TDR Targets

Basic information

Technical information

TDR Targets ID: 143489
Name: 7-bromo-2-methyl-4-(4-methylpiperazin-1-yl)-1 H-pyrazolo[4,3-c][1,5]benzodiazepine
MW: 375.266 | Formula: C16H19BrN6
H donors: 1 H acceptors: 2 LogP: 2.65 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1nc2cc(Br)ccc2[nH]c2c1cn(n2)C
InChi: 1S/C16H19BrN6/c1-21-5-7-23(8-6-21)16-12-10-22(2)20-15(12)18-13-4-3-11(17)9-14(13)19-16/h3-4,9-10H,5-8H2,1-2H3,(H,18,20)
InChiKey: IYGACQNPUQTXDA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-bromo-2-methyl-4-(4-methyl-1-piperazinyl)-1H-pyrazolo[4,3-c][1,5]benzodiazepine
7-bromo-2-methyl-4-(4-methylpiperazino)-1H-pyrazolo[4,3-c][1,5]benzodiazepine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine D2 receptor	Starlite/ChEMBL	References
Rattus norvegicus	Muscarinic acetylcholine receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Dopamine D2 receptor	444 aa	386 aa	19.7 %
Schistosoma mansoni	biogenic amine receptor	Muscarinic acetylcholine receptor	466 aa	484 aa	24.4 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Muscarinic acetylcholine receptor	466 aa	461 aa	23.9 %
Schistosoma mansoni	growth hormone secretagogue receptor	Muscarinic acetylcholine receptor	466 aa	462 aa	19.9 %
Schistosoma mansoni	amine GPCR	Dopamine D2 receptor	444 aa	424 aa	32.1 %
Echinococcus granulosus	g protein coupled receptor	Dopamine D2 receptor	444 aa	457 aa	21.0 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Dopamine D2 receptor	444 aa	474 aa	23.4 %
Schistosoma japonicum	Octopamine receptor, putative	Dopamine D2 receptor	444 aa	456 aa	29.4 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D2 receptor	444 aa	432 aa	30.8 %
Schistosoma japonicum	Octopamine receptor 1, putative	Muscarinic acetylcholine receptor	466 aa	412 aa	22.6 %
Schistosoma mansoni	biogenic amine receptor	Dopamine D2 receptor	444 aa	452 aa	30.1 %
Onchocerca volvulus		Dopamine D2 receptor	444 aa	418 aa	23.0 %
Echinococcus multilocularis	serotonin receptor	Dopamine D2 receptor	444 aa	428 aa	31.3 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Dopamine D2 receptor	444 aa	494 aa	26.3 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Muscarinic acetylcholine receptor	466 aa	459 aa	20.0 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Dopamine D2 receptor	444 aa	476 aa	24.2 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Dopamine D2 receptor	444 aa	487 aa	23.8 %
Loa Loa (eye worm)	hypothetical protein	Dopamine D2 receptor	444 aa	433 aa	21.2 %
Echinococcus multilocularis	alpha 1A adrenergic receptor	Muscarinic acetylcholine receptor	466 aa	459 aa	21.1 %
Onchocerca volvulus		Muscarinic acetylcholine receptor	466 aa	472 aa	24.6 %
Echinococcus granulosus	biogenic amine 5HT receptor	Dopamine D2 receptor	444 aa	429 aa	31.7 %
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Muscarinic acetylcholine receptor	466 aa	461 aa	26.0 %
Loa Loa (eye worm)	TYRA-2 protein	Muscarinic acetylcholine receptor	466 aa	497 aa	24.7 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Dopamine D2 receptor	444 aa	440 aa	30.0 %
Echinococcus multilocularis	g protein coupled receptor	Dopamine D2 receptor	444 aa	465 aa	21.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0101	0.1734	0.1734
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	hypothetical protein	0.0103	0.176	0.2623
Schistosoma mansoni	hypothetical protein	0.0101	0.1734	0.2585
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0101	0.1734	0.2585
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	g-protein coupled receptor	0.0101	0.1734	0.2585
Brugia malayi	MH2 domain containing protein	0.0035	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0101	0.1734	0.1734
Schistosoma mansoni	opsin-like receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	neuropeptide F-like receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	g protein coupled receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	opsin-like receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	neuropeptides capa receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	hypothetical protein	0.0222	0.4166	0.621
Loa Loa (eye worm)	nuclear factor I	0.0019	0.0075	0.0075
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0101	0.1734	0.2585
Echinococcus granulosus	g protein coupled receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	transcription factor SMAD2	0.0511	1	1
Loa Loa (eye worm)	Smad1	0.0035	0.0389	0.0389
Echinococcus granulosus	g protein coupled receptor	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	Smad4	0.0035	0.0389	0.0579
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0101	0.1734	0.1734
Echinococcus multilocularis	allatostatin A receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	smad	0.0035	0.0389	0.0579
Brugia malayi	Dopamine receptor	0.0101	0.1734	0.1734
Schistosoma mansoni	hypothetical protein	0.0101	0.1734	0.2585
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	Latrophilin receptor protein 2	0.0103	0.176	0.176
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Brugia malayi	latrophilin 2 splice variant baaae	0.0222	0.4166	0.4166
Echinococcus granulosus	Smad4	0.0035	0.0389	0.0579
Schistosoma mansoni	biogenic amine receptor	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Brugia malayi	follicle stimulating hormone receptor	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.1734	0.2585
