Detailed information for compound 1434467

Basic information

Technical information
  • TDR Targets ID: 1434467
  • Name: N-(2-methylphenyl)-4-oxochromene-2-carboxamid e
  • MW: 279.29 | Formula: C17H13NO3
  • H donors: 1 H acceptors: 2 LogP: 2.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(=O)c2c(o1)cccc2)Nc1ccccc1C
  • InChi: 1S/C17H13NO3/c1-11-6-2-4-8-13(11)18-17(20)16-10-14(19)12-7-3-5-9-15(12)21-16/h2-10H,1H3,(H,18,20)
  • InChiKey: IUUPUVRMFSPLHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-methylphenyl)-4-oxo-chromene-2-carboxamide
  • N-(2-methylphenyl)-4-oxo-2-chromenecarboxamide
  • 4-keto-N-(2-methylphenyl)chromene-2-carboxamide
  • ZINC00189196
  • T5595227
  • MLS000577334
  • N-(2-methylphenyl)-4-oxo-4H-chromene-2-carboxamide
  • SMR000197444
  • Oprea1_731571

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0257 0.0257
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0076 0.0769 1
Loa Loa (eye worm) calcium ATPase 0.0041 0.0238 0.0457
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0257 0.0257
Brugia malayi RNA binding protein 0.0076 0.0772 0.1362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0834 0.1482
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0315 0.4397 1
Echinococcus granulosus NADH dehydrogenase subunit 1 0.015 0.1887 0.1887
Onchocerca volvulus 0.004 0.0223 0.0116
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0071 0.0683 0.1451
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0044 0.0279 0.0135
Brugia malayi E1-E2 ATPase family protein 0.0047 0.0327 0.0493
Echinococcus multilocularis nervana 2 0.0195 0.2567 0.2567
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0315 0.4397 0.8457
Brugia malayi nuclear hormone receptor 0.0038 0.0187 0.0221
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0187 0.036
Onchocerca volvulus 0.0172 0.2228 0.6603
Trichomonas vaginalis cation-transporting ATPase, putative 0.007 0.067 0.1188
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0195 0.2567 0.2567
Onchocerca volvulus 0.0172 0.2228 0.6603
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.143 0.2749
Loa Loa (eye worm) hypothetical protein 0.0037 0.0167 0.032
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.1188
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.2542
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0834 0.1482
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0186 0.2433 0.2433
Loa Loa (eye worm) hypothetical protein 0.0192 0.2519 0.4844
Entamoeba histolytica rodhanase-like domain containing protein 0.0172 0.2228 1
Brugia malayi hypothetical protein 0.0043 0.027 0.0382
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0834 0.0834
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.2542
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.0834 0.0834
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0187 0.0221
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0166 0.2129 0.4094
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0257 0.0493
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0834 0.0834
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0167 0.0215
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0071 0.0683 0.0683
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.0104 0.1188 0.1188
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0071 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Brugia malayi steroid hormone receptor 0.0081 0.0834 0.1482
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0315 0.4397 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.007 0.067 0.1378
Entamoeba histolytica rodhanase-like domain containing protein 0.0172 0.2228 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Trypanosoma brucei P-type H+-ATPase, putative 0.0041 0.0227 0.0354
Leishmania major calcium-transporting ATPase, putative 0.0071 0.0683 0.1409
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.0834 0.1482
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0772 0.1362
Loa Loa (eye worm) hypothetical protein 0.0172 0.2228 0.4285
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0167 0.0167
Echinococcus multilocularis nervana 2 0.0195 0.2567 0.2567
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0071 0.0683 0.1188
Echinococcus multilocularis microtubule associated protein 2 0.0684 1 1
Echinococcus granulosus Na:K ATPase alpha subunit 0.0186 0.2433 0.2433
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0071 0.0683 0.122
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0159 0.2029 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0129 0.0108
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0187 0.0187
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0187 0.0221
Loa Loa (eye worm) DR-78 0.0038 0.0187 0.036
Loa Loa (eye worm) hypothetical protein 0.0172 0.2228 0.4285
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0235 0.3185 0.3185
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0042 0.0241 0.0489
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0257 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0834 0.1603
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Entamoeba histolytica hypothetical protein 0.0043 0.027 0.0629
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0315 0.4397 0.8435
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0834 0.1482
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0071 0.0683 0.0683
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0315 0.4397 0.4397
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0074 0.005
Trichomonas vaginalis cation-transporting ATPase, putative 0.007 0.067 0.1188
Brugia malayi nuclear receptor NHR-88 0.0038 0.0187 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0449 0.0449
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0834 0.1482
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0045 0.0293 0.0563
Trichomonas vaginalis cation-transporting ATPase, putative 0.0041 0.0227 0.0143
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0071 0.0683 0.1451
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0167 0.0136
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0187 0.036
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0035 0.0141 0.0131
Brugia malayi Pax transcription factor protein 2 0.0242 0.3278 0.6251
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.1188
