Detailed information for compound 1432722

Basic information

Technical information
  • TDR Targets ID: 1432722
  • Name: 4-methoxy-N-[(Z)-1-(1-methylindol-3-yl)-3-mor pholin-4-yl-3-oxoprop-1-en-2-yl]benzamide
  • MW: 419.473 | Formula: C24H25N3O4
  • H donors: 1 H acceptors: 2 LogP: 2.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N/C(=C\c1cn(c2c1cccc2)C)/C(=O)N1CCOCC1
  • InChi: 1S/C24H25N3O4/c1-26-16-18(20-5-3-4-6-22(20)26)15-21(24(29)27-11-13-31-14-12-27)25-23(28)17-7-9-19(30-2)10-8-17/h3-10,15-16H,11-14H2,1-2H3,(H,25,28)/b21-15-
  • InChiKey: WMNLUPKVQLPPAG-QNGOZBTKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methoxy-N-[(Z)-2-(1-methylindol-3-yl)-1-(morpholine-4-carbonyl)vinyl]benzamide
  • 4-methoxy-N-[(Z)-2-(1-methyl-3-indolyl)-1-(morpholino-oxomethyl)vinyl]benzamide
  • 4-methoxy-N-[(Z)-1-(1-methylindol-3-yl)-3-morpholin-4-yl-3-oxo-prop-1-en-2-yl]benzamide
  • STOCK3S-27217
  • ZINC02357995

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Plasmodium vivax protein kinase, putative 0.0025 0.291 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.2586 0.5338
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0025 0.291 0.291
Trichomonas vaginalis AGC family protein kinase 0.0025 0.291 1
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Toxoplasma gondii protein kinase domain-containing protein 0.0025 0.291 0.1461
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Entamoeba histolytica serine/threonine kinase, putative 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0068 0.9169 1
Echinococcus multilocularis cpg binding protein 0.0037 0.4619 0.4733
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.291 0.2505
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.2586 0.5338
Brugia malayi Tyrosine-protein kinase abl-1 0.0068 0.9169 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.2586 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.4331 0.4373
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0068 0.9169 1
Schistosoma mansoni protein tyrosine kinase 0.0025 0.291 0.291
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0025 0.291 0.291
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Loa Loa (eye worm) TK/ACK protein kinase 0.0025 0.291 0.272
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0025 0.291 0.291
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.291 0.2755
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.7542 0.8108
Echinococcus multilocularis tyrosine kinase 0.0025 0.291 0.2755
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Echinococcus multilocularis tyrosine protein kinase shark 0.0068 0.9169 1
Echinococcus multilocularis c src tyrosine kinase 0.0068 0.9169 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0025 0.291 0.2755
Schistosoma mansoni nck2/grb4 0.0043 0.5533 0.5533
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.2586 0.2343
Schistosoma mansoni cytochrome P450 0.0018 0.1894 0.1894
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0043 0.5533 0.5771
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.3191 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0043 0.5533 0.5533
Loa Loa (eye worm) STAT protein 0.0043 0.5533 0.5771
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Brugia malayi Cytochrome P450 family protein 0.0057 0.7542 0.8052
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.291 0.2755
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0025 0.291 0.1461
Echinococcus granulosus hypothetical protein 0.0043 0.5533 0.5791
Loa Loa (eye worm) hypothetical protein 0.0068 0.9169 1
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Echinococcus multilocularis tyrosine protein kinase pr2 0.0025 0.291 0.2755
Echinococcus granulosus tyrosine kinase 0.0068 0.9169 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0025 0.291 0.272
Entamoeba histolytica cysteine surface protein, putative 0.0025 0.291 0.0493
Echinococcus multilocularis tensin 0.0043 0.5533 0.5791
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.291 0.2755
Schistosoma mansoni cpg binding protein 0.0037 0.4619 0.4619
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Echinococcus granulosus N chimaerin 0.0043 0.5533 0.5791
Echinococcus granulosus fibroblast growth factor receptor 4 0.0025 0.291 0.2755
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0025 0.291 0.291
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0025 0.291 0.2755
Brugia malayi CXXC zinc finger family protein 0.0035 0.4331 0.4206
Schistosoma mansoni tyrosine kinase 0.0068 0.9169 0.9169
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0068 0.9169 1
Brugia malayi Protein kinase domain containing protein 0.0068 0.9169 1
Echinococcus multilocularis SH2 motif 0.0043 0.5533 0.5791
Echinococcus granulosus activated cdc42 kinase 1 0.0025 0.291 0.2755
Giardia lamblia Kinase, NEK 0.0025 0.291 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0043 0.5533 0.5533
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0025 0.291 0.291
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0025 0.291 0.2505
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Echinococcus granulosus tyrosine protein kinase Blk 0.0068 0.9169 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0043 0.5533 0.5791
Echinococcus granulosus tyrosine protein kinase 0.0025 0.291 0.2755
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0068 0.9169 1
