Detailed information for compound 1433796

Basic information

Technical information
  • TDR Targets ID: 1433796
  • Name: 3-(4-morpholin-4-yldiazenylphenyl)sulfonyl-1, 3-thiazolidine-2-carboxylic acid
  • MW: 386.447 | Formula: C14H18N4O5S2
  • H donors: 1 H acceptors: 4 LogP: 1.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1SCCN1S(=O)(=O)c1ccc(cc1)N=NN1CCOCC1
  • InChi: 1S/C14H18N4O5S2/c19-14(20)13-18(7-10-24-13)25(21,22)12-3-1-11(2-4-12)15-16-17-5-8-23-9-6-17/h1-4,13H,5-10H2,(H,19,20)
  • InChiKey: LUFWANKMKMLTFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-morpholinoazophenyl)sulfonylthiazolidine-2-carboxylic acid
  • 3-(4-morpholinoazophenyl)sulfonyl-2-thiazolidinecarboxylic acid
  • MLS000713638
  • SMR000273119
  • 3-[4-(Morpholin-4-ylazo)-benzenesulfonyl]-thiazolidine-2-carboxylic acid
  • BAS 00608605
  • Oprea1_554254
  • Oprea1_619204
  • STOCK1S-27455

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax protein kinase, putative 0.0043 0.4022 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Schistosoma mansoni tensin-related 0.0027 0.0649 0.0649
Echinococcus granulosus c src tyrosine kinase 0.007 0.933 0.933
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.933 0.933
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi Tensin 0.0027 0.0649 0.0696
Schistosoma mansoni tyrosine protein kinase 0.0043 0.4022 0.4022
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Echinococcus granulosus NCK adaptor protein 0.0027 0.0649 0.0649
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine kinase 0.007 0.933 0.933
Echinococcus granulosus tyrosine protein kinase HCK 0.0043 0.4022 0.4022
Brugia malayi Sex muscle abnormal protein 5 0.0027 0.0649 0.0696
Loa Loa (eye worm) serine/threonine protein kinase 0.0043 0.4022 0.4311
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Echinococcus granulosus protein kinase 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0027 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi RhoGAP domain containing protein 0.0027 0.0649 0.0696
Schistosoma mansoni ephrin receptor 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.007 0.933 0.933
Loa Loa (eye worm) TK/ALK protein kinase 0.0043 0.4022 0.4311
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0027 0.0649 0.0649
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.007 0.933 0.933
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.4022 0.4022
Echinococcus granulosus suppressor of cytokine signaling 6 0.0027 0.0649 0.0649
Schistosoma mansoni aldehyde dehydrogenase 0.0073 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0027 0.0649 0.0649
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Brugia malayi hypothetical protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0043 0.4022 0.4311
Echinococcus granulosus tyrosine protein kinase shark 0.007 0.933 0.933
Echinococcus granulosus tyrosine protein kinase Src42A 0.0027 0.0649 0.0649
Echinococcus granulosus tyrosine kinase 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni growth factor receptor-bound protein 0.0027 0.0649 0.0649
Onchocerca volvulus 0.0043 0.4022 0.3885
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0043 0.4022 0.4022
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Brugia malayi Tyrosine-protein kinase PR2 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Onchocerca volvulus 0.0043 0.4022 0.3885
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni tensin 0.0027 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis protein KINase family member (kin 25) 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine kinase 0.007 0.933 0.933
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0027 0.0649 0.0649
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis tyrosine protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni adapter molecule crk 0.0027 0.0649 0.0649
Schistosoma mansoni tensin-related 0.0027 0.0649 0.0649
Schistosoma mansoni hypothetical protein 0.0027 0.0649 0.0649
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Trypanosoma brucei protein kinase, putative 0.0043 0.4022 1
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0043 0.4022 0.4022
Echinococcus multilocularis tensin 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Onchocerca volvulus 0.0043 0.4022 0.3885
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Entamoeba histolytica ankyrin repeat protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine kinase 0.007 0.933 0.933
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0027 0.0649 0.0696
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.007 0.933 0.933
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Schistosoma mansoni serine/threonine RGC 0.0043 0.4022 0.4022
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Echinococcus granulosus SH2 domain containing adapter protein F 0.0027 0.0649 0.0649
Echinococcus granulosus insulin receptor 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0043 0.4022 0.3885
Echinococcus granulosus kinase suppressor of Ras 1 0.0043 0.4022 0.4022
Brugia malayi SRC-1 0.007 0.933 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/FAK protein kinase 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis protein kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0649 0.0649
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Echinococcus granulosus activated cdc42 kinase 1 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/INSR protein kinase 0.0043 0.4022 0.4311
Brugia malayi bone morphogenetic protein type 1 receptor 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.007 0.933 0.933
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein kinase Src42A 0.007 0.933 0.933
Echinococcus multilocularis tyrosine protein kinase pr2 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein kinase HCK 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/DDR protein kinase 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.007 0.933 0.933
Echinococcus multilocularis SH2 motif 0.0027 0.0649 0.0649
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Echinococcus granulosus ephrin type A receptor 4 A 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.007 0.933 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.4022 0.4022
