Detailed information for compound 1432911

Basic information

Technical information
  • TDR Targets ID: 1432911
  • Name: bis(2-methylpropoxy)phosphoryl-(2,4-dimethoxy phenyl)methanol
  • MW: 360.382 | Formula: C17H29O6P
  • H donors: 1 H acceptors: 2 LogP: 3.02 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1C(P(=O)(OCC(C)C)OCC(C)C)O
  • InChi: 1S/C17H29O6P/c1-12(2)10-22-24(19,23-11-13(3)4)17(18)15-8-7-14(20-5)9-16(15)21-6/h7-9,12-13,17-18H,10-11H2,1-6H3
  • InChiKey: APXDFYZRZIKOBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • diisobutoxyphosphoryl-(2,4-dimethoxyphenyl)methanol
  • diisobutyl [(2,4-dimethoxyphenyl)(hydroxy)methyl]phosphonate
  • STOCK3S-13033
  • MLS000679136
  • SMR000270081

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0165 0.1118 0.112
Trypanosoma cruzi amidase, putative 0.0165 0.1118 0.1472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Mycobacterium ulcerans hypothetical protein 0.1005 0.7311 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Plasmodium vivax PST-A protein 0.1005 0.7311 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0049 0.0049
Plasmodium falciparum alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Plasmodium falciparum alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Plasmodium vivax unspecified product 0.0059 0.0337 0.0396
Mycobacterium ulcerans amidase 0.0165 0.1118 0.112
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0049 0.0067
Toxoplasma gondii hypothetical protein 0.0059 0.0337 1
Trypanosoma cruzi serine peptidase, putative 0.0059 0.0337 0.0396
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1369 1 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Brugia malayi Cathepsin L-like precursor 0.002 0.0049 0.0049
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0165 0.1118 0.1118
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0165 0.1118 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0337 0.0337
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0165 0.1118 0.1118
Plasmodium falciparum prodrug activation and resistance esterase 0.0059 0.0337 0.0396
Brugia malayi MGC79044 protein 0.0059 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0049 0.0067
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0165 0.1118 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Loa Loa (eye worm) hypothetical protein 0.1369 1 1
Plasmodium vivax PST-A protein 0.0059 0.0337 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Echinococcus granulosus fatty acid amide hydrolase 1 0.1369 1 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1005 0.7311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Plasmodium vivax unspecified product 0.0059 0.0337 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Onchocerca volvulus 0.002 0.0049 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1005 0.7311 1
Toxoplasma gondii protein c14orf29, putative 0.0059 0.0337 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0059 0.0337 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0059 0.0337 0.0461
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0337 0.0396
Loa Loa (eye worm) hypothetical protein 0.0059 0.0337 0.0337
Toxoplasma gondii phospholipase 0.0059 0.0337 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Onchocerca volvulus 0.002 0.0049 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0049 0.0049
Plasmodium vivax PST-A protein 0.0059 0.0337 0.0396
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0059 0.0337 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0059 0.0337 0.0396
Brugia malayi putative amidase 0.0165 0.1118 0.1118
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0165 0.1118 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0059 0.0337 0.5
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0059 0.0337 0.0337
Schistosoma mansoni amidase 0.1369 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0059 0.0337 0.0461
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1005 0.7311 1
Entamoeba histolytica hypothetical protein 0.0059 0.0337 0.0461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1005 0.7311 1
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0165 0.1118 0.112
Plasmodium vivax alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Loa Loa (eye worm) hypothetical protein 0.0059 0.0337 0.0337
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1369 1 1
Mycobacterium ulcerans peptide amidase, GatA 0.0165 0.1118 0.112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0049 0.0049
Echinococcus granulosus fatty acid amide hydrolase 1 0.0165 0.1118 0.1118
Plasmodium vivax PST-A protein 0.0059 0.0337 0.0396
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0049 0.0049
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0165 0.1118 0.112
Schistosoma mansoni fatty-acid amide hydrolase 0.0165 0.1118 0.1118
Schistosoma mansoni fatty-acid amide hydrolase 0.1369 1 1
Leishmania major cathepsin L-like protease 0.0077 0.0468 0.0577
Leishmania major cathepsin L-like protease 0.0077 0.0468 0.0577
Echinococcus multilocularis abhydrolase domain containing 3 0.0059 0.0337 0.0289
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0165 0.1118 0.112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0419 0.0509
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0337 0.0396
Echinococcus granulosus cathepsin l1 0.002 0.0049 0.0049
Echinococcus multilocularis Phospholipase carboxylesterase 0.0059 0.0337 0.0289
Plasmodium falciparum lysophospholipase, putative 0.1005 0.7311 1
Plasmodium falciparum lysophospholipase, putative 0.1005 0.7311 1
Mycobacterium tuberculosis Possible lysophospholipase 0.1005 0.7311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Plasmodium vivax lysophospholipase, putative 0.0059 0.0337 0.0396
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0059 0.0337 0.0396
Toxoplasma gondii peptidase S15, putative 0.0059 0.0337 1
Plasmodium falciparum lysophospholipase, putative 0.0059 0.0337 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Plasmodium falciparum esterase, putative 0.1005 0.7311 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0468 0.0577
Schistosoma mansoni peptidase 0.0059 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Onchocerca volvulus Cathepsin L homolog 0.002 0.0049 1
Leishmania major hypothetical protein, conserved 0.0059 0.0337 0.0396
Plasmodium vivax alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0059 0.0337 0.0461
Mycobacterium ulcerans lysophospholipase 0.1005 0.7311 1
Onchocerca volvulus 0.002 0.0049 1
Mycobacterium ulcerans amidase 0.0165 0.1118 0.112
Leishmania major hypothetical protein, conserved 0.0165 0.1118 0.1472
