Detailed information for compound 1433216

Basic information

Technical information
  • TDR Targets ID: 1433216
  • Name: 2-(2-methylpropylsulfanyl)-1-(phenylmethyl)-5 ,6-dihydroimidazo[4,5-d]pyridazine-4,7-dione
  • MW: 330.405 | Formula: C16H18N4O2S
  • H donors: 2 H acceptors: 5 LogP: 3.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CSc1nc2c(n1Cc1ccccc1)c(O)nnc2O)C
  • InChi: 1S/C16H18N4O2S/c1-10(2)9-23-16-17-12-13(15(22)19-18-14(12)21)20(16)8-11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3,(H,18,21)(H,19,22)
  • InChiKey: KOPPNJUZEQMEHA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-isobutylsulfanyl-1-(phenylmethyl)-5,6-dihydroimidazo[4,5-d]pyridazine-4,7-dione
  • 2-(isobutylthio)-1-(phenylmethyl)-5,6-dihydroimidazo[4,5-d]pyridazine-4,7-dione
  • 1-(benzyl)-2-(isobutylthio)-5,6-dihydroimidazo[4,5-d]pyridazine-4,7-quinone
  • AM-944/40947879
  • ZINC04631835
  • SMR000113580
  • 1-benzyl-2-(isobutylsulfanyl)-1H-imidazo[4,5-d]pyridazine-4,7-diol
  • MLS000549891

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0061 0.01
Leishmania major alpha glucosidase II subunit, putative 0.0028 0.0049 0.1681
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0108 0.0251 0.3635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0053 0.0303
Echinococcus granulosus GPCR family 2 0.0046 0.0095 0.0279
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0185
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0037 0.0456
Schistosoma mansoni apoferritin-2 0.0017 0.002 0.006
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.001 0.0005 0.0149
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0133 0.0766
Echinococcus granulosus mitogen activated protein kinase 0.0099 0.0228 0.0673
Onchocerca volvulus Huntingtin homolog 0.012 0.0282 0.8386
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0053 0.0305
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0002 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0127 0.0298 0.1717
Loa Loa (eye worm) cysteine protease 0.0032 0.006 0.0346
Giardia lamblia Replication factor C, subunit 1 0.001 0.0002 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.005 0.0286
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0009 0 0.0001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0071 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0053 0.1565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Brugia malayi Cathepsin L-like precursor 0.0032 0.006 0.0347
Leishmania major cathepsin L-like protease 0.0032 0.006 0.2064
Schistosoma mansoni ferritin 0.0017 0.002 0.006
Echinococcus granulosus lamin dm0 0.0106 0.0246 0.0726
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0303
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0013 0.0077
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0037 0.1273
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0025 0.0308
Echinococcus granulosus histone deacetylase 6 0.0039 0.0076 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0053 0.0305
Schistosoma mansoni histone deacetylase 4 5 0.0039 0.0076 0.0225
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0108 0.0251 0.0251
Plasmodium vivax unspecified product 0.0011 0.0005 0.0663
Echinococcus multilocularis lysosomal alpha glucosidase 0.0127 0.0298 0.0297
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0013 0.0039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.0691 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.006 0.006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0185
Brugia malayi hypothetical protein 0.012 0.0282 0.1627
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0008 0.0092
Plasmodium vivax histone deacetylase 2, putative 0.0039 0.0076 1
Trichomonas vaginalis alpha-glucosidase, putative 0.001 0.0005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.01
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0107 0.0107
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0002 0.0067
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0013 0.0077
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0276 0.1589
Leishmania major cathepsin L-like protease 0.0032 0.006 0.2064
Echinococcus granulosus histone deacetylase 6 0.0045 0.0091 0.027
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0025 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0053 0.0156
Brugia malayi ecdysteroid receptor 0.003 0.0053 0.0305
Mycobacterium ulcerans aldehyde dehydrogenase 0.0098 0.0226 0.0379
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0002 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Echinococcus granulosus expressed protein 0.0017 0.002 0.006
Leishmania major cathepsin L-like protease 0.0124 0.0291 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0204 0.0602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Onchocerca volvulus 0.0022 0.0033 0.0978
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0013 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0053 0.0156
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0146
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0121 0.0699
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.0997 0.0997
Trypanosoma cruzi cysteine protease, putative 0.0017 0.002 0.0695
Trichomonas vaginalis alpha-glucosidase, putative 0.001 0.0005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0013 0.0039
Leishmania major cathepsin L-like protease 0.0032 0.006 0.2064
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0018 0.01
Onchocerca volvulus 0.0106 0.0246 0.7301
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.042 0.2423
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Toxoplasma gondii histone deacetylase HDAC1 0.0039 0.0076 0.0129
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.005 0.0727
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0589
Brugia malayi topoisomerase 0.001 0.0002 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.005 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0251 0.3095
Echinococcus multilocularis geminin 0.0492 0.1222 0.1221
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0099 0.0228 0.7831
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.002 0.0031
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.002 0.0695
Onchocerca volvulus 0.0032 0.006 0.1785
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0049 0.0602
Plasmodium falciparum histone deacetylase, putative 0.0039 0.0076 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0053 0.0305