Echinococcus multilocularis growth factor receptor bound protein 2 0.0027 0.0649 0.0649
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis SHC transforming protein 3 0.0027 0.0649 0.0649
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0043 0.4022 0.4022
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Schistosoma mansoni shc transforming protein 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK/ROR protein kinase 0.0043 0.4022 0.4311
Echinococcus granulosus epidermal growth factor receptor 0.0043 0.4022 0.4022
Echinococcus granulosus SH2 domain containing protein 7 0.0027 0.0649 0.0649
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis protein kinase atn1, putative 0.0043 0.4022 1
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.4022 1
Giardia lamblia Kinase 0.0043 0.4022 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0043 0.4022 0.4022
Trypanosoma cruzi protein kinase, putative 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus granulosus N chimaerin 0.0027 0.0649 0.0649
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0027 0.0649 0.0649
Brugia malayi SH2 domain containing protein 0.007 0.933 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) TK/ACK protein kinase 0.0043 0.4022 0.4311
Onchocerca volvulus 0.0043 0.4022 0.3885
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis protein tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0043 0.4022 0.4022
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus granulosus tyrosine protein kinase 0.0043 0.4022 0.4022
Brugia malayi ephrin receptor 1 precursor 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase shark 0.007 0.933 0.933
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.007 0.933 0.933
Onchocerca volvulus Tyrosine kinase homolog 0.0043 0.4022 0.3885
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.007 0.933 0.933
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0043 0.4022 0.4311
Brugia malayi Protein kinase domain containing protein 0.007 0.933 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0043 0.4022 0.5
Echinococcus granulosus SH2 motif 0.0027 0.0649 0.0649
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0043 0.4022 1
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0043 0.4022 0.4022
Echinococcus granulosus integrin linked protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Echinococcus granulosus fibroblast growth factor receptor 4 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.007 0.933 0.933
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0043 0.4022 0.4022
Echinococcus granulosus activated cdc42 kinase 1 0.0043 0.4022 0.4022
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0649 0.0649
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Echinococcus multilocularis SH2 motif 0.0027 0.0649 0.0649
Echinococcus granulosus tyrosine protein kinase csk 0.0043 0.4022 0.4022
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0027 0.0649 0.0696
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Leishmania major protein kinase, putative 0.0043 0.4022 0.4022
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0027 0.0649 0.0649
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus granulosus receptor type guanylyl cyclase 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein kinase Src64B 0.007 0.933 0.933
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Schistosoma mansoni suppressor of cytokine signaling 0.0027 0.0649 0.0649
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.4022 0.4311
Onchocerca volvulus 0.0043 0.4022 0.3885
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0649 0.0696
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Schistosoma mansoni hypothetical protein 0.0027 0.0649 0.0649
Schistosoma mansoni SH2A 0.0027 0.0649 0.0649
Echinococcus multilocularis signal transduction protein lnk realted 0.0027 0.0649 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Echinococcus granulosus epidermal growth factor receptor 0.0043 0.4022 0.4022
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Echinococcus granulosus tyrosine protein kinase Blk 0.007 0.933 0.933
Schistosoma mansoni signal transduction protein lnk-related 0.0027 0.0649 0.0649
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Srms 0.007 0.933 0.933
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis protein kinase 0.0043 0.4022 0.4022
Plasmodium falciparum protein kinase, putative 0.0043 0.4022 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.933 0.933
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/EGFR protein kinase 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.007 0.933 0.933
Schistosoma mansoni suppressor of cytokine signaling 0.0027 0.0649 0.0649
Schistosoma mansoni hypothetical protein 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0043 0.4022 0.4022
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0027 0.0649 0.0649
Brugia malayi Protein kinase domain containing protein 0.007 0.933 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus granulosus tyrosine kinase 0.007 0.933 0.933
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0043 0.4022 0.4022
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0027 0.0649 0.0649
Echinococcus granulosus protein tyrosine kinase 0.0043 0.4022 0.4022
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Echinococcus granulosus SHC transforming protein 3 0.0027 0.0649 0.0649
Echinococcus granulosus growth factor receptor bound protein 2 0.0027 0.0649 0.0649
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 1 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis kinase suppressor of Ras 1 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK protein kinase 0.007 0.933 1
Brugia malayi Guanylyl cyclase protein 23 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni growth factor receptor-bound protein 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Plasmodium falciparum protein kinase, putative 0.0043 0.4022 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis epidermal growth factor receptor 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0043 0.4022 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.4022 0.4022
Echinococcus multilocularis N chimaerin 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0027 0.0649 0.0649