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0025 0.291 0.272
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0043 0.5533 0.5533
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis protein kinase atn1, putative 0.0025 0.291 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.291 0.2755
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni hypothetical protein 0.0018 0.1894 0.1894
Echinococcus multilocularis heat shock protein 70 0.0025 0.291 0.2755
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.2586 0.8697
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0025 0.291 0.2755
Brugia malayi Tyrosine-protein kinase PR2 0.0025 0.291 0.2505
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Loa Loa (eye worm) TK/FAK protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0839 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Leishmania major hypothetical protein, conserved 0.0025 0.291 0.784
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0025 0.291 0.272
Brugia malayi Protein kinase domain containing protein 0.0068 0.9169 1
Brugia malayi Variant SH3 domain containing protein 0.0043 0.5533 0.5646
Trichomonas vaginalis STE family protein kinase 0.0025 0.291 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0025 0.291 0.0493
Schistosoma mansoni tyrosine kinase 0.0068 0.9169 0.9169
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Leishmania major protein kinase, putative 0.0025 0.291 0.784
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0025 0.291 0.272
Echinococcus multilocularis ephrin type A receptor 4 A 0.0025 0.291 0.2755
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.291 0.2755
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0043 0.5533 0.5771
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Brugia malayi Cytochrome P450 family protein 0.0018 0.1894 0.1287
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0025 0.291 0.2505
Echinococcus granulosus tyrosine protein kinase Fyn 0.0068 0.9169 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0025 0.291 0.1461
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0043 0.5533 0.5533
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0068 0.9169 1
Loa Loa (eye worm) CYP4Cod1 0.0027 0.3191 0.3046
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Echinococcus granulosus suppressor of cytokine signaling 6 0.0043 0.5533 0.5791
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.5533 0.5533
Schistosoma mansoni SH2A 0.0043 0.5533 0.5533
Toxoplasma gondii STE kinase 0.0025 0.291 0.1461
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.3191 0.3046
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0068 0.9169 1
Entamoeba histolytica protein kinase, putative 0.0043 0.5533 0.4477
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.2586 0.2116
Echinococcus granulosus tyrosine protein kinase Srms 0.0068 0.9169 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.2586 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0025 0.291 0.272
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0068 0.9169 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0025 0.291 0.2505
Onchocerca volvulus 0.0043 0.5533 0.4191
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.3191 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0025 0.291 0.2755
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Brugia malayi Sex muscle abnormal protein 5 0.0043 0.5533 0.5646
Loa Loa (eye worm) protein kinase domain-containing protein 0.0025 0.291 0.272
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Schistosoma mansoni tensin-related 0.0043 0.5533 0.5533
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.5533 0.5791
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0043 0.5533 0.5646
Schistosoma mansoni cpg binding protein 0.0035 0.4331 0.4331
Echinococcus granulosus integrin linked protein kinase 0.0025 0.291 0.2755
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0068 0.9169 1
Schistosoma mansoni serine/threonine RGC 0.0025 0.291 0.291
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Schistosoma mansoni hypothetical protein 0.0043 0.5533 0.5533
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus insulin receptor 0.0025 0.291 0.2755
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.3191 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0025 0.291 0.2755
Echinococcus granulosus SH2 motif 0.0043 0.5533 0.5791
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.9169 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.291 0.2505
Echinococcus multilocularis protein KINase family member (kin 25) 0.0025 0.291 0.2755
Trypanosoma cruzi protein kinase, putative 0.0025 0.291 0.784
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.291 0.2755
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.8854 1
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Brugia malayi cytokine inducible SH2-containing protein 5 0.0043 0.5533 0.5646
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.5533 0.5771
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0043 0.5533 0.5791
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trypanosoma brucei protein kinase, putative 0.0025 0.291 0.784
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tensin-related 0.0043 0.5533 0.5533
Echinococcus granulosus tyrosine kinase 0.0025 0.291 0.2755