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0002 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0276 0.1589
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Echinococcus multilocularis histone deacetylase 3 0.0012 0.0008 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.013 0.0384
Schistosoma mansoni microtubule-associated protein tau 0.1347 0.3382 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0053 0.0156
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0076 0.2623
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0695
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Giardia lamblia Kinase, CMGC MAPK 0.0099 0.0228 0.3292
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0347 0.1999
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0071 0.2423
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0098 0.0226 0.0355
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.002 0.0031
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0133 0.0764
Echinococcus granulosus mitogen activated protein kinase 3 0.0099 0.0228 0.0673
Schistosoma mansoni patched 1 0.0041 0.0081 0.024
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0015 0.0015 0.0045
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0071 0.0867
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0204 0.1175
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0017 0.0567
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.006 0.2064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0071 0.2423
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0017 0.0095
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0025 0.0308
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0013 0.0039
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0081 0.024
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.006 0.0177
Onchocerca volvulus 0.0106 0.0246 0.7301
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0133 0.0392
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2347 0.5907 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0025 0.0861
Brugia malayi Cathepsin L-like precursor 0.0032 0.006 0.0347
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0081 0.0081
Onchocerca volvulus 0.003 0.0053 0.1565
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0071 0.0867
Echinococcus granulosus ferritin 0.0017 0.002 0.006
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0108 0.0251 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0013 0.0039
Echinococcus multilocularis ferritin 0.0017 0.002 0.002
Echinococcus multilocularis lamin 0.0106 0.0246 0.0245
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.005 0.1729
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Schistosoma mansoni glutaminase 0.033 0.0812 0.2401
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0008 0.0092
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.006 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.001 0.0005 0.0053
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0081 0.024
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Echinococcus granulosus ubiquitin specific protease 41 0.0108 0.0251 0.0743
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0025 0.0074
Onchocerca volvulus Cathepsin L homolog 0.0032 0.006 0.1785
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0291 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0053 0.0156
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0099 0.0228 0.7831
Echinococcus granulosus cathepsin L 0.0017 0.002 0.006
Echinococcus multilocularis expressed conserved protein 0.0089 0.0204 0.0204
Brugia malayi glutaminase DH11.1 0.033 0.0812 0.4684
Trypanosoma brucei histone deacetylase 3 0.0039 0.0076 0.2623
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0053 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.029
Echinococcus multilocularis neutral alpha glucosidase AB 0.0028 0.0049 0.0049
Schistosoma mansoni histone deacetylase 4 5 0.0039 0.0076 0.0225
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.001 0.0005 0.0149
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0279
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0218 0.126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Brugia malayi AMP-binding enzyme family protein 0.0029 0.005 0.0291
Brugia malayi Intermediate filament tail domain containing protein 0.0106 0.0246 0.1416
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0184
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0015 0.0087
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0033 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0204 0.0204
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0071 0.2423
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0053 0.0156
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0 0.0000068911
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0222 0.0656
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0049 0.0602
Trichomonas vaginalis sucrase-isomaltase, putative 0.0028 0.0049 0.0602
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0013 0.0076
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2347 0.5907 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0218 0.0218
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0049 0.0602
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.006 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0053 0.0303
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0025 0.3305
Schistosoma mansoni alpha-glucosidase 0.0109 0.0253 0.0748
Trypanosoma cruzi cruzipain precursor, putative 0.0011 0.0005 0.0174
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0029 0.0021
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0053 0.0156
Echinococcus multilocularis protein dispatched 1 0.0047 0.0096 0.0096
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0012 0.0008 0.0092
Loa Loa (eye worm) histone deacetylase 3 0.0012 0.0008 0.0043
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0018 0.0051
Brugia malayi intermediate filament protein 0.0106 0.0246 0.1416
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Echinococcus granulosus histone deacetylase 8 0.0012 0.0008 0.0022
Leishmania major cathepsin L-like protease 0.0124 0.0291 1
Entamoeba histolytica hypothetical protein 0.001 0.0002 0.0028
Echinococcus granulosus lysosomal alpha glucosidase 0.0127 0.0298 0.088
Leishmania major cathepsin L-like protease 0.0124 0.0291 1
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0053 0.0305
Brugia malayi isocitrate dehydrogenase 0.0015 0.0017 0.0096
