulus 0.0082 0.018 0.1967
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0057 0.0186
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0009 0.001
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.004 0.013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0063 0.0109
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.054
Onchocerca volvulus 0.0057 0.0095 0.0939
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0095 0.0173
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0095 0.0173
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.02 0.0649
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0029 0.0069
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Brugia malayi nuclear receptor NHR-88 0.0088 0.02 0.0649
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0043 0.0045 0.0151
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi steroid hormone receptor 0.0088 0.02 0.0649
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 0.02 0.0649
Onchocerca volvulus 0.0057 0.0095 0.0939
Plasmodium falciparum cysteine--tRNA ligase 0.0043 0.0045 1
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0015 0.0048
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.002 0.0004
Echinococcus granulosus hypothetical protein 0.0057 0.0095 0.0173
Trypanosoma cruzi squalene synthase, putative 0.0303 0.0937 0.3852
Loa Loa (eye worm) hypothetical protein 0.0046 0.0057 0.0186
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 0.02 0.0649
Brugia malayi Ets-domain containing protein 0.007 0.0138 0.0448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 0.02 0.0391
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0158 0.0439 0.1426
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.002 0.0004
Onchocerca volvulus 0.0057 0.0095 0.0939
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0029 0.0096
Schistosoma mansoni biogenic amine receptor 0.0057 0.0095 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0029 0.0096
Echinococcus granulosus g protein coupled receptor 0.0057 0.0095 0.0173
Schistosoma mansoni nuclear receptor 0.0042 0.004 0.0072
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0138 0.0448
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0095 0.0173
Brugia malayi hypothetical protein 0.0107 0.0264 0.0858
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0522 0.1724
Chlamydia trachomatis cysteine--tRNA ligase 0.0043 0.0045 0.5
Trichomonas vaginalis set domain proteins, putative 0.0276 0.0847 0.2817
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0166 0.0529
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0062 0.0109 0.0201
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.054
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.004 0.013
Echinococcus granulosus cysteinyl tRNA synthetase 0.0043 0.0045 0.0073
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0926 0.3078 1
Brugia malayi RE15519p 0.0057 0.0095 0.0308
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.002 0.0072
Echinococcus granulosus leucyl tRNA synthetase 0.0043 0.0045 0.0073
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 0.02 0.0649
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0009 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0088 0.02 0.0391
Onchocerca volvulus 0.0056 0.0089 0.0868
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.002 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0166 0.0529
Brugia malayi Pre-SET motif family protein 0.0035 0.0017 0.0055
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0027 0.0077
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 0.02 0.2203
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0095 0.0182
Trypanosoma cruzi phytoene synthase, putative 0.0094 0.0221 0.0884
Echinococcus granulosus geminin 0.0514 0.1663 0.3309
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0095 0.0173
Onchocerca volvulus 0.0043 0.0045 0.0335
Treponema pallidum cysteinyl-tRNA synthetase 0.0043 0.0045 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0037 0.0095
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0029
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0057 0.0186
Leishmania major cytochrome p450-like protein 0.0036 0.002 0.005
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0734 0.242 0.7862
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.002 0.0012
Brugia malayi neuropeptide F receptor 0.0057 0.0095 0.0308
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0014 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.004 0.0279
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0029 0.0088
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0062 0.0109 0.0201
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0027 0.0087
Leishmania major squalene synthase, putative 0.0303 0.0937 0.3852
Brugia malayi MH2 domain containing protein 0.012 0.031 0.1008
Echinococcus multilocularis FTZ F1 alpha 0.0088 0.02 0.0383
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0095 0.0308
Schistosoma mansoni nuclear hormone receptor 0.0042 0.004 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0095 0.0173
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.002 0.0004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0095 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Onchocerca volvulus 0.0057 0.0095 0.0939
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.042 0.1365
Loa Loa (eye worm) hypothetical protein 0.0734 0.242 0.7862
Echinococcus multilocularis GPCR, family 2 0.0048 0.0063 0.0109
Mycobacterium tuberculosis Possible penicillin-binding protein 0.05 0.1614 0.1607
Schistosoma mansoni hypothetical protein 0.0107 0.0264 0.052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0009 0.0029
Onchocerca volvulus 0.0057 0.0095 0.0939
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.08 0.26
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Brugia malayi AKH receptor 0.0057 0.0095 0.0308
