Detailed information for compound 1431763

Basic information

Technical information
  • TDR Targets ID: 1431763
  • Name: 6-bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-p yridin-2-ylquinoline-4-carboxamide
  • MW: 440.316 | Formula: C19H14BrN5OS
  • H donors: 1 H acceptors: 5 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nnc(s1)NC(=O)c1cc(nc2c1cc(Br)cc2)c1ccccn1
  • InChi: 1S/C19H14BrN5OS/c1-2-17-24-25-19(27-17)23-18(26)13-10-16(15-5-3-4-8-21-15)22-14-7-6-11(20)9-12(13)14/h3-10H,2H2,1H3,(H,23,25,26)
  • InChiKey: FXHFMSTZNHHKAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(2-pyridyl)quinoline-4-carboxamide
  • 6-bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(2-pyridyl)-4-quinolinecarboxamide
  • 6-bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(2-pyridyl)cinchoninamide
  • 6-bromo-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-pyridin-2-yl-quinoline-4-carboxamide
  • IVK/4002767

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0207 0.0263
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0182 0.023
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Schistosoma mansoni acetylcholine receptor-related 0.0054 0.0705 0.0894
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0182 0.0182
Loa Loa (eye worm) cytochrome P450 family protein 0.0212 0.3283 0.3283
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0117 0.1731 0.1731
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0155 0.0155
Onchocerca volvulus 0.0021 0.0161 0.0043
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Onchocerca volvulus 0.0054 0.0705 0.3493
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0101 0.1474 0.2984
Brugia malayi hypothetical protein 0.0054 0.0705 0.0705
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.057 0.9121 0.9121
Brugia malayi hypothetical protein 0.0054 0.0705 0.0705
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0117 0.1731 0.2195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0155 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0155 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0155 0.0155
Brugia malayi SWIRM domain containing protein 0.0022 0.0182 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0155 0.0155
Brugia malayi hypothetical protein 0.0022 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0155 0.0196
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0117 0.1731 0.1731
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0207 0.0263
Onchocerca volvulus 0.0054 0.0705 0.3493
Trypanosoma cruzi cytochrome P450, putative 0.0212 0.3283 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0155 0.0196
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0101 0.1474 0.2984
Schistosoma mansoni lipoxygenase 0.0123 0.1829 0.2319
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0155 0.0196
Onchocerca volvulus 0.0027 0.0273 0.0751
Echinococcus granulosus cytochrome P450 2K1 0.0101 0.1474 0.1869
Onchocerca volvulus 0.0117 0.1731 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0054 0.0705 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Brugia malayi CXXC zinc finger family protein 0.0035 0.0393 0.0393
Brugia malayi Cytochrome P450 family protein 0.0101 0.1474 0.1474
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0207 0.0082
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0155 0.0196
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0022 0.0182 0.023
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Schistosoma mansoni thyroid hormone receptor 0.002 0.0155 0.0196
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.1731 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0161 0.0161
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0101 0.1474 0.2984
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Entamoeba histolytica hypothetical protein 0.0063 0.0853 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0155 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0155 0.0155
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0273 0.0751
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0054 0.0705 0.0705
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0207 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0155 0.0196
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0117 0.1731 0.2195
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0309 0.4867 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0101 0.1474 0.2758
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0101 0.1474 0.4167
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0207 0.0263
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0287 0.4512 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.509
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0054 0.0705 0.0894
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0161
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0117 0.1731 0.2195
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0117 0.1731 0.2195
Loa Loa (eye worm) acetylcholine receptor protein 0.0054 0.0705 0.0705
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0117 0.1731 0.1731
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0117 0.1731 0.2195
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0182 0.023
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0022 0.0182 0.023
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0117 0.1731 0.2195
Echinococcus granulosus nAChR subunit 0.0117 0.1731 0.2195
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0155 0.0196
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0101 0.1474 0.4167
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0101 0.1474 0.2984
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0155 0.0196
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0273 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0155 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Onchocerca volvulus 0.0117 0.1731 1
Schistosoma mansoni amine oxidase 0.0022 0.0182 0.023
Brugia malayi Cation transporter family protein 0.0117 0.1731 0.1731
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0101 0.1474 0.2984
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0207 0.0054
Onchocerca volvulus 0.0117 0.1731 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0101 0.1474 0.2984
Brugia malayi hypothetical protein 0.0054 0.0705 0.0705