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0025 0.291 0.2755
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0025 0.291 0.2755
Leishmania major cytochrome p450-like protein 0.0027 0.3191 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Plasmodium vivax tyrosine kinase-like protein, putative 0.0025 0.291 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0068 0.9169 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0068 0.9169 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.2586 0.2379
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Schistosoma mansoni adapter molecule crk 0.0043 0.5533 0.5533
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0025 0.291 0.1461
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.291 0.272
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Echinococcus multilocularis SH2 motif 0.0043 0.5533 0.5791
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.291 0.0493
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Echinococcus multilocularis activated cdc42 kinase 1 0.0025 0.291 0.2755
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0043 0.5533 0.5771
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni signal transduction protein lnk-related 0.0043 0.5533 0.5533
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.1894 0.1578
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Plasmodium falciparum protein kinase, putative 0.0025 0.291 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0025 0.291 0.272
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0068 0.9169 1
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Brugia malayi C-terminal src kinase protein 1 0.0025 0.291 0.2505
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Schistosoma mansoni tensin 0.0043 0.5533 0.5533
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0025 0.291 0.2755
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0043 0.5533 0.5791
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.9169 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0068 0.9169 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0068 0.9169 1
Brugia malayi Tensin 0.0043 0.5533 0.5646
Echinococcus multilocularis SH2 motif 0.0043 0.5533 0.5791
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.9169 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0068 0.9169 1
Echinococcus granulosus protein kinase 0.0025 0.291 0.2755
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.2586 0.5338
Onchocerca volvulus 0.0043 0.5533 0.4191
Loa Loa (eye worm) TK protein kinase 0.0068 0.9169 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus multilocularis SH2 domain containing protein 7 0.0043 0.5533 0.5791
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0025 0.291 0.784
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0068 0.9169 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0025 0.291 0.2755
Brugia malayi tRNA modification GTPase TrmE family protein 0.0043 0.5533 0.5646
Echinococcus granulosus protein tyrosine kinase 0.0025 0.291 0.2755
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Echinococcus granulosus natriuretic peptide receptor 1 0.0025 0.291 0.2755
Schistosoma mansoni hypothetical protein 0.0043 0.5533 0.5533
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.291 0.2755
Echinococcus granulosus raf serine:threonine protein kinase 0.0025 0.291 0.2755
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus multilocularis tyrosine kinase 0.0068 0.9169 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.291 0.291
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0043 0.5533 0.5771
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0043 0.5533 0.5791
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.291 0.2755
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica receptor protein kinase, putative 0.0025 0.291 0.0493
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Echinococcus granulosus tyrosine protein kinase ABL1 0.0068 0.9169 1
Schistosoma mansoni cpg binding protein 0.0037 0.4619 0.4619
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0043 0.5533 0.5771
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus signal transduction protein lnk realted 0.0043 0.5533 0.5791
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Schistosoma mansoni tensin 0.0043 0.5533 0.5533
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0068 0.9169 1
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0043 0.5533 0.5791
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Entamoeba histolytica ankyrin repeat protein 0.0025 0.291 0.0493
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Brugia malayi SRC-1 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Schistosoma mansoni suppressor of cytokine signaling 0.0043 0.5533 0.5533
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trichomonas vaginalis TK family protein kinase 0.0025 0.291 1
Echinococcus multilocularis integrin linked protein kinase 0.0025 0.291 0.2755
Echinococcus multilocularis tyrosine protein kinase Blk 0.0068 0.9169 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.5533 0.5771
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0025 0.291 0.2755
Entamoeba histolytica serine/threonine kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Brugia malayi Cytochrome P450 family protein 0.0027 0.3191 0.284
