Detailed information for compound 1433183

Basic information

Technical information
  • TDR Targets ID: 1433183
  • Name: 1-[[(2,5-dioxopyrrolidin-1-yl)methyl-[2-(2-ox o-1,3-oxazolidin-3-yl)ethyl]amino]methyl]pyrr olidine-2,5-dione
  • MW: 352.343 | Formula: C15H20N4O6
  • H donors: 0 H acceptors: 5 LogP: -2.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OCCN1CCN(CN1C(=O)CCC1=O)CN1C(=O)CCC1=O
  • InChi: 1S/C15H20N4O6/c20-11-1-2-12(21)18(11)9-16(5-6-17-7-8-25-15(17)24)10-19-13(22)3-4-14(19)23/h1-10H2
  • InChiKey: JQUQXMFJXIBYML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[(2,5-dioxopyrrolidin-1-yl)methyl-[2-(2-oxooxazolidin-3-yl)ethyl]amino]methyl]pyrrolidine-2,5-dione
  • 1-[[(2,5-dioxo-1-pyrrolidinyl)methyl-[2-(2-oxo-3-oxazolidinyl)ethyl]amino]methyl]pyrrolidine-2,5-dione
  • 1-[[2-(2-ketooxazolidin-3-yl)ethyl-(succinimidomethyl)amino]methyl]pyrrolidine-2,5-quinone
  • A2979/0125607
  • 1-({[(2,5-dioxopyrrolidin-1-yl)methyl][2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]amino}methyl)pyrrolidine-2,5-dione
  • MLS000045646
  • SMR000027603