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0108 0.0251 0.3095
Schistosoma mansoni nuclear receptor 0.0014 0.0013 0.0039
Schistosoma mansoni topbp1 0.001 0.0002 0.0006
Echinococcus granulosus cysteine protease 0.0017 0.002 0.006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0013 0.0039
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0015 0.0015 0.1976
Schistosoma mansoni aldehyde dehydrogenase 0.0098 0.0226 0.0667
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0053 0.1565
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Schistosoma mansoni aldehyde dehydrogenase 0.0098 0.0226 0.0667
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0015 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0158
Brugia malayi hypothetical protein 0.0695 0.1734 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.002 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.001 0.0005 0.0053
Plasmodium falciparum histone deacetylase 1 0.0012 0.0008 0.0981
Mycobacterium ulcerans aldehyde dehydrogenase 0.0098 0.0226 0.0379
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0455 0.1127 0.6501
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0049 0.0602
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0049 0.0602
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0156 0.0461
Loa Loa (eye worm) DR-78 0.0014 0.0013 0.0076
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0013 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Echinococcus multilocularis microtubule associated protein 2 0.1347 0.3382 0.3381
Loa Loa (eye worm) hypothetical protein 0.0146 0.0347 0.1998
Echinococcus granulosus geminin 0.0492 0.1222 0.3612
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0156 0.0461
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Schistosoma mansoni lamin 0.0106 0.0246 0.0726
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0037 0.0535
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0037 0.0535
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0071 0.0208
Schistosoma mansoni hypothetical protein 0.0142 0.0336 0.0994
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.002 0.0266
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0218 0.3157
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0025 0.0144
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0102 0.0589
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.001 0.0005 0.0063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0025 0.0846
Echinococcus granulosus lamin 0.0106 0.0246 0.0726
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0108 0.0251 0.8646
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0025 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0114 0.0192
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Brugia malayi nuclear receptor NHR-88 0.003 0.0053 0.0305
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0071 0.0116
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0017 0.0567
Loa Loa (eye worm) hypothetical protein 0.012 0.0282 0.1626
Brugia malayi hypothetical protein 0.001 0.0002 0.0012
Brugia malayi nuclear receptor RXR 0.0016 0.0018 0.0101
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0108 0.0251 0.0743
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0133 0.0392
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0053 0.0305
Schistosoma mansoni ferritin 0.0017 0.002 0.006
Schistosoma mansoni histone deacetylase 1 2 3 0.0012 0.0008 0.0022
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0071 0.007
Brugia malayi hypothetical protein 0.007 0.0156 0.0901
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0017 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0053 0.0156
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0015 0.0087
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0002 0.0024
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0071 0.1019
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0013 0.0039
Echinococcus granulosus cpg binding protein 0.003 0.0054 0.0158
Brugia malayi conserved hypotetical protein 0.0014 0.0013 0.0077
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.001 0.0005 0.0129
Trypanosoma brucei unspecified product 0.0019 0.0025 0.0861
Giardia lamblia Histone deacetylase 0.0012 0.0008 0.0108
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.006 0.006
Trypanosoma cruzi cruzipain precursor, putative 0.0124 0.0291 1
Echinococcus multilocularis survival motor neuron protein 1 0.0695 0.1734 0.1733
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0029 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0053 0.0305
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Brugia malayi RNA binding protein 0.0061 0.0133 0.0766
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0013 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0018 0.0101
Loa Loa (eye worm) intermediate filament protein 0.0106 0.0246 0.1415
Brugia malayi follicle stimulating hormone receptor 0.0455 0.1127 0.6501
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Loa Loa (eye worm) hypothetical protein 0.0022 0.0033 0.019
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0061 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0291 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.006 0.7871
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0017 0.0567
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0043
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0037 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.0861
Loa Loa (eye worm) histone deacetylase 1 0.0012 0.0008 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0029 0.0021
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0013 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0146
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0012 0.0008 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0358
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0095 0.0545
Brugia malayi hypothetical protein 0.0014 0.0013 0.0077
Brugia malayi steroid hormone receptor 0.003 0.0053 0.0305
Trichomonas vaginalis ferritin, putative 0.0017 0.002 0.025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0053 0.0305
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0015 0.0015 0.0518
Loa Loa (eye worm) hypothetical protein 0.0022 0.0033 0.019
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.002 0.0695
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0025 0.0861
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0408 0.5024
