Detailed information for compound 1432009

Basic information

Technical information
  • TDR Targets ID: 1432009
  • Name: 3-(2,4-dichlorophenyl)-1-(pyridin-2-ylmethyl) urea
  • MW: 296.152 | Formula: C13H11Cl2N3O
  • H donors: 2 H acceptors: 2 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1Cl)Cl)NCc1ccccn1
  • InChi: 1S/C13H11Cl2N3O/c14-9-4-5-12(11(15)7-9)18-13(19)17-8-10-3-1-2-6-16-10/h1-7H,8H2,(H2,17,18,19)
  • InChiKey: DLNFRXBGRFOBNJ-UHFFFAOYSA-N  


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Synonyms

  • 3-(2,4-dichlorophenyl)-1-(2-pyridylmethyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0043 0.0522
Echinococcus multilocularis protein patched 0.0051 0.048 0.0439
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0043 0.0721
Onchocerca volvulus 0.0008 0.0043 0.0312
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.025 0.5408
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0631 1
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0022 0.0236
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0158
Onchocerca volvulus 0.0046 0.0424 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0065 0.0081
Echinococcus granulosus Protein patched homolog 1 0.0051 0.048 0.1631
Toxoplasma gondii patched family protein 0.0007 0.0031 0.0306
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0065 0.0022
Loa Loa (eye worm) carboxylesterase 0.0046 0.0424 0.1521
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0079 0.1639
Loa Loa (eye worm) acetylcholinesterase 1 0.027 0.2723 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0079 0.1547
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0043 0.1276
Plasmodium falciparum lipid/sterol:H+ symporter 0.0007 0.0031 0.053
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0424 1
Loa Loa (eye worm) patched family protein 0.0007 0.0031 0.007
Loa Loa (eye worm) patched family protein 0.0007 0.0031 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Echinococcus multilocularis neuroligin 0.0046 0.0424 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0523 0.1899
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0079 0.1547
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0218 0.4545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0523 0.1792
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0079 0.0261
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0131 0.1934
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0176 0.0606
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0037 0.0778
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0424 0.0383
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0218 0.0176
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0424 0.8836
Echinococcus granulosus dna polymerase kappa 0.002 0.0167 0.0463
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0043 0.0497
Schistosoma mansoni acetylcholinesterase 0.0046 0.0424 0.1534
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0167 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0167 0.3432
Brugia malayi Myosin head containing protein 0.0007 0.0031 0.0032
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0043 0.0522
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0079 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Schistosoma mansoni hypothetical protein 0.0205 0.2055 0.7541
Onchocerca volvulus 0.0046 0.0424 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.025 0.5679
Plasmodium vivax patched family protein, putative 0.0007 0.0031 0.1263
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0176 0.9375
Brugia malayi protein C24B5.3 0.0007 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0247
Onchocerca volvulus 0.0046 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0022 0.0236
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0067 0.0203
Brugia malayi protein C24B5.3 0.0007 0.0031 0.0032
Brugia malayi DKFZp564C0469 protein 0.0012 0.0079 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0167 0.3457
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1195 0.4372
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.027 0.2723 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0065 0.0161
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0444 1
Schistosoma mansoni patched 1 0.0051 0.048 0.1739
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0176 0.3692
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0164 0.3388
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0043 0.0522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0037 0.0778
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.1762
Brugia malayi Patched related family protein 10 0.0007 0.0031 0.0032
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0176 0.3833
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0424 0.1534
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0079 0.1639
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Echinococcus granulosus carboxylesterase 5A 0.027 0.2723 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Brugia malayi hypothetical protein 0.0007 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0247
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1176 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0065 0.0022
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0043 0.2
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0043 0.0504
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.3587
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0078
Schistosoma mansoni DNA helicase recq1 0.0011 0.0065 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.048 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.025 0.5408
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.1957
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0079 0.1639
Schistosoma mansoni hypothetical protein 0.0049 0.0461 0.167
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0043 0.0504
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0012 0.0015
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0167 0.3604
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0043 0.0305
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0312 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0079 0.1639
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0078
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0424 0.1534
Brugia malayi hypothetical protein 0.0007 0.0031 0.0032
Brugia malayi Patched related family protein 4 0.0007 0.0031 0.0032
Echinococcus granulosus neuroligin 0.0046 0.0424 0.1422
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0067 0.0024
Echinococcus granulosus expressed conserved protein 0.0112 0.1102 0.3952
Brugia malayi Patched protein homolog 1 0.0007 0.0031 0.0032
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0043 0.0305
Brugia malayi topoisomerase 0.0012 0.0079 0.021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0523 0.0482
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0167 0.0572
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.025 0.2064
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0218 0.4545
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0043 0.0115
Entamoeba histolytica hypothetical protein 0.0012 0.0079 0.0592
Schistosoma mansoni cpg binding protein 0.0035 0.0312 0.1122
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0043 0.0497
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0167 0.0586
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Onchocerca volvulus 0.0029 0.025 0.5584
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1699 0.1664
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0043 0.0497
Schistosoma mansoni DNA ligase IV 0.0012 0.0079 0.0261
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0079 0.3448