Echinococcus granulosus	g-protein coupled receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	MH2 domain containing protein	0.0035	0.0389	0.0389
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0101	0.1734	0.2585
Brugia malayi	G protein-coupled receptor	0.0101	0.1734	0.1734
Onchocerca volvulus		0.0101	0.1734	0.4989
Onchocerca volvulus		0.0101	0.1734	0.4989
Schistosoma mansoni	tar DNA-binding protein	0.0348	0.6709	1
Loa Loa (eye worm)	TYRA-2 protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0103	0.176	0.2623
Echinococcus granulosus	sex peptide receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	melatonin receptor type 1A	0.0101	0.1734	0.1734
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0389	0.0579
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	MH1 domain containing protein	0.0035	0.0389	0.0389
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	7tm_1 domain containing protein	0.0101	0.1734	0.2585
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0324	0.624	0.624
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0101	0.1734	0.1734
Echinococcus granulosus	dro:myosuppressin receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0101	0.1734	0.1734
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0103	0.176	0.2623
Brugia malayi	MH1 domain containing protein	0.0035	0.0389	0.0389
Echinococcus granulosus	biogenic amine 5HT receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	growth hormone secretagogue receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	amine GPCR	0.0101	0.1734	0.2585
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0035	0.0389	0.0579
Schistosoma mansoni	amine GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	GPCR family 2	0.0103	0.176	0.2623
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0324	0.624	0.624
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	tar DNA binding protein	0.0348	0.6709	1
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	hypothetical protein	0.0103	0.176	0.2623
Brugia malayi	MH1 domain containing protein	0.0019	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	orexin receptor type 2	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.1734	0.2585
Schistosoma mansoni	tar DNA-binding protein	0.0348	0.6709	1
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	neuropeptide receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	biogenic amine 5HT receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0101	0.1734	0.2585
Echinococcus granulosus	neuropeptides capa receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	RE15519p	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0103	0.176	0.176
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0035	0.0389	0.0579
Onchocerca volvulus		0.0101	0.1734	0.4989
Echinococcus multilocularis	GPCR, family 2	0.0103	0.176	0.2623
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus multilocularis	neuropeptide s receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	fmrfamide receptor	0.0101	0.1734	0.2585
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	neuropeptide F-like receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	neuropeptides capa receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	orexin receptor type 2	0.0101	0.1734	0.2585
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0101	0.1734	0.1734
Echinococcus granulosus	neuropeptide Y receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	MH1 domain-containing protein	0.0035	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	neuropeptide FF receptor 2	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	tar DNA-binding protein	0.0348	0.6709	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0101	0.1734	0.2585
Schistosoma mansoni	neuropeptide receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	RNA binding protein	0.0348	0.6709	0.6709
Echinococcus granulosus	neuropeptide Y receptor	0.0101	0.1734	0.2585
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0188	0.3476	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0103	0.176	0.2623
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Echinococcus granulosus	G protein coupled receptor 139	0.0101	0.1734	0.2585
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	MH2 domain-containing protein	0.0035	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	GnHR receptor homolog	0.0101	0.1734	0.1734
Schistosoma mansoni	hypothetical protein	0.0101	0.1734	0.2585
Echinococcus multilocularis	neuropeptide Y receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	somatostatin receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	serotonin receptor	0.0101	0.1734	0.2585
Brugia malayi	Smad1	0.0035	0.0389	0.0389
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0101	0.1734	0.1734
Brugia malayi	G protein-coupled receptor F59B2.13	0.0101	0.1734	0.1734
Brugia malayi	putative neuropeptide receptor	0.0101	0.1734	0.1734
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0101	0.1734	0.2585
Brugia malayi	N-terminal motif family protein	0.0188	0.3476	0.3476
Brugia malayi	putative neuropeptide receptor NPR1	0.0101	0.1734	0.1734
Echinococcus granulosus	tar DNA binding protein	0.0348	0.6709	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0222	0.4166	0.4166