Schistosoma mansoni nuclear receptor 0.0038 0.0187 0.0187
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0834 0.2091
Trichomonas vaginalis cation-transporting ATPase, putative 0.007 0.067 0.1188
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0834 0.1482
Onchocerca volvulus 0.0185 0.242 0.7222
Plasmodium falciparum calcium-transporting ATPase 0.0071 0.0683 0.8882
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.007 0.067 0.2219
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0167 0.0167
Brugia malayi tailless protein 0.0038 0.0187 0.0221
Brugia malayi NADH dehydrogenase subunit 1, identical 0.004 0.0223 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0834 0.1482
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0772 0.0772
Schistosoma mansoni nuclear receptor 0.0038 0.0187 0.0187
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0187 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0159 0.2024 0.3892
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0172 0.2228 0.4873
Trypanosoma cruzi P-type H+-ATPase, putative 0.0041 0.0227 0.0402
Brugia malayi hypothetical protein 0.0038 0.0187 0.0221
Entamoeba histolytica hypothetical protein 0.0043 0.027 0.0629
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.007 0.067 0.1378
Loa Loa (eye worm) hypothetical protein 0.0115 0.136 0.2615
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0041 0.0238 0.0319
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.0834 0.0834
Echinococcus granulosus nervana 2 0.0235 0.3185 0.3185
Schistosoma mansoni zinc finger protein 0.0038 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.1188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0834 0.1603
Mycobacterium ulcerans membrane protein ComEA 0.007 0.0677 0.1395
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0195 0.2567 0.2567
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0834 0.0834
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0167 0.0263
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0187 0.0221
Mycobacterium ulcerans formate hydrogenlyase HycD 0.004 0.0223 0.0345
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0045 0.0293 0.0553
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0772 0.0772
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0235 0.3185 0.3185
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0834 0.0834
Schistosoma mansoni NADH dehydrogenase subunit 1 0.004 0.0223 0.0223
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.007 0.067 0.067
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0076 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Plasmodium vivax P-type ATPase4, putative 0.0076 0.0769 1
Echinococcus multilocularis nervana 2 0.0235 0.3185 0.3185
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0187 0.036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0449 0.0449
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0449 0.0449
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.037 0.0577
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0834 0.0834
Trypanosoma brucei P-type H+-ATPase, putative 0.0041 0.0227 0.0354
Brugia malayi nuclear receptor NHR-88 0.0081 0.0834 0.1482
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0187 0.0187
Brugia malayi Na,K-ATPase alpha subunit 0.0192 0.2519 0.477
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0071 0.0683 0.0683
Schistosoma mansoni ATPase 0.007 0.067 0.067
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0074 0.0142
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0166 0.2129 0.4009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0187 0.0187
Loa Loa (eye worm) pax transcription factor protein 2 0.0242 0.3278 0.6305
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Brugia malayi ecdysone receptor 0.0038 0.0187 0.0221
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.007 0.067 0.1378
Echinococcus granulosus FTZ F1 alpha 0.0081 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Loa Loa (eye worm) hypothetical protein 0.0188 0.246 0.4731
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0834 0.0834
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0172 0.2228 0.4873
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.007 0.067 0.142
Loa Loa (eye worm) hypothetical protein 0.0043 0.0257 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0834 0.1482
Onchocerca volvulus 0.0235 0.3185 0.9699
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0074 0.0142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0834 0.0834
Brugia malayi hypothetical protein 0.0043 0.0257 0.0356
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0315 0.4397 0.4397
Loa Loa (eye worm) hypothetical protein 0.0043 0.0257 0.0493
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0186 0.2433 0.2433
Loa Loa (eye worm) hypothetical protein 0.005 0.037 0.0711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0834 0.1603
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Leishmania major P-type ATPase, putative 0.0071 0.0683 0.1409
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0315 0.4397 0.4397
Echinococcus granulosus nervana 2 0.0195 0.2567 0.2567
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0834 0.0834
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0772 0.0772
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0315 0.4397 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0368 0.52 1
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0071 0.0683 0.8631
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0167 0.0263
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0187 0.0187
Loa Loa (eye worm) E1-E2 ATPase 0.0041 0.0227 0.0437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0449 0.0449
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0235 0.3185 0.3185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0834 0.1603
Brugia malayi calcium ATPase 0.0035 0.0141 0.0131
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0187 0.0187
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0187 0.0221
Onchocerca volvulus 0.0195 0.2567 0.77
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.004 0.0223 0.0429
Loa Loa (eye worm) hypothetical protein 0.0043 0.0257 0.0493
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0074 0.0142
Leishmania major P-type H -ATPase, putative 0.0041 0.0227 0.0354