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.4022 0.4022
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0043 0.4022 0.3885
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0043 0.4022 0.4311
Brugia malayi hypothetical protein 0.0027 0.0649 0.0696
Echinococcus multilocularis integrin linked protein kinase 0.0043 0.4022 0.4022
Trypanosoma brucei Flagellum attachment zone protein 20 0.0043 0.4022 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0043 0.4022 1
Echinococcus granulosus tensin 0.0027 0.0649 0.0649
Brugia malayi tRNA modification GTPase TrmE family protein 0.0027 0.0649 0.0696
Plasmodium falciparum tyrosine kinase-like protein 0.0043 0.4022 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.007 0.933 0.933
Echinococcus granulosus hypothetical protein 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) SRC-1 0.007 0.933 1
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0649 0.0649
Brugia malayi Furin-like cysteine rich region family protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis FL cytokine receptor 0.0043 0.4022 0.4022
Schistosoma mansoni tensin 0.0027 0.0649 0.0649
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.4022 0.4311
Onchocerca volvulus 0.007 0.933 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.933 0.933
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0043 0.4022 0.4022
Schistosoma mansoni protein tyrosine kinase 0.0043 0.4022 0.4022
Brugia malayi Receptor family ligand binding region containing protein 0.0043 0.4022 0.4311
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Echinococcus granulosus activin receptor type 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine kinase 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis SH2 domain containing protein 7 0.0027 0.0649 0.0649
Echinococcus multilocularis receptor type guanylyl cyclase 0.0043 0.4022 0.4022
Onchocerca volvulus 0.007 0.933 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0027 0.0649 0.0649
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi hypothetical protein 0.007 0.933 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0043 0.4022 0.4022
Entamoeba histolytica cysteine surface protein, putative 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Echinococcus granulosus raf serine:threonine protein kinase 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis NCK adaptor protein 0.0027 0.0649 0.0649
Trichomonas vaginalis AGC family protein kinase 0.0043 0.4022 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine kinase 0.007 0.933 0.933
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Echinococcus multilocularis raf serine:threonine protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) STAT protein 0.0027 0.0649 0.0696
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.007 0.933 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.933 0.933
Schistosoma mansoni GTPase activating protein 0.0027 0.0649 0.0649
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0027 0.0649 0.0696
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis tyrosine protein kinase ABL1 0.007 0.933 0.933
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.4022 0.4311
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein kinase csk 0.0043 0.4022 0.4022
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.4022 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Echinococcus granulosus suppressor of cytokine signaling 7 0.0027 0.0649 0.0649
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.933 0.933
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0043 0.4022 0.4022
Onchocerca volvulus 0.007 0.933 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0043 0.4022 0.4311
Brugia malayi Raf kinase 0.0043 0.4022 0.4311
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0649 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0649 0.0649
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis activin receptor type 0.0043 0.4022 0.4022
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0043 0.4022 1
Plasmodium falciparum protein kinase, putative 0.0043 0.4022 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0043 0.4022 0.4022
Echinococcus granulosus signal transduction protein lnk realted 0.0027 0.0649 0.0649
Loa Loa (eye worm) TK/RYK protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0649 0.0696
Echinococcus multilocularis transfer RNA-Thr 0.0043 0.4022 0.4022
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0027 0.0649 0.0649
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Onchocerca volvulus 0.007 0.933 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.4022 1
Leishmania major hypothetical protein, conserved 0.0043 0.4022 0.4022
Entamoeba histolytica SH2-protein kinase domain containing protein 0.007 0.933 1
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TK family protein kinase 0.0043 0.4022 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Brugia malayi Protein kinase domain containing protein 0.007 0.933 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Schistosoma mansoni tensin 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Brugia malayi C-terminal src kinase protein 1 0.0043 0.4022 0.4311
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0043 0.4022 0.4022
Giardia lamblia Kinase, NEK 0.0043 0.4022 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0027 0.0649 0.0649
Entamoeba histolytica ankyrin repeat protein 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Fgr 0.007 0.933 0.933
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Brugia malayi Tyrosine-protein kinase abl-1 0.007 0.933 1
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus granulosus retinal guanylyl cyclase 2 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein kinase Lyn 0.007 0.933 0.933
Loa Loa (eye worm) TK/ABL protein kinase 0.007 0.933 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Schistosoma mansoni aldehyde dehydrogenase 0.0073 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.933 0.933
Echinococcus granulosus tyrosine protein kinase ABL1 0.007 0.933 0.933
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Trypanosoma cruzi protein kinase, putative 0.0043 0.4022 1
Plasmodium falciparum tyrosine kinase-like protein 0.0043 0.4022 0.5