Onchocerca volvulus Cathepsin L homolog 0.002 0.0049 1
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0059 0.0337 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0468 0.0577
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0049
Echinococcus granulosus abhydrolase domain containing protein 13 0.0059 0.0337 0.0337
Trypanosoma cruzi serine peptidase, putative 0.0059 0.0337 0.0396
Brugia malayi Cathepsin L-like precursor 0.002 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.1005 0.7311 1
Plasmodium falciparum exported lipase 1 0.0059 0.0337 0.0396
Trypanosoma brucei monoglyceride lipase, putative 0.1005 0.7311 1
Mycobacterium ulcerans amidase 0.0165 0.1118 0.112
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0059 0.0337 0.0396
Echinococcus granulosus fatty acid amide hydrolase 1 0.1369 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Echinococcus granulosus abhydrolase domain containing 3 0.0059 0.0337 0.0337
Plasmodium vivax PST-A protein 0.0059 0.0337 0.0396
Echinococcus granulosus Phospholipase carboxylesterase 0.0059 0.0337 0.0337
Plasmodium falciparum esterase, putative 0.0059 0.0337 0.0396
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0468 0.0577
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0468 0.0577
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0165 0.1118 0.5
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1005 0.7311 1
Onchocerca volvulus 0.002 0.0049 1
Loa Loa (eye worm) cysteine protease 0.002 0.0049 0.0049
Plasmodium falciparum alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0165 0.1118 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.1005 0.7311 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0347 0.041
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Toxoplasma gondii hypothetical protein 0.0059 0.0337 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Plasmodium falciparum esterase, putative 0.0059 0.0337 0.0396
Trypanosoma cruzi amidase, putative 0.0165 0.1118 0.1472
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0059 0.0337 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Trypanosoma cruzi monoglyceride lipase, putative 0.1005 0.7311 1
Plasmodium falciparum epoxide hydrolase 2 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Toxoplasma gondii hypothetical protein 0.0059 0.0337 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Brugia malayi Amidase family protein 0.0165 0.1118 0.1118
Onchocerca volvulus Cathepsin F homolog 0.002 0.0049 1
Loa Loa (eye worm) ctsf protein 0.002 0.0049 0.0049
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0165 0.1118 0.1074
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0059 0.0337 0.0337
Trichomonas vaginalis valacyclovir hydrolase, putative 0.1005 0.7311 1
Plasmodium vivax lysophospholipase, putative 0.0059 0.0337 0.0396
Brugia malayi Cathepsin L-like precursor 0.002 0.0049 0.0049
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0165 0.1118 0.1074
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0059 0.0337 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0059 0.0337 0.0461
Onchocerca volvulus 0.002 0.0049 1
Mycobacterium ulcerans amidase 0.0165 0.1118 0.112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0049 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0059 0.0337 0.0461
Entamoeba histolytica hypothetical protein 0.0059 0.0337 0.0461
Leishmania major cathepsin L-like protease 0.0077 0.0468 0.0577
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1005 0.7311 1
Entamoeba histolytica ;Alias 0.0059 0.0337 0.0461
Toxoplasma gondii phospholipase/carboxylesterase 0.0059 0.0337 1
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0059 0.0337 0.0396
Loa Loa (eye worm) hypothetical protein 0.0059 0.0337 0.0337
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.1005 0.7311 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0049 0.0067
Leishmania major monoglyceride lipase, putative 0.1005 0.7311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Plasmodium falciparum lysophospholipase, putative 0.0059 0.0337 0.0396
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0049 0.0049
Plasmodium falciparum BEM46-like protein, putative 0.0059 0.0337 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Trypanosoma brucei monoglyceride lipase, putative 0.1005 0.7311 1
Loa Loa (eye worm) amidase 0.0165 0.1118 0.1118
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0049 0.0067
Brugia malayi Amidase family protein 0.0165 0.1118 0.1118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0468 0.0188
Brugia malayi Cathepsin L-like precursor 0.002 0.0049 0.0049
Plasmodium falciparum exported lipase 2 0.0059 0.0337 0.0396
Mycobacterium ulcerans amidase 0.0165 0.1118 0.112
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0165 0.1118 0.112
Plasmodium falciparum lysophospholipase, putative 0.1005 0.7311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0049 0.0067
Toxoplasma gondii hypothetical protein 0.0059 0.0337 1
Brugia malayi MGC83647 protein 0.0059 0.0337 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Onchocerca volvulus 0.002 0.0049 1
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0165 0.1118 0.112
Plasmodium vivax lysophospholipase, putative 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0059 0.0337 0.0461
Loa Loa (eye worm) amidase 0.0165 0.1118 0.1118
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0059 0.0337 0.0461
Brugia malayi Cathepsin L-like precursor 0.002 0.0049 0.0049
Leishmania major hypothetical protein, conserved 0.0059 0.0337 0.0396
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0165 0.1118 0.112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0059 0.0337 0.0337
Plasmodium falciparum alpha/beta hydrolase, putative 0.0059 0.0337 0.0396
Onchocerca volvulus 0.002 0.0049 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0059 0.0337 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0059 0.0337 0.0461
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0059 0.0337 1
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0059 0.0337 0.0396
Plasmodium vivax PST-A protein 0.0059 0.0337 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067
Brugia malayi Protein C20orf22 0.0059 0.0337 0.0337
Loa Loa (eye worm) fibroinase 0.002 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0337 0.0461
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0059 0.0337 0.0461
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1005 0.7311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0049 0.0067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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