Detailed information for compound 1432212

Basic information

Technical information
  • TDR Targets ID: 1432212
  • Name: propan-2-yl 2-[[3-cyano-4-furan-2-yl-6-methyl -5-(phenylcarbamoyl)-1,4-dihydropyridin-2-yl] sulfanyl]acetate
  • MW: 437.511 | Formula: C23H23N3O4S
  • H donors: 2 H acceptors: 3 LogP: 3.57 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(SCC(=O)OC(C)C)NC(=C(C1c1ccco1)C(=O)Nc1ccccc1)C
  • InChi: 1S/C23H23N3O4S/c1-14(2)30-19(27)13-31-23-17(12-24)21(18-10-7-11-29-18)20(15(3)25-23)22(28)26-16-8-5-4-6-9-16/h4-11,14,21,25H,13H2,1-3H3,(H,26,28)
  • InChiKey: RTGJNUGZZJCEHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl 2-[[3-cyano-4-(2-furyl)-6-methyl-5-(phenylcarbamoyl)-1,4-dihydropyridin-2-yl]sulfanyl]acetate
  • 2-[[3-cyano-4-(2-furyl)-6-methyl-5-[oxo-(phenylamino)methyl]-1,4-dihydropyridin-2-yl]thio]acetic acid isopropyl ester
  • 2-[[3-cyano-4-(2-furyl)-6-methyl-5-(phenylcarbamoyl)-1,4-dihydropyridin-2-yl]thio]acetic acid isopropyl ester
  • propan-2-yl 2-[[3-cyano-4-furan-2-yl-6-methyl-5-(phenylcarbamoyl)-1,4-dihydropyridin-2-yl]sulfanyl]ethanoate
  • Oprea1_316627
  • BAS 00635264
  • STOCK1S-21201
  • MLS000105853
  • SMR000102828
  • Oprea1_276418