Schistosoma mansoni microtubule-associated protein tau 0.1488 0.5009 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0118
Echinococcus granulosus transcription factor btf3 0.0038 0.0027 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0095 0.0308
Onchocerca volvulus 0.0042 0.004 0.0279
Brugia malayi G protein-coupled receptor 0.0057 0.0095 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.08 0.2661
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.002 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0095 0.0182
Onchocerca volvulus 0.0057 0.0095 0.0939
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0095 0.0173
Leishmania major basic transcription factor 3a, putative 0.0038 0.0027 0.0077
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0095 0.0173
Brugia malayi Serotonin receptor 0.0057 0.0095 0.0308
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0095 0.0173
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0095 0.0173
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0037 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 0.02 0.0649
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0095 0.0182
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0095 0.0173
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis transcription factor btf3 0.0038 0.0027 0.0037
Echinococcus granulosus intermediate filament protein 0.0056 0.0089 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.006
Brugia malayi hypothetical protein 0.0067 0.0126 0.041
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0095 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0898 0.2983 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0008 0.0022
Brugia malayi hypothetical protein 0.0042 0.004 0.013
Schistosoma mansoni amine GPCR 0.0057 0.0095 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0215 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 0.02 0.0649
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.002 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0088 0.02 0.0391
Loa Loa (eye worm) hypothetical protein 0.056 0.1821 0.5917
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.018 0.0344
Plasmodium falciparum cysteine--tRNA ligase 0.0043 0.0045 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0095 0.0182
Echinococcus multilocularis lamin 0.0056 0.0089 0.0161
Echinococcus granulosus g protein coupled receptor 0.0057 0.0095 0.0173
Brugia malayi hypothetical protein 0.0042 0.004 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.02 0.0649
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0057 0.0106
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0037 0.002
Echinococcus granulosus allatostatin A receptor 0.0057 0.0095 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0095 0.0173
Brugia malayi hypothetical protein 0.0046 0.0057 0.0186
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0057 0.0186
Loa Loa (eye worm) RNA binding protein 0.0131 0.0347 0.1128
Onchocerca volvulus 0.0057 0.0095 0.0939
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0095 0.0173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0037 0.0119
Onchocerca volvulus 0.0057 0.0095 0.0939
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.002 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0347 0.1128
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Loa Loa (eye worm) hypothetical protein 0.0375 0.1187 0.3855
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0112 0.0363
Echinococcus multilocularis sex peptide receptor 0.0057 0.0095 0.0173
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0292 0.09 0.1783
Brugia malayi follicle stimulating hormone receptor 0.0533 0.1728 0.5615
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0166 0.0316
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.002 0.005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0008 0.0027
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0166 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Brugia malayi larval opioid receptor 0.0057 0.0095 0.0308
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.002 0.0012
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0095 0.0173
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.004 0.0072
Onchocerca volvulus 0.0146 0.04 0.462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Mycobacterium ulcerans hypothetical protein 0.0078 0.0166 0.015
Schistosoma mansoni voltage-gated potassium channel 0.0065 0.012 0.0232
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0166 0.015
Schistosoma mansoni hypothetical protein 0.0036 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0057 0.0106
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0104 0.0255 0.0828
Echinococcus granulosus g protein coupled receptor 0.0057 0.0095 0.0173
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0043 0.0045 0.0151
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Plasmodium vivax SET domain protein, putative 0.0035 0.0017 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.0095 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0215 0.0414
Brugia malayi Serotonin receptor 0.0057 0.0095 0.0308
Schistosoma mansoni lamin 0.0056 0.0089 0.017
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0043 0.0045 0.0756
Schistosoma mansoni hypothetical protein 0.0104 0.0255 0.0501
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi Cytochrome P450 family protein 0.0036 0.002 0.0066
Brugia malayi GnHR receptor homolog 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.054
Brugia malayi nuclear receptor NHR-88 0.0042 0.004 0.013
Schistosoma mansoni cytochrome P450 0.0036 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0734 0.242 1
Schistosoma mansoni lamin 0.0056 0.0089 0.017
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0166 0.0158
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Brugia malayi TAR-binding protein 0.0131 0.0347 0.1128
