Detailed information for compound 1432027

Basic information

Technical information
  • TDR Targets ID: 1432027
  • Name: 2-[4-(3-bromophenyl)-4-methyl-2,5-dioxoimidaz olidin-1-yl]-N-(oxolan-2-ylmethyl)acetamide
  • MW: 410.262 | Formula: C17H20BrN3O4
  • H donors: 2 H acceptors: 3 LogP: 1.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)NC(C1=O)(C)c1cccc(c1)Br)NCC1CCCO1
  • InChi: 1S/C17H20BrN3O4/c1-17(11-4-2-5-12(18)8-11)15(23)21(16(24)20-17)10-14(22)19-9-13-6-3-7-25-13/h2,4-5,8,13H,3,6-7,9-10H2,1H3,(H,19,22)(H,20,24)
  • InChiKey: NNJAUIREZLHCLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(3-bromophenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-N-(tetrahydrofuran-2-ylmethyl)acetamide
  • 2-[4-(3-bromophenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-(2-tetrahydrofuranylmethyl)acetamide
  • 2-[4-(3-bromophenyl)-2,5-diketo-4-methyl-imidazolidin-1-yl]-N-(tetrahydrofurfuryl)acetamide
  • 2-[4-(3-bromophenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-N-(oxolan-2-ylmethyl)ethanamide
  • T0520-4183

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0021 0.1847 0.0183
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.1847 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.5597 0.4874
Giardia lamblia DINP protein human, muc B family 0.0021 0.1847 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.1847 0.0189
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.5597 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.1695 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.1847 0.0189
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.1847 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.1847 0.0183
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.1847 0.0183
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.1695 0.1747
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.1847 1
Leishmania major DNA polymerase eta, putative 0.0048 0.9701 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.1847 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.1847 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.9701 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.9701 0.964
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.1847 0.0183
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.1847 0.0189
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.9701 0.964
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.1847 0.1904
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.9701 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.1695 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 1 1
Leishmania major DNA polymerase eta, putative 0.0034 0.5597 0.4874
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.1847 0.1904
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.1847 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.1847 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.1847 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.1695 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.1847 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.1847 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Echinococcus granulosus dna polymerase kappa 0.0021 0.1847 0.0183
Trypanosoma brucei unspecified product 0.0021 0.1847 0.1904
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.1847 0.0183
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.1847 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.1847 0.0189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 1 1
Echinococcus granulosus dna polymerase eta 0.0048 0.9701 0.964
Schistosoma mansoni DNA polymerase eta 0.0048 0.9701 0.964
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.1695 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.1847 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.1847 0.1904
Echinococcus multilocularis dna polymerase eta 0.0048 0.9701 0.964

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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