Detailed information for compound 1431460

Basic information

Technical information
  • TDR Targets ID: 1431460
  • Name: N-(2,4-dichlorophenyl)-2-(4-ethylpyridin-1-iu m-1-yl)acetamide chloride
  • MW: 345.651 | Formula: C15H15Cl3N2O
  • H donors: 1 H acceptors: 1 LogP: 4.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc[n+](cc1)CC(=O)Nc1ccc(cc1Cl)Cl.[Cl-]
  • InChi: 1S/C15H14Cl2N2O.ClH/c1-2-11-5-7-19(8-6-11)10-15(20)18-14-4-3-12(16)9-13(14)17;/h3-9H,2,10H2,1H3;1H
  • InChiKey: CHFCBNVUNSHWLS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dichlorophenyl)-2-(4-ethyl-1-pyridin-1-iumyl)acetamide chloride
  • N-(2,4-dichlorophenyl)-2-(4-ethylpyridin-1-ium-1-yl)ethanamide chloride
  • MLS000516425
  • SMR000342550
  • T0518-3294

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi chromobox protein homolog 3 0.0039 0.0079 0.0069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni amine GPCR 0.0038 0.0071 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0085 0.0074
Echinococcus granulosus pyruvate kinase 0.0033 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0063 0.0247 0.0237
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.004 0.0202
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Echinococcus multilocularis glycine receptor subunit beta 0.004 0.0085 0.0074
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.004 0.0085 0.0074
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0071 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0071 0.0063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0085 0.0074
Echinococcus granulosus g protein coupled receptor 0.0038 0.0071 0.0063
Echinococcus granulosus glycine receptor subunit beta 0.004 0.0085 0.0077
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1446 0.1437
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0038 0.0071 0.0061
Plasmodium falciparum alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Schistosoma mansoni neuropeptide receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1475 1 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.004 0.0055
Echinococcus multilocularis g-protein coupled receptor 0.0038 0.0071 0.0061
Plasmodium vivax PST-A protein 0.0063 0.0247 0.0327
Schistosoma mansoni hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi G protein-coupled receptor F59B2.13 0.0038 0.0071 0.0061
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0071 0.0061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0085 0.0074
Echinococcus multilocularis abhydrolase domain containing 3 0.0063 0.0247 0.0237
Toxoplasma gondii peptidase S15, putative 0.0063 0.0247 1
Plasmodium vivax PST-A protein 0.0063 0.0247 0.0327
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0071 0.0063
Plasmodium vivax alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.004 0.0085 0.0074
Echinococcus multilocularis serotonin receptor 0.0691 0.4583 0.4577
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0071 0.0061
Plasmodium vivax lysophospholipase, putative 0.0063 0.0247 0.0327
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Onchocerca volvulus 0.0038 0.0071 0.0421
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0038 0.0071 0.0061
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Mycobacterium ulcerans amidase 0.0178 0.1038 0.1385
Echinococcus multilocularis pyruvate kinase 0.0033 0.004 0.0029
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0038 0.0071 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063
Echinococcus multilocularis serotonin receptor 0.0691 0.4583 0.4577
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Toxoplasma gondii protein c14orf29, putative 0.0063 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Schistosoma mansoni histamine h1 receptor 0.0038 0.0071 0.0061
Echinococcus granulosus somatostatin receptor 0.0038 0.0071 0.0063
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0085 0.0074
Schistosoma mansoni neuropeptide receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) melatonin receptor type 1A 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Echinococcus multilocularis nAChR subunit 0.004 0.0085 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Plasmodium falciparum lysophospholipase, putative 0.1077 0.725 1
Plasmodium falciparum esterase, putative 0.0063 0.0247 0.0327
Loa Loa (eye worm) amidase 0.0178 0.1038 0.1029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0038 0.0071 0.0061
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0178 0.1038 0.1385
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0247 0.0237
Toxoplasma gondii hypothetical protein 0.0063 0.0247 1
Plasmodium falciparum exported lipase 1 0.0063 0.0247 0.0327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Brugia malayi Pre-SET motif family protein 0.0209 0.125 0.124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Echinococcus granulosus neuropeptide s receptor 0.0499 0.3256 0.3251
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0178 0.1038 0.1385
Echinococcus multilocularis glycine receptor subunit beta 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0691 0.4583 0.4577
Trypanosoma brucei monoglyceride lipase, putative 0.1077 0.725 1
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0038 0.0071 0.0061
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0038 0.0071 0.0063