Trypanosoma brucei C-8 sterol isomerase, putative 0.0734 0.242 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.002 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0037 0.0119
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0043 0.0045 0.0121
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0063 0.0204
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.004 0.0279
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 0.02 0.0391
Schistosoma mansoni transcription factor btf3 0.0038 0.0027 0.0046
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.002 0.0004
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0057 0.0098
Loa Loa (eye worm) hypothetical protein 0.0046 0.0057 0.0186
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0043 0.0045 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0245 0.074 0.1463
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.0397 0.129
Schistosoma mansoni hypothetical protein 0.0514 0.1663 0.3315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 0.02 0.0383
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.004 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.031 0.1008
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0095 0.0182
Mycobacterium tuberculosis Conserved protein 0.0078 0.0166 0.0158
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Toxoplasma gondii ABC1 family protein 0.0078 0.0166 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.002 0.0004
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0095 0.0173
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0095 0.0173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0166 0.0158
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.004 0.0072
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0095 0.0939
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Trichomonas vaginalis esterase, putative 0.0078 0.0166 0.0529
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 0.02 0.0383
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.042 0.1365
Brugia malayi Nuclear hormone receptor E75 0.0042 0.004 0.013
Schistosoma mansoni amine GPCR 0.0057 0.0095 0.0182
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0095 0.0173
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0037 0.002
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0009 0.0001
Onchocerca volvulus 0.0056 0.0089 0.0868
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0095 0.0173
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0347 0.0686
Loa Loa (eye worm) hypothetical protein 0.0056 0.0089 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Mycobacterium ulcerans phytoene synthase, CrtB 0.0094 0.0221 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0095 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0037 0.014
Schistosoma mansoni jun-related protein 0.0069 0.0134 0.026
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.08 0.2661
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.002 0.0004
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0095 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0347 0.0686
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.031 0.1008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0095 0.0182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0095 0.0173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0166 0.054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0095 0.0173
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0009 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.02 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 0.02 0.0649
Schistosoma mansoni voltage-gated potassium channel 0.0036 0.002 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.02 0.0383
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 0.02 0.0383
Schistosoma mansoni coup transcription factor 0.0088 0.02 0.0391
Leishmania major C-8 sterol isomerase-like protein 0.0734 0.242 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis voltage gated potassium channel 0.0036 0.002 0.0024
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0095 0.0173
Echinococcus multilocularis jun protein 0.0085 0.0189 0.0361
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.002 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0166 0.0316
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.004 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.002 0.0012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.002 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0088 0.02 0.0391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.02 0.0383
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.002 0.0024
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0095 0.0173
Brugia malayi hypothetical protein 0.0046 0.0057 0.0186
Schistosoma mansoni neuropeptide receptor 0.0057 0.0095 0.0182
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0112 0.0363
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0062 0.0109 0.0353
Leishmania major hypothetical protein, conserved 0.0094 0.0221 0.0884
Leishmania major cytochrome p450-like protein 0.0036 0.002 0.005
Loa Loa (eye worm) fli-1 protein 0.0212 0.0627 0.2037
Leishmania major cytochrome p450-like protein 0.0062 0.0112 0.0429
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.002 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0063 0.0109
Schistosoma mansoni opsin-like receptor 0.0057 0.0095 0.0182
Echinococcus multilocularis thyroid hormone receptor alpha 0.0088 0.02 0.0383
Schistosoma mansoni hypothetical protein 0.0057 0.0095 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0037 0.014
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0009 0.0001
Brugia malayi beta-lactamase family protein 0.0078 0.0166 0.054
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0215 0.0423
