Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.1847 | 0.0183 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.1847 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 0.9701 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.1847 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.1847 | 0.0183 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.1847 | 0.0183 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1847 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.1695 | 0.1747 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.1847 | 0.0183 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.5597 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.1847 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.5597 | 0.4874 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.0189 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.1695 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.0189 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.5597 | 0.4874 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.9701 | 0.964 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.1847 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.1847 | 0.0183 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1695 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.1847 | 0.0183 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.1847 | 0.0183 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 0.9701 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.1847 | 0.0183 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 0.9701 | 0.964 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1847 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 0.9701 | 0.964 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 0.9701 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.1847 | 0.1904 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0048 | 0.9701 | 0.964 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.1904 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1695 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.0189 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.1847 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.0189 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.1847 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.1847 | 0.0189 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 0.9701 | 0.964 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.0189 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.1847 | 0.1904 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.1695 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.