Trypanosoma brucei histone deacetylase 2 0.0012 0.0008 0.0257
Toxoplasma gondii histone deacetylase HDAC4 0.0012 0.0008 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0291 1
Schistosoma mansoni ferritin 0.0017 0.002 0.006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.006 0.7871
Brugia malayi Histone deacetylase 1 0.0012 0.0008 0.0044
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Schistosoma mansoni hypothetical protein 0.0492 0.1222 0.3612
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.006 0.0347
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0053 0.0053
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0017 0.0567
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0053 0.0156
Brugia malayi cathepsin L-like precursor 0.0022 0.0033 0.0191
Onchocerca volvulus Cathepsin F homolog 0.0032 0.006 0.1785
Brugia malayi AMP-binding enzyme family protein 0.0029 0.005 0.0291
Echinococcus multilocularis cpg binding protein 0.003 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0033 0.0405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0025 0.0846
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0049 0.1681
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0133 0.0764
Brugia malayi MH2 domain containing protein 0.0118 0.0276 0.159
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2347 0.5907 1
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.006 0.0868
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0053 0.0303
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0015 0.0015 0.0025
Leishmania major DNA polymerase eta, putative 0.0019 0.0025 0.0861
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0005 0.003
Echinococcus multilocularis musashi 0.0106 0.0246 0.0245
Schistosoma mansoni alpha glucosidase 0.0028 0.0049 0.0144
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.006 0.006
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.006 0.0177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.006 0.0177
Echinococcus granulosus dna polymerase eta 0.0019 0.0025 0.0074
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0279
Echinococcus granulosus nibrin 0.001 0.0002 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0204 0.0602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0002 0.0257
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0013 0.0039
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.005 0.0082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0025 0.0142
Trypanosoma brucei glucosidase, putative 0.0028 0.0049 0.1681
Brugia malayi ecdysone receptor 0.0014 0.0013 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Entamoeba histolytica hypothetical protein 0.007 0.0156 0.2256
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0017 0.0567
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0228 0.2803
Echinococcus granulosus intermediate filament protein 0.0106 0.0246 0.0726
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0037 0.0215
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0292
Toxoplasma gondii histone deacetylase HDAC2 0.0012 0.0008 0.0013
Trypanosoma brucei glycosyl hydrolase-like protein 0.001 0.0005 0.0149
Loa Loa (eye worm) RNA binding protein 0.0061 0.0133 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Brugia malayi hypothetical protein 0.0009 0 0.0001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0127 0.0298 0.1716
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0032 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0053 0.0305
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0467
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.005 0.0082
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0037 0.0215
Leishmania major cathepsin L-like protease 0.0032 0.006 0.2064
Onchocerca volvulus Huntingtin homolog 0.012 0.0282 0.8386
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.005 0.1729
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0018 0.0017
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.006 0.7871
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Plasmodium vivax unspecified product 0.0017 0.002 0.265
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0224 0.0662
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0015 0.0015 0.0045
Schistosoma mansoni hypothetical protein 0.0492 0.1222 0.3612
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0053 0.0303
Brugia malayi Glycosyl hydrolases family 31 protein 0.001 0.0005 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0081 0.0998
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0002 0.0067
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.3224
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0098 0.0226 0.7765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Echinococcus multilocularis expressed protein 0.0017 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0269
Plasmodium vivax histone deacetylase 1, putative 0.0012 0.0008 0.0981
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0053 0.0305
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0846
Onchocerca volvulus 0.001 0.0002 0.0058
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0108 0.0251 0.0743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Entamoeba histolytica histone deacetylase, putative 0.0012 0.0008 0.0108
Schistosoma mansoni nuclear hormone receptor 0.003 0.0053 0.0156
Echinococcus granulosus tumor protein p63 0.0665 0.1658 0.4903
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0032 0.0026
Echinococcus granulosus neuropeptide s receptor 0.0459 0.1138 0.3366
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0133 0.0392
Brugia malayi nuclear hormone receptor 0.003 0.0053 0.0305
Trypanosoma brucei protein kinase, putative 0.0099 0.0228 0.7831
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.006
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0015 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0002 0.0067
Brugia malayi Histone deacetylase family protein 0.0039 0.0076 0.0441
Echinococcus multilocularis histone deacetylase 0.0039 0.0076 0.0076
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0015 0.0015 0.0015
Onchocerca volvulus 0.0032 0.006 0.1785
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0033 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Echinococcus multilocularis histone deacetylase 6 0.0045 0.0091 0.0091
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0358
Schistosoma mansoni histone deacetylase hda2 0.0012 0.0008 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0292