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0078
Trypanosoma brucei unspecified product 0.0014 0.0102 0.1887
Echinococcus multilocularis acetylcholinesterase 0.027 0.2723 0.2692
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.025 1
Onchocerca volvulus 0.0012 0.0079 0.122
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Loa Loa (eye worm) patched family protein 0.0007 0.0031 0.007
Loa Loa (eye worm) patched family protein 0.0007 0.0031 0.007
Brugia malayi hypothetical protein 0.0007 0.0031 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Giardia lamblia DINP protein human, muc B family 0.002 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1273 0.4651
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.025 1
Onchocerca volvulus 0.0035 0.0312 0.7161
Loa Loa (eye worm) hypothetical protein 0.0062 0.0598 0.2161
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.025 0.5679
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0022 0.074
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0247
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0079 0.1639
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0115
Brugia malayi Carboxylesterase family protein 0.0046 0.0424 0.1489
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0424 0.0383
Leishmania major DNA polymerase eta, putative 0.0033 0.0299 0.6568
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0043 0.0721
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0167 0.1348
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0176 1
Schistosoma mansoni DNA helicase recq5 0.0011 0.0065 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0164 0.3388
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0167 0.3432
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0424 0.8836
Echinococcus multilocularis expressed conserved protein 0.0112 0.1102 0.1064
Loa Loa (eye worm) hypothetical protein 0.027 0.2723 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1176 0.4294
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0164 0.3388
Brugia malayi hypothetical protein 0.0012 0.0079 0.021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0079 0.1639
Loa Loa (eye worm) carboxylesterase 0.0046 0.0424 0.1521
Loa Loa (eye worm) carboxylesterase 0.027 0.2723 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Echinococcus granulosus bloom syndrome protein 0.0025 0.0218 0.0654
Schistosoma mansoni hypothetical protein 0.0049 0.0461 0.167
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0102 0.1887
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0043 0.0721
Echinococcus multilocularis geminin 0.0205 0.2055 0.2021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0167 0.3432
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0043 0.0522
Trypanosoma brucei unspecified product 0.002 0.0167 0.3432
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0043 0.0522
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0167 0.0586
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.3587
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0167 0.3477
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0163 0.0572
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0424 0.1422
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0167 0.3604
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0037 0.0778
Echinococcus multilocularis carboxylesterase 5A 0.027 0.2723 0.2692
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.025 0.5679
Echinococcus multilocularis dna polymerase kappa 0.002 0.0167 0.0124
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Onchocerca volvulus 0.0046 0.0424 1
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0012 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0037 0.0778
Brugia malayi Carboxylesterase family protein 0.0046 0.0424 0.1489
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0523 0.1792
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0523 0.0482
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.088
Brugia malayi CXXC zinc finger family protein 0.0035 0.0312 0.1075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0247
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0247
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0043 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0711 0.2591
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0043 0.0305
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.025 0.5679
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.025 0.2064
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0045 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0029 0.025 0.0846
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0065 0.2945
Schistosoma mansoni gliotactin 0.0046 0.0424 0.1534
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0444 0.1564
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0096 0.0744
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0043 0.0522
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Echinococcus granulosus acetylcholinesterase 0.027 0.2723 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0176 0.0606
Loa Loa (eye worm) hypothetical protein 0.0021 0.0176 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Loa Loa (eye worm) RecQ helicase 0.0025 0.0218 0.0761
Leishmania major DNA polymerase kappa, putative 0.002 0.0167 0.3432
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0167 0.3477
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0305
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0022 0.0236
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0043 0.0522
Treponema pallidum DNA ligase (lig) 0.0012 0.0079 1
Echinococcus multilocularis nibrin 0.0012 0.0079 0.0036
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Loa Loa (eye worm) hypothetical protein 0.0051 0.048 0.1727
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0079 0.021
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Echinococcus multilocularis acetylcholinesterase 0.027 0.2723 0.2692
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.048 0.1631
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0065 0.2596
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0855
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.088
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0424 0.1534
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0022 0.0236
Schistosoma mansoni hypothetical protein 0.0049 0.0461 0.167
Echinococcus multilocularis dna polymerase eta 0.0048 0.0444 0.0403
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0167 0.3457
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.025 0.5679
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0043 0.0721
Brugia malayi Carboxylesterase family protein 0.0046 0.0424 0.1489
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0079 0.1639
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.025 0.5679
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0079 0.1343
Echinococcus multilocularis cpg binding protein 0.0037 0.0333 0.0291
Toxoplasma gondii hypothetical protein 0.0007 0.0031 0.0306
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Brugia malayi Carboxylesterase family protein 0.0046 0.0424 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0299 0.4648
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0079 0.0592
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Brugia malayi Patched related family protein 12 0.0007 0.0031 0.0032
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.048 0.0439
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0424 0.1422
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0102 0.1887
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0218 0.0726