Giardia lamblia Protein 21.1 0.0025 0.291 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Onchocerca volvulus 0.0043 0.5533 0.4191
Echinococcus multilocularis protein kinase 0.0025 0.291 0.2755
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Leishmania major protein kinase, putative 0.0025 0.291 0.784
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Echinococcus multilocularis protein kinase 0.0025 0.291 0.2755
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Schistosoma mansoni tyrosine protein kinase 0.0025 0.291 0.291
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.2586 1
Echinococcus granulosus tyrosine protein kinase shark 0.0068 0.9169 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0025 0.291 0.0493
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0068 0.9169 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0043 0.5533 0.5791
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0043 0.5533 0.5791
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0025 0.291 0.2755
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica receptor protein kinase, putative 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Onchocerca volvulus 0.0068 0.9169 1
Echinococcus multilocularis insulin receptor 0.0025 0.291 0.2755
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Giardia lamblia Kinase, NEK 0.0025 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Schistosoma mansoni ap endonuclease 0.0023 0.2586 0.2586
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0043 0.5533 0.5791
Plasmodium falciparum tyrosine kinase-like protein 0.0025 0.291 1
Onchocerca volvulus 0.0035 0.4331 0.227
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0025 0.291 0.2755
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0025 0.291 0.2755
Loa Loa (eye worm) SH2 domain-containing protein 0.0043 0.5533 0.5771
Echinococcus granulosus tyrosine protein kinase pr2 0.0025 0.291 0.2755
Echinococcus granulosus growth factor receptor bound protein 2 0.0043 0.5533 0.5791
Entamoeba histolytica tyrosin kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Onchocerca volvulus 0.0068 0.9169 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Brugia malayi integrin-linked kinase 0.0025 0.291 0.2505
Schistosoma mansoni ap endonuclease 0.0023 0.2586 0.2586
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Onchocerca volvulus 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Giardia lamblia Kinase 0.0025 0.291 1
Echinococcus granulosus c src tyrosine kinase 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Schistosoma mansoni suppressor of cytokine signaling 0.0043 0.5533 0.5533
Brugia malayi protein-tyrosine kinase 0.0068 0.9169 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Onchocerca volvulus 0.0043 0.5533 0.4191
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.291 0.291
Echinococcus multilocularis transfer RNA-Thr 0.0025 0.291 0.2755
Schistosoma mansoni hypothetical protein 0.0025 0.291 0.291
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0043 0.5533 0.5791
Echinococcus multilocularis growth factor receptor bound protein 2 0.0043 0.5533 0.5791
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Schistosoma mansoni tensin 0.0043 0.5533 0.5533
Loa Loa (eye worm) SRC-1 0.0068 0.9169 1
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.291 0.2505
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0025 0.291 0.2755
Echinococcus granulosus suppressor of cytokine signaling 7 0.0043 0.5533 0.5791
Trypanosoma brucei Flagellum attachment zone protein 20 0.0025 0.291 0.784
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Onchocerca volvulus 0.0068 0.9169 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0025 0.291 0.2755
Brugia malayi Cytochrome P450 family protein 0.0027 0.3191 0.284
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0025 0.291 1
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Schistosoma mansoni tyrosine kinase 0.0068 0.9169 0.9169
Brugia malayi Protein kinase domain containing protein 0.0068 0.9169 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0043 0.5533 0.5791
Echinococcus multilocularis N chimaerin 0.0043 0.5533 0.5791
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0025 0.291 0.2755
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0025 0.291 0.2755
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus multilocularis epidermal growth factor receptor 0.0025 0.291 0.2755
Schistosoma mansoni tyrosine kinase 0.0068 0.9169 0.9169
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0839 0.0311
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0025 0.291 0.2505
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.2586 0.8697
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Plasmodium vivax tyrosine kinase-like protein, putative 0.0025 0.291 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.3191 0.3046
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Toxoplasma gondii exonuclease III APE 0.0023 0.2586 0.0995
Loa Loa (eye worm) TK/Met protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0025 0.291 0.0493
Echinococcus multilocularis NCK adaptor protein 0.0043 0.5533 0.5791
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0043 0.5533 0.4477
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0068 0.9169 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0043 0.5533 0.4191