Echinococcus multilocularis histone deacetylase 1 0.0012 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.012 0.0282 0.1626
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0053 0.0305
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.002 0.006
Loa Loa (eye worm) histone deacetylase 0.0039 0.0076 0.044
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.01
Echinococcus multilocularis cysteine protease 0.0032 0.006 0.006
Giardia lamblia Hypothetical protein 0.0015 0.0015 0.0218
Loa Loa (eye worm) fibroinase 0.0032 0.006 0.0346
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Loa Loa (eye worm) histone deacetylase 7A 0.0039 0.0076 0.044
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0099 0.0228 0.7831
Brugia malayi Cathepsin L-like precursor 0.0032 0.006 0.0347
Leishmania major histone deacetylase, putative 0.0039 0.0076 0.2623
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0013 0.0077
Trypanosoma brucei histone deacetylase 1 0.0012 0.0008 0.0257
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0158
Schistosoma mansoni cpg binding protein 0.0028 0.005 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0053 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0024
Plasmodium vivax vivapain-1 0.0017 0.002 0.265
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0049 0.0283
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0108 0.0251 0.8646
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.006 0.0177
Brugia malayi MAP kinase sur-1 0.0099 0.0228 0.1314
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0028 0.0049 0.0083
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0024
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0015 0.0015 0.1976
Schistosoma mansoni ferritin light chain 0.0017 0.002 0.006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0204 0.1176
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0218 0.0645
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.029
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.005 0.0082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0098 0.0226 0.0667
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.002 0.0292
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0053 0.0305
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.005 0.0727
Plasmodium vivax histone deacetylase, putative 0.0039 0.0076 1
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0008 0.0092
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0015 0.0045
Loa Loa (eye worm) inositol-1 0.0037 0.0071 0.0406
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0347 0.1999
Brugia malayi ubiquitin specific protease 14 0.0009 0 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.005 0.0082
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0018 0.0051
Loa Loa (eye worm) glutaminase 2 0.033 0.0812 0.4683
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0185
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0037 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0024
Echinococcus multilocularis cathepsin L 0.0017 0.002 0.002
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.002 0.2677
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0037 0.0063
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0025 0.0074
Toxoplasma gondii pantoate-beta-alanine ligase 0.2347 0.5907 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0033 0.0405
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0016
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0049 0.0602
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0015 0.0088
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0076 0.2623
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0015 0.0015 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0018 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0024
Echinococcus granulosus survival motor neuron protein 1 0.0695 0.1734 0.5126
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0321 0.095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0053 0.0303
Onchocerca volvulus 0.0032 0.006 0.1785
Brugia malayi Histone deacetylase family protein 0.0039 0.0076 0.0441
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0097 0.0224 0.1291
Brugia malayi Cathepsin L-like precursor 0.0022 0.0033 0.0191
Trichomonas vaginalis chaperonin, putative 0.0023 0.0037 0.0456
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0002 0.0067
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0017 0.2163
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0142 0.0336 0.1939
Plasmodium vivax vivapain-2 0.0032 0.006 0.7871
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0017 0.2163
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0025 0.0362
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0204 0.0602
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0049
Toxoplasma gondii exonuclease III APE 0.0018 0.0025 0.0042
Schistosoma mansoni ferritin 0.0017 0.002 0.006
Onchocerca volvulus 0.0014 0.0013 0.0391
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.002 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0228 0.2803
Brugia malayi DKFZp564C0469 protein 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0029
Onchocerca volvulus Cathepsin L homolog 0.0032 0.006 0.1785
Echinococcus multilocularis histone deacetylase 8 0.0012 0.0008 0.0007
Brugia malayi CHE-14 protein 0.0041 0.0081 0.0469
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0037 0.0109
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0032 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0224 0.7697
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0053 0.0156
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0024
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0012 0.0008 0.0092
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0049 0.0602
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.1138 0.1138
Brugia malayi Cathepsin L-like precursor 0.0022 0.0033 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0053 0.0305
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0037 0.4855
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.029
Onchocerca volvulus 0.0142 0.0336 1
Onchocerca volvulus 0.0028 0.005 0.1473
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.0861
Schistosoma mansoni topbp1 0.001 0.0002 0.0006
Brugia malayi Cathepsin L-like precursor 0.0032 0.006 0.0347
Leishmania major histone deacetylase, putative 0.0012 0.0008 0.0257
Brugia malayi CXXC zinc finger family protein 0.0028 0.005 0.0287