Chlamydia trachomatis hydrolase 0.0063 0.0247 0.208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Onchocerca volvulus 0.004 0.0085 0.0516
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi hypothetical protein 0.0237 0.1446 0.1437
Onchocerca volvulus 0.0038 0.0071 0.0421
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0085 0.0074
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0178 0.1038 0.1029
Brugia malayi MGC83647 protein 0.0063 0.0247 0.0237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0071 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0085 0.0074
Plasmodium falciparum lysophospholipase, putative 0.1077 0.725 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.004 0.0029
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.004 0.0085 0.0074
Brugia malayi Pre-SET motif family protein 0.003 0.0015 0.0005
Brugia malayi Dopamine receptor 0.0038 0.0071 0.0061
Plasmodium falciparum alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0038 0.0071 0.0061
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0071 0.0061
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0178 0.1038 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.004 0.0085 0.0074
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0038 0.0071 0.0061
Plasmodium falciparum esterase, putative 0.0063 0.0247 0.0327
Onchocerca volvulus 0.0038 0.0071 0.0421
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0089 0.0079
Brugia malayi Melatonin receptor type 1A 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0015 0.0005
Plasmodium falciparum alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0079 0.0109
Plasmodium falciparum prodrug activation and resistance esterase 0.0063 0.0247 0.0327
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0071 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Plasmodium falciparum lysophospholipase, putative 0.0063 0.0247 0.0327
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0063 0.0247 0.0327
Loa Loa (eye worm) pyruvate kinase 0.0033 0.004 0.0029
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.004 0.0085 0.0074
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0178 0.1038 0.1419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Plasmodium vivax PST-A protein 0.0063 0.0247 0.0327
Onchocerca volvulus 0.004 0.0085 0.0516
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0247 0.0327
Echinococcus multilocularis orexin receptor type 2 0.0038 0.0071 0.0061
Brugia malayi Dopamine receptor protein 2 0.0038 0.0071 0.0061
Leishmania major hypothetical protein, conserved 0.0063 0.0247 0.0288
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0063 0.0247 0.0288
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0178 0.1038 0.5
Mycobacterium tuberculosis Possible lysophospholipase 0.1077 0.725 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0085 0.0074
Echinococcus granulosus neuropeptide receptor 0.0038 0.0071 0.0063
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0178 0.1038 0.1385
Brugia malayi putative neuropeptide receptor NPR1 0.0038 0.0071 0.0061
Mycobacterium ulcerans amidase 0.0178 0.1038 0.1385
Echinococcus granulosus serotonin receptor 0.0038 0.0071 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0005
Onchocerca volvulus 0.0038 0.0071 0.0421
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.004 0.0029
Plasmodium vivax PST-A protein 0.1077 0.725 1
Plasmodium vivax lysophospholipase, putative 0.0063 0.0247 0.0327
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0071 0.0063
Plasmodium falciparum epoxide hydrolase 2 0.0063 0.0247 0.0327
Echinococcus granulosus allatostatin A receptor 0.0038 0.0071 0.0063
Echinococcus granulosus biogenic amine 5HT receptor 0.1245 0.8408 0.8407
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.004 0.123
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus peregrin 0.0029 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus pyruvate kinase 0.0033 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.1475 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.0143 0.0132
Loa Loa (eye worm) ACC-1 protein 0.004 0.0085 0.0074
Toxoplasma gondii hypothetical protein 0.0063 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0247 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0038 0.0071 0.0061
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0099 0.0619
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0063 0.0247 0.0288
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus 7tm_1 domain containing protein 0.0038 0.0071 0.0063
Brugia malayi Serotonin receptor 0.0038 0.0071 0.0061
Onchocerca volvulus 0.0237 0.1449 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.001 0.0003
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1077 0.725 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0038 0.0071 0.0061
Echinococcus granulosus alpha 1A adrenergic receptor 0.0038 0.0071 0.0063
Echinococcus multilocularis neuropeptide FF receptor 2 0.0038 0.0071 0.0061
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.047 0.0462
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.004 0.0085 0.0074
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Giardia lamblia Pyruvate kinase 0.0033 0.004 0.123
Trypanosoma cruzi serine peptidase, putative 0.0063 0.0247 0.0288
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) TYRA-2 protein 0.0038 0.0071 0.0061
Onchocerca volvulus 0.0038 0.0071 0.0421
