Detailed information for compound 1433850

Basic information

Technical information
  • TDR Targets ID: 1433850
  • Name: 4-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)be nzamide
  • MW: 233.29 | Formula: C11H11N3OS
  • H donors: 1 H acceptors: 3 LogP: 2.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)Nc1nnc(s1)C
  • InChi: 1S/C11H11N3OS/c1-7-3-5-9(6-4-7)10(15)12-11-14-13-8(2)16-11/h3-6H,1-2H3,(H,12,14,15)
  • InChiKey: IKAJSLFVCPMOCD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-Methyl-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-benzamide
  • BAS 00337532
  • A2194/0092291
  • ZINC00040346
  • MLS000710779
  • SMR000280546

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0043 0.0163 0.0186
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1441 1 1
Brugia malayi putative amidase 0.0174 0.1081 0.1047
Mycobacterium ulcerans lysophospholipase 0.0986 0.6798 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0986 0.6798 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0644 0.0608
Onchocerca volvulus 0.0058 0.0268 0.9524
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0174 0.1081 0.1543
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0059 0.0087
Plasmodium falciparum alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0986 0.6798 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1868 0.1837
Mycobacterium ulcerans amidase 0.0174 0.1081 0.158
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0058 0.0267 0.0338
Echinococcus multilocularis Phospholipase carboxylesterase 0.0058 0.0267 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0095
Schistosoma mansoni importin beta-1 0.0035 0.0103 0.0065
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0059 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0217 0.0179
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0708 0.0672
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0986 0.6798 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0103 0.0065
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0174 0.1081 0.159
Leishmania major hypothetical protein, conserved 0.0058 0.0267 0.0338
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0103 0.283
Plasmodium falciparum exported lipase 1 0.0058 0.0267 0.0381
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0058 0.0267 0.0338
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0058 0.0267 0.0338
Mycobacterium ulcerans amidase 0.0174 0.1081 0.158
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0058 0.0267 0.023
Echinococcus granulosus snurportin 1 0.0372 0.2474 0.2446
Echinococcus granulosus importin subunit beta 1 0.0035 0.0103 0.0065
Loa Loa (eye worm) hypothetical protein 0.0058 0.0267 0.0259
Schistosoma mansoni patched 1 0.0051 0.0217 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0217 0.0264
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0986 0.6798 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0986 0.6798 1
Plasmodium falciparum esterase, putative 0.0986 0.6798 1
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0174 0.1081 0.159
Echinococcus granulosus abhydrolase domain containing 3 0.0058 0.0267 0.023
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0058 0.0267 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0059 0.0075
Schistosoma mansoni hypothetical protein 0.0049 0.0204 0.0166
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0056 0.0027
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0986 0.6798 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0058 0.0267 0.0338
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0217 0.0179
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0174 0.1081 0.158
Entamoeba histolytica hypothetical protein 0.0043 0.0163 0.0186
Loa Loa (eye worm) hypothetical protein 0.0058 0.0267 0.0259
Plasmodium vivax unspecified product 0.0058 0.0267 0.0381
Brugia malayi CHE-14 protein 0.0051 0.0217 0.0179
Onchocerca volvulus 0.006 0.0278 1
Plasmodium vivax lysophospholipase, putative 0.0058 0.0267 0.0381
Trypanosoma brucei monoglyceride lipase, putative 0.0986 0.6798 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0058 0.0267 0.0338
Schistosoma mansoni survival motor neuron protein 0.0058 0.0268 0.023
Schistosoma mansoni hypothetical protein 0.0049 0.0204 0.0166
Plasmodium falciparum esterase, putative 0.0058 0.0267 0.0381
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0058 0.0267 0.0338
Loa Loa (eye worm) hypothetical protein 0.0058 0.0267 0.0259
Loa Loa (eye worm) hypothetical protein 0.0058 0.0267 0.0259
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0278 0.0241
Echinococcus multilocularis abhydrolase domain containing 3 0.0058 0.0267 0.023
Entamoeba histolytica hypothetical protein 0.0043 0.0163 0.0186
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0059 0.0075
Echinococcus granulosus fatty acid amide hydrolase 1 0.1441 1 1
Toxoplasma gondii hypothetical protein 0.0058 0.0267 1
Echinococcus multilocularis protein patched 0.0051 0.0217 0.0179
Echinococcus multilocularis tumor protein p63 0.0408 0.273 0.2702
Plasmodium falciparum epoxide hydrolase 2 0.0058 0.0267 0.0381
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0695 0.0659
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0059 0.0075
Trypanosoma cruzi monoglyceride lipase, putative 0.0986 0.6798 1
Trichomonas vaginalis conserved hypothetical protein 0.0986 0.6798 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6751 0.6739
Schistosoma mansoni fatty-acid amide hydrolase 0.0174 0.1081 0.1047
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0174 0.1081 0.1047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0051
Brugia malayi hypothetical protein 0.0286 0.1868 0.1837