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.291 0.291
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0068 0.9169 0.9169
Entamoeba histolytica tyrosin kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0043 0.5533 0.5791
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Brugia malayi RhoGAP domain containing protein 0.0043 0.5533 0.5646
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Brugia malayi Variant SH3 domain containing protein 0.0043 0.5533 0.5646
Echinococcus multilocularis natriuretic peptide receptor 1 0.0025 0.291 0.2755
Entamoeba histolytica tyrosin kinase, putative 0.0025 0.291 0.0493
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica tyrosin kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica serine/threonine kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis SHC transforming protein 3 0.0043 0.5533 0.5791
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0531 0.0531
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Echinococcus granulosus tensin 0.0043 0.5533 0.5791
Schistosoma mansoni ephrin receptor 0.0025 0.291 0.291
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Echinococcus multilocularis tyrosine protein kinase Abl 0.0068 0.9169 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0025 0.291 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus epidermal growth factor receptor 0.0025 0.291 0.2755
Schistosoma mansoni vav2 0.0043 0.5533 0.5533
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0025 0.291 0.272
Echinococcus granulosus tyrosine protein kinase HCK 0.0025 0.291 0.2755
Echinococcus granulosus SH2 domain containing protein 7 0.0043 0.5533 0.5791
Schistosoma mansoni GTPase activating protein 0.0043 0.5533 0.5533
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis FL cytokine receptor 0.0025 0.291 0.2755
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0025 0.291 0.2755
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Loa Loa (eye worm) TK/EGFR protein kinase 0.0025 0.291 0.272
Echinococcus granulosus tyrosine protein kinase Fyn 0.0068 0.9169 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.2586 0.5338
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0025 0.291 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0025 0.291 0.2755
Brugia malayi Furin-like cysteine rich region family protein 0.0025 0.291 0.2505
Brugia malayi bone morphogenetic protein type 1 receptor 0.0025 0.291 0.2505
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Brugia malayi SH2 domain containing protein 0.0068 0.9169 1
Brugia malayi cytochrome P450 0.0018 0.1894 0.1287
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Onchocerca volvulus 0.0068 0.9169 1
Trypanosoma brucei Pseudokinase, putative 0.0025 0.291 0.784
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0839 0.0357
Echinococcus multilocularis protein tyrosine kinase 0.0025 0.291 0.2755
Brugia malayi hypothetical protein 0.0025 0.291 0.2505
Loa Loa (eye worm) TK/RYK protein kinase 0.0025 0.291 0.272
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Brugia malayi Raf kinase 0.0025 0.291 0.2505
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Onchocerca volvulus 0.0068 0.9169 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Plasmodium falciparum tyrosine kinase-like protein 0.0025 0.291 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.291 0.2755
Brugia malayi hypothetical protein 0.0043 0.5533 0.5646
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica serine/threonine kinase, putative 0.0025 0.291 0.0493
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.2586 0.2379
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0025 0.291 0.2755
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0043 0.5533 0.4191
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Schistosoma mansoni ephrin receptor 0.0025 0.291 0.291
Echinococcus granulosus epidermal growth factor receptor 0.0025 0.291 0.2755
Brugia malayi STAT protein, DNA binding domain containing protein 0.0043 0.5533 0.5646
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Entamoeba histolytica ankyrin repeat protein 0.0025 0.291 0.0493
Echinococcus multilocularis epidermal growth factor receptor 0.0025 0.291 0.2755
Echinococcus multilocularis signal transduction protein lnk realted 0.0043 0.5533 0.5791
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.291 0.784
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0043 0.5533 0.5791
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0025 0.291 0.2505
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.291 0.272
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.5533 0.5533
Trypanosoma cruzi protein kinase, putative 0.0025 0.291 0.784
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Echinococcus multilocularis tyrosine protein kinase 0.0025 0.291 0.2755
Echinococcus granulosus tyrosine protein kinase Fyn 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0043 0.5533 0.5791
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Echinococcus multilocularis activin receptor type 0.0025 0.291 0.2755
Echinococcus granulosus tyrosine kinase 0.0068 0.9169 1
Echinococcus granulosus activated cdc42 kinase 1 0.0025 0.291 0.2755
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Brugia malayi ephrin receptor 1 precursor 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) cytochrome P450 0.0018 0.1894 0.1538