Mycobacterium ulcerans amidase 0.0178 0.1038 0.1385
Loa Loa (eye worm) hypothetical protein 0.0033 0.004 0.0029
Schistosoma mansoni myosin xvIII 0.0038 0.0071 0.0061
Plasmodium vivax pyruvate kinase, putative 0.0033 0.004 0.004
Schistosoma mansoni amine GPCR 0.0038 0.0071 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Schistosoma mansoni biogenic amine (5HT) receptor 0.1245 0.8408 0.8407
Onchocerca volvulus Putative nachr subunit 0.004 0.0085 0.0516
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0071 0.0061
Brugia malayi larval opioid receptor 0.0038 0.0071 0.0061
Brugia malayi putative neuropeptide receptor 0.0038 0.0071 0.0061
Echinococcus granulosus Phospholipase carboxylesterase 0.0063 0.0247 0.024
Echinococcus granulosus sex peptide receptor 0.0038 0.0071 0.0063
Echinococcus multilocularis G protein coupled receptor 139 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.001
Trichomonas vaginalis valacyclovir hydrolase, putative 0.1077 0.725 1
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0063 0.0247 0.0327
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0063 0.0247 0.0341
Brugia malayi MGC79044 protein 0.0063 0.0247 0.0237
Schistosoma mansoni peptidase 0.0063 0.0247 0.0237
Schistosoma mansoni opsin-like receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Schistosoma mansoni hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni biogenic amine (5HT) receptor 0.0691 0.4583 0.4577
Schistosoma mansoni biogenic amine receptor 0.0038 0.0071 0.0061
Schistosoma mansoni neuropeptide receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus neuropeptide FF receptor 2 0.0038 0.0071 0.0063
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Trypanosoma cruzi amidase, putative 0.0178 0.1038 0.1385
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0053 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.1077 0.725 1
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.1077 0.725 1
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1475 1 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0063 0.0247 0.0288
Brugia malayi Serotonin receptor 0.0038 0.0071 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.1077 0.725 1
Schistosoma mansoni opsin-like receptor 0.0038 0.0071 0.0061
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0085 0.0074
Trichomonas vaginalis chromobox protein, putative 0.007 0.0291 0.0401
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0143 0.0132
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1077 0.725 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0085 0.0074
Brugia malayi AKH receptor 0.0038 0.0071 0.0061
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Echinococcus multilocularis somatostatin receptor 0.0038 0.0071 0.0061
Brugia malayi G protein-coupled receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0015 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0079 0.0109
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0071 0.0063
Trichomonas vaginalis chromobox protein, putative 0.007 0.0291 0.0401
Schistosoma mansoni pyruvate kinase 0.0033 0.004 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0247 0.0327
Echinococcus granulosus g protein coupled receptor 0.0038 0.0071 0.0063
Onchocerca volvulus 0.0041 0.0094 0.0583
Brugia malayi putative amidase 0.0178 0.1038 0.1029
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0063 0.0247 0.0341
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Brugia malayi neuropeptide F receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Plasmodium falciparum esterase, putative 0.1077 0.725 1
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Echinococcus multilocularis glycine receptor subunit alpha 1 0.004 0.0085 0.0074
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1077 0.725 1
Mycobacterium ulcerans amidase 0.0178 0.1038 0.1385
Echinococcus granulosus G protein coupled receptor 139 0.0038 0.0071 0.0063
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0038 0.0071 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0099 0.0137
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1077 0.725 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0089 0.0082
Plasmodium falciparum alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0178 0.1038 0.1385
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0038 0.0071 0.0061
Echinococcus granulosus glycine receptor subunit alpha 1 0.004 0.0085 0.0077
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0071 0.0061
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0071 0.0063
Onchocerca volvulus 0.0048 0.0143 0.0918
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0038 0.0071 0.0063
Leishmania major hypothetical protein, conserved 0.0178 0.1038 0.1385
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.004 0.0085 0.0074
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.004 0.0085 0.0077
Echinococcus granulosus g protein coupled receptor 0.0038 0.0071 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0071 0.0061
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Echinococcus multilocularis pyruvate kinase 0.0033 0.004 0.0029
Loa Loa (eye worm) pyruvate kinase 0.0033 0.004 0.0029
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0063 0.0247 0.0341
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0071 0.0061