Echinococcus multilocularis RUN 0.0021 0.0161 0.0205
Onchocerca volvulus 0.0117 0.1731 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Plasmodium falciparum protoporphyrinogen oxidase 0.0022 0.0182 1
Echinococcus multilocularis nAChR subunit 0.0063 0.0853 0.1081
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0101 0.1474 0.4167
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0002 0.0002
Brugia malayi Blistered cuticle protein 3 0.0027 0.0273 0.0273
Echinococcus multilocularis peroxidasin 0.0027 0.0273 0.0346
Echinococcus multilocularis cpg binding protein 0.0037 0.0425 0.0539
Leishmania major DNA polymerase eta, putative 0.0023 0.0207 0.0082
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.509
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0117 0.1731 0.2195
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0155 0.0196
Onchocerca volvulus 0.0022 0.0182 0.0172
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0054 0.0705 0.0894
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0182
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0101 0.1474 0.2758
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0207 0.0263
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0054 0.0705 0.0894
Onchocerca volvulus Putative nachr subunit 0.0117 0.1731 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.0207 0.0263
Schistosoma mansoni amine oxidase 0.0022 0.0182 0.023
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0853 0.1081
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0155 0.0155
Toxoplasma gondii cytochrome p450 superfamily protein 0.0101 0.1474 1
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0273 0.0751
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0536 0.0679
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Onchocerca volvulus 0.0117 0.1731 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0155 0.0155
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0182 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0117 0.1731 0.2195
Brugia malayi Peroxidasin 0.0027 0.0273 0.0273
Trypanosoma brucei cytochrome P450, putative 0.0212 0.3283 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0101 0.1474 0.2758
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0101 0.1474 0.2984
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0101 0.1474 0.2984
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0273 0.0273
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0117 0.1731 0.2195
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0207 0.037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0182
Brugia malayi hypothetical protein 0.0021 0.0161 0.0161
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0705 0.0705
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0155 0.0155
Loa Loa (eye worm) cytochrome P450 family protein 0.0212 0.3283 0.3283
Schistosoma mansoni hypothetical protein 0.0494 0.7887 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0101 0.1474 0.2984
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0063 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Brugia malayi Cytochrome P450 family protein 0.0212 0.3283 0.3283
Schistosoma mansoni nAChR subunit 0.0054 0.0705 0.0894
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Echinococcus granulosus glycine receptor subunit alpha 1 0.0117 0.1731 0.2195
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0101 0.1474 0.2984
Schistosoma mansoni cytochrome P450 0.0101 0.1474 0.1869
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0054 0.0705 0.0894
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0161 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0155 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0155 0.0155
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0063 0.0853 0.0853
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.1731 0.1731
Leishmania major cytochrome p450-like protein 0.0101 0.1474 0.4167
Echinococcus granulosus dna polymerase eta 0.0023 0.0207 0.0263
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0182
Schistosoma mansoni neurotransmitter gated ion channel 0.0054 0.0705 0.0894
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0161 0.0205
Onchocerca volvulus 0.0027 0.0273 0.0751
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0207 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0182
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0002
Echinococcus multilocularis glycine receptor subunit beta 0.0117 0.1731 0.2195
Onchocerca volvulus 0.0054 0.0705 0.3493
Echinococcus granulosus peroxidasin 0.0027 0.0273 0.0346
Schistosoma mansoni DNA polymerase eta 0.0023 0.0207 0.0263
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0117 0.1731 0.2195
Giardia lamblia DINP protein human, muc B family 0.0023 0.0207 0.5
Brugia malayi excitatory GABA receptor EXP-1A 0.0117 0.1731 0.1731
Brugia malayi hypothetical protein 0.0054 0.0705 0.0705
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0182 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0022 0.0182 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0101 0.1474 0.4336
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0207 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Echinococcus granulosus FTZ F1 alpha 0.002 0.0155 0.0196
Brugia malayi hypothetical protein 0.0021 0.0161 0.0161
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0117 0.1731 0.2195
Brugia malayi Cation transporter family protein 0.0117 0.1731 0.1731
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0054 0.0705 0.0705
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0101 0.1474 0.2984
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0207 0.0207
Mycobacterium leprae Conserved hypothetical protein 0.0101 0.1474 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0155 0.0155
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0273 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0155 0.0155
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0161 0.0205
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0101 0.1474 0.2758
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Brugia malayi ecdysteroid receptor 0.002 0.0155 0.0155
Leishmania major cytochrome p450-like protein 0.0212 0.3283 1
Loa Loa (eye worm) GABA receptor subunit 0.0063 0.0853 0.0853
