Detailed information for compound 1433925

Basic information

Technical information
  • TDR Targets ID: 1433925
  • Name: (4-acetylphenyl) (E)-3-phenylprop-2-enoate
  • MW: 266.291 | Formula: C17H14O3
  • H donors: 0 H acceptors: 2 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1ccc(cc1)C(=O)C)/C=C/c1ccccc1
  • InChi: 1S/C17H14O3/c1-13(18)15-8-10-16(11-9-15)20-17(19)12-7-14-5-3-2-4-6-14/h2-12H,1H3/b12-7+
  • InChiKey: FHZWBHDYSWXZGX-KPKJPENVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-acetylphenyl) 3-phenylprop-2-enoate
  • 3-phenylprop-2-enoic acid (4-acetylphenyl) ester
  • (E)-3-phenylprop-2-enoic acid (4-acetylphenyl) ester
  • 3-phenylacrylic acid (4-acetylphenyl) ester
  • (E)-3-phenylacrylic acid (4-acetylphenyl) ester
  • (4-ethanoylphenyl) (E)-3-phenylprop-2-enoate
  • (4-ethanoylphenyl) 3-phenylprop-2-enoate
  • ZINC00299321
  • 4-acetylphenyl 3-phenylacrylate
  • MLS001001640
  • SMR000496172

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.001 0.0468 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0485 0.0485
Loa Loa (eye worm) E1-E2 ATPase 0.001 0.0468 0.0468
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.029 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0485 0.0485
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0485 0.157
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.1766 0.5717
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.1766 0.5717
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.029 0.0201
Plasmodium falciparum copper-transporting ATPase 0.001 0.0468 0.102
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.001 0.0468 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1766 0.5513
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.029 0.0546
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.001 0.0468 0.185
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.001 0.0468 0.1388
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.001 0.0468 0.089
Brugia malayi AMP-binding enzyme family protein 0.0008 0.029 0.029
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.001 0.0468 0.102
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0468 0.1521
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.2294 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2294 0.2294
Loa Loa (eye worm) hypothetical protein 0.001 0.0468 0.0468
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Trypanosoma cruzi cation-transporting ATPase, putative 0.001 0.0468 0.102
Brugia malayi AMP-binding enzyme family protein 0.0008 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0007 0.0174 0.0174
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.001 0.0468 0.139
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1766 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.029 0.029
Echinococcus granulosus cation transporting atpase worm 0.001 0.0468 0.1516
Loa Loa (eye worm) hypothetical protein 0.001 0.0468 0.0468
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.6745 0.6745
Trypanosoma cruzi proton motive ATPase 1, putative 0.001 0.0468 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2294 0.2294
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.029 0.0546
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1766 0.1766
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.001 0.0468 0.102
Schistosoma mansoni copper ABC transporter ATPase 0.001 0.0468 0.0468
Schistosoma mansoni hypothetical protein 0.0016 0.1061 0.1061
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.029 0.0402
Onchocerca volvulus 0.0035 0.2893 0.9391
Echinococcus granulosus phospholipid transporting ATPase VA 0.001 0.0468 0.1516
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.029 0.0548
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.2294 0.734
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0485 0.157
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.029 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0485 0.0485
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0311 0.1006
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.2294 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0468 0.1516
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0485 0.0485
Leishmania major proton motive ATPase, putative 0.001 0.0468 0.102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.2294 1
Schistosoma mansoni hypothetical protein 0.0016 0.1061 0.1061
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0485 0.157
Schistosoma mansoni cation-transporting ATPase 0.001 0.0468 0.0468
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.001 0.0468 0.0468
Leishmania major hypothetical protein, conserved 0.0036 0.3062 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0485 0.0485
Echinococcus multilocularis cation transporting ATPase 13A3 0.001 0.0468 0.1516
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Brugia malayi AMP-binding enzyme family protein 0.0008 0.029 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1766 0.7511
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.4527 0.4527
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0485 0.157
Trypanosoma cruzi P-type H+-ATPase, putative 0.001 0.0468 0.102
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.001 0.0468 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.001 0.0468 0.102
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.029 0.0546
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0468 0.1516
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.001 0.0468 0.0468
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0468 0.1521
Brugia malayi ecdysteroid receptor 0.001 0.0485 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.2294 1
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.001 0.0468 0.185
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.2294 1
Plasmodium vivax cation transporting ATPase, putative 0.001 0.0468 0.102
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Toxoplasma gondii kringle domain-containing protein 0.0036 0.3062 0.4985
Loa Loa (eye worm) hypothetical protein 0.0051 0.4527 0.4527
Loa Loa (eye worm) hypothetical protein 0.0008 0.029 0.029
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.001 0.0468 0.185
Echinococcus multilocularis cation transporting ATPase 13A1 0.001 0.0468 0.1516
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1766 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.029 0.0548
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.001 0.0468 0.0468
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.029 0.0938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0485 0.0485
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0468 0.1521