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0063 0.0247 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.004 0.0085 0.0074
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1077 0.725 1
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0178 0.1038 0.1385
Echinococcus multilocularis neuropeptide receptor A26 0.0499 0.3256 0.3249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0015 0.0005
Onchocerca volvulus 0.0038 0.0071 0.0421
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1245 0.8408 0.8407
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0178 0.1038 0.1385
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0015 0.0005
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0178 0.1038 0.1385
Plasmodium falciparum BEM46-like protein, putative 0.0063 0.0247 0.0327
Mycobacterium ulcerans hypothetical protein 0.0063 0.0247 0.0288
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0247 0.0288
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0063 0.0247 0.024
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0063 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Trypanosoma cruzi monoglyceride lipase, putative 0.1077 0.725 1
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.004 0.0085 0.0074
Onchocerca volvulus 0.0038 0.0071 0.0421
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0038 0.0071 0.0061
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0063 0.0247 0.0237
Schistosoma mansoni chromobox protein 0.007 0.0291 0.0281
Trypanosoma cruzi amidase, putative 0.0178 0.1038 0.1385
Mycobacterium ulcerans peptide amidase, GatA 0.0178 0.1038 0.1385
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0079 0.0477
Echinococcus granulosus biogenic amine 5HT receptor 0.0691 0.4583 0.4579
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.004 0.0085 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0085 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni adenoreceptor 0.0038 0.0071 0.0061
Brugia malayi Amidase family protein 0.0178 0.1038 0.1029
Onchocerca volvulus 0.0038 0.0071 0.0421
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0063 0.0247 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0071 0.0061
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0053 0.0043
Brugia malayi ORL1-like opioid receptor 0.0038 0.0071 0.0061
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0178 0.1038 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Onchocerca volvulus 0.0038 0.0071 0.0421
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0015 0.0204
Echinococcus granulosus neuropeptide receptor A26 0.0499 0.3256 0.3251
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.004 0.0202
Echinococcus granulosus 7TM GPCR rhodopsin 0.0038 0.0071 0.0063
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0063 0.0247 0.0341
Onchocerca volvulus 0.0038 0.0071 0.0421
Schistosoma mansoni fatty-acid amide hydrolase 0.1475 1 1
Mycobacterium ulcerans hypothetical protein 0.0063 0.0247 0.0288
Echinococcus granulosus fatty acid amide hydrolase 1 0.1475 1 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0178 0.1038 0.1419
Echinococcus granulosus nAChR subunit 0.004 0.0085 0.0077
Leishmania major hypothetical protein, conserved 0.0063 0.0247 0.0288
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0237 0.1446 0.1437
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Plasmodium vivax lysophospholipase, putative 0.0063 0.0247 0.0327
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Schistosoma mansoni hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus neuropeptide receptor 0.0038 0.0071 0.0063
Mycobacterium ulcerans hydrolase 0.0063 0.0247 0.0288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0071 0.0061
Schistosoma mansoni biogenic amine receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0225 0.0215
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.004 0.0055
Echinococcus granulosus glycine receptor subunit alpha 1 0.004 0.0085 0.0077
Trypanosoma cruzi serine peptidase, putative 0.0063 0.0247 0.0288
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0063 0.0247 0.0341
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0038 0.0071 0.0061
Echinococcus granulosus glycine receptor subunit beta 0.004 0.0085 0.0077
Brugia malayi Cation transporter family protein 0.004 0.0085 0.0074
Onchocerca volvulus 0.004 0.0085 0.0516
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.004 0.0085 0.0074
Brugia malayi excitatory GABA receptor EXP-1A 0.004 0.0085 0.0074
Schistosoma mansoni chromobox protein 0.007 0.0291 0.0281
Onchocerca volvulus 0.0038 0.0071 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0071 0.0061
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0063 0.0247 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0038 0.0071 0.0061
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0085 0.0074
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0063 0.0247 0.0341
Brugia malayi sulfakinin receptor protein 0.0038 0.0071 0.0061
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0063 0.0247 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0071 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0085 0.0074
Loa Loa (eye worm) pyruvate kinase 0.0033 0.004 0.0029
Echinococcus multilocularis allatostatin A receptor 0.0038 0.0071 0.0061
Brugia malayi Heterochromatin protein 1 0.007 0.0291 0.0281