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0117 0.1731 0.2195
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0101 0.1474 0.2984
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0022 0.0182 0.023
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0101 0.1474 0.2984
Onchocerca volvulus 0.0021 0.0161 0.0043
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Loa Loa (eye worm) ACC-1 protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) cytochrome P450 0.0101 0.1474 0.1474
Brugia malayi cytochrome P450 0.0101 0.1474 0.1474
Onchocerca volvulus 0.0027 0.0273 0.0751
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0207 0.0082
Schistosoma mansoni nAChR subunit 0.0054 0.0705 0.0894
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.1829 0.2319
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Brugia malayi Cytochrome P450 family protein 0.0364 0.5761 0.5761
Schistosoma mansoni rab6-interacting 0.0021 0.0161 0.0205
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0117 0.1731 0.2195
Onchocerca volvulus 0.0063 0.0853 0.4428
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0309 0.4867 1
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Schistosoma mansoni rab6-interacting 0.0021 0.0161 0.0205
Schistosoma mansoni acetylcholine receptor subunit beta 0.0054 0.0705 0.0894
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0155 0.0196
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0155 0.0196
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0101 0.1474 0.2758
Loa Loa (eye worm) LGC-31 protein 0.0117 0.1731 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0536 0.0679
Brugia malayi hypothetical protein 0.0027 0.0273 0.0273
Leishmania major DNA polymerase kappa, putative 0.0023 0.0207 0.0082
Loa Loa (eye worm) hypothetical protein 0.0111 0.1636 0.1636
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0155 0.0196
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0117 0.1731 0.2195
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0054 0.0705 0.0894
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0207 0.0082
Leishmania major cytochrome p450-like protein 0.0101 0.1474 0.4167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0155 0.0155
Schistosoma mansoni cpg binding protein 0.0035 0.0393 0.0498
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0155 0.0196
Onchocerca volvulus Peroxidase homolog 0.0027 0.0273 0.0751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0155 0.0196
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0207 0.037
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0117 0.1731 0.1731
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0182 0.5
Trypanosoma brucei unspecified product 0.0023 0.0207 0.037
Schistosoma mansoni hypothetical protein 0.0021 0.0161 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0101 0.1474 0.2984
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7887 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0054 0.0705 0.0894
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0117 0.1731 0.2195
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0161 0.0205
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0207 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0155 0.0196
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0155 0.0196
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Brugia malayi Doublecortin family protein 0.0021 0.0161 0.0161
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0117 0.1731 0.2195
Onchocerca volvulus 0.0035 0.0393 0.151
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Brugia malayi steroid hormone receptor 0.002 0.0155 0.0155
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0063 0.0853 0.1081
Schistosoma mansoni cpg binding protein 0.0037 0.0425 0.0539
Mycobacterium leprae putative cytochrome p450 0.0101 0.1474 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0155 0.0196
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0207 0.0082
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0117 0.1731 0.2195
Onchocerca volvulus 0.0117 0.1731 1
Schistosoma mansoni peroxidasin 0.0027 0.0273 0.0346
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.1731 0.1731
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.1731 0.1731
Schistosoma mansoni thyroid hormone receptor 0.002 0.0155 0.0196
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0054 0.0705 0.0705
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0117 0.1731 0.2195
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0101 0.1474 0.2984
Brugia malayi hypothetical protein 0.0043 0.0536 0.0536
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0182 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0207 0.0207
Echinococcus granulosus glycine receptor subunit alpha 1 0.0117 0.1731 0.2195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0155 0.0196
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0101 0.1474 0.2758
Echinococcus multilocularis 0.0101 0.1474 0.1869
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Schistosoma mansoni polycystin 1-related 0.0021 0.0161 0.0205
Schistosoma mansoni cpg binding protein 0.0037 0.0425 0.0539
Schistosoma mansoni hypothetical protein 0.0101 0.1474 0.1869
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0161 0.0205
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Schistosoma mansoni lipoxygenase 0.0086 0.1226 0.1555
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0155 0.0196
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0101 0.1474 0.2758
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0101 0.1474 0.2758
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0273 0.0273
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0155 0.0196
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0273 0.0751
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0117 0.1731 0.1731
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0117 0.1731 0.1731
Brugia malayi Cation transporter family protein 0.0117 0.1731 0.1731
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0207 0.0054
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0705 0.0705
Loa Loa (eye worm) cytochrome P450 family protein 0.0364 0.5761 0.5761
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0853 0.0853
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0101 0.1474 0.2984