Echinococcus granulosus microtubule associated protein 2 0.1488 0.5009 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0009 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 0.02 0.0649
Brugia malayi polk-prov protein 0.0031 0.0003 0.001
Echinococcus multilocularis microtubule associated protein 2 0.1488 0.5009 1
Echinococcus granulosus dna polymerase kappa 0.0041 0.0037 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0029 0.1337
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi Dopamine receptor protein 1 0.0057 0.0095 0.0308
Mycobacterium tuberculosis Conserved protein 0.0078 0.0166 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0029 0.0088
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0008 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 0.02 0.0383
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0063 0.0204
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.02 0.0649
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.02 0.0391
Loa Loa (eye worm) hypothetical protein 0.0046 0.0057 0.0186
Brugia malayi Fli-1 protein 0.0212 0.0627 0.2037
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.004 0.013
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0145
Schistosoma mansoni nuclear receptor 0.0042 0.004 0.0072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0063 0.0204
Echinococcus multilocularis serotonin receptor 0.0057 0.0095 0.0173
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0347 0.1128
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0255 0.0828
Entamoeba histolytica hypothetical protein 0.0107 0.0264 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 0.02 0.0391
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.002 0.0012
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0094 0.0221 0.0213
Onchocerca volvulus 0.0078 0.0166 0.1799
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.02 0.0649
Brugia malayi beta-NAC-like protein 0.0038 0.0027 0.0087
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0264 0.0511
Brugia malayi nuclear receptor RXR 0.0046 0.0057 0.0186
Brugia malayi Cytochrome P450 family protein 0.0062 0.0112 0.0363
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0095 0.0308
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0029 0.0088
Echinococcus granulosus sex peptide receptor 0.0057 0.0095 0.0173
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0166 0.0158
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0043 0.0045 0.2307
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0095 0.0173
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0008 0.0009
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus granulosus neuropeptide receptor 0.0057 0.0095 0.0173
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.0095 0.0182
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0029 0.0042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0095 0.0308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Leishmania major cysteinyl-tRNA synthetase, putative 0.0043 0.0045 0.0151
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 0.02 0.0391
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.002 0.0012
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.004 0.013
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.006 0.0103 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0095 0.0173
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Brugia malayi Melatonin receptor type 1A 0.0057 0.0095 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.02 0.0649
Schistosoma mansoni hypothetical protein 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0095 0.0173
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0094 0.0221 0.072
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.004 0.0063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0095 0.0173
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.015 0.0488
Brugia malayi beta-lactamase 0.0078 0.0166 0.054
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Schistosoma mansoni voltage-gated potassium channel 0.0036 0.002 0.0033
Echinococcus multilocularis Squalene phytoene synthase 0.0094 0.0221 0.0426
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0009 0.0001
Schistosoma mansoni biogenic amine receptor 0.0057 0.0095 0.0182
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0036 0.002 0.0066
Brugia malayi ecdysone receptor 0.0042 0.004 0.013
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.004 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 0.02 0.0649
Echinococcus granulosus neuropeptide receptor 0.0057 0.0095 0.0173
Onchocerca volvulus 0.0067 0.0126 0.1316
Brugia malayi Dopamine receptor protein 2 0.0057 0.0095 0.0308
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0095 0.0173
Schistosoma mansoni intermediate filament proteins 0.0056 0.0089 0.017
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0009 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0088 0.02 0.0383
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0095 0.0182
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0112 0.0429
Brugia malayi Pre-SET motif family protein 0.0243 0.0731 0.2377
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0095 0.0173
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0095 0.0173
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0118
Brugia malayi PAS domain containing protein 0.0047 0.0059 0.0191
Echinococcus granulosus orexin receptor type 2 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni amine GPCR 0.0057 0.0095 0.0182
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0118
Schistosoma mansoni RAR-like nuclear receptor 0.0088 0.02 0.0391
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0095 0.0173
Schistosoma mansoni opsin-like receptor 0.0057 0.0095 0.0182
Schistosoma mansoni ets-related 0.0212 0.0627 0.1245
Schistosoma mansoni hypothetical protein 0.0514 0.1663 0.3315
Schistosoma mansoni ap endonuclease 0.0038 0.0029 0.0051