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.029 0.029
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0507 0.0507
Echinococcus granulosus tissue type plasminogen activator 0.0036 0.3062 0.9912
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.001 0.0468 0.1516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1766 0.5513
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.001 0.0468 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0485 0.0485
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.1061 0.1061
Brugia malayi CXXC zinc finger family protein 0.0035 0.2893 0.2893
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1049 0.55
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.1577 0.4857
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.3062 0.3062
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.001 0.0468 0.139
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.029 0.029
Brugia malayi steroid hormone receptor 0.001 0.0485 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Brugia malayi AMP-binding enzyme family protein 0.0008 0.029 0.029
Echinococcus granulosus cation transporting ATPase 13A3 0.001 0.0468 0.1516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0106 1 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.001 0.0468 0.102
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.001 0.0468 0.1388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.1461 0.6071
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0485 0.157
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.001 0.0468 0.0509
Loa Loa (eye worm) hypothetical protein 0.0036 0.3062 0.3062
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.1061 0.3435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0485 0.0485
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0485 0.157
Loa Loa (eye worm) hypothetical protein 0.0021 0.1577 0.1577
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0485 0.157
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0485 0.0485
Toxoplasma gondii cation-transporting atpase family protein 0.001 0.0468 0.0509
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.052 0.1684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.1461 0.6071
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.2294 0.734
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.1521
Trypanosoma brucei P-type H+-ATPase, putative 0.001 0.0468 0.185
Plasmodium vivax copper-transporting ATPase, putative 0.001 0.0468 0.102
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.001 0.0468 0.1516
Echinococcus multilocularis cation transporting atpase worm 0.001 0.0468 0.1516
Schistosoma mansoni hypothetical protein 0.0035 0.2923 0.2923
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.001 0.0468 0.0509
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.029 0.0548
Trypanosoma brucei cation-transporting ATPase, putative 0.001 0.0468 0.185
Echinococcus granulosus GPCR family 2 0.0016 0.1061 0.3435
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.029 0.029
Echinococcus granulosus dna polymerase eta 0.0023 0.1766 0.5717
Trypanosoma cruzi P-type H+-ATPase, putative 0.001 0.0468 0.102
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.029 0.0402
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.1766 0.1766
Brugia malayi Na,K-ATPase alpha subunit 0.001 0.0468 0.0468
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.1577 0.4857
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.1521
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.001 0.0468 0.0468
Trypanosoma brucei unspecified product 0.0023 0.1766 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1766 0.1766
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.001 0.0468 0.0509
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1766 0.5513
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.1061 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0485 0.0485
Brugia malayi Latrophilin receptor protein 2 0.0016 0.1061 0.1061
Trypanosoma brucei unspecified product 0.0016 0.1049 0.55
Leishmania major calcium-translocating P-type ATPase 0.001 0.0468 0.102
Loa Loa (eye worm) hypothetical protein 0.0035 0.2923 0.2923
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.001 0.0468 0.102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0485 0.0485
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.1577 1
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.001 0.0468 0.139
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.029 0.0402
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.2294 0.734
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.2893 0.2893
Schistosoma mansoni hypothetical protein 0.0016 0.1061 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0485 0.0485
Schistosoma mansoni thyroid hormone receptor 0.001 0.0485 0.0485
Schistosoma mansoni cation-transporting atpase worm 0.001 0.0468 0.0468
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.1766 0.1766
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.1766 0.7511
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.029 0.0548
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0485 0.157
Schistosoma mansoni eyes absent homolog 0.0106 1 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.1061 0.3435
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0468 0.1521
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Echinococcus multilocularis dna polymerase eta 0.0023 0.1766 0.5717
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.029 0.0355
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0485 0.157
Loa Loa (eye worm) hypothetical protein 0.001 0.0468 0.0468
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.029 0.0938
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.001 0.0468 0.1521
Brugia malayi hypothetical protein 0.001 0.0468 0.0468
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.001 0.0468 0.139
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.001 0.0468 0.1516
Schistosoma mansoni coup transcription factor 0.001 0.0485 0.0485
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.029 0.0402
Brugia malayi Protein kinase domain containing protein 0.0036 0.3062 0.3062
Treponema pallidum hypothetical protein 0.001 0.0468 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.2294 1
Onchocerca volvulus 0.001 0.0485 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0485 0.0485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.4527 0.4527
Echinococcus granulosus dna polymerase kappa 0.0023 0.1766 0.5717
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.001 0.0468 0.1521
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.001 0.0468 0.1388
