Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.3253 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0109 | 0.0334 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0052 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.1856 | 0.5704 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0091 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.1957 | 0.1957 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0109 | 0.0334 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0306 | 0.3253 | 0.3253 |
Brugia malayi | Carboxylesterase family protein | 0.0306 | 0.3253 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1957 | 0.1957 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.1796 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1856 | 0.1856 |
Echinococcus multilocularis | acetylcholinesterase | 0.0306 | 0.3253 | 0.3253 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1957 | 0.1957 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1856 | 0.1856 |
Onchocerca volvulus | 0.0114 | 0.0794 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0306 | 0.3253 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.1796 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.1547 | 0.3643 |
Echinococcus granulosus | acetylcholinesterase | 0.0306 | 0.3253 | 0.3253 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.4005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0109 | 0.0334 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0306 | 0.3253 | 0.3253 |
Echinococcus multilocularis | acetylcholinesterase | 0.0306 | 0.3253 | 0.3253 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.4005 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.4005 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0109 | 0.0334 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1957 | 0.1957 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.4005 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.1856 | 0.1856 |
Echinococcus granulosus | carboxylesterase 5A | 0.0306 | 0.3253 | 0.3253 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.1505 | 0.1505 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0306 | 0.3253 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.1505 | 0.1505 |
Brugia malayi | Carboxylesterase family protein | 0.0306 | 0.3253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.3253 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.1856 | 0.5704 |
Echinococcus granulosus | acetylcholinesterase | 0.0306 | 0.3253 | 0.3253 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.