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ferritin 0.0035 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0161
Plasmodium falciparum glutathione reductase 0.0103 0.0877 0.5267
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0174 0.0889
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.2744 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0164 0.1509 0.5894
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0328 0.0448
Echinococcus multilocularis neuropeptide s receptor 0.056 0.5637 0.5637
Entamoeba histolytica hypothetical protein 0.03 0.2928 1
Schistosoma mansoni ferritin 0.0035 0.0166 0.0235
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0328 0.0328
Brugia malayi Bromodomain containing protein 0.0075 0.0583 0.1992
Schistosoma mansoni ferritin 0.0035 0.0166 0.0235
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0075 0.0258
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0877 0.3197
Echinococcus multilocularis ferritin 0.0035 0.0166 0.0166
Schistosoma mansoni microtubule-associated protein tau 0.07 0.7097 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0839
Brugia malayi Bromodomain containing protein 0.0038 0.0201 0.0686
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0174 0.0059
Echinococcus multilocularis tumor protein p63 0.0722 0.7317 0.7317
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0166 0.0834
Brugia malayi follicle stimulating hormone receptor 0.0283 0.2744 0.9373
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0174 0.0524
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0037 0.005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0734
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0174
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0328 0.0448
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0877 1
Echinococcus granulosus tumor protein p63 0.0722 0.7317 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0161
Brugia malayi mbt repeat family protein 0.0051 0.0328 0.112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0262 0.2529 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0164 0.1509 1
Schistosoma mansoni zinc finger protein 0.002 0.0006 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0889
Entamoeba histolytica hypothetical protein 0.03 0.2928 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0236 0.2256 0.8898
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0262 0.2529 1
Schistosoma mansoni hypothetical protein 0.0021 0.0017 0.0023
Brugia malayi Thioredoxin reductase 0.0103 0.0877 0.2997
Schistosoma mansoni hypothetical protein 0.0307 0.3001 0.4228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.03 0.2928 0.4001
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0429 0.1464
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0429 0.1562
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0174 0.0059
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.023 0.0786
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1875 0.1875
Echinococcus granulosus expressed protein 0.0035 0.0166 0.0227
Plasmodium falciparum thioredoxin reductase 0.0103 0.0877 0.5267
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0424 0.0424
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0174 0.0596
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0401 0.0401
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0238
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0328 0.3308
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.0166 0.0492
Echinococcus granulosus zinc finger protein 0.002 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.03 0.2928 1
Leishmania major trypanothione reductase 0.0103 0.0877 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0401 0.1369
Schistosoma mansoni hypothetical protein 0.0041 0.023 0.0324
Mycobacterium tuberculosis Probable reductase 0.0236 0.2256 0.8898
Loa Loa (eye worm) MBCTL1 0.0058 0.0401 0.146
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0075 0.0258
Toxoplasma gondii thioredoxin reductase 0.0103 0.0877 0.5267
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0164 0.1509 1
Trypanosoma brucei trypanothione reductase 0.0103 0.0877 1
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0328 0.1195
Entamoeba histolytica hypothetical protein 0.03 0.2928 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0174 0.5
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.0902 0.1271
Echinococcus multilocularis expressed protein 0.0035 0.0166 0.0166
Echinococcus multilocularis microtubule associated protein 2 0.07 0.7097 0.7097
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0174 0.0059
Loa Loa (eye worm) hypothetical protein 0.0106 0.0902 0.3286
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0166 0.0492
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0164 0.1509 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0226 0.0824
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0164 0.1509 0.5894
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0174 0.1562
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0151
Loa Loa (eye worm) hypothetical protein 0.0043 0.0246 0.0897
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0174 0.0059
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0166 0.0834
Onchocerca volvulus 0.0051 0.0328 0.3308
Echinococcus granulosus neuropeptide receptor A26 0.056 0.5637 0.7704
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0037 0.0051
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0236 0.2256 0.8898
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0176 0.0176
Schistosoma mansoni bromodomain containing protein 0.0063 0.0461 0.065
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0236 0.2256 0.8898
Schistosoma mansoni ferritin light chain 0.0035 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0058 0.0401 0.146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0236 0.2256 0.8898
Echinococcus granulosus neuropeptide s receptor 0.056 0.5637 0.7704
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0328 0.0462
Plasmodium falciparum enoyl-acyl carrier reductase 0.0164 0.1509 1
Schistosoma mansoni apoferritin-2 0.0035 0.0166 0.0235
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0877 0.3352
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0151
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1875 0.2563
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.1562
Schistosoma mansoni hypothetical protein 0.03 0.2928 0.4126
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0174 0.1562
Schistosoma mansoni transcription factor LCR-F1 0.03 0.2928 0.4126
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0328 0.0462
Loa Loa (eye worm) glutathione reductase 0.0103 0.0877 0.3197
Brugia malayi PHD-finger family protein 0.0025 0.0061 0.0209
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0328 0.0328
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0877 0.0877
Onchocerca volvulus 0.0106 0.0902 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0424 0.0579
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.03 0.2928 0.2928
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0017 0.0061
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0164 0.1509 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0174 0.0246
Echinococcus granulosus ferritin 0.0035 0.0166 0.0227
Brugia malayi glutathione reductase 0.0103 0.0877 0.2997
Loa Loa (eye worm) hypothetical protein 0.006 0.0429 0.1562
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0161
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0401 0.0565
Trichomonas vaginalis hypothetical protein 0.0164 0.1509 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0166 0.0492
Mycobacterium tuberculosis Probable oxidoreductase 0.0262 0.2529 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0236 0.2256 0.8898
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0401 0.0548
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0401 0.0401
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0401 0.0548
Echinococcus granulosus microtubule associated protein 2 0.07 0.7097 0.9699
Echinococcus multilocularis zinc finger protein 0.002 0.0006 0.0006
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.5637 0.5637
Brugia malayi hypothetical protein 0.03 0.2928 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0037 0.0037
Plasmodium vivax glutathione reductase, putative 0.0103 0.0877 0.5267
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0176 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0151
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0262 0.2529 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0174 0.0889
Loa Loa (eye worm) hypothetical protein 0.0071 0.0539 0.1962
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0174 0.1562
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0877 0.5267
Schistosoma mansoni apoferritin-2 0.0035 0.0166 0.0235
Schistosoma mansoni ferritin light chain 0.0035 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0328 0.1195
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0164 0.1509 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0877 0.1199
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0429 0.1464
Brugia malayi mbt repeat family protein 0.0051 0.0328 0.112
Schistosoma mansoni ferritin 0.0035 0.0166 0.0235
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0236 0.2256 0.8898
Treponema pallidum NADH oxidase 0.0036 0.0174 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0328 0.0462

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 141.2538 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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