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0207 0.0207
Loa Loa (eye worm) CYP4Cod1 0.0212 0.3283 0.3283
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Echinococcus granulosus RUN 0.0021 0.0161 0.0205
Echinococcus granulosus dna polymerase kappa 0.0023 0.0207 0.0263
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0101 0.1474 0.2758
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Brugia malayi Cytochrome P450 family protein 0.0212 0.3283 0.3283
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0155 0.0196
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.1829 0.2319
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0101 0.1474 0.2758
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0054 0.0705 0.0705
Schistosoma mansoni coup transcription factor 0.002 0.0155 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0155 0.0155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1027 0.1302
Echinococcus granulosus glycine receptor subunit beta 0.0117 0.1731 0.2195
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0101 0.1474 0.2758
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0022 0.0182 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0207 0.0082
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0101 0.1474 0.2758
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0101 0.1474 0.2758
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7887 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0155
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0117 0.1731 0.2195
Brugia malayi nuclear receptor NHR-88 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0101 0.1474 0.4167
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0273 0.0273
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0155 0.0196
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0899 0.5551
Echinococcus granulosus nAChR subunit 0.0063 0.0853 0.1081
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.0216 0.0267
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0101 0.1474 0.2758
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0101 0.1474 0.2758
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0101 0.1474 0.2984
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0273 0.0273
Loa Loa (eye worm) ACC-1 protein 0.0117 0.1731 0.1731
Schistosoma mansoni nAChR subunit 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0117 0.1731 0.1731
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0207 0.037
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0273 0.0273
Echinococcus multilocularis 0.0022 0.0182 0.023
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0117 0.1731 0.1731
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0101 0.1474 0.2984
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0155 0.0196
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0022 0.0182 1
Echinococcus granulosus glycine receptor subunit beta 0.0117 0.1731 0.2195
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0161
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0117 0.1731 0.1731
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0101 0.1474 0.2758
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0155 0.0155
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0155 0.0155
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0101 0.1474 0.2758
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0207 0.037
Echinococcus multilocularis nAChR subunit 0.0117 0.1731 0.2195
Echinococcus granulosus cpg binding protein 0.0037 0.0425 0.0539
Brugia malayi nuclear hormone receptor 0.002 0.0155 0.0155
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0117 0.1731 0.1731
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0101 0.1474 0.2758
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0117 0.1731 0.1731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0063 0.0853 0.0853
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0393 0.0393
Schistosoma mansoni loxhd1 0.0021 0.0161 0.0205
Loa Loa (eye worm) hypothetical protein 0.0117 0.1731 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0273 0.0273
Trypanosoma cruzi cytochrome P450, putative 0.0212 0.3283 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0207 0.037
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0536 0.0679
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0207 0.0059
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0117 0.1731 0.1731
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0623 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.509
Echinococcus multilocularis protoporphyrinogen oxidase 0.0022 0.0182 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0101 0.1474 0.2984
Onchocerca volvulus Peroxidase homolog 0.0027 0.0273 0.0751
Schistosoma mansoni hypothetical protein 0.0043 0.0536 0.0679
Schistosoma mansoni nuclear hormone receptor 0.002 0.0155 0.0196
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0207 0.0263
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0117 0.1731 0.2195
Onchocerca volvulus 0.0063 0.0853 0.4428
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0273 0.0273
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0101 0.1474 0.2758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0027 0.0273 0.0273
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0207 0.0207
Brugia malayi hypothetical protein 0.0054 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0054 0.0705 0.0705
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0155 0.0196
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0155 0.0196
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0161 0.0205
Schistosoma mansoni peroxidasin 0.0027 0.0273 0.0346
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0212 0.3283 0.6619
Schistosoma mansoni neurotransmitter gated ion channel 0.0063 0.0853 0.1081
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0101 0.1474 0.2758
Echinococcus multilocularis glycine receptor subunit beta 0.0117 0.1731 0.2195
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0117 0.1731 0.1731
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0101 0.1474 0.2984
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0155 0.0155

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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