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	MH2 domain-containing protein	0.0511	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0101	0.1734	0.2585
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	serotonin receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	neuropeptide F receptor	0.0101	0.1734	0.1734
Brugia malayi	Dopamine receptor protein 1	0.0101	0.1734	0.1734
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0101	0.1734	0.1734
Schistosoma mansoni	neuropeptide receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	neuropeptide receptor A26	0.0101	0.1734	0.2585
Schistosoma mansoni	tar DNA-binding protein	0.0348	0.6709	1
Onchocerca volvulus		0.0101	0.1734	0.4989
Schistosoma mansoni	neuropeptide f receptor 76f	0.0101	0.1734	0.2585
Echinococcus granulosus	neuropeptide receptor A26	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Onchocerca volvulus		0.0101	0.1734	0.4989
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	RNA binding protein	0.0348	0.6709	0.6709
Brugia malayi	RNA recognition motif domain containing protein	0.0348	0.6709	0.6709
Echinococcus granulosus	somatostatin receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0101	0.1734	0.2585
Echinococcus multilocularis	smad	0.0035	0.0389	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	hypothetical protein	0.0101	0.1734	0.1734
Onchocerca volvulus		0.0101	0.1734	0.4989
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0101	0.1734	0.2585
Brugia malayi	TAR-binding protein	0.0348	0.6709	0.6709
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	amine GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	mothers against decapentaplegic 5	0.0035	0.0389	0.0579
Brugia malayi	larval opioid receptor	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	neuropeptide F receptor	0.0101	0.1734	0.1734
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus granulosus	allatostatin A receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	amine GPCR	0.0101	0.1734	0.2585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0035	0.0389	0.0579
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0101	0.1734	0.2585
Brugia malayi	Serotonin receptor	0.0101	0.1734	0.1734
Schistosoma mansoni	histamine h1 receptor	0.0101	0.1734	0.2585
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0101	0.1734	0.4989
Schistosoma mansoni	hypothetical protein	0.0103	0.176	0.2623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus granulosus	hypothetical protein	0.0101	0.1734	0.2585
Schistosoma mansoni	opsin-like receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0035	0.0389	0.0579
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Echinococcus multilocularis	neuropeptides capa receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	neuropeptide receptor	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0101	0.1734	0.2585
Echinococcus multilocularis	neuropeptide receptor	0.0101	0.1734	0.2585
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0324	0.624	0.624
Brugia malayi	neuropeptide F receptor	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	biogenic amine receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.1734	0.2585
Brugia malayi	G-protein coupled receptor	0.0101	0.1734	0.1734
Brugia malayi	Melatonin receptor type 1A	0.0101	0.1734	0.1734
Schistosoma mansoni	tar DNA-binding protein	0.0348	0.6709	1
Echinococcus multilocularis	Smad4	0.0035	0.0389	0.0579
Loa Loa (eye worm)	G-protein coupled receptor	0.0101	0.1734	0.1734
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.1734	0.2585
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0101	0.1734	0.2585
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0324	0.624	0.624
Echinococcus multilocularis	neuropeptide Y receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Onchocerca volvulus		0.0101	0.1734	0.4989
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	neuropeptide receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.1734	0.2585
Loa Loa (eye worm)	neuropeptide F receptor	0.0101	0.1734	0.1734
Schistosoma mansoni	amine GPCR	0.0101	0.1734	0.2585
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Onchocerca volvulus		0.0101	0.1734	0.4989
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0103	0.176	0.176
Echinococcus granulosus	7TM GPCR rhodopsin	0.0101	0.1734	0.2585
Schistosoma mansoni	hypothetical protein	0.0103	0.176	0.2623
Echinococcus granulosus	neuropeptide s receptor	0.0101	0.1734	0.2585
Brugia malayi	AKH receptor	0.0101	0.1734	0.1734
Brugia malayi	sulfakinin receptor protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	serotonin receptor	0.0101	0.1734	0.2585
Brugia malayi	ORL1-like opioid receptor	0.0101	0.1734	0.1734
Brugia malayi	G-protein coupled receptor	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0101	0.1734	0.1734
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Schistosoma mansoni	hypothetical protein	0.0101	0.1734	0.2585
Echinococcus multilocularis	sex peptide receptor	0.0101	0.1734	0.2585
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0101	0.1734	0.4989
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Onchocerca volvulus		0.0101	0.1734	0.4989
Loa Loa (eye worm)	G-protein coupled receptor	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Brugia malayi	MH1 domain containing protein	0.0019	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0188	0.3476	0.3476
