TDR Targets

Basic information

Technical information

TDR Targets ID: 1434475
Name: (4-cyclohexylpiperazin-1-yl)-[5-[(4-methoxyph enyl)sulfonylmethyl]furan-2-yl]methanone
MW: 446.56 | Formula: C23H30N2O5S
H donors: 0 H acceptors: 3 LogP: 3.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)Cc1ccc(o1)C(=O)N1CCN(CC1)C1CCCCC1
InChi: 1S/C23H30N2O5S/c1-29-19-7-10-21(11-8-19)31(27,28)17-20-9-12-22(30-20)23(26)25-15-13-24(14-16-25)18-5-3-2-4-6-18/h7-12,18H,2-6,13-17H2,1H3
InChiKey: WFKRHGQRBKQHPT-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(4-cyclohexylpiperazin-1-yl)-[5-[(4-methoxyphenyl)sulfonylmethyl]-2-furyl]methanone
(4-cyclohexyl-1-piperazinyl)-[5-[(4-methoxyphenyl)sulfonylmethyl]-2-furyl]methanone
MLS000120223
SMR000097140

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Schistosoma mansoni	hypothetical protein	0.0111	0.0711	0.666
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0111	0.0711	0.1579
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0332	0.4389	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0126	0.096	0.096
Loa Loa (eye worm)	ACC-1 protein	0.0126	0.096	0.096
Brugia malayi	Cytochrome P450 family protein	0.0111	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0111	0.0711	0.1436
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0126	0.096	0.266
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0111	0.0711	0.1579
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0126	0.096	0.096
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0126	0.096	0.266
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0111	0.0711	0.1579
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0126	0.096	0.266
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0111	0.0711	0.1436
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0111	0.0711	0.1436
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0126	0.096	0.266
Loa Loa (eye worm)	CYP4Cod1	0.0233	0.2733	0.2733
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0126	0.096	0.9002
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0126	0.096	0.096
Onchocerca volvulus		0.0126	0.096	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0094	0.0259
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0111	0.0711	0.1436
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0126	0.096	0.096
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0111	0.0711	0.1579
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0233	0.2733	0.6144
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0126	0.096	0.9002
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0111	0.0711	0.1579
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0309	0.4001	1
Brugia malayi	Cation transporter family protein	0.0126	0.096	0.096
Echinococcus multilocularis	glycine receptor subunit beta	0.0126	0.096	0.266
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0126	0.096	0.266
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0111	0.0711	0.1436
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0111	0.0711	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0111	0.0711	0.2338
Schistosoma mansoni	lipoxygenase	0.0132	0.1067	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0126	0.096	0.266
Schistosoma mansoni	lipoxygenase	0.0092	0.0408	0.3827
Onchocerca volvulus		0.0126	0.096	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0126	0.096	0.096
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0111	0.0711	1
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0111	0.0711	0.1579
Brugia malayi	hypothetical protein	0.0286	0.3611	0.3611
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0111	0.0711	0.1436
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0126	0.096	0.266
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0126	0.096	0.266
Brugia malayi	Cytochrome P450 family protein	0.0398	0.5482	0.5482
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0111	0.0711	0.1436
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0126	0.096	0.266
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Onchocerca volvulus		0.0126	0.096	1
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0111	0.0711	0.1436
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0111	0.0711	0.1436
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.3611	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0111	0.0711	0.1436
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0111	0.0711	0.1579
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0126	0.096	0.9002
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0126	0.096	0.266
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0126	0.096	0.266
Entamoeba histolytica	hypothetical protein	0.0068	0	0.5
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0132	0.1067	0.2955
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0126	0.096	0.266
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0126	0.096	0.096
Mycobacterium leprae	putative cytochrome p450	0.0111	0.0711	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0111	0.0711	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0126	0.096	0.096
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0111	0.0711	0.1579
Loa Loa (eye worm)	LGC-31 protein	0.0126	0.096	0.096
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Leishmania major	cytochrome p450-like protein	0.0111	0.0711	0.2338
