Detailed information for compound 1433845

Basic information

Technical information
  • TDR Targets ID: 1433845
  • Name: ethyl 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl) -4-(2,4,5-trimethoxyphenyl)-4H-pyran-3-carbox ylate
  • MW: 446.45 | Formula: C22H26N2O8
  • H donors: 1 H acceptors: 3 LogP: 2.18 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(CC(=O)OCC)OC(=C(C1c1cc(OC)c(cc1OC)OC)C#N)N
  • InChi: 1S/C22H26N2O8/c1-6-30-18(25)10-17-20(22(26)31-7-2)19(13(11-23)21(24)32-17)12-8-15(28-4)16(29-5)9-14(12)27-3/h8-9,19H,6-7,10,24H2,1-5H3
  • InChiKey: IOXJACJFBTUQPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-amino-5-cyano-2-(2-ethoxy-2-oxo-ethyl)-4-(2,4,5-trimethoxyphenyl)-4H-pyran-3-carboxylate
  • 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl)-4-(2,4,5-trimethoxyphenyl)-4H-pyran-3-carboxylic acid ethyl ester
  • 6-amino-5-cyano-2-(2-ethoxy-2-keto-ethyl)-4-(2,4,5-trimethoxyphenyl)-4H-pyran-3-carboxylic acid ethyl ester
  • SMR000035059
  • Oprea1_528512
  • MLS000028113
  • STOCK1S-61065

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0464 0.4587 1
Trichomonas vaginalis conserved hypothetical protein 0.0464 0.4587 1
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0055 0.0278 0.021
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0055 0.0278 0.0463
Mycobacterium ulcerans lysophospholipase 0.0464 0.4587 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0453 0.4471 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1516 0.2873
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3414 1
Loa Loa (eye worm) amidase 0.0055 0.0278 0.0475
Leishmania major monoglyceride lipase, putative 0.0464 0.4587 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0453 0.4471 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1259 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0464 0.4587 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0055 0.0278 0.021
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0055 0.0278 0.0463
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0464 0.4587 1
Loa Loa (eye worm) amidase 0.0055 0.0278 0.0475
Loa Loa (eye worm) hypothetical protein 0.0148 0.1259 0.2702
Brugia malayi Amidase family protein 0.0055 0.0278 0.0475
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0316 0.056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Brugia malayi putative amidase 0.0055 0.0278 0.0475
Plasmodium vivax PST-A protein 0.0464 0.4587 1
Brugia malayi Amidase family protein 0.0055 0.0278 0.0475
Trypanosoma brucei monoglyceride lipase, putative 0.0464 0.4587 1
Loa Loa (eye worm) hypothetical protein 0.0453 0.4471 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1259 0.2702
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0464 0.4587 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0055 0.0278 0.0475
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0464 0.4587 1
Brugia malayi hypothetical protein 0.0148 0.1259 0.2702
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0464 0.4587 1
Plasmodium falciparum lysophospholipase, putative 0.0464 0.4587 1
Echinococcus granulosus snurportin 1 0.0372 0.3612 0.8048
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Trypanosoma brucei monoglyceride lipase, putative 0.0464 0.4587 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Leishmania major hypothetical protein, conserved 0.0055 0.0278 0.0607
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0055 0.0278 0.0463
Mycobacterium ulcerans hypothetical protein 0.0464 0.4587 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3612 0.8048
Onchocerca volvulus Huntingtin homolog 0.0148 0.1259 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2706 0.2655
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0453 0.4471 0.4432
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0464 0.4587 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0055 0.0278 0.0475
Echinococcus granulosus fatty acid amide hydrolase 1 0.0453 0.4471 1
Brugia malayi RNA, U transporter 1 0.0099 0.0744 0.1534
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1516 0.2873
Trypanosoma cruzi monoglyceride lipase, putative 0.0464 0.4587 1
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0464 0.4587 1
Brugia malayi amidase 0.0453 0.4471 1
Schistosoma mansoni amidase 0.0453 0.4471 1
Trichomonas vaginalis conserved hypothetical protein 0.0464 0.4587 1
Trypanosoma cruzi amidase, putative 0.0055 0.0278 0.0607
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0453 0.4471 0.4432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0069 0.5
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0055 0.0278 0.0475
Plasmodium falciparum lysophospholipase, putative 0.0464 0.4587 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3414 0.5
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0055 0.0278 0.0475
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0464 0.4587 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2706 0.599
Schistosoma mansoni hypothetical protein 0.0372 0.3612 0.8048
Plasmodium falciparum lysophospholipase, putative 0.0464 0.4587 1
Schistosoma mansoni hypothetical protein 0.0058 0.0316 0.056
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0055 0.0278 0.5
Brugia malayi hypothetical protein 0.0286 0.2706 0.599
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0055 0.0278 0.5
Trypanosoma cruzi amidase, putative 0.0055 0.0278 0.0607
Plasmodium falciparum esterase, putative 0.0464 0.4587 1
Echinococcus multilocularis snurportin 1 0.0372 0.3612 0.3567
Mycobacterium tuberculosis Possible lysophospholipase 0.0464 0.4587 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3414 0.7444
Loa Loa (eye worm) hypothetical protein 0.0286 0.2706 0.599
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1516 0.2873
Schistosoma mansoni survival motor neuron protein 0.0058 0.0316 0.056

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5397 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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