Loa Loa (eye worm) hypothetical protein 0.0159 0.2024 0.3892
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0167 0.0181
Treponema pallidum nitrogen fixation protein (rnfC) 0.007 0.0677 0.5
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0368 0.52 0.52
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0071 0.0683 0.0683
Trichomonas vaginalis cdc25c, putative 0.0172 0.2228 0.4873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0449 0.0449
Trichomonas vaginalis cdc25b, putative 0.0172 0.2228 0.4873
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0167 0.0167
Echinococcus granulosus nervana 2 0.0195 0.2567 0.2567
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.037 0.0711
Loa Loa (eye worm) hypothetical protein 0.013 0.1587 0.3052
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0169 0.2176 0.6434
Trypanosoma brucei RNA helicase, putative 0.0104 0.1188 0.2576
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0187 0.0221
Brugia malayi nuclear hormone receptor 0.0081 0.0834 0.1482
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.007 0.067 0.1378
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0772 0.1484
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Loa Loa (eye worm) hypothetical protein 0.0235 0.3185 0.6126
Schistosoma mansoni ATPase 0.007 0.067 0.067
Echinococcus granulosus calcium transporting atpase 0.0071 0.0683 0.0683
Schistosoma mansoni transmemberane protein 0.0235 0.3185 0.3185
Loa Loa (eye worm) hypothetical protein 0.0144 0.1802 0.3466
Entamoeba histolytica hypothetical protein 0.0043 0.027 0.0629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0449 0.0449
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0257 0.0356
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0167 0.0167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0834 0.0834
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.0834 0.0834
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0172 0.2228 0.2228
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0187 0.0187
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0076 0.0769 0.0769
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0172 0.2228 0.2228
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0834 0.1482
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0167 0.0215
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0834 0.1482
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0071 0.0683 0.1409
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0271
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0044 0.0279 0.0475
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.015 0.1887 0.3987
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0187 0.0187
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.007 0.067 0.1378
Brugia malayi hypothetical protein 0.0038 0.0187 0.0221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0834 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0834 0.1482
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.143 0.2749
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0315 0.4397 1
Plasmodium vivax calcium-transporting ATPase, putative 0.0076 0.0769 1
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0071 0.0683 0.0683
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0187 0.0187
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.027 0.027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.0834 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0834 0.1482
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0195 0.2567 0.2567
Brugia malayi glutathione transferase 0.0188 0.246 0.4655
Loa Loa (eye worm) hypothetical protein 0.0045 0.0293 0.0563
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0167 0.0167
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0368 0.52 0.52
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0315 0.4397 1
Trypanosoma brucei calcium-translocating P-type ATPase 0.0071 0.0683 0.1409
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0186 0.2433 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0167 0.0167
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0315 0.4397 1
Brugia malayi Rhodanese-like domain containing protein 0.0172 0.2228 0.4203
Toxoplasma gondii P-type ATPase4, putative 0.0076 0.0769 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0677 0.1088
Brugia malayi nuclear receptor RXR 0.0038 0.0187 0.0221
Brugia malayi Rhodanese-like domain containing protein 0.0172 0.2228 0.4203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0834 0.1482
Schistosoma mansoni hypothetical protein 0.0034 0.0129 0.0129
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0187 0.0187
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0192 0.2519 0.2519
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0071 0.0683 0.0683
Leishmania major calcium motive p-type ATPase, putative 0.0071 0.0683 0.1409
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0195 0.2567 0.2567
Schistosoma mansoni coup transcription factor 0.0081 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0449 0.0732
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0187 0.0187
Trypanosoma brucei calcium-transporting ATPase, putative 0.0045 0.0293 0.0506
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0235 0.3185 0.3185
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0834 0.1482
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0172 0.2228 0.4873
Brugia malayi calcium ATPase 0.0036 0.0152 0.0152
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0172 0.2228 0.4873
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Schistosoma mansoni hypothetical protein 0.0043 0.027 0.027
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0064 0.0584 0.1839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0834 0.1603
Leishmania major P-type H -ATPase, putative 0.0041 0.0227 0.0354
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0076 0.0769 0.3017
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0235 0.3185 0.3185
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.037 0.0577
Loa Loa (eye worm) hypothetical protein 0.007 0.067 0.1287
Toxoplasma gondii P-type ATPase PMA1 0.0041 0.0227 0.1369
Loa Loa (eye worm) hypothetical protein 0.0235 0.3185 0.6126
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0167 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0449 0.0449
