Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | Niemann-Pick disease, type C1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0157 | 0.1159 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.033 | 0.2963 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0227 | 0.1674 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0051 | 0.0349 | 0.2119 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0051 | 0.0349 | 0.0333 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1357 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.098 | 0.614 |
Schistosoma mansoni | dihydropteridine reductase | 0.0039 | 0.0227 | 0.1991 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0039 | 0.0227 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0445 | 0.3276 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0039 | 0.0227 | 0.0211 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.1055 | 0.104 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0039 | 0.0227 | 0.1991 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0157 | 0.0896 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.0349 | 0.3144 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0157 | 0.0141 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0039 | 0.0227 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0017 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0468 | 0.3452 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0157 | 0.0141 |
Onchocerca volvulus | 0.0039 | 0.0227 | 0.0583 | |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1357 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.033 | 0.2963 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0445 | 0.3276 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0039 | 0.0227 | 0.1674 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0157 | 0.0896 |
Leishmania major | pteridine reductase 1 | 0.0039 | 0.0227 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1357 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1357 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0445 | 0.3276 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1357 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0157 | 0.1159 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.1585 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.058 | 0.585 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0017 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0445 | 0.3276 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0246 | 0.1817 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0017 | 0.0123 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0051 | 0.0349 | 0.2573 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0246 | 0.2174 |
Trypanosoma brucei | pteridine reductase 1 | 0.0039 | 0.0227 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0039 | 0.0227 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0151 | 0.1113 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.058 | 0.585 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0039 | 0.0227 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.033 | 0.2963 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0051 | 0.0349 | 0.2119 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0039 | 0.0227 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.058 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0246 | 0.1817 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0039 | 0.0227 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0039 | 0.0227 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0039 | 0.0227 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.0424 | 0.0408 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.098 | 0.0965 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0157 | 0.1159 |
Loa Loa (eye worm) | oxidoreductase | 0.0039 | 0.0227 | 0.1674 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.1055 | 0.6618 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.1055 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0157 | 0.0141 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0039 | 0.0227 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.1074 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0157 | 0.1159 |
Schistosoma mansoni | lamin | 0.0033 | 0.0157 | 0.1329 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.058 | 0.585 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.1055 | 0.7774 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0039 | 0.0227 | 0.1674 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.033 | 0.2963 |
Brugia malayi | CHE-14 protein | 0.0051 | 0.0349 | 0.2573 |
Echinococcus multilocularis | protein patched | 0.0051 | 0.0349 | 0.0333 |
Schistosoma mansoni | lamin | 0.0033 | 0.0157 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0017 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0157 | 0.1159 |
Echinococcus granulosus | lamin | 0.0033 | 0.0157 | 0.0896 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0039 | 0.0227 | 0.1674 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.1585 | 0.1571 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0039 | 0.0227 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.0227 | 0.0583 | |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0157 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0349 | 0.2573 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1055 | 0.7774 |
Trichomonas vaginalis | hypothetical protein | 0.058 | 0.585 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.058 | 0.585 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.058 | 0.585 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.058 | 0.585 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.058 | 0.585 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0039 | 0.0227 | 0.1342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.