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.005 0.0082
Onchocerca volvulus Histone deacetylase 10 homolog 0.0012 0.0008 0.0222
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0108 0.0251 0.0743
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.005 0.0082
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.023 0.1326
Brugia malayi hypothetical protein 0.0016 0.0018 0.0101
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.1138 0.1138
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Echinococcus multilocularis dna polymerase eta 0.0019 0.0025 0.0025
Echinococcus granulosus histone deacetylase 0.0039 0.0076 0.0225
Echinococcus multilocularis cysteine protease 0.0032 0.006 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.005 0.1729
Echinococcus granulosus FTZ F1 alpha 0.003 0.0053 0.0156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0303
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0053 0.0156
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.1138 0.3366
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0156 0.0156
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.002 0.0695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0695
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0049 0.1681
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0015 0.0015 0.1976
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0032 0.4195
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.01 0.023 0.1325
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0025 0.0861
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0013 0.0391
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0071 0.2423
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0011
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0107 0.0316
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0017 0.0028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0013 0.0391
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0053 0.0156
Loa Loa (eye worm) ctsf protein 0.0032 0.006 0.0346
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0037 0.0213
Loa Loa (eye worm) hypothetical protein 0.0095 0.0218 0.1259
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0015 0.0015 0.1976
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0008 0.0092
Echinococcus granulosus histone deacetylase 6 0.0039 0.0076 0.0225
Schistosoma mansoni coup transcription factor 0.003 0.0053 0.0156
Echinococcus multilocularis lysosomal alpha glucosidase 0.0127 0.0298 0.0297
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0071 0.0867
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0015 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0018 0.0051
Echinococcus granulosus cathepsin l1 0.0022 0.0033 0.0097
Brugia malayi histone deacetylase 3 (HD3) 0.0012 0.0008 0.0044
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0037 0.4855
Mycobacterium ulcerans hypothetical protein 0.0029 0.005 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0204 0.0602
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Echinococcus granulosus neutral alpha glucosidase AB 0.0028 0.0049 0.0144
Schistosoma mansoni zinc finger protein 0.0014 0.0013 0.0039
Toxoplasma gondii aldehyde dehydrogenase 0.0098 0.0226 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0204 0.0602
Schistosoma mansoni hypothetical protein 0.007 0.0156 0.0461
Schistosoma mansoni peptidase 0.001 0.0002 0.0007
Onchocerca volvulus 0.0032 0.006 0.1785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0204 0.0204
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0104 0.0241 0.1387
Brugia malayi hypothetical protein 0.0016 0.0018 0.0101
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.005 0.0082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0053 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.006 0.0346
Echinococcus granulosus cathepsin l1 0.0032 0.006 0.0177
Plasmodium falciparum histone deacetylase 2 0.0039 0.0076 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.0691 1
Echinococcus multilocularis lamin dm0 0.0106 0.0246 0.0245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Schistosoma mansoni histone deacetylase hda2 0.0045 0.0091 0.027
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0108 0.0251 0.145
Echinococcus multilocularis nibrin 0.001 0.0002 0.0002
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0015 0.0015 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.006 0.0739
Mycobacterium ulcerans glutaminase 0.033 0.0812 0.1371
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Schistosoma mansoni lamin 0.0106 0.0246 0.0726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Loa Loa (eye worm) hypothetical protein 0.0106 0.0246 0.1415
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0229
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0846
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.005 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0011
Schistosoma mansoni inositol monophosphatase 0.0037 0.0071 0.0208
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0053 0.0156
Loa Loa (eye worm) hypothetical protein 0.0108 0.0251 0.1449
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.0264 0.9066
Leishmania major cysteine peptidase A (CPA) 0.0032 0.006 0.2064
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0013 0.0013
Brugia malayi nuclear receptor NHR-88 0.0014 0.0013 0.0077
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.0003
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0002 0.0012
Trypanosoma brucei histone deacetylase, putative 0.0039 0.0076 0.2623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0099 0.0228 0.7831
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0015 0.0015 0.0218
Entamoeba histolytica hypothetical protein 0.007 0.0156 0.2256
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0025 0.0073
Schistosoma mansoni DNA polymerase eta 0.0019 0.0025 0.0074
Trichomonas vaginalis glutaminase, putative 0.033 0.0812 1
Schistosoma mansoni nuclear receptor 0.0014 0.0013 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0095 0.0279
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0017 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0053 0.0053
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0099 0.0228 0.7831
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0008 0.0092
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0095 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0133 0.0392