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.001 0.0468 0.0468
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.001 0.0468 0.1521
Echinococcus multilocularis tissue type plasminogen activator 0.0036 0.3062 0.9912
Schistosoma mansoni cpg binding protein 0.0035 0.2893 0.2893
Echinococcus granulosus cpg binding protein 0.0037 0.3089 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.1521
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1766 0.7511
Echinococcus multilocularis phospholipid transporting ATPase VA 0.001 0.0468 0.1516
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.001 0.0468 0.1521
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0485 0.0485
Schistosoma mansoni atpase class VI type 11c 0.001 0.0468 0.0468
Echinococcus granulosus cation transporting ATPase 13A1 0.001 0.0468 0.1516
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.1766 0.5513
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1577 0.1577
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.001 0.0468 0.102
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.001 0.0468 0.089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.1461 0.6071
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0311 0.1006
Brugia malayi nuclear hormone receptor 0.001 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0021 0.1577 0.1577
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.029 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1049 0.55
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.001 0.0468 0.1516
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.1766 0.5513
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.052 0.1684
Loa Loa (eye worm) hypothetical protein 0.0029 0.2294 0.2294
Loa Loa (eye worm) hypothetical protein 0.001 0.0485 0.0485
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.2294 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0485 0.0485
Echinococcus multilocularis dna polymerase kappa 0.0023 0.1766 0.5717
Schistosoma mansoni hypothetical protein 0.0016 0.1061 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0008 0.029 0.029
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.001 0.0468 0.102
Echinococcus multilocularis cpg binding protein 0.0037 0.3089 1
Onchocerca volvulus 0.0029 0.2294 0.7229
Brugia malayi AMP-binding enzyme family protein 0.0029 0.2294 0.2294
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.1766 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.001 0.0468 0.185
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.029 0.0402
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.029 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.1766 0.1766
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0468 0.1516
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.029 0.0548
Toxoplasma gondii P-type ATPase PMA1 0.001 0.0468 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0485 0.0485
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0485 0.157
Echinococcus multilocularis copper transporting ATPase 1 0.001 0.0468 0.1516
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0174 0.0174
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.001 0.0468 0.102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0485 0.0485
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0485 0.157
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.1521
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.001 0.0468 0.089
Schistosoma mansoni ATPase 0.001 0.0468 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1766 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.4527 0.4527
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.001 0.0468 0.089
Treponema pallidum cation-transporting ATPase, P-type 0.001 0.0468 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0485 0.157
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.029 0.0546
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.001 0.0468 0.102
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.001 0.0468 0.0468
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.001 0.0468 0.0509
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.029 0.0402
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0468 0.1516
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0485 0.0485
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0485 0.157
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.001 0.0468 0.185
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0485 0.0485
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.029 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.3062 1
Toxoplasma gondii propionate-CoA ligase 0.0008 0.029 0.0201
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0485 0.0485
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.001 0.0468 0.139
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1766 0.1766
Leishmania major P-type H -ATPase, putative 0.001 0.0468 0.102
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.2294 1
Brugia malayi E1-E2 ATPase family protein 0.001 0.0468 0.0468
Trypanosoma cruzi Calcium ATPase SERCA-like 0.001 0.0468 0.102
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.1577 0.6617
Brugia malayi Kringle domain containing protein 0.0036 0.3062 0.3062
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1049 0.55
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0485 0.0485
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0485 0.0703
Schistosoma mansoni cpg binding protein 0.0037 0.3089 0.3089
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.029 0.0548
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.1061 0.3435
Loa Loa (eye worm) hypothetical protein 0.0106 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.2294 1
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.001 0.0468 0.0468
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0485 0.157
Leishmania major DNA polymerase eta, putative 0.0023 0.1766 0.5513
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.029 0.0355
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.029 0.0548
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.029 0.0546
Schistosoma mansoni hypothetical protein 0.0036 0.3062 0.3062
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.029 0.0402
Loa Loa (eye worm) calcium ATPase 0.001 0.0468 0.0468
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.001 0.0468 0.089
Schistosoma mansoni DNA polymerase eta 0.0023 0.1766 0.1766
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0485 0.0485
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0468 0.1516
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.1521