Loa Loa (eye worm) hypothetical protein 0.0146 0.04 0.1301
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.018 0.0344
Schistosoma mansoni hypothetical protein 0.0057 0.0095 0.0182
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.002 0.0012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.054
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.1365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Echinococcus granulosus somatostatin receptor 0.0057 0.0095 0.0173
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.002 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 0.02 0.0649
Schistosoma mansoni biogenic amine receptor 0.0057 0.0095 0.0182
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0095 0.0182
Trypanosoma brucei squalene synthase, putative 0.0303 0.0937 0.3865
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0037 0.0119
Onchocerca volvulus 0.0057 0.0095 0.0939
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0037 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0065 0.012 0.0232
Loa Loa (eye worm) CYP4Cod1 0.0062 0.0112 0.0363
Schistosoma mansoni hypothetical protein 0.0057 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0095 0.0308
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.018 0.0585
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.0649
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0166 0.0529
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.0066
Brugia malayi hypothetical protein 0.0146 0.04 0.1301
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0009 0.0001
Onchocerca volvulus 0.0057 0.0095 0.0939
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0522 0.1724
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0347 0.0686
Loa Loa (eye worm) hypothetical protein 0.0057 0.0092 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.049 0.1617
Leishmania major hypothetical protein, conserved 0.0078 0.0166 0.0655
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0095 0.0308
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.002 0.0004
Echinococcus granulosus single minded 2 0.0038 0.0028 0.004
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.002 0.0004
Schistosoma mansoni ap endonuclease 0.0038 0.0029 0.0051
Brugia malayi Dopamine receptor 0.0057 0.0095 0.0308
Schistosoma mansoni retinoic acid receptor RXR 0.0292 0.09 0.179
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0009 0.001
Mycobacterium leprae Probable lipase LipE 0.0078 0.0166 0.0146
Echinococcus multilocularis serotonin receptor 0.0057 0.0095 0.0173
Echinococcus granulosus Squalene phytoene synthase 0.0094 0.0221 0.0426
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0029 0.0109
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.004 0.0072
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0095 0.0182
Onchocerca volvulus 0.0088 0.02 0.2203
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0166 0.0655
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0095 0.0173
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0095 0.0173
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0089 0.0289
Schistosoma mansoni single-minded 0.0047 0.0059 0.011
Schistosoma mansoni myosin xvIII 0.0057 0.0095 0.0182
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0347 0.0678
Brugia malayi hypothetical protein 0.0158 0.0439 0.1426
Onchocerca volvulus 0.0276 0.0847 1
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0095 0.0173
Mycobacterium ulcerans lipase LipD 0.0078 0.0166 0.015
Brugia malayi putative neuropeptide receptor 0.0057 0.0095 0.0308
Brugia malayi ecdysteroid receptor 0.0088 0.02 0.0649
Echinococcus granulosus lamin 0.0056 0.0089 0.0161
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0166 0.0158
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0138 0.0259
Onchocerca volvulus 0.0078 0.0166 0.1799
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0046 0.0057 0.0186
Onchocerca volvulus 0.0057 0.0095 0.0939
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.004 0.013
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0095 0.0182
Mycobacterium ulcerans beta-lactamase 0.0078 0.0166 0.015
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Echinococcus multilocularis somatostatin receptor 0.0057 0.0095 0.0173
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0095 0.0173
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0095 0.0173
Echinococcus multilocularis lamin dm0 0.0056 0.0089 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0037 0.014
Brugia malayi hypoxia-induced factor 1 0.0145 0.0397 0.129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0095 0.0182
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0013 0.0009
Schistosoma mansoni hypothetical protein 0.0069 0.0134 0.026
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.002 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0063 0.0109
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0215 0.07
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0095 0.0173
Entamoeba histolytica hypothetical protein 0.0107 0.0264 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 0.02 0.0649
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0215 0.0414
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0062 0.0109 0.0353
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0027 0.5078
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0095 0.0308
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0347 0.1128
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0043 0.0045 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0264 0.0511
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0017 0.0553
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0264 0.052
Schistosoma mansoni neuropeptide receptor 0.0057 0.0095 0.0182
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2941 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0095 0.0308