Echinococcus granulosus abhydrolase domain containing 3 0.0063 0.0247 0.024
Echinococcus multilocularis sex peptide receptor 0.0038 0.0071 0.0061
Echinococcus granulosus chromobox protein 1 0.007 0.0291 0.0284
Echinococcus granulosus chromobox protein 1 0.007 0.0291 0.0284
Schistosoma mansoni pyruvate kinase 0.0033 0.004 0.0029
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0178 0.1038 0.1385
Toxoplasma gondii hypothetical protein 0.0063 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0155 0.0144
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0038 0.0071 0.0061
Plasmodium falciparum exported lipase 2 0.0063 0.0247 0.0327
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0178 0.1038 0.1029
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1077 0.725 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) ACC-1 protein 0.004 0.0085 0.0074
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0178 0.1038 0.1029
Brugia malayi RE15519p 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni alpha-1 adrenergic receptor 0.0038 0.0071 0.0061
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0053 0.0043
Brugia malayi jmjC domain containing protein 0.0035 0.0053 0.0043
Schistosoma mansoni hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0071 0.0061
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1446 0.1439
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0071 0.0061
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.004 0.0085 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Plasmodium falciparum lysophospholipase, putative 0.0063 0.0247 0.0327
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0071 0.0061
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.004 0.0085 0.0074
Echinococcus granulosus dro:myosuppressin receptor 0.0038 0.0071 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0499 0.3256 0.3249
Onchocerca volvulus 0.004 0.0085 0.0516
Schistosoma mansoni amine GPCR 0.0038 0.0071 0.0061
Echinococcus granulosus g-protein coupled receptor 0.0038 0.0071 0.0063
Loa Loa (eye worm) hypothetical protein 0.0063 0.0247 0.0237
Onchocerca volvulus 0.004 0.0085 0.0516
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.004 0.0085 0.0074
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0063 0.0247 0.0237
Schistosoma mansoni nAChR subunit 0.004 0.0085 0.0074
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.004 0.0085 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0247 0.0327
Echinococcus multilocularis chromobox protein 1 0.007 0.0291 0.0281
Schistosoma mansoni growth hormone secretagogue receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0053 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni neuropeptide f receptor 76f 0.0038 0.0071 0.0061
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0038 0.0071 0.0421
Schistosoma mansoni opsin-like receptor 0.0038 0.0071 0.0061
Schistosoma mansoni survival motor neuron protein 0.0048 0.0143 0.0132
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0071 0.0063
Mycobacterium ulcerans lysophospholipase 0.1077 0.725 1
Echinococcus granulosus hypothetical protein 0.0038 0.0071 0.0063
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.125 0.124
Loa Loa (eye worm) amidase 0.0178 0.1038 0.1029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi Dopamine receptor protein 1 0.0038 0.0071 0.0061
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1449 0.1998
Schistosoma mansoni fatty-acid amide hydrolase 0.0178 0.1038 0.1029
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0085 0.0074
Onchocerca volvulus 0.004 0.0085 0.0516
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0071 0.0061
Mycobacterium ulcerans hypothetical protein 0.1077 0.725 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0038 0.0071 0.0061
Schistosoma mansoni amine GPCR 0.0038 0.0071 0.0061
Brugia malayi neuropeptide F receptor 0.0038 0.0071 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0247 0.0341
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.004 0.0085 0.0077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Plasmodium falciparum alpha/beta hydrolase, putative 0.0063 0.0247 0.0327
Echinococcus granulosus tachykinin peptides receptor 99D 0.0038 0.0071 0.0063
Onchocerca volvulus 0.0038 0.0071 0.0421
Echinococcus multilocularis glycine receptor subunit alpha 1 0.004 0.0085 0.0074
Plasmodium vivax PST-A protein 0.0063 0.0247 0.0327
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0063 0.0247 0.0288
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0071 0.0061
Schistosoma mansoni amidase 0.1475 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0291 0.0281
Plasmodium vivax SET domain protein, putative 0.003 0.0015 0.0007
Brugia malayi jmjC domain containing protein 0.0096 0.047 0.046
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0178 0.1038 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0038 0.0071 0.0061
Echinococcus granulosus fatty acid amide hydrolase 1 0.0178 0.1038 0.1031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0334 0.0324
Echinococcus multilocularis dro:myosuppressin receptor 0.0038 0.0071 0.0061
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0063 0.0247 0.0237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.004 0.0085 0.0074
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.004 0.0202
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus glycine receptor subunit alpha 1 0.004 0.0085 0.0077