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Schistosoma mansoni tyrosine kinase 0.0068 0.9169 0.9169
Trichomonas vaginalis protein tyrosine kinase, putative 0.0025 0.291 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Echinococcus granulosus expressed conserved protein 0.0043 0.5533 0.5791
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Plasmodium falciparum protein kinase, putative 0.0025 0.291 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Brugia malayi SH2 domain containing protein 0.0068 0.9169 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.291 0.272
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.291 0.2755
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0043 0.5533 0.5533
Echinococcus granulosus NCK adaptor protein 0.0043 0.5533 0.5791
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0068 0.9169 0.9169
Echinococcus multilocularis tyrosine protein kinase Srms 0.0068 0.9169 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0043 0.5533 0.5771
Echinococcus granulosus SH2 motif 0.0043 0.5533 0.5791
Echinococcus multilocularis tensin 0.0043 0.5533 0.5791
Brugia malayi Protein kinase domain containing protein 0.0068 0.9169 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.291 0.272
Echinococcus granulosus ephrin type A receptor 4 A 0.0025 0.291 0.2755
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.1894 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Echinococcus multilocularis 0.0043 0.5533 0.5791
Brugia malayi Variant SH3 domain containing protein 0.0043 0.5533 0.5646
Onchocerca volvulus 0.0043 0.5533 0.4191
Echinococcus granulosus cpg binding protein 0.0037 0.4619 0.4733
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.5533 0.5791
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.291 0.2755
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.291 0.2755
Entamoeba histolytica tyrosine kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.291 0.2755
Loa Loa (eye worm) TK/FER protein kinase 0.0068 0.9169 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0025 0.291 0.2755
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Loa Loa (eye worm) TK/INSR protein kinase 0.0025 0.291 0.272
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Brugia malayi SH2 domain containing protein 0.0043 0.5533 0.5646
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.291 1
Schistosoma mansoni tyrosine kinase 0.0025 0.291 0.291
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.291 0.272
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Loa Loa (eye worm) hypothetical protein 0.0043 0.5533 0.5771
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Trypanosoma brucei cytochrome P450, putative 0.0027 0.3191 1
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.291 0.2755
Entamoeba histolytica hypothetical protein 0.0025 0.291 0.0493
Brugia malayi hypothetical protein 0.0068 0.9169 1
Brugia malayi Variant SH3 domain containing protein 0.0043 0.5533 0.5646
Echinococcus granulosus kinase suppressor of Ras 1 0.0025 0.291 0.2755
Plasmodium falciparum protein kinase, putative 0.0025 0.291 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0025 0.291 0.272
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.291 0.291
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.291 0.0493
Echinococcus granulosus SHC transforming protein 3 0.0043 0.5533 0.5791
Entamoeba histolytica protein kinase, putative 0.0025 0.291 0.0493
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.291 0.784
Entamoeba histolytica serine/threonine kinase, putative 0.0025 0.291 0.0493
Echinococcus multilocularis 0.0018 0.1894 0.1578
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0068 0.9169 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0025 0.291 0.272
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0025 0.291 0.272
Entamoeba histolytica serine/threonine kinase, putative 0.0025 0.291 0.0493
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Brugia malayi hypothetical protein 0.0025 0.291 0.2505
Schistosoma mansoni shc transforming protein 0.0043 0.5533 0.5533
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.291 0.291
Entamoeba histolytica SH2 domain containing protein 0.0043 0.5533 0.4477
Onchocerca volvulus 0.0043 0.5533 0.4191
Schistosoma mansoni protein kinase 0.0025 0.291 0.291
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.291 0.784
Loa Loa (eye worm) hypothetical protein 0.0025 0.291 0.272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.2586 0.5338
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0068 0.9169 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Brugia malayi Protein kinase domain containing protein 0.0025 0.291 0.2505
Mycobacterium leprae putative cytochrome p450 0.0018 0.1894 0.5
Toxoplasma gondii protein kinase 0.0025 0.291 0.1461
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0043 0.5533 0.5791
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0025 0.291 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0025 0.291 0.2755
Echinococcus granulosus activin receptor type 0.0025 0.291 0.2755
Trichomonas vaginalis TKL family protein kinase 0.0025 0.291 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.0621 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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