Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0105 | 0.1302 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.025 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Carboxylesterase family protein | 0.0624 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1323 | 0.1307 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0109 | 0.1364 | 0.1349 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0309 | 0.4717 | 0.4708 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.1102 | 0.1102 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0352 | 0.0335 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0144 | 0.0879 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1356 | 0.134 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | acetylcholinesterase | 0.0624 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0624 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0624 | 1 | 1 |
Onchocerca volvulus | 0.0229 | 0.3375 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0309 | 0.4717 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0362 | 0.0345 |
Onchocerca volvulus | 0.0036 | 0.0144 | 0.0377 | |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.025 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0352 | 0.0335 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0362 | 0.0345 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0105 | 0.1302 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0309 | 0.4717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2067 | 0.2053 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.1204 | 0.1188 |
Echinococcus granulosus | carbonic anhydrase II | 0.0309 | 0.4717 | 0.4717 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.1204 | 0.1188 |
Echinococcus granulosus | acetylcholinesterase | 0.0624 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.1204 | 1 |
Echinococcus granulosus | neuroligin | 0.0105 | 0.1302 | 0.1302 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0309 | 0.4717 | 0.4708 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.1458 | 0.1443 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.1204 | 0.1204 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0309 | 0.4717 | 0.4708 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0362 | 0.0362 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0115 | 0.1458 | 0.1443 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.2909 | 0.2896 |
Echinococcus granulosus | carboxylesterase 5A | 0.0624 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0105 | 0.1302 | 0.3584 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.3545 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.1229 | 0.1214 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.2067 | 0.2053 |
Loa Loa (eye worm) | carboxylesterase | 0.0624 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.025 | 0.0233 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.2067 | 0.2053 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.1458 | 0.1458 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.025 | 0.0328 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0309 | 0.4717 | 0.4708 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.0843 | 0.0826 |
Echinococcus granulosus | transcription factor eb | 0.0109 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.025 | 0.0233 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0362 | 0.0362 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.2067 | 0.2067 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.1458 | 0.1458 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.1559 | 0.1544 |
Echinococcus multilocularis | transcription factor eb | 0.0109 | 0.1364 | 0.1349 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0144 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.3435 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0105 | 0.1302 | 0.1302 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.1323 | 0.1307 |
Leishmania major | carbonic anhydrase-like protein | 0.0309 | 0.4717 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0144 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.2067 | 0.2053 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.3545 | 0.3545 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.025 | 0.0233 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0144 | 0.0144 |
Onchocerca volvulus | 0.0036 | 0.0144 | 0.0377 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Onchocerca volvulus | 0.0049 | 0.0352 | 0.0995 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0105 | 0.1302 | 0.1302 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0352 | 0.0334 |
Loa Loa (eye worm) | carboxylesterase | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.2909 | 0.2896 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.1559 | 0.1544 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0362 | 0.0345 |
Plasmodium falciparum | carbonic anhydrase | 0.0115 | 0.1458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.2151 | 0.2137 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0144 | 0.0127 |
Onchocerca volvulus | 0.0036 | 0.0144 | 0.0377 | |
Brugia malayi | CHE-14 protein | 0.0043 | 0.025 | 0.0233 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0144 | 0.0127 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Loa Loa (eye worm) | hypothetical protein | 0.0624 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.0843 | 0.0826 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.025 | 0.0233 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0105 | 0.1302 | 0.1287 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0105 | 0.1302 | 0.3518 |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Onchocerca volvulus | 0.0105 | 0.1302 | 0.3826 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0105 | 0.1302 | 0.3518 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | acetylcholinesterase | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.1458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0309 | 0.4717 | 0.4708 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.1458 | 0.1443 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0309 | 0.4717 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.1559 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0412 | 0.0394 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2151 | 0.2137 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0109 | 0.1356 | 0.134 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0843 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0624 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.1323 | 0.1307 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | hypothetical protein | 0.0239 | 0.3545 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2067 | 0.2053 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.192 | 0.192 |
Brugia malayi | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | carboxylesterase | 0.0105 | 0.1302 | 0.1287 |
Schistosoma mansoni | gliotactin | 0.0105 | 0.1302 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.1458 | 0.1443 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0105 | 0.1302 | 0.3584 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0144 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0105 | 0.1302 | 0.1302 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0843 | 0.0826 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.1458 | 0.1458 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.192 | 0.1906 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0144 | 0.0127 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0144 | 0.0127 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0144 | 0.0127 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0362 | 0.0345 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.3375 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.2151 | 0.2137 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0144 | 0.0127 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.1458 | 0.1443 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0352 | 0.0335 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0309 | 0.4717 | 0.4708 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.1102 | 0.1086 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0224 | 0.0207 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1204 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3545 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.1458 | 0.1443 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1458 | 0.1443 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.2151 | 0.2137 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.0843 | 0.0843 |
Echinococcus multilocularis | neuroligin | 0.0105 | 0.1302 | 0.1287 |
Brugia malayi | Carboxylesterase family protein | 0.0105 | 0.1302 | 0.1287 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.025 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0115 | 0.1458 | 0.1443 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0362 | 0.0345 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0309 | 0.4717 | 0.4708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 247800 ng min-1 ml-1 | Area under the serum concentration vs time curve was determined | ChEMBL. | 8355256 |
CIT (ADMET) | = 9.9 ml min-1 kg-1 | Total body clearance was determined | ChEMBL. | 8355256 |
IC50 (functional) | = 9.6 nM | Tested for the inhibition of p24 production in HIV-1 IIIB infected human peripheral blood mononuclear cells (PBMC) | ChEMBL. | 8355256 |
IC90 (functional) | = 46.7 nM | Tested for the inhibition of p24 production in HIV-1 IIIB infected human peripheral blood mononuclear cells (PBMC) | ChEMBL. | 8355256 |
T1/2 beta (ADMET) | = 50.3 min | Half life of the compound was determined | ChEMBL. | 8355256 |
Vbeta (ADMET) | = 727 ml kg-1 | Vbeta of the compound was determined | ChEMBL. | 8355256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.