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0015 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Echinococcus granulosus dna polymerase kappa 0.0019 0.0025 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0053 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0005 0.003
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Schistosoma mansoni cathepsin s 0.0011 0.0005 0.0015
Schistosoma mansoni thyroid hormone receptor 0.003 0.0053 0.0156
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0002 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0053 0.0305
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0327 0.0526
Loa Loa (eye worm) hypothetical protein 0.0022 0.0033 0.019
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0037 0.0109
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.005 0.0057
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0013 0.0076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0013 0.0039
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0099 0.0228 0.1313
Entamoeba histolytica cysteine proteinase 2 0.0017 0.002 0.0292
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0108 0.0251 0.8646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Leishmania major glycosyl hydrolase-like protein 0.001 0.0005 0.0149
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0053 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0013 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0025 0.0014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0005 0.0029
Echinococcus granulosus replication factor c subunit 1 0.001 0.0002 0.0006
Toxoplasma gondii cathepsin CPL 0.0032 0.006 0.0102
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0025 0.0038
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0053 0.0053
Leishmania major histone deacetylase, putative 0.0039 0.0076 0.2623
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0037 0.1273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.005 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Brugia malayi nuclear hormone receptor 0.0014 0.0013 0.0077
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0033 0.0475
Loa Loa (eye worm) hypothetical protein 0.0695 0.1734 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.006
Schistosoma mansoni alpha-glucosidase 0.0109 0.0253 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0099 0.0228 0.7831
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0228 0.0673
Onchocerca volvulus 0.0014 0.0013 0.0391
Echinococcus multilocularis mitogen activated protein kinase 3 0.0099 0.0228 0.0228
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0053 0.0303
Echinococcus granulosus expressed conserved protein 0.0089 0.0204 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0013 0.0077
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0081 0.0467
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.001 0.0005 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0025
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0291 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0108 0.0251 0.8646
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.006 0.006
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.0691 1
Trypanosoma brucei unspecified product 0.0013 0.0011 0.0358
Schistosoma mansoni hypothetical protein 0.0046 0.0095 0.0279
Loa Loa (eye worm) hypothetical protein 0.0175 0.042 0.2422
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Plasmodium vivax vivapain-3 0.0017 0.002 0.265
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0008 0.0257
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0076 0.0076
Brugia malayi histone deacetylase 11 0.0012 0.0008 0.0044
Trypanosoma brucei histone deacetylase 4 0.0039 0.0076 0.2623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0053 0.0303
Echinococcus multilocularis mitogen activated protein kinase 0.0099 0.0228 0.0228
Echinococcus multilocularis tumor protein p63 0.0665 0.1658 0.1658
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0695
Brugia malayi Inositol-1 0.0037 0.0071 0.0407
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0025 0.0356
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0025 0.0039
Schistosoma mansoni thyroid hormone receptor 0.003 0.0053 0.0156
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0049 0.0707
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0108 0.0251 0.0743
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0185
Giardia lamblia DINP protein human, muc B family 0.0019 0.0025 0.0362
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0691 0.8514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0249
Onchocerca volvulus 0.0029 0.005 0.1495
Brugia malayi Cathepsin L-like precursor 0.0032 0.006 0.0347
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.002 0.265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0095 0.0279
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0028 0.0049 0.0282
Echinococcus granulosus dnaJ subfamily B 0.0403 0.0997 0.2949
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0053 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Brugia malayi hypothetical protein 0.0014 0.0013 0.0077
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0121 0.07
Echinococcus granulosus histone deacetylase 1 0.0012 0.0008 0.0022
Entamoeba histolytica cysteine protease, putative 0.0032 0.006 0.0868
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0228 0.2803
Echinococcus granulosus histone deacetylase 7 0.0039 0.0076 0.0225
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0229
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0008 0.0257
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Schistosoma mansoni histone deacetylase 0.0012 0.0008 0.0022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0053 0.1565
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0049 0.0707
Brugia malayi TAR-binding protein 0.0061 0.0133 0.0766
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0099 0.0228 0.7831
Onchocerca volvulus 0.0073 0.0163 0.4844
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0025 0.0861
Leishmania major cathepsin L-like protease 0.0032 0.006 0.2064
Echinococcus multilocularis protein patched 0.0041 0.0081 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Leishmania major histone deacetylase, putative 0.0012 0.0008 0.0257
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.005 0.0291
Onchocerca volvulus 0.0032 0.006 0.1785
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0002 0.0067
Leishmania major DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0358