Onchocerca volvulus 0.0008 0.0043 0.0312
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0043 0.0115
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0424 0.1534
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0079 0.1639
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Schistosoma mansoni hypothetical protein 0.0205 0.2055 0.7541
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0102 0.1887
Onchocerca volvulus 0.0046 0.0424 1
Leishmania major DNA polymerase eta, putative 0.0048 0.0444 1
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0079 0.4146
Echinococcus granulosus acetylcholinesterase 0.027 0.2723 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.027 0.2723 1
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0096 0.2009
Brugia malayi AMP-binding enzyme family protein 0.0029 0.025 0.0846
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1176 0.1138
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.025 0.5408
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0043 0.0522
Schistosoma mansoni cpg binding protein 0.0037 0.0333 0.1197
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0043 0.0305
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0043 0.0305
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0523 0.1856
Loa Loa (eye worm) hypothetical protein 0.0046 0.0424 0.1521
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0043 0.0497
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0043 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0079 0.1547
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1176 0.4228
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0043 0.0504
Toxoplasma gondii patched family protein 0.0007 0.0031 0.0306
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0079 0.141
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0305
Echinococcus granulosus nibrin 0.0012 0.0079 0.0133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0176 0.0606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0195
Brugia malayi Patched family protein 0.0007 0.0031 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Brugia malayi hypothetical protein 0.0012 0.0079 0.021
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Brugia malayi AMP-binding enzyme family protein 0.0029 0.025 0.0846
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0176 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0078
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0043 0.0895
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0079 0.1547
Toxoplasma gondii patched family protein 0.0007 0.0031 0.0306
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.1762
Loa Loa (eye worm) hypothetical protein 0.0048 0.0444 0.1595
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.025 0.558
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.025 0.558
Toxoplasma gondii patched family protein 0.0007 0.0031 0.0306
Schistosoma mansoni topbp1 0.0012 0.0079 0.0261
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0022 0.0165
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0424 0.0383
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0079 0.1082
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Loa Loa (eye worm) oxidoreductase 0.0008 0.0043 0.0115
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0424 0.1422
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0043 0.0305
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0424 0.1534
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0037 0.0778
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0043 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0299 0.6649
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.048 0.1727
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0079 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.025 0.5679
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0079 0.0036
Trichomonas vaginalis helicase, putative 0.0008 0.0037 0.0778
Loa Loa (eye worm) patched family protein 0.0007 0.0031 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0523 0.1899
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.025 0.2064
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0305
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0079 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0043 0.0522
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.3587
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0523 0.1887
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0043 0.0522
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0158
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.3587
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0065 0.0195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0067 0.0089
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0079 0.1639
Echinococcus multilocularis protein dispatched 1 0.0058 0.0554 0.0513
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0167 0.3432
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0043 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Echinococcus granulosus cpg binding protein 0.0037 0.0333 0.1081
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0079 0.1081
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0043 0.0497
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0037 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.3432
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1176 0.4273
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0424 1
Schistosoma mansoni topbp1 0.0012 0.0079 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0079 0.1639
Schistosoma mansoni hypothetical protein 0.0049 0.0461 0.167
Loa Loa (eye worm) hypothetical protein 0.0021 0.0176 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0037 0.0778
Onchocerca volvulus 0.0008 0.0043 0.0312
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0045 0.0138
Echinococcus granulosus geminin 0.0205 0.2055 0.7509
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0167 0.0537
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0045 0.0002
Brugia malayi hypothetical protein 0.0007 0.0031 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0523 0.1899
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0167 0.0463
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0043 0.0305
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0079 0.3912
Brugia malayi hypothetical protein 0.0046 0.0424 0.1489
Schistosoma mansoni cpg binding protein 0.0037 0.0333 0.1197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0037 0.0778
Schistosoma mansoni DNA polymerase eta 0.0048 0.0444 0.1608
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Onchocerca volvulus 0.0008 0.0043 0.0312
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0037 0.0778
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0022 0.0165
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0079 0.1722
Brugia malayi Carboxylesterase family protein 0.027 0.2723 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1699 0.6181
Brugia malayi Carboxylesterase family protein 0.027 0.2723 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0134 0.7439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0164 0.3388
Brugia malayi CHE-14 protein 0.0051 0.048 0.1696
Trypanosoma brucei unspecified product 0.0014 0.0102 0.1887
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0186 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.025 0.5679
Echinococcus granulosus dna polymerase eta 0.0048 0.0444 0.1498
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0065 0.0081

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1836 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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