Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0119 | 0.081 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1722 | 0.2434 |
Echinococcus multilocularis | neuroligin | 0.0119 | 0.081 | 0.081 |
Onchocerca volvulus | 0.0119 | 0.081 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0119 | 0.081 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0706 | 0.7077 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0119 | 0.081 | 0.081 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0119 | 0.081 | 0.1144 |
Onchocerca volvulus | 0.0119 | 0.081 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0119 | 0.081 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0706 | 0.7077 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0706 | 0.7077 | 0.7077 |
Echinococcus multilocularis | acetylcholinesterase | 0.0706 | 0.7077 | 0.7077 |
Schistosoma mansoni | acetylcholinesterase | 0.0119 | 0.081 | 0.1144 |
Onchocerca volvulus | 0.0119 | 0.081 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.1722 | 0.2434 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0119 | 0.081 | 0.1144 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0119 | 0.081 | 0.1144 |
Onchocerca volvulus | 0.0119 | 0.081 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0119 | 0.081 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0119 | 0.081 | 0.1144 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0119 | 0.081 | 0.1144 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0119 | 0.081 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0706 | 0.7077 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0119 | 0.081 | 0.081 |
Loa Loa (eye worm) | carboxylesterase | 0.0706 | 0.7077 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0119 | 0.081 | 0.1144 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0119 | 0.081 | 0.1144 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0119 | 0.081 | 0.081 |
Echinococcus granulosus | neuroligin | 0.0119 | 0.081 | 0.1144 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1722 | 0.2434 |
Echinococcus granulosus | acetylcholinesterase | 0.0706 | 0.7077 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0119 | 0.081 | 0.1144 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1722 | 0.1722 |
Brugia malayi | hypothetical protein | 0.0119 | 0.081 | 0.1144 |
Brugia malayi | Carboxylesterase family protein | 0.0119 | 0.081 | 0.1144 |
Loa Loa (eye worm) | hypothetical protein | 0.0706 | 0.7077 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0119 | 0.081 | 0.1144 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0119 | 0.081 | 0.1144 |
Brugia malayi | Carboxylesterase family protein | 0.0119 | 0.081 | 0.1144 |
Schistosoma mansoni | gliotactin | 0.0119 | 0.081 | 0.1144 |
Onchocerca volvulus | 0.0119 | 0.081 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0706 | 0.7077 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0119 | 0.081 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0706 | 0.7077 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0706 | 0.7077 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0706 | 0.7077 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0706 | 0.7077 | 0.7077 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.3115 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 2.9093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.