Echinococcus granulosus expressed conserved protein 0.0112 0.0644 0.0608
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0058 0.0267 0.023
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0058 0.0267 0.0338
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0986 0.6798 1
Mycobacterium ulcerans hypothetical protein 0.0058 0.0267 0.0381
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0058 0.0267 0.0381
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0058 0.0267 0.0338
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0059 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0059 0.0031
Plasmodium falciparum lysophospholipase, putative 0.0986 0.6798 1
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0174 0.1081 0.1047
Brugia malayi MGC83647 protein 0.0058 0.0267 0.023
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1441 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0298 0.029
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0695 0.0659
Trypanosoma cruzi amidase, putative 0.0174 0.1081 0.1543
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0174 0.1081 0.159
Loa Loa (eye worm) hypothetical protein 0.0058 0.0267 0.0259
Toxoplasma gondii phospholipase 0.0058 0.0267 1
Plasmodium falciparum prodrug activation and resistance esterase 0.0058 0.0267 0.0381
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0174 0.1081 0.158
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0986 0.6798 1
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0267 0.0381
Loa Loa (eye worm) hypothetical protein 0.0119 0.0695 0.0687
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0059 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0059 0.0075
Plasmodium falciparum lysophospholipase, putative 0.0986 0.6798 1
Mycobacterium ulcerans hypothetical protein 0.0058 0.0267 0.0381
Plasmodium vivax PST-A protein 0.0058 0.0267 0.0381
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0058 0.0267 0.023
Loa Loa (eye worm) amidase 0.0174 0.1081 0.1074
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0174 0.1081 0.1047
Toxoplasma gondii phospholipase/carboxylesterase 0.0058 0.0267 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0217 0.0209
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0174 0.1081 0.1516
Mycobacterium ulcerans amidase 0.0174 0.1081 0.158
Loa Loa (eye worm) hypothetical protein 0.1441 1 1
Plasmodium vivax unspecified product 0.0058 0.0267 0.0381
Leishmania major importin beta-1 subunit, putative 0.0028 0.0056 0.0027
Plasmodium falciparum importin beta, putative 0.0035 0.0103 0.0139
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0267 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Brugia malayi Importin beta-1 subunit 0.0035 0.0103 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0986 0.6798 1
Leishmania major monoglyceride lipase, putative 0.0986 0.6798 1
Plasmodium vivax PST-A protein 0.0986 0.6798 1
Entamoeba histolytica hypothetical protein 0.0058 0.0267 0.0338
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0217 0.0209
Plasmodium falciparum lysophospholipase, putative 0.0058 0.0267 0.0381
Mycobacterium ulcerans amidase 0.0174 0.1081 0.158
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0174 0.1081 0.1516
Toxoplasma gondii hypothetical protein 0.0058 0.0267 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1054 0.102
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0103 0.0096
Mycobacterium ulcerans hypothetical protein 0.0986 0.6798 1
Plasmodium falciparum BEM46-like protein, putative 0.0058 0.0267 0.0381
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0059 0.0075
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0058 0.0267 0.0338
Trypanosoma cruzi serine peptidase, putative 0.0058 0.0267 0.0338
Plasmodium falciparum alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Brugia malayi hypothetical protein 0.0043 0.0163 0.0126
Entamoeba histolytica hypothetical protein 0.0058 0.0267 0.0338
Plasmodium vivax PST-A protein 0.0058 0.0267 0.0381
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1868 0.1837
Schistosoma mansoni peptidase 0.0058 0.0267 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0059 0.0087
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0038 0.0044
Mycobacterium ulcerans amidase 0.0174 0.1081 0.158
Toxoplasma gondii hypothetical protein 0.0058 0.0267 1
Leishmania major hypothetical protein, conserved 0.0058 0.0267 0.0338
Schistosoma mansoni hypothetical protein 0.0205 0.1298 0.1265
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0058 0.0267 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0058 0.0267 0.0338
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0058 0.0267 0.0338
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0217 0.0179
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0174 0.1081 0.5
Chlamydia trachomatis hydrolase 0.0058 0.0267 0.241
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0058 0.0267 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0059 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0163 0.0126
Mycobacterium ulcerans peptide amidase, GatA 0.0174 0.1081 0.158
Plasmodium falciparum lysophospholipase, putative 0.0986 0.6798 1
Plasmodium vivax lysophospholipase, putative 0.0058 0.0267 0.0381
Echinococcus granulosus fatty acid amide hydrolase 1 0.0174 0.1081 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0058 0.0267 0.0338
Trypanosoma brucei monoglyceride lipase, putative 0.0986 0.6798 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0695 0.0971
Plasmodium falciparum esterase, putative 0.0058 0.0267 0.0381
Plasmodium vivax PST-A protein 0.0058 0.0267 0.0381