Trypanosoma cruzi	cytochrome P450, putative	0.0233	0.2733	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0111	0.0711	0.1579
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0111	0.0711	0.1436
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0126	0.096	0.266
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0126	0.096	0.9002
Echinococcus multilocularis	glycine receptor subunit beta	0.0126	0.096	0.266
Loa Loa (eye worm)	cytochrome P450 family protein	0.0398	0.5482	0.5482
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0111	0.0711	0.1579
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0111	0.0711	0.1436
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0111	0.0711	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0671	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0094	0.0877
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0122	0.09	0.09
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0126	0.096	0.266
Loa Loa (eye worm)	cytochrome P450 family protein	0.0233	0.2733	0.2733
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0111	0.0711	0.1579
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0111	0.0711	0.1579
Onchocerca volvulus	Putative nachr subunit	0.0126	0.096	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0111	0.0711	0.1579
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0126	0.096	0.9002
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0111	0.0711	0.1436
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0126	0.096	0.266
Loa Loa (eye worm)	ACC-1 protein	0.0126	0.096	0.096
Brugia malayi	Cation transporter family protein	0.0126	0.096	0.096
Trypanosoma cruzi	cytochrome P450, putative	0.0233	0.2733	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.3611	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0126	0.096	0.096
Brugia malayi	cytochrome P450	0.0111	0.0711	0.0711
Loa Loa (eye worm)	cytochrome P450 family protein	0.0233	0.2733	0.2733
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0126	0.096	0.266
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0111	0.0711	0.1436
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0126	0.096	0.266
Echinococcus granulosus	cytochrome P450 2K1	0.0111	0.0711	0.1968
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0111	0.0711	0.1436
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0111	0.0711	0.1579
Brugia malayi	Cytochrome P450 family protein	0.0233	0.2733	0.2733
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0111	0.0711	0.1579
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0111	0.0711	0.1579
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0126	0.096	0.096
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0094	0.0877
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0132	0.1067	0.2955
Brugia malayi	excitatory GABA receptor EXP-1A	0.0126	0.096	0.096
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0126	0.096	0.266
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0126	0.096	0.266
Loa Loa (eye worm)	hypothetical protein	0.0613	0.904	0.904
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0126	0.096	0.096
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Echinococcus granulosus	glycine receptor subunit beta	0.0126	0.096	0.266
Echinococcus granulosus	nAChR subunit	0.0126	0.096	0.266
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0111	0.0711	0.1579
Schistosoma mansoni	cytochrome P450	0.0111	0.0711	0.666
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0111	0.0711	0.1436
Trypanosoma brucei	cytochrome P450, putative	0.0233	0.2733	1
Onchocerca volvulus		0.0126	0.096	1
Onchocerca volvulus		0.0126	0.096	1
Leishmania major	cytochrome p450-like protein	0.0233	0.2733	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3611	0.3611
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0111	0.0711	0.1436
Echinococcus multilocularis		0.0111	0.0711	0.1968
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0126	0.096	0.9002
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0126	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0126	0.096	0.096
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Leishmania major	cytochrome p450-like protein	0.0111	0.0711	0.2338
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0126	0.096	0.266
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0126	0.096	0.096
Echinococcus multilocularis	nAChR subunit	0.0126	0.096	0.266
Brugia malayi	Cytochrome P450 family protein	0.0233	0.2733	0.2733
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0111	0.0711	0.1436
Schistosoma mansoni	nAChR subunit	0.0126	0.096	0.9002
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0094	0.0259
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0332	0.4389	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0126	0.096	0.096
Loa Loa (eye worm)	cytochrome P450	0.0111	0.0711	0.0711
Echinococcus granulosus	glycine receptor subunit beta	0.0126	0.096	0.266
Brugia malayi	Cation transporter family protein	0.0126	0.096	0.096
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0111	0.0711	0.1436
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0111	0.0711	0.1579
Onchocerca volvulus		0.0126	0.096	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0126	0.096	0.266
Mycobacterium leprae	Conserved hypothetical protein	0.0111	0.0711	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1575166

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1434475