Brugia malayi TAR-binding protein 0.0076 0.0772 0.1362
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0076 0.0769 0.0769
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0187 0.0221
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0074 0.005
Echinococcus multilocularis calcium transporting atpase 0.0071 0.0683 0.0683
Schistosoma mansoni microtubule-associated protein tau 0.0684 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0834 0.0834
Trypanosoma cruzi Calcium ATPase SERCA-like 0.007 0.067 0.142
Brugia malayi nuclear receptor NHR-67 0.0038 0.0187 0.0221
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.007 0.067 0.8418
Onchocerca volvulus 0.004 0.0223 0.0116
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.007 0.067 0.142
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0315 0.4397 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0834 0.1603
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0257 0.0356
Loa Loa (eye worm) RNA binding protein 0.0076 0.0772 0.1484
Trypanosoma cruzi P-type H+-ATPase, putative 0.0041 0.0227 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0834 0.1603
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.2542
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.027 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0834 0.1482
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0071 0.0683 0.0683
Leishmania major calcium-translocating P-type ATPase 0.007 0.067 0.1378
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0043 0.0257 0.0493
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0834 0.0834
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0235 0.3185 0.3185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0834 0.1603
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0834 0.2091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0772 0.1484
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0315 0.4397 1
Entamoeba histolytica hypothetical protein 0.0043 0.027 0.0629
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0035 0.0141 0.0271
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0449 0.0863
Echinococcus multilocularis thyroid hormone receptor alpha 0.0081 0.0834 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0834 0.1482
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0187 0.0187
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.015 0.1887 0.4194
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0834 0.0834
Brugia malayi MH2 domain containing protein 0.012 0.143 0.2645
Loa Loa (eye worm) hypothetical protein 0.0043 0.0257 0.0493
Brugia malayi hypothetical protein 0.004 0.0223 0.0291
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0035 0.0141 0.0204
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0076 0.0769 0.0769
Brugia malayi NADH dehydrogenase subunit 1 0.004 0.0223 0.0291
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0315 0.4397 1
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0071 0.0683 0.0683
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0192 0.2519 0.4844
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0834 0.0834
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0772 0.0772
Entamoeba histolytica rodhanase-like domain containing protein 0.0172 0.2228 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0368 0.52 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.007 0.067 0.1188
Trypanosoma cruzi P-type H+-ATPase, putative 0.0035 0.0141 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0834 0.1603
Onchocerca volvulus 0.0242 0.3278 1
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.007 0.067 0.1188
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0315 0.4397 1
Echinococcus granulosus nervana 2 0.0235 0.3185 0.3185
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0772 0.0772
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0172 0.2228 0.2228
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.015 0.1887 0.1887
Loa Loa (eye worm) hypothetical protein 0.0034 0.0129 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0834 0.0834
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0368 0.52 0.52
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0834 0.0834
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0187 0.0187
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0187 0.0187
Brugia malayi ecdysteroid receptor 0.0081 0.0834 0.1482
Echinococcus granulosus tar DNA binding protein 0.0076 0.0772 0.0772
Trichomonas vaginalis cdc25b, putative 0.0172 0.2228 0.4873
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0076 0.0769 0.1607
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0035 0.0141 0.0204
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0076 0.0769 0.1423
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0076 0.0769 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0257 0.0257
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0834 0.0834
Onchocerca volvulus 0.0172 0.2228 0.6603
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0172 0.2228 0.4873
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0185 0.242 0.5425
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0045 0.0293 0.0427
Brugia malayi hypothetical protein 0.0043 0.0257 0.0356
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0834 0.0834
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0834 0.2091
Onchocerca volvulus 0.0081 0.0834 0.2091
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0041 0.0238 0.0475
Echinococcus multilocularis nervana 2 0.0235 0.3185 0.3185
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0187 0.0187
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.007 0.067 0.067
Brugia malayi Membrane calcium atpase protein 3 0.0071 0.0683 0.1188
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0834 0.0834
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0235 0.3185 0.3185
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0834 0.0834
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0235 0.3185 0.3185
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.036
Brugia malayi nuclear receptor RXR 0.0043 0.0257 0.0356
Brugia malayi conserved hypotetical protein 0.0038 0.0187 0.0221
Onchocerca volvulus 0.0172 0.2228 0.6603

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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