Echinococcus granulosus SH2 motif 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 1 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.4022 0.4022
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Brugia malayi hypothetical protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0043 0.4022 0.4311
Echinococcus granulosus expressed conserved protein 0.0027 0.0649 0.0649
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi protein-tyrosine kinase 0.007 0.933 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.007 0.933 0.933
Onchocerca volvulus 0.007 0.933 1
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Schistosoma mansoni nck2/grb4 0.0027 0.0649 0.0649
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Schistosoma mansoni ephrin receptor 0.0043 0.4022 0.4022
Onchocerca volvulus 0.007 0.933 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Onchocerca volvulus 0.0043 0.4022 0.3885
Echinococcus multilocularis tyrosine protein kinase Src42A 0.007 0.933 0.933
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica SH2 domain containing protein 0.0027 0.0649 0.0696
Giardia lamblia Kinase, NEK 0.0043 0.4022 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.007 0.933 0.933
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica receptor protein kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis epidermal growth factor receptor 0.0043 0.4022 0.4022
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0043 0.4022 0.4311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus multilocularis insulin receptor 0.0043 0.4022 0.4022
Echinococcus multilocularis tensin 0.0027 0.0649 0.0649
Trypanosoma brucei Pseudokinase, putative 0.0043 0.4022 1
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) TK/Met protein kinase 0.0043 0.4022 0.4311
Echinococcus multilocularis ephrin type A receptor 4 A 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi SH2 domain containing protein 0.0027 0.0649 0.0696
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0043 0.4022 1
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) SH2 domain-containing protein 0.0027 0.0649 0.0696
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0027 0.0649 0.0649
Onchocerca volvulus 0.0043 0.4022 0.3885
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein kinase pr2 0.0043 0.4022 0.4022
Echinococcus granulosus tyrosine protein kinase Fps85D 0.007 0.933 0.933
Entamoeba histolytica receptor protein kinase, putative 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) SH2 domain-containing protein 0.0027 0.0649 0.0696
Echinococcus multilocularis SH2 motif 0.0027 0.0649 0.0649
Echinococcus multilocularis natriuretic peptide receptor 1 0.0043 0.4022 0.4022
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Leishmania major protein kinase, putative 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0649 0.0696
Brugia malayi STAT protein, DNA binding domain containing protein 0.0027 0.0649 0.0696
Toxoplasma gondii aldehyde dehydrogenase 0.0073 1 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Echinococcus multilocularis activated cdc42 kinase 1 0.0043 0.4022 0.4022
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.933 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Giardia lamblia Protein 21.1 0.0043 0.4022 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0027 0.0649 0.0696
Brugia malayi SH2 domain containing protein 0.007 0.933 1
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.4022 0.4022
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.4022 0.4311
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0649 0.0696
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0027 0.0649 0.0649
Onchocerca volvulus 0.0043 0.4022 0.3885
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Entamoeba histolytica protein kinase, putative 0.0027 0.0649 0.0696
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.007 0.933 0.933
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.4022 0.4311
Plasmodium vivax tyrosine kinase-like protein, putative 0.0043 0.4022 0.5
Echinococcus multilocularis c src tyrosine kinase 0.007 0.933 0.933
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0027 0.0649 0.0696
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Schistosoma mansoni tyrosine kinase 0.007 0.933 0.933
Trichomonas vaginalis STE family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0043 0.4022 0.4022
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0043 0.4022 0.4022
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.4022 1
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.4022 0.4311
Schistosoma mansoni vav2 0.0027 0.0649 0.0649
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine protein kinase Abl 0.007 0.933 0.933
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.007 0.933 0.933
Echinococcus granulosus tyrosine protein kinase Srms 0.007 0.933 0.933
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Brugia malayi integrin-linked kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0043 0.4022 0.4311
Loa Loa (eye worm) TK/CSK protein kinase 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0649 0.0696
Onchocerca volvulus 0.0043 0.4022 0.3885
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0649 0.0696
Loa Loa (eye worm) TK protein kinase 0.0043 0.4022 0.4311
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.4022 0.4311
Loa Loa (eye worm) protein kinase domain-containing protein 0.0043 0.4022 0.4311
Entamoeba histolytica hypothetical protein 0.0043 0.4022 0.4311
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.4022 0.4311
Echinococcus multilocularis tyrosine kinase 0.007 0.933 0.933
Echinococcus multilocularis heat shock protein 70 0.0043 0.4022 0.4022
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0649 0.0696
Schistosoma mansoni protein kinase 0.0043 0.4022 0.4022
Brugia malayi Protein kinase domain containing protein 0.007 0.933 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.4022 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.933 0.933
Schistosoma mansoni tyrosine kinase 0.0043 0.4022 0.4022
Entamoeba histolytica protein kinase, putative 0.0043 0.4022 0.4311

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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