Loa Loa (eye worm) hypothetical protein 0.0046 0.0095 0.0545
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0327 0.0549
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0008 0.0092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0053 0.0053
Schistosoma mansoni DNA ligase IV 0.001 0.0002 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0108 0.0251 0.3095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0095 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0347 0.1998
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.3224
Trypanosoma cruzi histone deacetylase 1, putative 0.0012 0.0008 0.0257
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0095 0.0094
Brugia malayi nuclear receptor RXR 0.0014 0.0013 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0106 0.0246 0.1415
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0013 0.0013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0015 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0015 0.0087
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0015 0.0015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0025 0.0328
Mycobacterium ulcerans aldehyde dehydrogenase 0.0098 0.0226 0.0379
Echinococcus multilocularis histone deacetylase 7 0.0039 0.0076 0.0076
Toxoplasma gondii histone deacetylase HDAC3 0.0012 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0184
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0029
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Brugia malayi nuclear receptor NHR-67 0.0014 0.0013 0.0077
Brugia malayi histone deacetylase 1 (HD1) 0.0012 0.0008 0.0044
Echinococcus multilocularis GPCR, family 2 0.0046 0.0095 0.0094
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0053 0.0156
Brugia malayi Cathepsin L-like precursor 0.0032 0.006 0.0347
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0002 0.0257
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0053 0.0156
Schistosoma mansoni hypothetical protein 0.01 0.023 0.0679
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0099 0.0228 0.0385
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0303
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0095 0.0546
Trypanosoma cruzi histone deacetylase 1, putative 0.0012 0.0008 0.0257
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0108 0.0251 0.3635
Schistosoma mansoni ferritin light chain 0.0017 0.002 0.006
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0017 0.0096
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0071 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0005 0.0174
Loa Loa (eye worm) histone deacetylase 11 0.0012 0.0008 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.006 0.0739
Schistosoma mansoni inositol monophosphatase 0.0037 0.0071 0.0208
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0144
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0025 0.0356
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0076 0.2623
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.01
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.0356
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0015 0.0015 0.0218
Schistosoma mansoni apoferritin-2 0.0017 0.002 0.006
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0015 0.0015 0.0087
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0015 0.0015 0.0025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0327 0.0549
Plasmodium vivax vivapain-2 0.0032 0.006 0.7871
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0025 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.006 0.0739
Loa Loa (eye worm) hypothetical protein 0.005 0.0104 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0053 0.0305
Schistosoma mansoni histone deacetylase 0.0012 0.0008 0.0022
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.0691 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0133 0.0392
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0098 0.0226 0.0226
Echinococcus granulosus microtubule associated protein 2 0.1347 0.3382 1
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0037 0.1273
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0049 0.0602
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0025 0.0074
Schistosoma mansoni intermediate filament proteins 0.0106 0.0246 0.0726
Brugia malayi tailless protein 0.0014 0.0013 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.001 0.0005 0.0053
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0229
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0321 0.0321
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0015 0.0518
Trichomonas vaginalis maltase-glucoamylase, putative 0.001 0.0005 0.0053
Onchocerca volvulus 0.0097 0.0224 0.6661
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.005 0.0082
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.006 0.0739
Toxoplasma gondii histone deacetylase HDAC5 0.0012 0.0008 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0025 0.0014
Loa Loa (eye worm) glutaminase 0.033 0.0812 0.4683
Trypanosoma brucei unspecified product 0.0013 0.0011 0.0358
Entamoeba histolytica hypothetical protein 0.007 0.0156 0.2256
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292
Entamoeba histolytica hypothetical protein 0.007 0.0156 0.2256
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.001 0.0005 0.0053
Plasmodium vivax histone deacetylase, putative 0.0012 0.0008 0.0981
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0013 0.0077
Echinococcus multilocularis ubiquitin specific protease 41 0.0108 0.0251 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0029 0.0021
Onchocerca volvulus 0.0032 0.006 0.1785
Echinococcus granulosus histone deacetylase 3 0.0012 0.0008 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0053 0.0156
Echinococcus granulosus tar DNA binding protein 0.0061 0.0133 0.0392
Schistosoma mansoni hypothetical protein 0.0403 0.0997 0.2949
Onchocerca volvulus 0.0032 0.006 0.1785
Schistosoma mansoni survival motor neuron protein 0.0142 0.0336 0.0994
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0292
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0025 0.0014
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0032 0.4195
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0617
Brugia malayi hypothetical protein 0.001 0.0002 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0228 0.2803
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0292

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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