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus granulosus neuropeptide s receptor 0.0058 0.2393 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0642 0.0992
Schistosoma mansoni hypothetical protein 0.0018 0.0225 0.0942
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.2393 0.3694
Echinococcus multilocularis neuropeptide receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.2282 0.3523
Echinococcus multilocularis neuropeptide receptor A26 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.2393 0.3694
Echinococcus multilocularis serotonin receptor 0.0058 0.2393 1
Brugia malayi neuropeptide F receptor 0.0058 0.2393 0.3694
Schistosoma mansoni amine GPCR 0.0058 0.2393 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0225 0.0348
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.2393 1
Schistosoma mansoni hypothetical protein 0.0058 0.2393 1
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.2393 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni biogenic amine receptor 0.0058 0.2393 1
Schistosoma mansoni biogenic amine receptor 0.0058 0.2393 1
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.2393 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0198 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.2393 0.3694
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.2393 1
Brugia malayi Serotonin receptor 0.0058 0.2393 0.3694
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.2393 0.3694
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.2393 0.3694
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 0.2393 0.3694
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.6478 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Trichomonas vaginalis hypothetical protein 0.0198 1 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi G-protein coupled receptor 0.0058 0.2393 0.3694
Echinococcus multilocularis g protein coupled receptor 0.0058 0.2393 1
Echinococcus granulosus neuropeptide receptor A26 0.0058 0.2393 1
Brugia malayi Dopamine receptor protein 1 0.0058 0.2393 0.3694
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus multilocularis g-protein coupled receptor 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus granulosus GPCR family 2 0.0018 0.0225 0.0942
Brugia malayi Serotonin receptor 0.0058 0.2393 0.3694
Schistosoma mansoni neuropeptide receptor 0.0058 0.2393 1
Schistosoma mansoni adenoreceptor 0.0058 0.2393 1
Echinococcus multilocularis fmrfamide receptor 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 0.2393 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi ORL1-like opioid receptor 0.0058 0.2393 0.3694
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Echinococcus granulosus allatostatin A receptor 0.0058 0.2393 1
Schistosoma mansoni hypothetical protein 0.0018 0.0225 0.0942
Onchocerca volvulus 0.0058 0.2393 1
Brugia malayi RE15519p 0.0058 0.2393 0.3694
Echinococcus multilocularis GPCR, family 2 0.0018 0.0225 0.0942
Echinococcus multilocularis g protein coupled receptor 0.0058 0.2393 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0013 0 0.5
Schistosoma mansoni amine GPCR 0.0058 0.2393 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.2393 1
Brugia malayi GnHR receptor homolog 0.0058 0.2393 0.3694
Plasmodium falciparum enoyl-acyl carrier reductase 0.0198 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus granulosus fmrfamide receptor 0.0058 0.2393 1
Echinococcus granulosus sex peptide receptor 0.0058 0.2393 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.2393 1
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.2393 0.3694
Schistosoma mansoni neuropeptide receptor 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni myosin xvIII 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Schistosoma mansoni neuropeptide receptor 0.0058 0.2393 1
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.2393 1
Trypanosoma brucei pteridine reductase 1 0.0013 0 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 0.2393 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0038 0.133 0.2053
Echinococcus granulosus neuropeptide receptor 0.0058 0.2393 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 0.2393 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.2393 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.2393 1
Brugia malayi neuropeptide F receptor 0.0058 0.2393 0.3694
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 0.2393 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.2393 1
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi follicle stimulating hormone receptor 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.6478 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.2282 0.3523
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0198 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.2393 0.3694
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Echinococcus granulosus somatostatin receptor 0.0058 0.2393 1
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.2393 0.3694
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0225 0.0348
Echinococcus multilocularis neuropeptide receptor 0.0058 0.2393 1
Echinococcus granulosus serotonin receptor 0.0058 0.2393 1
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.2393 0.3694
Brugia malayi AKH receptor 0.0058 0.2393 0.3694
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0642 0.0992
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.2393 1
Echinococcus multilocularis g protein coupled receptor 0.0058 0.2393 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0225 0.0942
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.2393 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Leishmania major oxidoreductase-like protein 0.0013 0 0.5
Onchocerca volvulus 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 0.2393 1
Schistosoma mansoni neuropeptide receptor 0.0058 0.2393 1
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni opsin-like receptor 0.0058 0.2393 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.2393 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0198 1 1
Echinococcus granulosus orexin receptor type 2 0.0058 0.2393 1
Echinococcus multilocularis sex peptide receptor 0.0058 0.2393 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0018 0.0225 0.0348
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.2393 1
Schistosoma mansoni opsin-like receptor 0.0058 0.2393 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0198 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi sulfakinin receptor protein 0.0058 0.2393 0.3694
Schistosoma mansoni amine GPCR 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni hypothetical protein 0.0018 0.0225 0.0942
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni hypothetical protein 0.0058 0.2393 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0225 0.0942
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.2393 1
Schistosoma mansoni opsin-like receptor 0.0058 0.2393 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.2393 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Schistosoma mansoni amine GPCR 0.0058 0.2393 1
Echinococcus multilocularis orexin receptor type 2 0.0058 0.2393 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.2393 1
Echinococcus granulosus g protein coupled receptor 0.0058 0.2393 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.2393 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.2393 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.2393 1
Schistosoma mansoni hypothetical protein 0.0058 0.2393 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.2393 0.3694
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.2393 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi Melatonin receptor type 1A 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0056 0.2282 0.3523
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 0.2393 1
Schistosoma mansoni amine GPCR 0.0058 0.2393 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.2393 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Echinococcus multilocularis allatostatin A receptor 0.0058 0.2393 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.2393 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0225 0.0942
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0058 0.2393 1
Brugia malayi G-protein coupled receptor 0.0058 0.2393 0.3694
Echinococcus multilocularis somatostatin receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis neuropeptide s receptor 0.0058 0.2393 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0058 0.2393 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 0.2393 1
Brugia malayi larval opioid receptor 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.133 0.2053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Schistosoma mansoni biogenic amine receptor 0.0058 0.2393 1
Schistosoma mansoni hypothetical protein 0.0058 0.2393 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.2393 0.3694
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.2393 0.3694
Leishmania major pteridine reductase 1 0.0013 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.2393 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 0.2393 1
Brugia malayi G protein-coupled receptor 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 0.2393 1
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.2393 0.3694
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.2393 0.3694
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0013 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0058 0.2393 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0198 1 1
Echinococcus granulosus g protein coupled receptor 0.0058 0.2393 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2393 1
Brugia malayi Dopamine receptor protein 2 0.0058 0.2393 0.3694
Echinococcus granulosus G protein coupled receptor 139 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi putative neuropeptide receptor 0.0058 0.2393 0.3694
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.2393 0.3694
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 0.2393 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 0.2393 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus multilocularis G protein coupled receptor 139 0.0058 0.2393 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Echinococcus multilocularis serotonin receptor 0.0058 0.2393 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0225 0.0942
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 0.2393 1
Echinococcus multilocularis fmrfamide receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni hypothetical protein 0.0018 0.0225 0.0942
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2393 1
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.2393 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2393 1
Onchocerca volvulus 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Echinococcus granulosus g-protein coupled receptor 0.0058 0.2393 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2393 0.3694
Schistosoma mansoni histamine h1 receptor 0.0058 0.2393 1
Echinococcus granulosus g protein coupled receptor 0.0058 0.2393 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.2282 0.3523
Schistosoma mansoni hypothetical protein 0.0038 0.133 0.5558
Brugia malayi MH2 domain containing protein 0.0133 0.6478 1
Echinococcus granulosus hypothetical protein 0.0058 0.2393 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 0.2393 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0198 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.2393 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.2393 1
Brugia malayi Dopamine receptor 0.0058 0.2393 0.3694
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.2393 0.3694
Trypanosoma brucei oxidoreductase-like protein 0.0013 0 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 0.2393 1
Brugia malayi hypothetical protein 0.0058 0.2393 0.3694
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0225 0.0348

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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