Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0156 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0156 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0156 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0156 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0156 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0156 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0156 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0156 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0156 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0156 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activation (functional) | = 10.2 % | Influence of the compound (2 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 5 mins | ChEMBL. | 12182864 |
Activation (functional) | = 18.9 % | Influence of the compound (2 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 10 mins | ChEMBL. | 12182864 |
Activation (functional) | = 39.9 % | Influence of the compound (2 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 20 mins | ChEMBL. | 12182864 |
Activation (functional) | = 57.6 % | Influence of the compound (2 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 30 mins | ChEMBL. | 12182864 |
Activity (functional) | = 2.25 | Effect of compound on AFB1-induced micronuclei formation in rat bone marrow cells (Activity : Micronucletaed cells/1000 cells) | ChEMBL. | 12182864 |
Activity (functional) | = 3.75 | Effect of compound on AFB1-induced micronuclei formation in rat bone marrow cells in the presence of AFB1 (Activity : Micronucletaed cells/1000 cells) | ChEMBL. | 12182864 |
Activity (binding) | = 25.82 % | Effect on TAase activity assessed as activitation of liver microsomal NADPH cytochrome P450 at 5 uM | ChEMBL. | 17182154 |
GI50 (functional) | -4.755 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.576 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.571 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.548 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.536 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.423 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.238 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Inhibition (binding) | = 15.16 % | Effect on TAase activity assessed as inhibition of GST in liver microsome at 50 uM | ChEMBL. | 17182154 |
Inhibition (binding) | = 19 % | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 10 mins | ChEMBL. | 12182864 |
Inhibition (binding) | = 19 % | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 10 mins | ChEMBL. | 12182864 |
Inhibition (binding) | = 37.5 % | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 20 mins | ChEMBL. | 12182864 |
Inhibition (binding) | = 37.5 % | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 20 mins | ChEMBL. | 12182864 |
Inhibition (binding) | = 56.8 % | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 30 mins | ChEMBL. | 12182864 |
Inhibition (binding) | = 56.8 % | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 30 mins | ChEMBL. | 12182864 |
Inhibition (binding) | = 58.4 % | Inhibition of liver microsomal EROD at 25 uM | ChEMBL. | 17182154 |
Inhibition (functional) | = 65 % | Inhibition of micronuclei formation in benzene-induced in Wistar Albino rat bone marrow cells at 300 mg/ kg, ip after 1 hr | ChEMBL. | 17182154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.