Echinococcus multilocularis	fmrfamide receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Schistosoma mansoni	adenoreceptor	0.0101	0.1734	0.2585
Schistosoma mansoni	neuropeptide receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	fmrfamide receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0101	0.1734	0.2585
Echinococcus granulosus	neuropeptide receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	G protein coupled receptor 139	0.0101	0.1734	0.2585
Brugia malayi	Dopamine receptor protein 2	0.0101	0.1734	0.1734
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0101	0.1734	0.2585
Brugia malayi	Serotonin receptor	0.0101	0.1734	0.1734
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	TAR-binding protein	0.0348	0.6709	0.6709
Echinococcus granulosus	smad	0.0035	0.0389	0.0579
Onchocerca volvulus		0.0101	0.1734	0.4989
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0389	0.0579
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0103	0.176	0.176
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0389	0.0579
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0103	0.176	0.2623
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0348	0.6709	0.6709
Schistosoma mansoni	biogenic amine receptor	0.0101	0.1734	0.2585
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.1734	0.2585
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	myosin xvIII	0.0101	0.1734	0.2585
Echinococcus multilocularis	dro:myosuppressin receptor	0.0101	0.1734	0.2585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.1734	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1734	0.1734

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Compound behavior in rat; NT is Not Tested	ChEMBL.	2573732
Activity (functional)	= 0.5	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (conflict) following dose of 0 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 2	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (timeout) following dose of 0 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 2.1	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (timeout) following dose of 2.5 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 2.2	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (conflict) following dose of 2.5 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 2.6	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (conflict) following dose of 5.0 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 4.1	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (conflic) following dose of 20 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 4.4	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (timeout) following dose of 20 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 5	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (conflict) following dose of 10 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 6	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (timeout) following dose of 5.0 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 8	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (timeout) following dose of 10 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 14.1	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (reward) following dose of 20 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 18.7	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (reward) following dose of 0 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 21.9	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (reward) following dose of 2.5 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 22.1	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (reward) following dose of 5.0 mg/kg po	ChEMBL.	2573732
Activity (functional)	= 23	The compound was evaluated for the anticonflict behavior in male wistar rats as rate of responses (reward) following dose of 10 mg/kg po	ChEMBL.	2573732
ED (functional)	> 5 mg kg-1	Compound administered perorally was evaluated for the conditioned avoidance response in rats	ChEMBL.	2573732
ED (functional)	> 10 mg kg-1	Rotarod response in rat to assess muscular incoordination (following p.o. dosing)	ChEMBL.	2573732
EDmin (functional)	= 12.5 mg kg-1	Compound administered perorally was evaluated for the hypothermia (rectal temperature) in mice	ChEMBL.	2573732
EDmin (functional)	= 12.5 mg kg-1	Compound administered perorally was evaluated for the hypothermia (rectal temperature) in mice	ChEMBL.	2573732
EDmin (functional)	= 25 mg kg-1	Dose below which no catalepsy was observed at any time period (following p.o. dosing)	ChEMBL.	2573732
EDmin (functional)	= 25 mg kg-1	Dose below which no catalepsy was observed at any time period (following p.o. dosing)	ChEMBL.	2573732
IC50 (binding)	= 0.68 uM	Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from striatum of the rat brain	ChEMBL.	2573732
IC50 (binding)	= 0.68 uM	Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from striatum of the rat brain	ChEMBL.	2573732
IC50 (binding)	> 10 uM	Compound was evaluated for the inhibition of [3H]-QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.	ChEMBL.	2573732
IC50 (binding)	> 10 uM	Compound was evaluated for the inhibition of [3H]-QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.	ChEMBL.	2573732

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL86484
PubChem: 12888791

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 143489