Echinococcus granulosus abhydrolase domain containing protein 13 0.0058 0.0267 0.023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0268 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Brugia malayi RNA, U transporter 1 0.0099 0.0555 0.0519
Loa Loa (eye worm) hypothetical protein 0.006 0.0278 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0008 0.0012
Brugia malayi Amidase family protein 0.0174 0.1081 0.1047
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0174 0.1081 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0059 0.0075
Schistosoma mansoni hypothetical protein 0.0043 0.0163 0.0126
Trypanosoma cruzi amidase, putative 0.0174 0.1081 0.1543
Echinococcus granulosus geminin 0.0205 0.1298 0.1265
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2474 0.2468
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0059 0.0075
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0038 0.0044
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0986 0.6798 1
Plasmodium vivax lysophospholipase, putative 0.0058 0.0267 0.0381
Entamoeba histolytica ;Alias 0.0058 0.0267 0.0338
Schistosoma mansoni hypothetical protein 0.0058 0.0268 0.023
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0267 0.0381
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0174 0.1081 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Echinococcus granulosus tumor protein p63 0.0408 0.273 0.2702
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0695 0.0659
Toxoplasma gondii protein c14orf29, putative 0.0058 0.0267 1
Loa Loa (eye worm) amidase 0.0174 0.1081 0.1074
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0103 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0051
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0058 0.0267 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0058 0.0267 0.0338
Brugia malayi Protein C20orf22 0.0058 0.0267 0.023
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0059 0.0031
Plasmodium falciparum lysophospholipase, putative 0.0058 0.0267 0.0381
Brugia malayi MGC79044 protein 0.0058 0.0267 0.023
Schistosoma mansoni hypothetical protein 0.0049 0.0204 0.0166
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0058 0.0267 0.0338
Plasmodium vivax PST-A protein 0.0058 0.0267 0.0381
Plasmodium falciparum exported lipase 2 0.0058 0.0267 0.0381
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0056 0.0027
Echinococcus multilocularis geminin 0.0205 0.1298 0.1265
Echinococcus granulosus Phospholipase carboxylesterase 0.0058 0.0267 0.023
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0056 0.0027
Entamoeba histolytica hypothetical protein 0.0028 0.0056 0.0027
Echinococcus multilocularis snurportin 1 0.0372 0.2474 0.2446
Trypanosoma cruzi serine peptidase, putative 0.0058 0.0267 0.0338
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0174 0.1081 0.159
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0163 0.0126
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0056 0.0027
Schistosoma mansoni amidase 0.1441 1 1
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0058 0.0267 0.0381
Schistosoma mansoni fatty-acid amide hydrolase 0.1441 1 1
Chlamydia trachomatis acyltransferase family protein 0.0058 0.0267 0.241
Plasmodium vivax importin-beta 2, putative 0.0035 0.0103 0.0139
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0174 0.1081 0.1047
Entamoeba histolytica hypothetical protein 0.0043 0.0163 0.0186
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0174 0.1081 0.159
Loa Loa (eye worm) hypothetical protein 0.0286 0.1868 0.1861
Schistosoma mansoni hypothetical protein 0.0205 0.1298 0.1265
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0267 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0058 0.0267 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Plasmodium vivax alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0058 0.0267 0.0338
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0058 0.0267 0.023
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0174 0.1081 0.158
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0038 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1054 0.102
Leishmania major hypothetical protein, conserved 0.0174 0.1081 0.1543
Echinococcus granulosus fatty acid amide hydrolase 1 0.1441 1 1
Schistosoma mansoni hypothetical protein 0.0372 0.2474 0.2446
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0059 0.0075
Plasmodium falciparum alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Schistosoma mansoni hypothetical protein 0.0049 0.0204 0.0166
Brugia malayi Amidase family protein 0.0174 0.1081 0.1047
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0059 0.0031
Toxoplasma gondii hypothetical protein 0.0058 0.0267 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0058 0.0267 0.0338
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0163 0.0126
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0058 0.0267 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0059 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0059 0.0031
Plasmodium vivax alpha/beta hydrolase, putative 0.0058 0.0267 0.0381
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0986 0.6798 1
Mycobacterium ulcerans hydrolase 0.0058 0.0267 0.0381
Echinococcus multilocularis protein dispatched 1 0.0058 0.0268 0.023
Toxoplasma gondii peptidase S15, putative 0.0058 0.0267 1
Plasmodium vivax PST-A protein 0.0058 0.0267 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0267 0.0338
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0058 0.0267 0.0338

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1582 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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