Schistosoma mansoni hypothetical protein 0.0101 0.0245 0.0482
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0017 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0095 0.0173
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0095 0.0173
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.002 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0037 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0215 0.0423
Brugia malayi neuropeptide F receptor 0.0057 0.0095 0.0308
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0095 0.0308
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0095 0.0308
Loa Loa (eye worm) DR-78 0.0042 0.004 0.013
Onchocerca volvulus 0.0057 0.0095 0.0939
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Echinococcus multilocularis 0.0036 0.002 0.0024
Brugia malayi Steroid receptor seven-up type 2 0.0088 0.02 0.0649
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Echinococcus multilocularis geminin 0.0514 0.1663 0.3309
Brugia malayi Nuclear hormone receptor E75 0.0042 0.004 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0166 0.0675
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0095 0.0173
Loa Loa (eye worm) cytochrome P450 0.0036 0.002 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0166 0.0529
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0095 0.0173
Brugia malayi bZIP transcription factor family protein 0.0085 0.0189 0.0613
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0009 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0029 0.011
Plasmodium vivax cysteine--tRNA ligase, putative 0.0043 0.0045 0.2307
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0078 0.0166 0.054
Onchocerca volvulus 0.0042 0.004 0.0279
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 0.02 0.0391
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0017 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0215 0.07
Brugia malayi sulfakinin receptor protein 0.0057 0.0095 0.0308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0215 0.0414
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.02 0.0649
Onchocerca volvulus Bile acid receptor homolog 0.0088 0.02 0.2203
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0189 0.0361
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.004 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 0.02 0.0649
Brugia malayi nuclear receptor RXR 0.0042 0.004 0.013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0003 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0095 0.0173
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0059 0.011
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0166 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 0.02 0.0391
Entamoeba histolytica hypothetical protein 0.0107 0.0264 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Echinococcus granulosus lamin dm0 0.0056 0.0089 0.0161
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Echinococcus granulosus fmrfamide receptor 0.0057 0.0095 0.0173
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0009 0.001
Brugia malayi small heat shock protein 0.056 0.1821 0.5917
Brugia malayi hypothetical protein 0.0057 0.0095 0.0308
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Loa Loa (eye worm) hypothetical protein 0.0926 0.3078 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0166 0.0655
Onchocerca volvulus 0.0057 0.0095 0.0939
Brugia malayi cytochrome P450 0.0036 0.002 0.0066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 0.02 0.0383
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0008 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.0088 0.02 0.0649
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0027 0.1172
Trypanosoma cruzi squalene synthase, putative 0.0303 0.0937 0.3852
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0089 0.0289
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.013
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.002 0.0012
Onchocerca volvulus 0.0057 0.0095 0.0939
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0308
Onchocerca volvulus 0.0057 0.0095 0.0939
Brugia malayi beta-lactamase family protein 0.0078 0.0166 0.054
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0043 0.0045 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.08 0.2661
Giardia lamblia Cysteinyl-tRNA synthetase 0.0043 0.0045 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0181 0.0587
Brugia malayi nuclear hormone receptor 0.0088 0.02 0.0649
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 0.02 0.0383
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0029 0.0042
Mycobacterium tuberculosis Conserved protein 0.0078 0.0166 0.0158
Onchocerca volvulus 0.0057 0.0095 0.0939
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 0.02 0.0383
Echinococcus granulosus tar DNA binding protein 0.0131 0.0347 0.0678
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0095 0.0939
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0166 0.0146

Activities

Activity type Activity value Assay description Source Reference
ED50 (binding) 0 mg kg-1 Effective dose of the compound to inhibit rat liver microsomal Squalene Synthase was determined by peroral administration at a dose of 30 mg/kg; In active ChEMBL. 7629799
ED50 (binding) = 0.05 mg kg-1 Effective dose of the compound to inhibit rat liver microsomal Squalene Synthase was determined by intravenous administration ChEMBL. 7629799
ED50 (binding) = 0.05 mg kg-1 Effective dose of the compound to inhibit rat liver microsomal Squalene Synthase was determined by intravenous administration ChEMBL. 7629799
IC50 (binding) = 4.2 nM Inhibition rat liver microsomal squalene synthase ChEMBL. 7629799
IC50 (binding) = 4.2 nM Inhibition rat liver microsomal squalene synthase ChEMBL. 7629799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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