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.004 0.0085 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Schistosoma mansoni amine GPCR 0.0038 0.0071 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Loa Loa (eye worm) LGC-31 protein 0.004 0.0085 0.0074
Echinococcus granulosus orexin receptor type 2 0.0038 0.0071 0.0063
Echinococcus multilocularis G-protein coupled receptor, putative 0.0038 0.0071 0.0061
Brugia malayi Protein C20orf22 0.0063 0.0247 0.0237
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.004 0.0085 0.0077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0071 0.0061
Plasmodium falciparum lysophospholipase, putative 0.1077 0.725 1
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0178 0.1038 0.1385
Brugia malayi Amidase family protein 0.0178 0.1038 0.1029
Echinococcus granulosus fmrfamide receptor 0.0038 0.0071 0.0063
Onchocerca volvulus Neuropeptide F receptor homolog 0.0038 0.0071 0.0421
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0085 0.0077
Echinococcus multilocularis glycine receptor subunit alpha 1 0.004 0.0085 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0099 0.0137
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi follicle stimulating hormone receptor 0.0038 0.0071 0.0061
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0063 0.0247 0.0288
Plasmodium vivax PST-A protein 0.0063 0.0247 0.0327
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0071 0.0063
Chlamydia trachomatis acyltransferase family protein 0.0063 0.0247 0.208
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0063 0.0247 0.0341
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063
Onchocerca volvulus 0.0038 0.0071 0.0421
Loa Loa (eye worm) hypothetical protein 0.0063 0.0247 0.0237
Toxoplasma gondii phospholipase 0.0063 0.0247 1
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0063 0.0247 0.0288
Toxoplasma gondii phospholipase/carboxylesterase 0.0063 0.0247 1
Brugia malayi Cation transporter family protein 0.004 0.0085 0.0074
Onchocerca volvulus 0.0038 0.0071 0.0421
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0094 0.0084
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.004 0.0085 0.0077
Onchocerca volvulus 0.0031 0.0021 0.007
Onchocerca volvulus 0.0038 0.0071 0.0421
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0071 0.0061
Onchocerca volvulus 0.0038 0.0071 0.0421
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0071 0.0061
Leishmania major monoglyceride lipase, putative 0.1077 0.725 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0053 0.0045
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0063 0.0247 0.0341
Brugia malayi Cation transporter family protein 0.004 0.0085 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0071 0.0061
Echinococcus multilocularis chromobox protein 1 0.007 0.0291 0.0281
Brugia malayi G-protein coupled receptor 0.0038 0.0071 0.0061
Plasmodium vivax unspecified product 0.0063 0.0247 0.0327
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.004 0.0085 0.0074
Echinococcus multilocularis Phospholipase carboxylesterase 0.0063 0.0247 0.0237
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0063 0.0247 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0691 0.4583 0.4577
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.004 0.0085 0.0074
Mycobacterium ulcerans amidase 0.0178 0.1038 0.1385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0071 0.0061
Toxoplasma gondii hypothetical protein 0.0063 0.0247 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0038 0.0071 0.0061
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.004 0.0085 0.0077
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0063 0.0247 0.0288
Brugia malayi GnHR receptor homolog 0.0038 0.0071 0.0061
Schistosoma mansoni neuropeptide receptor 0.0038 0.0071 0.0061
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1077 0.725 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Brugia malayi hypothetical protein 0.0038 0.0071 0.0061
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0038 0.0071 0.0061
Plasmodium vivax unspecified product 0.0063 0.0247 0.0327
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0061
Echinococcus granulosus abhydrolase domain containing protein 13 0.0063 0.0247 0.024
Onchocerca volvulus 0.0038 0.0071 0.0421
Schistosoma mansoni biogenic amine receptor 0.0038 0.0071 0.0061
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.004 0.0085 0.0077
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.047 0.046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0063 0.0247 0.0341
Plasmodium falciparum pyruvate kinase 0.0033 0.004 0.004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0085 0.0074
Echinococcus granulosus fatty acid amide hydrolase 1 0.1475 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0074
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.004 0.0085 0.0074
Brugia malayi G-protein coupled receptor 0.0038 0.0071 0.0061
Echinococcus granulosus peptide allatostatin:somatostatin 0.0038 0.0071 0.0063
Trypanosoma brucei monoglyceride lipase, putative 0.1077 0.725 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0071 0.0063

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.3294 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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