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.001 0.0468 0.1388
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.029 0.0546
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.2294 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.029 0.0402
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.1766 0.7511
Plasmodium vivax calcium-transporting ATPase, putative 0.001 0.0468 0.102
Leishmania major copper-transporting ATPase-like protein, putative 0.001 0.0468 0.102
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.089
Onchocerca volvulus 0.001 0.0468 0.0644
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.2294 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0485 0.157
Leishmania major P-type H -ATPase, putative 0.001 0.0468 0.102
Schistosoma mansoni type V p-type atpase isoform 0.001 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0016 0.1061 0.1061
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.2294 1
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.001 0.0468 0.139
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.029 0.0402
Schistosoma mansoni ATPase 0.001 0.0468 0.0468
Trypanosoma brucei unspecified product 0.0016 0.1049 0.55
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.2294 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0485 0.157
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.029 0.0546
Loa Loa (eye worm) hypothetical protein 0.0021 0.1577 0.1577
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.029 0.0548
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.001 0.0468 0.089
Schistosoma mansoni thyroid hormone receptor 0.001 0.0485 0.0485
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.001 0.0468 0.089
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.001 0.0468 0.0468
Giardia lamblia DINP protein human, muc B family 0.0023 0.1766 1
Echinococcus granulosus phospholipid transporting ATPase IIB 0.001 0.0468 0.1516
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.1766 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0468 0.089
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0485 0.0485
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1766 0.5513
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.001 0.0468 0.139
Loa Loa (eye worm) histone methyltransferase 0.0011 0.052 0.052
Loa Loa (eye worm) oxidoreductase 0.0008 0.029 0.029
Trypanosoma cruzi copper-transporting ATPase, putative 0.001 0.0468 0.102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.1061 0.3435
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1766 1
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.001 0.0468 0.1388
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0311 0.0311
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.001 0.0468 0.139
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.029 0.073
Echinococcus granulosus copper transporting ATPase 1 0.001 0.0468 0.1516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.1461 0.6071
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0485 0.0485
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0468 0.1516
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.1766 1
Schistosoma mansoni cation-transporting atpase worm 0.001 0.0468 0.0468
Trypanosoma brucei P-type H+-ATPase, putative 0.001 0.0468 0.185
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.1061 0.3435
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0485 0.157
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0036 0.3062 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.5967 1
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0485 0.0703
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.001 0.0468 0.185
Schistosoma mansoni cpg binding protein 0.0037 0.3089 0.3089
Brugia malayi AMP-binding enzyme family protein 0.0029 0.2294 0.2294
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.029 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.0468 0.0468
Brugia malayi E1-E2 ATPase family protein 0.001 0.0468 0.0468
Schistosoma mansoni phosphoserine phosphatase 0.001 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0021 0.1577 0.1577
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.2294 1
Brugia malayi polk-prov protein 0.0007 0.0174 0.0174
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.029 0.029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.1766 0.7367
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.001 0.0468 0.089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0485 0.0485
Toxoplasma gondii P-type ATPase4, putative 0.001 0.0468 0.0509
Brugia malayi AMP-binding enzyme family protein 0.0029 0.2294 0.2294
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.029 0.0546
Plasmodium falciparum cysteine repeat modular protein 1 0.0036 0.3062 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0485 0.0485
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0468 0.1521
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0485 0.0485
Echinococcus granulosus FTZ F1 alpha 0.001 0.0485 0.157
Giardia lamblia Copper-transporting P-type ATPase 0.001 0.0468 0.185
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0485 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0485 0.0485
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.2294 1
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.001 0.0468 0.089
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0311 0.1006
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.029 0.073
Leishmania major DNA polymerase kappa, putative 0.0023 0.1766 0.5513
Onchocerca volvulus 0.0036 0.3062 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0485 0.0703
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0485 0.0485
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.001 0.0468 0.139
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.1577 0.6617
Echinococcus granulosus calcium transporting ATPase type 2C member 0.001 0.0468 0.1516
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.001 0.0468 0.1516
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0311 0.1006
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.001 0.0468 0.1516
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.2923 0.2923
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0485 0.0485
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.001 0.0468 0.089
Plasmodium vivax P-type ATPase4, putative 0.001 0.0468 0.102
Schistosoma mansoni nuclear hormone receptor 0.001 0.0485 0.0485
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0485 0.0485

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6855 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 4.2569 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.